DatasetNSCLC_collapsed_to_symbols.NSCLC.cls
#SEN_versus_RES.NSCLC.cls
#SEN_versus_RES_repos
PhenotypeNSCLC.cls#SEN_versus_RES_repos
Upregulated in class0
GeneSetBX-517 ANALOG (COMPOUND 7B)_MRC
Enrichment Score (ES)-0.40035683
Normalized Enrichment Score (NES)-1.2761818
Nominal p-value0.14349777
FDR q-value0.5812558
FWER p-Value1.0
Table: GSEA Results Summary



Fig 1: Enrichment plot: BX-517 ANALOG (COMPOUND 7B)_MRC   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEGENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1SYKSYK
Entrez,  Source
spleen tyrosine kinase4710.2680.0337No
2DYRK2DYRK2
Entrez,  Source
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 212300.1420.0129No
3LCKLCK
Entrez,  Source
lymphocyte-specific protein tyrosine kinase13100.1360.0422No
4STK3STK3
Entrez,  Source
serine/threonine kinase 3 (STE20 homolog, yeast)15530.1200.0547No
5RPS6KA1RPS6KA1
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 116860.1130.0739No
6MAPK3MAPK3
Entrez,  Source
mitogen-activated protein kinase 317660.1090.0961No
7PIM2PIM2
Entrez,  Source
pim-2 oncogene29560.0710.0241No
8YES1YES1
Entrez,  Source
v-yes-1 Yamaguchi sarcoma viral oncogene homolog 130360.0700.0362No
9PIM1PIM1
Entrez,  Source
pim-1 oncogene41360.050-0.0344No
10FLT1FLT1
Entrez,  Source
fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)48820.039-0.0809No
11INSRRINSRR
Entrez,  Source
insulin receptor-related receptor53320.033-0.1066No
12BTKBTK
Entrez,  Source
Bruton agammaglobulinemia tyrosine kinase56280.029-0.1216No
13PAK7PAK7
Entrez,  Source
p21(CDKN1A)-activated kinase 758810.025-0.1341No
14IKBKEIKBKE
Entrez,  Source
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon72160.004-0.2345No
15PRKAA2PRKAA2
Entrez,  Source
protein kinase, AMP-activated, alpha 2 catalytic subunit74180.001-0.2495No
16MAP2K1MAP2K1
Entrez,  Source
mitogen-activated protein kinase kinase 17939-0.008-0.2870No
17IGF1RIGF1R
Entrez,  Source
insulin-like growth factor 1 receptor7959-0.008-0.2862No
18MELKMELK
Entrez,  Source
maternal embryonic leucine zipper kinase8047-0.010-0.2903No
19PDK1PDK1
Entrez,  Source
pyruvate dehydrogenase kinase, isozyme 18449-0.018-0.3161No
20PHKA2PHKA2
Entrez,  Source
phosphorylase kinase, alpha 2 (liver)9057-0.032-0.3540No
21MAPKAPK2MAPKAPK2
Entrez,  Source
mitogen-activated protein kinase-activated protein kinase 29187-0.035-0.3548No
22CDK2CDK2
Entrez,  Source
cyclin-dependent kinase 29409-0.040-0.3611No
23PRKD1PRKD1
Entrez,  Source
protein kinase D19827-0.052-0.3795No
24CHEK2CHEK2
Entrez,  Source
CHK2 checkpoint homolog (S. pombe)10102-0.059-0.3850Yes
25HIPK2HIPK2
Entrez,  Source
homeodomain interacting protein kinase 210151-0.061-0.3728Yes
26DYRK1ADYRK1A
Entrez,  Source
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A10303-0.066-0.3672Yes
27MARK3MARK3
Entrez,  Source
MAP/microtubule affinity-regulating kinase 310374-0.068-0.3549Yes
28RPS6KB1RPS6KB1
Entrez,  Source
ribosomal protein S6 kinase, 70kDa, polypeptide 110717-0.081-0.3600Yes
29TBK1TBK1
Entrez,  Source
TANK-binding kinase 110732-0.082-0.3399Yes
30BRSK2BRSK2
Entrez,  Source
BR serine/threonine kinase 210749-0.082-0.3199Yes
31SRCSRC
Entrez,  Source
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)10776-0.083-0.3003Yes
32CHEK1CHEK1
Entrez,  Source
CHK1 checkpoint homolog (S. pombe)10792-0.084-0.2797Yes
33MAPKAPK5MAPKAPK5
Entrez,  Source
mitogen-activated protein kinase-activated protein kinase 510962-0.092-0.2687Yes
34GSK3BGSK3B
Entrez,  Source
glycogen synthase kinase 3 beta11131-0.100-0.2556Yes
35MYLKMYLK
Entrez,  Source
myosin, light chain kinase11255-0.105-0.2378Yes
36ROCK2ROCK2
Entrez,  Source
Rho-associated, coiled-coil containing protein kinase 212033-0.152-0.2575Yes
37DYRK3DYRK3
Entrez,  Source
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 312238-0.171-0.2288Yes
38PKN2PKN2
Entrez,  Source
protein kinase N212286-0.175-0.1870Yes
39FGFR1FGFR1
Entrez,  Source
fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome)13121-0.486-0.1245Yes
40SGK113133-0.4980.0037Yes
Table: GSEA details [plain text format]



Fig 2: BX-517 ANALOG (COMPOUND 7B)_MRC   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: BX-517 ANALOG (COMPOUND 7B)_MRC: Random ES distribution   
Gene set null distribution of ES for BX-517 ANALOG (COMPOUND 7B)_MRC