DatasetNSCLC_collapsed_to_symbols.NSCLC.cls
#SEN_versus_RES.NSCLC.cls
#SEN_versus_RES_repos
PhenotypeNSCLC.cls#SEN_versus_RES_repos
Upregulated in class1
GeneSetCRIZOTINIB_LINCS
Enrichment Score (ES)0.32271585
Normalized Enrichment Score (NES)1.1864914
Nominal p-value0.15296052
FDR q-value0.62859815
FWER p-Value1.0
Table: GSEA Results Summary



Fig 1: Enrichment plot: CRIZOTINIB_LINCS   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEGENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1MST1RMST1R
Entrez,  Source
macrophage stimulating 1 receptor (c-met-related tyrosine kinase)540.6360.0449Yes
2EPHA1EPHA1
Entrez,  Source
EPH receptor A1940.5450.0840Yes
3RIPK4RIPK4
Entrez,  Source
receptor-interacting serine-threonine kinase 4950.5440.1259Yes
4DDR1DDR1
Entrez,  Source
discoidin domain receptor family, member 12120.4040.1481Yes
5FRKFRK
Entrez,  Source
fyn-related kinase2960.3430.1682Yes
6MST43180.3310.1921Yes
7SYKSYK
Entrez,  Source
spleen tyrosine kinase4710.2680.2011Yes
8METMET
Entrez,  Source
met proto-oncogene (hepatocyte growth factor receptor)4990.2590.2190Yes
9ROS1ROS1
Entrez,  Source
v-ros UR2 sarcoma virus oncogene homolog 1 (avian)5050.2580.2385Yes
10IKBKBIKBKB
Entrez,  Source
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta5530.2450.2538Yes
11MAP3K13MAP3K13
Entrez,  Source
mitogen-activated protein kinase kinase kinase 136240.2300.2661Yes
12EPHB6EPHB6
Entrez,  Source
EPH receptor B67010.2150.2769Yes
13EPHA4EPHA4
Entrez,  Source
EPH receptor A47980.1970.2848Yes
14TAOK3TAOK3
Entrez,  Source
TAO kinase 39710.1700.2847Yes
15TXKTXK
Entrez,  Source
TXK tyrosine kinase10450.1600.2914Yes
16DYRK2DYRK2
Entrez,  Source
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 212300.1420.2883Yes
17LCKLCK
Entrez,  Source
lymphocyte-specific protein tyrosine kinase13100.1360.2927Yes
18TNK1TNK1
Entrez,  Source
tyrosine kinase, non-receptor, 113600.1310.2991Yes
19EPHA7EPHA7
Entrez,  Source
EPH receptor A714120.1280.3050Yes
20STK3STK3
Entrez,  Source
serine/threonine kinase 3 (STE20 homolog, yeast)15530.1200.3035Yes
21INSRINSR
Entrez,  Source
insulin receptor16640.1140.3039Yes
22NTRK2NTRK2
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 217040.1120.3095Yes
23TESK1TESK1
Entrez,  Source
testis-specific kinase 118550.1050.3061Yes
24RIOK3RIOK3
Entrez,  Source
RIO kinase 3 (yeast)19420.1010.3073Yes
25LYNLYN
Entrez,  Source
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog19740.1000.3126Yes
26CASKCASK
Entrez,  Source
calcium/calmodulin-dependent serine protein kinase (MAGUK family)20070.0990.3178Yes
27PTK2BPTK2B
Entrez,  Source
PTK2B protein tyrosine kinase 2 beta20420.0980.3227Yes
28ULK2ULK2
Entrez,  Source
unc-51-like kinase 2 (C. elegans)22440.0910.3143No
29TIE1TIE1
Entrez,  Source
tyrosine kinase with immunoglobulin-like and EGF-like domains 123280.0880.3147No
30JAK3JAK3
Entrez,  Source
Janus kinase 3 (a protein tyrosine kinase, leukocyte)24440.0840.3124No
31MERTKMERTK
Entrez,  Source
c-mer proto-oncogene tyrosine kinase25220.0820.3129No
32TAOK1TAOK1
Entrez,  Source
TAO kinase 125520.0820.3170No
33ADCK4ADCK4
Entrez,  Source
aarF domain containing kinase 427150.0770.3106No
34LIMK2LIMK2
Entrez,  Source
LIM domain kinase 227990.0760.3100No
35MAP4K1MAP4K1
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 128490.0740.3120No
36EPHA3EPHA3
Entrez,  Source
EPH receptor A328700.0740.3161No
37TNK2TNK2
Entrez,  Source
tyrosine kinase, non-receptor, 230050.0700.3113No
38FLT3FLT3
Entrez,  Source
fms-related tyrosine kinase 334030.0630.2857No
39BLKBLK
Entrez,  Source
B lymphoid tyrosine kinase34190.0620.2894No
40CSF1RCSF1R
Entrez,  Source
colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog34540.0620.2915No
41EPHB4EPHB4
Entrez,  Source
EPH receptor B438790.0540.2633No
42PRKD2PRKD2
Entrez,  Source
protein kinase D239000.0540.2659No
43EPHB1EPHB1
Entrez,  Source
EPH receptor B140000.0520.2624No
44ALKALK
Entrez,  Source
anaplastic lymphoma kinase (Ki-1)40730.0510.2608No
45MUSKMUSK
Entrez,  Source
muscle, skeletal, receptor tyrosine kinase41390.0500.2597No
46FGRFGR
Entrez,  Source
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog41930.0490.2594No
47MAP3K1MAP3K1
Entrez,  Source
mitogen-activated protein kinase kinase kinase 142810.0480.2564No
48ACVR1BACVR1B
Entrez,  Source
activin A receptor, type IB43280.0470.2566No
49AURKCAURKC
Entrez,  Source
aurora kinase C44130.0460.2537No
50LIMK1LIMK1
Entrez,  Source
LIM domain kinase 144680.0450.2530No
51CDKL2CDKL2
Entrez,  Source
cyclin-dependent kinase-like 2 (CDC2-related kinase)45480.0440.2504No
52NEK7NEK7
Entrez,  Source
NIMA (never in mitosis gene a)-related kinase 748770.0390.2283No
53EPHA2EPHA2
Entrez,  Source
EPH receptor A248800.0390.2311No
54ULK1ULK1
Entrez,  Source
unc-51-like kinase 1 (C. elegans)51570.0350.2127No
55ACVR1ACVR1
Entrez,  Source
activin A receptor, type I52300.0340.2098No
56TNNI3KTNNI3K
Entrez,  Source
TNNI3 interacting kinase52740.0330.2091No
57INSRRINSRR
Entrez,  Source
insulin receptor-related receptor53320.0330.2073No
58EPHA5EPHA5
Entrez,  Source
EPH receptor A554750.0310.1988No
59SRPK3SRPK3
Entrez,  Source
SFRS protein kinase 358600.0260.1714No
60MAP3K3MAP3K3
Entrez,  Source
mitogen-activated protein kinase kinase kinase 359210.0250.1687No
61NTRK1NTRK1
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 160970.0220.1570No
62FESFES
Entrez,  Source
feline sarcoma oncogene61260.0220.1565No
63IRAK1IRAK1
Entrez,  Source
interleukin-1 receptor-associated kinase 161790.0210.1541No
64AURKAAURKA
Entrez,  Source
aurora kinase A64270.0170.1365No
65DCLK264620.0160.1352No
66PIP4K2B65940.0150.1263No
67BMPR1BBMPR1B
Entrez,  Source
bone morphogenetic protein receptor, type IB67770.0120.1133No
68GRK4GRK4
Entrez,  Source
G protein-coupled receptor kinase 467880.0120.1134No
69MAP4K2MAP4K2
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 268940.0100.1062No
70MAPK7MAPK7
Entrez,  Source
mitogen-activated protein kinase 769130.0100.1055No
71BMP2KBMP2K
Entrez,  Source
BMP2 inducible kinase70290.0080.0974No
72TEKTEK
Entrez,  Source
TEK tyrosine kinase, endothelial (venous malformations, multiple cutaneous and mucosal)70350.0080.0976No
73SIK274350.0010.0671No
74MKNK2MKNK2
Entrez,  Source
MAP kinase interacting serine/threonine kinase 27841-0.0060.0366No
75IGF1RIGF1R
Entrez,  Source
insulin-like growth factor 1 receptor7959-0.0080.0283No
76TAOK2TAOK2
Entrez,  Source
TAO kinase 28059-0.0100.0215No
77KITKIT
Entrez,  Source
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog8134-0.0120.0167No
78LTKLTK
Entrez,  Source
leukocyte tyrosine kinase8158-0.0120.0159No
79DMPKDMPK
Entrez,  Source
dystrophia myotonica-protein kinase8344-0.0160.0030No
80PTK2PTK2
Entrez,  Source
PTK2 protein tyrosine kinase 28356-0.0160.0034No
81NTRK3NTRK3
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 38500-0.019-0.0061No
82ROCK1ROCK1
Entrez,  Source
Rho-associated, coiled-coil containing protein kinase 18741-0.025-0.0225No
83AURKBAURKB
Entrez,  Source
aurora kinase B8856-0.027-0.0292No
84CDK11A9060-0.032-0.0422No
85TYK2TYK2
Entrez,  Source
tyrosine kinase 29438-0.041-0.0680No
86PAK3PAK3
Entrez,  Source
p21 (CDKN1A)-activated kinase 39490-0.042-0.0686No
87NEK9NEK9
Entrez,  Source
NIMA (never in mitosis gene a)- related kinase 99810-0.051-0.0891No
88PRKD1PRKD1
Entrez,  Source
protein kinase D19827-0.052-0.0864No
89DCLK19840-0.052-0.0833No
90DDR2DDR2
Entrez,  Source
discoidin domain receptor family, member 210235-0.064-0.1086No
91MARK3MARK3
Entrez,  Source
MAP/microtubule affinity-regulating kinase 310374-0.068-0.1139No
92PLK4PLK4
Entrez,  Source
polo-like kinase 4 (Drosophila)10581-0.075-0.1238No
93JAK1JAK1
Entrez,  Source
Janus kinase 1 (a protein tyrosine kinase)10585-0.076-0.1182No
94RPS6KB1RPS6KB1
Entrez,  Source
ribosomal protein S6 kinase, 70kDa, polypeptide 110717-0.081-0.1220No
95CAMKK2CAMKK2
Entrez,  Source
calcium/calmodulin-dependent protein kinase kinase 2, beta10729-0.081-0.1166No
96TBK1TBK1
Entrez,  Source
TANK-binding kinase 110732-0.082-0.1105No
97SRCSRC
Entrez,  Source
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)10776-0.083-0.1074No
98PIP5K1APIP5K1A
Entrez,  Source
phosphatidylinositol-4-phosphate 5-kinase, type I, alpha10780-0.083-0.1012No
99PRKAA1PRKAA1
Entrez,  Source
protein kinase, AMP-activated, alpha 1 catalytic subunit10906-0.089-0.1039No
100NUAK1NUAK1
Entrez,  Source
NUAK family, SNF1-like kinase, 111032-0.095-0.1062No
101ABL2ABL2
Entrez,  Source
v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)11090-0.098-0.1030No
102CDK7CDK7
Entrez,  Source
cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase)11160-0.101-0.1005No
103STK10STK10
Entrez,  Source
serine/threonine kinase 1011218-0.103-0.0969No
104RIPK2RIPK2
Entrez,  Source
receptor-interacting serine-threonine kinase 211349-0.110-0.0984No
105FERFER
Entrez,  Source
fer (fps/fes related) tyrosine kinase (phosphoprotein NCP94)11371-0.111-0.0915No
106RIPK1RIPK1
Entrez,  Source
receptor (TNFRSF)-interacting serine-threonine kinase 111427-0.113-0.0870No
107STK4STK4
Entrez,  Source
serine/threonine kinase 411518-0.118-0.0848No
108JAK2JAK2
Entrez,  Source
Janus kinase 2 (a protein tyrosine kinase)11530-0.119-0.0765No
109TYRO3TYRO3
Entrez,  Source
TYRO3 protein tyrosine kinase11601-0.123-0.0723No
110SLKSLK
Entrez,  Source
STE20-like kinase (yeast)11672-0.128-0.0679No
111MAP4K5MAP4K5
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 511705-0.130-0.0603No
112FYNFYN
Entrez,  Source
FYN oncogene related to SRC, FGR, YES11767-0.133-0.0547No
113ROCK2ROCK2
Entrez,  Source
Rho-associated, coiled-coil containing protein kinase 212033-0.152-0.0633No
114MAP3K2MAP3K2
Entrez,  Source
mitogen-activated protein kinase kinase kinase 212210-0.168-0.0638No
115MAP3K12MAP3K12
Entrez,  Source
mitogen-activated protein kinase kinase kinase 1212384-0.186-0.0627No
116MAP4K3MAP4K3
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 312403-0.189-0.0495No
117TGFBR1TGFBR1
Entrez,  Source
transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kDa)12447-0.195-0.0378No
118IRAK3IRAK3
Entrez,  Source
interleukin-1 receptor-associated kinase 312451-0.196-0.0229No
119ABL1ABL1
Entrez,  Source
v-abl Abelson murine leukemia viral oncogene homolog 112463-0.197-0.0086No
120MAP3K7MAP3K7
Entrez,  Source
mitogen-activated protein kinase kinase kinase 712613-0.221-0.0030No
121AXLAXL
Entrez,  Source
AXL receptor tyrosine kinase12789-0.2570.0034No
122PRKD3PRKD3
Entrez,  Source
protein kinase D313008-0.3450.0133No
Table: GSEA details [plain text format]



Fig 2: CRIZOTINIB_LINCS   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: CRIZOTINIB_LINCS: Random ES distribution   
Gene set null distribution of ES for CRIZOTINIB_LINCS