DatasetNSCLC_collapsed_to_symbols.NSCLC.cls
#SEN_versus_RES.NSCLC.cls
#SEN_versus_RES_repos
PhenotypeNSCLC.cls#SEN_versus_RES_repos
Upregulated in class1
GeneSetREGORAFENIB_FDA
Enrichment Score (ES)0.47073787
Normalized Enrichment Score (NES)1.3343201
Nominal p-value0.0979021
FDR q-value0.6322433
FWER p-Value1.0
Table: GSEA Results Summary



Fig 1: Enrichment plot: REGORAFENIB_FDA   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEGENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1FGFR3FGFR3
Entrez,  Source
fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism)1530.4650.1243Yes
2FGFR2FGFR2
Entrez,  Source
ffer syndrome, Jackson-Weiss syndrome)2100.4060.2385Yes
3DDR1DDR1
Entrez,  Source
discoidin domain receptor family, member 12120.4040.3564Yes
4FRKFRK
Entrez,  Source
fyn-related kinase2960.3430.4503Yes
5EPHA4EPHA4
Entrez,  Source
EPH receptor A47980.1970.4699Yes
6LCKLCK
Entrez,  Source
lymphocyte-specific protein tyrosine kinase13100.1360.4707Yes
7KDRKDR
Entrez,  Source
kinase insert domain receptor (a type III receptor tyrosine kinase)31460.0680.3510No
8CSF1RCSF1R
Entrez,  Source
colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog34540.0620.3457No
9BRAFBRAF
Entrez,  Source
v-raf murine sarcoma viral oncogene homolog B137720.0560.3380No
10EPHA2EPHA2
Entrez,  Source
EPH receptor A248800.0390.2653No
11FLT1FLT1
Entrez,  Source
fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)48820.0390.2766No
12FLT4FLT4
Entrez,  Source
fms-related tyrosine kinase 448980.0390.2869No
13MAPK11MAPK11
Entrez,  Source
mitogen-activated protein kinase 1153920.0320.2588No
14EPHA5EPHA5
Entrez,  Source
EPH receptor A554750.0310.2616No
15NTRK1NTRK1
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 160970.0220.2208No
16RETRET
Entrez,  Source
ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease)64710.0160.1972No
17MAPK14MAPK14
Entrez,  Source
mitogen-activated protein kinase 1464920.0160.2004No
18TEKTEK
Entrez,  Source
TEK tyrosine kinase, endothelial (venous malformations, multiple cutaneous and mucosal)70350.0080.1615No
19MAP2K3MAP2K3
Entrez,  Source
mitogen-activated protein kinase kinase 37798-0.0050.1052No
20PDGFRBPDGFRB
Entrez,  Source
platelet-derived growth factor receptor, beta polypeptide7824-0.0060.1050No
21RAF1RAF1
Entrez,  Source
v-raf-1 murine leukemia viral oncogene homolog 18015-0.0090.0932No
22KITKIT
Entrez,  Source
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog8134-0.0120.0877No
23NTRK3NTRK3
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 38500-0.0190.0656No
24HIPK3HIPK3
Entrez,  Source
homeodomain interacting protein kinase 39770-0.050-0.0164No
25DDR2DDR2
Entrez,  Source
discoidin domain receptor family, member 210235-0.064-0.0331No
26RPS6KB1RPS6KB1
Entrez,  Source
ribosomal protein S6 kinase, 70kDa, polypeptide 110717-0.081-0.0460No
27MAP2K6MAP2K6
Entrez,  Source
mitogen-activated protein kinase kinase 611934-0.144-0.0963No
28PDGFRAPDGFRA
Entrez,  Source
platelet-derived growth factor receptor, alpha polypeptide12211-0.168-0.0682No
29FGFR1FGFR1
Entrez,  Source
fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome)13121-0.4860.0046No
Table: GSEA details [plain text format]



Fig 2: REGORAFENIB_FDA   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: REGORAFENIB_FDA: Random ES distribution   
Gene set null distribution of ES for REGORAFENIB_FDA