DatasetNSCLC_collapsed_to_symbols.NSCLC.cls
#SEN_versus_RES.NSCLC.cls
#SEN_versus_RES_repos
PhenotypeNSCLC.cls#SEN_versus_RES_repos
Upregulated in class1
GeneSetTG-101348_KINOME SCAN
Enrichment Score (ES)0.28870344
Normalized Enrichment Score (NES)1.0553937
Nominal p-value0.3408
FDR q-value0.76474756
FWER p-Value1.0
Table: GSEA Results Summary



Fig 1: Enrichment plot: TG-101348_KINOME SCAN   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEGENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1DAPK1DAPK1
Entrez,  Source
death-associated protein kinase 1880.5570.0393Yes
2EPHA1EPHA1
Entrez,  Source
EPH receptor A1940.5450.0840Yes
3FGFR3FGFR3
Entrez,  Source
fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism)1530.4650.1180Yes
4FGFR2FGFR2
Entrez,  Source
ffer syndrome, Jackson-Weiss syndrome)2100.4060.1472Yes
5FRKFRK
Entrez,  Source
fyn-related kinase2960.3430.1690Yes
6ROS1ROS1
Entrez,  Source
v-ros UR2 sarcoma virus oncogene homolog 1 (avian)5050.2580.1744Yes
7IKBKBIKBKB
Entrez,  Source
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta5530.2450.1911Yes
8MAP3K13MAP3K13
Entrez,  Source
mitogen-activated protein kinase kinase kinase 136240.2300.2047Yes
9EGFREGFR
Entrez,  Source
epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)6250.2300.2237Yes
10EPHB6EPHB6
Entrez,  Source
EPH receptor B67010.2150.2358Yes
11MAPK10MAPK10
Entrez,  Source
mitogen-activated protein kinase 1010690.1570.2207Yes
12LCKLCK
Entrez,  Source
lymphocyte-specific protein tyrosine kinase13100.1360.2135Yes
13GAKGAK
Entrez,  Source
cyclin G associated kinase13400.1330.2223Yes
14TNK1TNK1
Entrez,  Source
tyrosine kinase, non-receptor, 113600.1310.2317Yes
15CAMK1DCAMK1D
Entrez,  Source
calcium/calmodulin-dependent protein kinase ID13870.1290.2404Yes
16STK17BSTK17B
Entrez,  Source
serine/threonine kinase 17b (apoptosis-inducing)15540.1190.2376Yes
17WEE1WEE1
Entrez,  Source
WEE1 homolog (S. pombe)16390.1150.2407Yes
18INSRINSR
Entrez,  Source
insulin receptor16640.1140.2483Yes
19RPS6KA1RPS6KA1
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 116860.1130.2560Yes
20CAMK2ACAMK2A
Entrez,  Source
calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha18010.1070.2561Yes
21CAMK2GCAMK2G
Entrez,  Source
calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma18110.1070.2642Yes
22DAPK2DAPK2
Entrez,  Source
death-associated protein kinase 218380.1050.2709Yes
23RIOK3RIOK3
Entrez,  Source
RIO kinase 3 (yeast)19420.1010.2714Yes
24LYNLYN
Entrez,  Source
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog19740.1000.2773Yes
25PTK2BPTK2B
Entrez,  Source
PTK2B protein tyrosine kinase 2 beta20420.0980.2802Yes
26MARK1MARK1
Entrez,  Source
MAP/microtubule affinity-regulating kinase 121590.0930.2790Yes
27AAK1AAK1
Entrez,  Source
AP2 associated kinase 122120.0920.2827Yes
28ULK2ULK2
Entrez,  Source
unc-51-like kinase 2 (C. elegans)22440.0910.2878Yes
29TIE1TIE1
Entrez,  Source
tyrosine kinase with immunoglobulin-like and EGF-like domains 123280.0880.2887Yes
30JAK3JAK3
Entrez,  Source
Janus kinase 3 (a protein tyrosine kinase, leukocyte)24440.0840.2869No
31MERTKMERTK
Entrez,  Source
c-mer proto-oncogene tyrosine kinase25220.0820.2878No
32ADCK4ADCK4
Entrez,  Source
aarF domain containing kinase 427150.0770.2795No
33TNK2TNK2
Entrez,  Source
tyrosine kinase, non-receptor, 230050.0700.2632No
34EIF2AK1EIF2AK1
Entrez,  Source
eukaryotic translation initiation factor 2-alpha kinase 130080.0700.2689No
35YES1YES1
Entrez,  Source
v-yes-1 Yamaguchi sarcoma viral oncogene homolog 130360.0700.2726No
36FLT3FLT3
Entrez,  Source
fms-related tyrosine kinase 334030.0630.2497No
37BLKBLK
Entrez,  Source
B lymphoid tyrosine kinase34190.0620.2537No
38CSF1RCSF1R
Entrez,  Source
colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog34540.0620.2562No
39ALKALK
Entrez,  Source
anaplastic lymphoma kinase (Ki-1)40730.0510.2131No
40MUSKMUSK
Entrez,  Source
muscle, skeletal, receptor tyrosine kinase41390.0500.2123No
41FGRFGR
Entrez,  Source
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog41930.0490.2123No
42AURKCAURKC
Entrez,  Source
aurora kinase C44130.0460.1993No
43LIMK1LIMK1
Entrez,  Source
LIM domain kinase 144680.0450.1989No
44RPS6KA6RPS6KA6
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 646850.0420.1859No
45NEK7NEK7
Entrez,  Source
NIMA (never in mitosis gene a)-related kinase 748770.0390.1745No
46ULK1ULK1
Entrez,  Source
unc-51-like kinase 1 (C. elegans)51570.0350.1560No
47ACVR1ACVR1
Entrez,  Source
activin A receptor, type I52300.0340.1533No
48BTKBTK
Entrez,  Source
Bruton agammaglobulinemia tyrosine kinase56280.0290.1253No
49STK16STK16
Entrez,  Source
serine/threonine kinase 1657780.0270.1161No
50SRPK3SRPK3
Entrez,  Source
SFRS protein kinase 358600.0260.1121No
51NTRK1NTRK1
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 160970.0220.0958No
52FESFES
Entrez,  Source
feline sarcoma oncogene61260.0220.0955No
53IRAK1IRAK1
Entrez,  Source
interleukin-1 receptor-associated kinase 161790.0210.0932No
54PHKG1PHKG1
Entrez,  Source
phosphorylase kinase, gamma 1 (muscle)62450.0200.0899No
55DCLK264620.0160.0747No
56RETRET
Entrez,  Source
ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease)64710.0160.0754No
57PIP4K2B65940.0150.0673No
58BMPR1BBMPR1B
Entrez,  Source
bone morphogenetic protein receptor, type IB67770.0120.0544No
59GRK4GRK4
Entrez,  Source
G protein-coupled receptor kinase 467880.0120.0546No
60MAPK8MAPK8
Entrez,  Source
mitogen-activated protein kinase 868290.0110.0524No
61MAPK7MAPK7
Entrez,  Source
mitogen-activated protein kinase 769130.0100.0469No
62BMP2KBMP2K
Entrez,  Source
BMP2 inducible kinase70290.0080.0388No
63IKBKEIKBKE
Entrez,  Source
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon72160.0040.0249No
64ITKITK
Entrez,  Source
IL2-inducible T-cell kinase72200.0040.0250No
65SIK274350.0010.0087No
66SNRKSNRK
Entrez,  Source
SNF related kinase7658-0.003-0.0081No
67PDGFRBPDGFRB
Entrez,  Source
platelet-derived growth factor receptor, beta polypeptide7824-0.006-0.0202No
68MAPK9MAPK9
Entrez,  Source
mitogen-activated protein kinase 97830-0.006-0.0201No
69MKNK2MKNK2
Entrez,  Source
MAP kinase interacting serine/threonine kinase 27841-0.006-0.0203No
70TAOK2TAOK2
Entrez,  Source
TAO kinase 28059-0.010-0.0361No
71KITKIT
Entrez,  Source
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog8134-0.012-0.0408No
72RPS6KA4RPS6KA4
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 48181-0.013-0.0433No
73MAP2K5MAP2K5
Entrez,  Source
mitogen-activated protein kinase kinase 58199-0.013-0.0435No
74MARK4MARK4
Entrez,  Source
MAP/microtubule affinity-regulating kinase 48259-0.014-0.0468No
75DMPKDMPK
Entrez,  Source
dystrophia myotonica-protein kinase8344-0.016-0.0519No
76PTK2PTK2
Entrez,  Source
PTK2 protein tyrosine kinase 28356-0.016-0.0514No
77AURKBAURKB
Entrez,  Source
aurora kinase B8856-0.027-0.0873No
78STK11STK11
Entrez,  Source
serine/threonine kinase 119183-0.035-0.1094No
79TYK2TYK2
Entrez,  Source
tyrosine kinase 29438-0.041-0.1255No
80CSNK2A2CSNK2A2
Entrez,  Source
casein kinase 2, alpha prime polypeptide9758-0.049-0.1458No
81NEK9NEK9
Entrez,  Source
NIMA (never in mitosis gene a)- related kinase 99810-0.051-0.1455No
82DCLK19840-0.052-0.1435No
83TTKTTK
Entrez,  Source
TTK protein kinase9930-0.055-0.1457No
84STK17ASTK17A
Entrez,  Source
serine/threonine kinase 17a (apoptosis-inducing)10017-0.057-0.1476No
85HIPK2HIPK2
Entrez,  Source
homeodomain interacting protein kinase 210151-0.061-0.1528No
86DDR2DDR2
Entrez,  Source
discoidin domain receptor family, member 210235-0.064-0.1539No
87MARK3MARK3
Entrez,  Source
MAP/microtubule affinity-regulating kinase 310374-0.068-0.1588No
88CITCIT
Entrez,  Source
citron (rho-interacting, serine/threonine kinase 21)10420-0.070-0.1565No
89PLK1PLK1
Entrez,  Source
polo-like kinase 1 (Drosophila)10440-0.071-0.1521No
90PLK4PLK4
Entrez,  Source
polo-like kinase 4 (Drosophila)10581-0.075-0.1565No
91JAK1JAK1
Entrez,  Source
Janus kinase 1 (a protein tyrosine kinase)10585-0.076-0.1505No
92TBK1TBK1
Entrez,  Source
TANK-binding kinase 110732-0.082-0.1550No
93SRCSRC
Entrez,  Source
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)10776-0.083-0.1514No
94PIP5K1APIP5K1A
Entrez,  Source
phosphatidylinositol-4-phosphate 5-kinase, type I, alpha10780-0.083-0.1447No
95CDK4CDK4
Entrez,  Source
cyclin-dependent kinase 410871-0.087-0.1444No
96NUAK1NUAK1
Entrez,  Source
NUAK family, SNF1-like kinase, 111032-0.095-0.1488No
97DAPK3DAPK3
Entrez,  Source
death-associated protein kinase 311066-0.096-0.1434No
98SRPK1SRPK1
Entrez,  Source
SFRS protein kinase 111068-0.096-0.1355No
99ABL2ABL2
Entrez,  Source
v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)11090-0.098-0.1290No
100CDK7CDK7
Entrez,  Source
cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase)11160-0.101-0.1260No
101MYLKMYLK
Entrez,  Source
myosin, light chain kinase11255-0.105-0.1245No
102SRPK2SRPK2
Entrez,  Source
SFRS protein kinase 211496-0.117-0.1332No
103JAK2JAK2
Entrez,  Source
Janus kinase 2 (a protein tyrosine kinase)11530-0.119-0.1259No
104SLKSLK
Entrez,  Source
STE20-like kinase (yeast)11672-0.128-0.1262No
105FYNFYN
Entrez,  Source
FYN oncogene related to SRC, FGR, YES11767-0.133-0.1224No
106NEK3NEK3
Entrez,  Source
NIMA (never in mitosis gene a)-related kinase 311797-0.135-0.1134No
107HIPK1HIPK1
Entrez,  Source
homeodomain interacting protein kinase 111798-0.135-0.1022No
108PRPF4BPRPF4B
Entrez,  Source
PRP4 pre-mRNA processing factor 4 homolog B (yeast)11856-0.139-0.0951No
109CSNK2A1CSNK2A1
Entrez,  Source
casein kinase 2, alpha 1 polypeptide11861-0.139-0.0839No
110MAP3K2MAP3K2
Entrez,  Source
mitogen-activated protein kinase kinase kinase 212210-0.168-0.0966No
111SIK112319-0.179-0.0901No
112IRAK3IRAK3
Entrez,  Source
interleukin-1 receptor-associated kinase 312451-0.196-0.0840No
113ABL1ABL1
Entrez,  Source
v-abl Abelson murine leukemia viral oncogene homolog 112463-0.197-0.0685No
114ZAKZAK
Entrez,  Source
-12544-0.209-0.0574No
115CDK1712578-0.213-0.0423No
116AXLAXL
Entrez,  Source
AXL receptor tyrosine kinase12789-0.257-0.0371No
117CHUKCHUK
Entrez,  Source
conserved helix-loop-helix ubiquitous kinase12978-0.325-0.0246No
118FGFR1FGFR1
Entrez,  Source
fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome)13121-0.4860.0047No
Table: GSEA details [plain text format]



Fig 2: TG-101348_KINOME SCAN   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: TG-101348_KINOME SCAN: Random ES distribution   
Gene set null distribution of ES for TG-101348_KINOME SCAN