DatasetNSCLC_collapsed_to_symbols.NSCLC.cls
#SEN_versus_RES.NSCLC.cls
#SEN_versus_RES_repos
PhenotypeNSCLC.cls#SEN_versus_RES_repos
Upregulated in class0
GeneSetAZD4547_LINCS
Enrichment Score (ES)-0.21493001
Normalized Enrichment Score (NES)-0.8271866
Nominal p-value0.84415585
FDR q-value0.959837
FWER p-Value1.0
Table: GSEA Results Summary



Fig 1: Enrichment plot: AZD4547_LINCS   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEGENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1FGFR3FGFR3
Entrez,  Source
fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism)1530.4650.0312No
2FGFR2FGFR2
Entrez,  Source
ffer syndrome, Jackson-Weiss syndrome)2100.4060.0643No
3DDR1DDR1
Entrez,  Source
discoidin domain receptor family, member 12120.4040.1015No
4FRKFRK
Entrez,  Source
fyn-related kinase2960.3430.1268No
5MST43180.3310.1557No
6EPHB6EPHB6
Entrez,  Source
EPH receptor B67010.2150.1463No
7CDK187600.2040.1607No
8TAOK3TAOK3
Entrez,  Source
TAO kinase 39710.1700.1603No
9TNIKTNIK
Entrez,  Source
TRAF2 and NCK interacting kinase11970.1450.1564No
10LCKLCK
Entrez,  Source
lymphocyte-specific protein tyrosine kinase13100.1360.1604No
11TNK1TNK1
Entrez,  Source
tyrosine kinase, non-receptor, 113600.1310.1688No
12CAMK1DCAMK1D
Entrez,  Source
calcium/calmodulin-dependent protein kinase ID13870.1290.1787No
13STK3STK3
Entrez,  Source
serine/threonine kinase 3 (STE20 homolog, yeast)15530.1200.1771No
14INSRINSR
Entrez,  Source
insulin receptor16640.1140.1792No
15MAP3K9MAP3K9
Entrez,  Source
mitogen-activated protein kinase kinase kinase 916990.1120.1870No
16NTRK2NTRK2
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 217040.1120.1970No
17CAMK2ACAMK2A
Entrez,  Source
calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha18010.1070.1995No
18MARK1MARK1
Entrez,  Source
MAP/microtubule affinity-regulating kinase 121590.0930.1808No
19AAK1AAK1
Entrez,  Source
AP2 associated kinase 122120.0920.1853No
20ULK2ULK2
Entrez,  Source
unc-51-like kinase 2 (C. elegans)22440.0910.1913No
21MAP3K11MAP3K11
Entrez,  Source
mitogen-activated protein kinase kinase kinase 1122950.0890.1957No
22TIE1TIE1
Entrez,  Source
tyrosine kinase with immunoglobulin-like and EGF-like domains 123280.0880.2014No
23JAK3JAK3
Entrez,  Source
Janus kinase 3 (a protein tyrosine kinase, leukocyte)24440.0840.2004No
24MERTKMERTK
Entrez,  Source
c-mer proto-oncogene tyrosine kinase25220.0820.2021No
25TAOK1TAOK1
Entrez,  Source
TAO kinase 125520.0820.2074No
26TNK2TNK2
Entrez,  Source
tyrosine kinase, non-receptor, 230050.0700.1793No
27EIF2AK1EIF2AK1
Entrez,  Source
eukaryotic translation initiation factor 2-alpha kinase 130080.0700.1856No
28MINK1MINK1
Entrez,  Source
misshapen-like kinase 1 (zebrafish)30800.0690.1865No
29KDRKDR
Entrez,  Source
kinase insert domain receptor (a type III receptor tyrosine kinase)31460.0680.1878No
30FLT3FLT3
Entrez,  Source
fms-related tyrosine kinase 334030.0630.1740No
31BLKBLK
Entrez,  Source
B lymphoid tyrosine kinase34190.0620.1786No
32TSSK1B34450.0620.1824No
33CSF1RCSF1R
Entrez,  Source
colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog34540.0620.1875No
34MARK2MARK2
Entrez,  Source
MAP/microtubule affinity-regulating kinase 238340.0550.1635No
35ALKALK
Entrez,  Source
anaplastic lymphoma kinase (Ki-1)40730.0510.1500No
36MUSKMUSK
Entrez,  Source
muscle, skeletal, receptor tyrosine kinase41390.0500.1497No
37FGRFGR
Entrez,  Source
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog41930.0490.1502No
38CAMK2BCAMK2B
Entrez,  Source
calcium/calmodulin-dependent protein kinase (CaM kinase) II beta42130.0490.1532No
39AURKCAURKC
Entrez,  Source
aurora kinase C44130.0460.1422No
40NEK2NEK2
Entrez,  Source
NIMA (never in mitosis gene a)-related kinase 244830.0450.1411No
41CDKL2CDKL2
Entrez,  Source
cyclin-dependent kinase-like 2 (CDC2-related kinase)45480.0440.1403No
42FGFR4FGFR4
Entrez,  Source
fibroblast growth factor receptor 447150.0410.1314No
43PHKG2PHKG2
Entrez,  Source
phosphorylase kinase, gamma 2 (testis)47920.0400.1293No
44FLT1FLT1
Entrez,  Source
fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)48820.0390.1261No
45FLT4FLT4
Entrez,  Source
fms-related tyrosine kinase 448980.0390.1285No
46ULK1ULK1
Entrez,  Source
unc-51-like kinase 1 (C. elegans)51570.0350.1120No
47INSRRINSRR
Entrez,  Source
insulin receptor-related receptor53320.0330.1017No
48STK24STK24
Entrez,  Source
serine/threonine kinase 24 (STE20 homolog, yeast)55870.0290.0850No
49STK16STK16
Entrez,  Source
serine/threonine kinase 1657780.0270.0729No
50PAK7PAK7
Entrez,  Source
p21(CDKN1A)-activated kinase 758810.0250.0675No
51MAP3K3MAP3K3
Entrez,  Source
mitogen-activated protein kinase kinase kinase 359210.0250.0668No
52NTRK1NTRK1
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 160970.0220.0554No
53FESFES
Entrez,  Source
feline sarcoma oncogene61260.0220.0553No
54PHKG1PHKG1
Entrez,  Source
phosphorylase kinase, gamma 1 (muscle)62450.0200.0481No
55AURKAAURKA
Entrez,  Source
aurora kinase A64270.0170.0358No
56DCLK264620.0160.0347No
57RETRET
Entrez,  Source
ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease)64710.0160.0356No
58MAP3K10MAP3K10
Entrez,  Source
mitogen-activated protein kinase kinase kinase 1065490.0150.0311No
59BMPR1BBMPR1B
Entrez,  Source
bone morphogenetic protein receptor, type IB67770.0120.0148No
60MAP4K2MAP4K2
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 268940.0100.0069No
61CLK4CLK4
Entrez,  Source
CDC-like kinase 469350.0100.0047No
62BMP2KBMP2K
Entrez,  Source
BMP2 inducible kinase70290.008-0.0017No
63TEKTEK
Entrez,  Source
TEK tyrosine kinase, endothelial (venous malformations, multiple cutaneous and mucosal)70350.008-0.0013No
64TGFBR2TGFBR2
Entrez,  Source
transforming growth factor, beta receptor II (70/80kDa)71030.007-0.0058No
65CLK2CLK2
Entrez,  Source
CDC-like kinase 271810.005-0.0113No
66PRKAA2PRKAA2
Entrez,  Source
protein kinase, AMP-activated, alpha 2 catalytic subunit74180.001-0.0292No
67SIK274350.001-0.0304No
68PDGFRBPDGFRB
Entrez,  Source
platelet-derived growth factor receptor, beta polypeptide7824-0.006-0.0595No
69IGF1RIGF1R
Entrez,  Source
insulin-like growth factor 1 receptor7959-0.008-0.0690No
70MELKMELK
Entrez,  Source
maternal embryonic leucine zipper kinase8047-0.010-0.0748No
71KITKIT
Entrez,  Source
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog8134-0.012-0.0803No
72MAP2K5MAP2K5
Entrez,  Source
mitogen-activated protein kinase kinase 58199-0.013-0.0839No
73MARK4MARK4
Entrez,  Source
MAP/microtubule affinity-regulating kinase 48259-0.014-0.0871No
74CDK168353-0.016-0.0928No
75NTRK3NTRK3
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 38500-0.019-0.1021No
76STK25STK25
Entrez,  Source
serine/threonine kinase 25 (STE20 homolog, yeast)8561-0.021-0.1048No
77AURKBAURKB
Entrez,  Source
aurora kinase B8856-0.027-0.1248No
78ZAP70ZAP70
Entrez,  Source
zeta-chain (TCR) associated protein kinase 70kDa8954-0.030-0.1295No
79TYK2TYK2
Entrez,  Source
tyrosine kinase 29438-0.041-0.1627No
80DCLK19840-0.052-0.1886No
81MAP4K4MAP4K4
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 49922-0.055-0.1898No
82HCKHCK
Entrez,  Source
hemopoietic cell kinase9981-0.056-0.1890No
83STK17ASTK17A
Entrez,  Source
serine/threonine kinase 17a (apoptosis-inducing)10017-0.057-0.1864No
84DDR2DDR2
Entrez,  Source
discoidin domain receptor family, member 210235-0.064-0.1972No
85MARK3MARK3
Entrez,  Source
MAP/microtubule affinity-regulating kinase 310374-0.068-0.2014No
86RPS6KA3RPS6KA3
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 310427-0.070-0.1989No
87PLK4PLK4
Entrez,  Source
polo-like kinase 4 (Drosophila)10581-0.075-0.2037No
88CAMKK2CAMKK2
Entrez,  Source
calcium/calmodulin-dependent protein kinase kinase 2, beta10729-0.081-0.2074Yes
89TBK1TBK1
Entrez,  Source
TANK-binding kinase 110732-0.082-0.2001Yes
90SRCSRC
Entrez,  Source
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)10776-0.083-0.1957Yes
91CHEK1CHEK1
Entrez,  Source
CHK1 checkpoint homolog (S. pombe)10792-0.084-0.1891Yes
92CDK4CDK4
Entrez,  Source
cyclin-dependent kinase 410871-0.087-0.1870Yes
93NUAK1NUAK1
Entrez,  Source
NUAK family, SNF1-like kinase, 111032-0.095-0.1905Yes
94DAPK3DAPK3
Entrez,  Source
death-associated protein kinase 311066-0.096-0.1841Yes
95SRPK1SRPK1
Entrez,  Source
SFRS protein kinase 111068-0.096-0.1753Yes
96ABL2ABL2
Entrez,  Source
v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)11090-0.098-0.1679Yes
97CDK7CDK7
Entrez,  Source
cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase)11160-0.101-0.1639Yes
98STK10STK10
Entrez,  Source
serine/threonine kinase 1011218-0.103-0.1588Yes
99MYLKMYLK
Entrez,  Source
myosin, light chain kinase11255-0.105-0.1518Yes
100RIPK2RIPK2
Entrez,  Source
receptor-interacting serine-threonine kinase 211349-0.110-0.1488Yes
101RIPK1RIPK1
Entrez,  Source
receptor (TNFRSF)-interacting serine-threonine kinase 111427-0.113-0.1443Yes
102STK4STK4
Entrez,  Source
serine/threonine kinase 411518-0.118-0.1403Yes
103JAK2JAK2
Entrez,  Source
Janus kinase 2 (a protein tyrosine kinase)11530-0.119-0.1302Yes
104SLKSLK
Entrez,  Source
STE20-like kinase (yeast)11672-0.128-0.1292Yes
105MAP4K5MAP4K5
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 511705-0.130-0.1197Yes
106FYNFYN
Entrez,  Source
FYN oncogene related to SRC, FGR, YES11767-0.133-0.1121Yes
107MAP2K2MAP2K2
Entrez,  Source
mitogen-activated protein kinase kinase 211895-0.142-0.1087Yes
108WNK1WNK1
Entrez,  Source
WNK lysine deficient protein kinase 112184-0.165-0.1155Yes
109MAP3K2MAP3K2
Entrez,  Source
mitogen-activated protein kinase kinase kinase 212210-0.168-0.1020Yes
110PDGFRAPDGFRA
Entrez,  Source
platelet-derived growth factor receptor, alpha polypeptide12211-0.168-0.0865Yes
111SIK112319-0.179-0.0782Yes
112MAP4K3MAP4K3
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 312403-0.189-0.0671Yes
113ABL1ABL1
Entrez,  Source
v-abl Abelson murine leukemia viral oncogene homolog 112463-0.197-0.0534Yes
114ZAKZAK
Entrez,  Source
-12544-0.209-0.0403Yes
115MAP3K7MAP3K7
Entrez,  Source
mitogen-activated protein kinase kinase kinase 712613-0.221-0.0251Yes
116AXLAXL
Entrez,  Source
AXL receptor tyrosine kinase12789-0.257-0.0148Yes
117FGFR1FGFR1
Entrez,  Source
fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome)13121-0.4860.0047Yes
Table: GSEA details [plain text format]



Fig 2: AZD4547_LINCS   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: AZD4547_LINCS: Random ES distribution   
Gene set null distribution of ES for AZD4547_LINCS