DatasetNSCLC_collapsed_to_symbols.NSCLC.cls
#SEN_versus_RES.NSCLC.cls
#SEN_versus_RES_repos
PhenotypeNSCLC.cls#SEN_versus_RES_repos
Upregulated in class1
GeneSetR406_KINOME SCAN
Enrichment Score (ES)0.35690925
Normalized Enrichment Score (NES)1.3900514
Nominal p-value0.012345679
FDR q-value0.56800586
FWER p-Value1.0
Table: GSEA Results Summary



Fig 1: Enrichment plot: R406_KINOME SCAN   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEGENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1MST1RMST1R
Entrez,  Source
macrophage stimulating 1 receptor (c-met-related tyrosine kinase)540.6360.0280Yes
2DAPK1DAPK1
Entrez,  Source
death-associated protein kinase 1880.5570.0536Yes
3EPHA1EPHA1
Entrez,  Source
EPH receptor A1940.5450.0808Yes
4RIPK4RIPK4
Entrez,  Source
receptor-interacting serine-threonine kinase 4950.5440.1082Yes
5MAPK13MAPK13
Entrez,  Source
mitogen-activated protein kinase 131100.5250.1337Yes
6PTK6PTK6
Entrez,  Source
PTK6 protein tyrosine kinase 61410.4790.1556Yes
7FGFR3FGFR3
Entrez,  Source
fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism)1530.4650.1783Yes
8PAK6PAK6
Entrez,  Source
p21(CDKN1A)-activated kinase 61580.4590.2011Yes
9FGFR2FGFR2
Entrez,  Source
ffer syndrome, Jackson-Weiss syndrome)2100.4060.2177Yes
10DDR1DDR1
Entrez,  Source
discoidin domain receptor family, member 12120.4040.2380Yes
11FRKFRK
Entrez,  Source
fyn-related kinase2960.3430.2490Yes
12SYKSYK
Entrez,  Source
spleen tyrosine kinase4710.2680.2491Yes
13METMET
Entrez,  Source
met proto-oncogene (hepatocyte growth factor receptor)4990.2590.2601Yes
14ROS1ROS1
Entrez,  Source
v-ros UR2 sarcoma virus oncogene homolog 1 (avian)5050.2580.2728Yes
15IKBKBIKBKB
Entrez,  Source
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta5530.2450.2815Yes
16EGFREGFR
Entrez,  Source
epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)6250.2300.2877Yes
17PAK1PAK1
Entrez,  Source
p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast)6740.2190.2951Yes
18EPHB6EPHB6
Entrez,  Source
EPH receptor B67010.2150.3039Yes
19EPHA4EPHA4
Entrez,  Source
EPH receptor A47980.1970.3065Yes
20EPHB2EPHB2
Entrez,  Source
EPH receptor B28680.1850.3106Yes
21TXKTXK
Entrez,  Source
TXK tyrosine kinase10450.1600.3051Yes
22MAPK10MAPK10
Entrez,  Source
mitogen-activated protein kinase 1010690.1570.3113Yes
23DYRK2DYRK2
Entrez,  Source
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 212300.1420.3062Yes
24LCKLCK
Entrez,  Source
lymphocyte-specific protein tyrosine kinase13100.1360.3070Yes
25GAKGAK
Entrez,  Source
cyclin G associated kinase13400.1330.3115Yes
26TNK1TNK1
Entrez,  Source
tyrosine kinase, non-receptor, 113600.1310.3166Yes
27CAMK1DCAMK1D
Entrez,  Source
calcium/calmodulin-dependent protein kinase ID13870.1290.3212Yes
28EPHA7EPHA7
Entrez,  Source
EPH receptor A714120.1280.3258Yes
29NEK11NEK11
Entrez,  Source
NIMA (never in mitosis gene a)- related kinase 1115220.1220.3235Yes
30STK17BSTK17B
Entrez,  Source
serine/threonine kinase 17b (apoptosis-inducing)15540.1190.3272Yes
31WEE1WEE1
Entrez,  Source
WEE1 homolog (S. pombe)16390.1150.3266Yes
32PIP4K2C16760.1140.3295Yes
33RPS6KA1RPS6KA1
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 116860.1130.3345Yes
34MAP3K9MAP3K9
Entrez,  Source
mitogen-activated protein kinase kinase kinase 916990.1120.3393Yes
35NTRK2NTRK2
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 217040.1120.3446Yes
36CAMK2GCAMK2G
Entrez,  Source
calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma18110.1070.3419Yes
37ERBB4ERBB4
Entrez,  Source
v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)18130.1070.3472Yes
38DAPK2DAPK2
Entrez,  Source
death-associated protein kinase 218380.1050.3507Yes
39TESK1TESK1
Entrez,  Source
testis-specific kinase 118550.1050.3547Yes
40RIOK3RIOK3
Entrez,  Source
RIO kinase 3 (yeast)19420.1010.3532Yes
41LYNLYN
Entrez,  Source
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog19740.1000.3559Yes
42PTK2BPTK2B
Entrez,  Source
PTK2B protein tyrosine kinase 2 beta20420.0980.3556Yes
43MARK1MARK1
Entrez,  Source
MAP/microtubule affinity-regulating kinase 121590.0930.3514Yes
44AAK1AAK1
Entrez,  Source
AP2 associated kinase 122120.0920.3521Yes
45ULK2ULK2
Entrez,  Source
unc-51-like kinase 2 (C. elegans)22440.0910.3543Yes
46MAP3K11MAP3K11
Entrez,  Source
mitogen-activated protein kinase kinase kinase 1122950.0890.3549Yes
47TIE1TIE1
Entrez,  Source
tyrosine kinase with immunoglobulin-like and EGF-like domains 123280.0880.3569Yes
48JAK3JAK3
Entrez,  Source
Janus kinase 3 (a protein tyrosine kinase, leukocyte)24440.0840.3523No
49MAP3K4MAP3K4
Entrez,  Source
mitogen-activated protein kinase kinase kinase 424890.0830.3532No
50MERTKMERTK
Entrez,  Source
c-mer proto-oncogene tyrosine kinase25220.0820.3549No
51TAOK1TAOK1
Entrez,  Source
TAO kinase 125520.0820.3568No
52RPS6KA5RPS6KA5
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 526100.0800.3564No
53ADCK4ADCK4
Entrez,  Source
aarF domain containing kinase 427150.0770.3523No
54EPHA3EPHA3
Entrez,  Source
EPH receptor A328700.0740.3442No
55MKNK1MKNK1
Entrez,  Source
MAP kinase interacting serine/threonine kinase 129070.0730.3451No
56TNK2TNK2
Entrez,  Source
tyrosine kinase, non-receptor, 230050.0700.3412No
57YES1YES1
Entrez,  Source
v-yes-1 Yamaguchi sarcoma viral oncogene homolog 130360.0700.3424No
58CSKCSK
Entrez,  Source
c-src tyrosine kinase30690.0690.3435No
59KDRKDR
Entrez,  Source
kinase insert domain receptor (a type III receptor tyrosine kinase)31460.0680.3410No
60FLT3FLT3
Entrez,  Source
fms-related tyrosine kinase 334030.0630.3245No
61BLKBLK
Entrez,  Source
B lymphoid tyrosine kinase34190.0620.3265No
62TSSK1B34450.0620.3277No
63CSF1RCSF1R
Entrez,  Source
colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog34540.0620.3302No
64BRAFBRAF
Entrez,  Source
v-raf murine sarcoma viral oncogene homolog B137720.0560.3087No
65MARK2MARK2
Entrez,  Source
MAP/microtubule affinity-regulating kinase 238340.0550.3067No
66EPHB4EPHB4
Entrez,  Source
EPH receptor B438790.0540.3061No
67EPHB1EPHB1
Entrez,  Source
EPH receptor B140000.0520.2995No
68ALKALK
Entrez,  Source
anaplastic lymphoma kinase (Ki-1)40730.0510.2966No
69MUSKMUSK
Entrez,  Source
muscle, skeletal, receptor tyrosine kinase41390.0500.2941No
70FGRFGR
Entrez,  Source
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog41930.0490.2925No
71AURKCAURKC
Entrez,  Source
aurora kinase C44130.0460.2780No
72LIMK1LIMK1
Entrez,  Source
LIM domain kinase 144680.0450.2761No
73NEK2NEK2
Entrez,  Source
NIMA (never in mitosis gene a)-related kinase 244830.0450.2773No
74CAMK1GCAMK1G
Entrez,  Source
calcium/calmodulin-dependent protein kinase IG45030.0450.2781No
75FGFR4FGFR4
Entrez,  Source
fibroblast growth factor receptor 447150.0410.2640No
76PHKG2PHKG2
Entrez,  Source
phosphorylase kinase, gamma 2 (testis)47920.0400.2602No
77BMXBMX
Entrez,  Source
BMX non-receptor tyrosine kinase48260.0400.2596No
78NEK7NEK7
Entrez,  Source
NIMA (never in mitosis gene a)-related kinase 748770.0390.2578No
79EPHA2EPHA2
Entrez,  Source
EPH receptor A248800.0390.2596No
80FLT1FLT1
Entrez,  Source
fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)48820.0390.2615No
81FLT4FLT4
Entrez,  Source
fms-related tyrosine kinase 448980.0390.2623No
82GRK1GRK1
Entrez,  Source
G protein-coupled receptor kinase 149070.0390.2637No
83PAK4PAK4
Entrez,  Source
p21(CDKN1A)-activated kinase 450140.0370.2574No
84ULK1ULK1
Entrez,  Source
unc-51-like kinase 1 (C. elegans)51570.0350.2482No
85TNNI3KTNNI3K
Entrez,  Source
TNNI3 interacting kinase52740.0330.2410No
86EPHA5EPHA5
Entrez,  Source
EPH receptor A554750.0310.2272No
87PDPK1PDPK1
Entrez,  Source
3-phosphoinositide dependent protein kinase-155490.0300.2231No
88BTKBTK
Entrez,  Source
Bruton agammaglobulinemia tyrosine kinase56280.0290.2185No
89STK16STK16
Entrez,  Source
serine/threonine kinase 1657780.0270.2084No
90SRPK3SRPK3
Entrez,  Source
SFRS protein kinase 358600.0260.2035No
91PAK7PAK7
Entrez,  Source
p21(CDKN1A)-activated kinase 758810.0250.2032No
92MAP3K3MAP3K3
Entrez,  Source
mitogen-activated protein kinase kinase kinase 359210.0250.2015No
93NTRK1NTRK1
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 160970.0220.1892No
94FESFES
Entrez,  Source
feline sarcoma oncogene61260.0220.1881No
95IRAK1IRAK1
Entrez,  Source
interleukin-1 receptor-associated kinase 161790.0210.1851No
96AURKAAURKA
Entrez,  Source
aurora kinase A64270.0170.1670No
97RETRET
Entrez,  Source
ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease)64710.0160.1645No
98EIF2AK2EIF2AK2
Entrez,  Source
eukaryotic translation initiation factor 2-alpha kinase 264890.0160.1640No
99MAP3K10MAP3K10
Entrez,  Source
mitogen-activated protein kinase kinase kinase 1065490.0150.1603No
100PLK3PLK3
Entrez,  Source
polo-like kinase 3 (Drosophila)67550.0120.1451No
101BMPR1BBMPR1B
Entrez,  Source
bone morphogenetic protein receptor, type IB67770.0120.1441No
102PKN1PKN1
Entrez,  Source
protein kinase N167830.0120.1443No
103GRK4GRK4
Entrez,  Source
G protein-coupled receptor kinase 467880.0120.1446No
104MAPK8MAPK8
Entrez,  Source
mitogen-activated protein kinase 868290.0110.1421No
105PIP5K1CPIP5K1C
Entrez,  Source
phosphatidylinositol-4-phosphate 5-kinase, type I, gamma68810.0100.1387No
106MAP4K2MAP4K2
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 268940.0100.1383No
107CLK4CLK4
Entrez,  Source
CDC-like kinase 469350.0100.1357No
108TEKTEK
Entrez,  Source
TEK tyrosine kinase, endothelial (venous malformations, multiple cutaneous and mucosal)70350.0080.1285No
109TGFBR2TGFBR2
Entrez,  Source
transforming growth factor, beta receptor II (70/80kDa)71030.0070.1236No
110IKBKEIKBKE
Entrez,  Source
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon72160.0040.1153No
111ITKITK
Entrez,  Source
IL2-inducible T-cell kinase72200.0040.1153No
112PRKAA2PRKAA2
Entrez,  Source
protein kinase, AMP-activated, alpha 2 catalytic subunit74180.0010.1002No
113SIK274350.0010.0990No
114PI4KB7697-0.0030.0791No
115MAP2K3MAP2K3
Entrez,  Source
mitogen-activated protein kinase kinase 37798-0.0050.0716No
116PDGFRBPDGFRB
Entrez,  Source
platelet-derived growth factor receptor, beta polypeptide7824-0.0060.0700No
117MAPK9MAPK9
Entrez,  Source
mitogen-activated protein kinase 97830-0.0060.0699No
118MKNK2MKNK2
Entrez,  Source
MAP kinase interacting serine/threonine kinase 27841-0.0060.0695No
119MAP2K1MAP2K1
Entrez,  Source
mitogen-activated protein kinase kinase 17939-0.0080.0624No
120RAF1RAF1
Entrez,  Source
v-raf-1 murine leukemia viral oncogene homolog 18015-0.0090.0571No
121TAOK2TAOK2
Entrez,  Source
TAO kinase 28059-0.0100.0543No
122PRKACAPRKACA
Entrez,  Source
protein kinase, cAMP-dependent, catalytic, alpha8112-0.0110.0509No
123KITKIT
Entrez,  Source
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog8134-0.0120.0499No
124LTKLTK
Entrez,  Source
leukocyte tyrosine kinase8158-0.0120.0487No
125RPS6KA4RPS6KA4
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 48181-0.0130.0477No
126MAP2K5MAP2K5
Entrez,  Source
mitogen-activated protein kinase kinase 58199-0.0130.0470No
127MARK4MARK4
Entrez,  Source
MAP/microtubule affinity-regulating kinase 48259-0.0140.0432No
128PTK2PTK2
Entrez,  Source
PTK2 protein tyrosine kinase 28356-0.0160.0366No
129NTRK3NTRK3
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 38500-0.0190.0266No
130ROCK1ROCK1
Entrez,  Source
Rho-associated, coiled-coil containing protein kinase 18741-0.0250.0094No
131AURKBAURKB
Entrez,  Source
aurora kinase B8856-0.0270.0020No
132ZAP70ZAP70
Entrez,  Source
zeta-chain (TCR) associated protein kinase 70kDa8954-0.030-0.0039No
133IRAK4IRAK4
Entrez,  Source
interleukin-1 receptor-associated kinase 48996-0.031-0.0055No
134TYK2TYK2
Entrez,  Source
tyrosine kinase 29438-0.041-0.0374No
135PAK3PAK3
Entrez,  Source
p21 (CDKN1A)-activated kinase 39490-0.042-0.0392No
136CSNK2A2CSNK2A2
Entrez,  Source
casein kinase 2, alpha prime polypeptide9758-0.049-0.0572No
137NEK9NEK9
Entrez,  Source
NIMA (never in mitosis gene a)- related kinase 99810-0.051-0.0586No
138HCKHCK
Entrez,  Source
hemopoietic cell kinase9981-0.056-0.0688No
139PLK2PLK2
Entrez,  Source
polo-like kinase 2 (Drosophila)9994-0.057-0.0669No
140STK17ASTK17A
Entrez,  Source
serine/threonine kinase 17a (apoptosis-inducing)10017-0.057-0.0657No
141DDR2DDR2
Entrez,  Source
discoidin domain receptor family, member 210235-0.064-0.0792No
142DYRK1ADYRK1A
Entrez,  Source
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A10303-0.066-0.0810No
143CITCIT
Entrez,  Source
citron (rho-interacting, serine/threonine kinase 21)10420-0.070-0.0864No
144PLK1PLK1
Entrez,  Source
polo-like kinase 1 (Drosophila)10440-0.071-0.0843No
145PLK4PLK4
Entrez,  Source
polo-like kinase 4 (Drosophila)10581-0.075-0.0912No
146JAK1JAK1
Entrez,  Source
Janus kinase 1 (a protein tyrosine kinase)10585-0.076-0.0877No
147TBK1TBK1
Entrez,  Source
TANK-binding kinase 110732-0.082-0.0948No
148SRCSRC
Entrez,  Source
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)10776-0.083-0.0939No
149PAK2PAK2
Entrez,  Source
p21 (CDKN1A)-activated kinase 210809-0.085-0.0921No
150PRKAA1PRKAA1
Entrez,  Source
protein kinase, AMP-activated, alpha 1 catalytic subunit10906-0.089-0.0950No
151NUAK1NUAK1
Entrez,  Source
NUAK family, SNF1-like kinase, 111032-0.095-0.0998No
152DAPK3DAPK3
Entrez,  Source
death-associated protein kinase 311066-0.096-0.0975No
153SRPK1SRPK1
Entrez,  Source
SFRS protein kinase 111068-0.096-0.0927No
154ABL2ABL2
Entrez,  Source
v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)11090-0.098-0.0894No
155GSK3BGSK3B
Entrez,  Source
glycogen synthase kinase 3 beta11131-0.100-0.0874No
156PRKACBPRKACB
Entrez,  Source
protein kinase, cAMP-dependent, catalytic, beta11179-0.102-0.0859No
157STK10STK10
Entrez,  Source
serine/threonine kinase 1011218-0.103-0.0836No
158RIPK2RIPK2
Entrez,  Source
receptor-interacting serine-threonine kinase 211349-0.110-0.0880No
159FERFER
Entrez,  Source
fer (fps/fes related) tyrosine kinase (phosphoprotein NCP94)11371-0.111-0.0840No
160NEK1NEK1
Entrez,  Source
NIMA (never in mitosis gene a)-related kinase 111428-0.113-0.0826No
161JAK2JAK2
Entrez,  Source
Janus kinase 2 (a protein tyrosine kinase)11530-0.119-0.0844No
162TLK2TLK2
Entrez,  Source
tousled-like kinase 211621-0.124-0.0850No
163SLKSLK
Entrez,  Source
STE20-like kinase (yeast)11672-0.128-0.0824No
164FYNFYN
Entrez,  Source
FYN oncogene related to SRC, FGR, YES11767-0.133-0.0829No
165NEK3NEK3
Entrez,  Source
NIMA (never in mitosis gene a)-related kinase 311797-0.135-0.0783No
166HIPK1HIPK1
Entrez,  Source
homeodomain interacting protein kinase 111798-0.135-0.0715No
167MAP2K4MAP2K4
Entrez,  Source
mitogen-activated protein kinase kinase 411811-0.136-0.0655No
168CSNK2A1CSNK2A1
Entrez,  Source
casein kinase 2, alpha 1 polypeptide11861-0.139-0.0622No
169MAP2K2MAP2K2
Entrez,  Source
mitogen-activated protein kinase kinase 211895-0.142-0.0576No
170MAP2K6MAP2K6
Entrez,  Source
mitogen-activated protein kinase kinase 611934-0.144-0.0532No
171ROCK2ROCK2
Entrez,  Source
Rho-associated, coiled-coil containing protein kinase 212033-0.152-0.0531No
172CAMK1CAMK1
Entrez,  Source
calcium/calmodulin-dependent protein kinase I12150-0.162-0.0538No
173MAP3K2MAP3K2
Entrez,  Source
mitogen-activated protein kinase kinase kinase 212210-0.168-0.0499No
174PDGFRAPDGFRA
Entrez,  Source
platelet-derived growth factor receptor, alpha polypeptide12211-0.168-0.0414No
175SIK112319-0.179-0.0406No
176IRAK3IRAK3
Entrez,  Source
interleukin-1 receptor-associated kinase 312451-0.196-0.0408No
177ABL1ABL1
Entrez,  Source
v-abl Abelson murine leukemia viral oncogene homolog 112463-0.197-0.0317No
178TLK1TLK1
Entrez,  Source
tousled-like kinase 112558-0.210-0.0283No
179CDK1712578-0.213-0.0190No
180MAP3K7MAP3K7
Entrez,  Source
mitogen-activated protein kinase kinase kinase 712613-0.221-0.0104No
181AXLAXL
Entrez,  Source
AXL receptor tyrosine kinase12789-0.257-0.0109No
182CHUKCHUK
Entrez,  Source
conserved helix-loop-helix ubiquitous kinase12978-0.325-0.0089No
183FGFR1FGFR1
Entrez,  Source
fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome)13121-0.4860.0047No
Table: GSEA details [plain text format]



Fig 2: R406_KINOME SCAN   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: R406_KINOME SCAN: Random ES distribution   
Gene set null distribution of ES for R406_KINOME SCAN