DatasetNSCLC_collapsed_to_symbols.NSCLC.cls
#SEN_versus_RES.NSCLC.cls
#SEN_versus_RES_repos
PhenotypeNSCLC.cls#SEN_versus_RES_repos
Upregulated in class1
GeneSetCP466722_LINCS
Enrichment Score (ES)0.2849662
Normalized Enrichment Score (NES)1.0335896
Nominal p-value0.38980263
FDR q-value0.7270519
FWER p-Value1.0
Table: GSEA Results Summary



Fig 1: Enrichment plot: CP466722_LINCS   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEGENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1ERBB3ERBB3
Entrez,  Source
v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)121.0340.1020Yes
2DAPK1DAPK1
Entrez,  Source
death-associated protein kinase 1880.5570.1517Yes
3EPHA1EPHA1
Entrez,  Source
EPH receptor A1940.5450.2056Yes
4RIPK4RIPK4
Entrez,  Source
receptor-interacting serine-threonine kinase 4950.5440.2597Yes
5EPHB6EPHB6
Entrez,  Source
EPH receptor B67010.2150.2348Yes
6MAPK10MAPK10
Entrez,  Source
mitogen-activated protein kinase 1010690.1570.2224Yes
7DYRK2DYRK2
Entrez,  Source
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 212300.1420.2243Yes
8LCKLCK
Entrez,  Source
lymphocyte-specific protein tyrosine kinase13100.1360.2318Yes
9GAKGAK
Entrez,  Source
cyclin G associated kinase13400.1330.2429Yes
10TNK1TNK1
Entrez,  Source
tyrosine kinase, non-receptor, 113600.1310.2545Yes
11PIK3C2GPIK3C2G
Entrez,  Source
phosphoinositide-3-kinase, class 2, gamma polypeptide14980.1230.2563Yes
12STK17BSTK17B
Entrez,  Source
serine/threonine kinase 17b (apoptosis-inducing)15540.1190.2640Yes
13PIP4K2C16760.1140.2660Yes
14RPS6KA1RPS6KA1
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 116860.1130.2765Yes
15DAPK2DAPK2
Entrez,  Source
death-associated protein kinase 218380.1050.2755Yes
16CSNK1DCSNK1D
Entrez,  Source
casein kinase 1, delta18510.1050.2850Yes
17AAK1AAK1
Entrez,  Source
AP2 associated kinase 122120.0920.2666No
18ULK2ULK2
Entrez,  Source
unc-51-like kinase 2 (C. elegans)22440.0910.2733No
19CLK3CLK3
Entrez,  Source
CDC-like kinase 323490.0870.2740No
20TAOK1TAOK1
Entrez,  Source
TAO kinase 125520.0820.2667No
21ADCK4ADCK4
Entrez,  Source
aarF domain containing kinase 427150.0770.2620No
22EPHA3EPHA3
Entrez,  Source
EPH receptor A328700.0740.2576No
23FLT3FLT3
Entrez,  Source
fms-related tyrosine kinase 334030.0630.2231No
24BLKBLK
Entrez,  Source
B lymphoid tyrosine kinase34190.0620.2281No
25CSNK1A1CSNK1A1
Entrez,  Source
casein kinase 1, alpha 136980.0580.2126No
26ACVRL1ACVRL1
Entrez,  Source
activin A receptor type II-like 137150.0570.2171No
27PIM1PIM1
Entrez,  Source
pim-1 oncogene41360.0500.1899No
28ACVR1BACVR1B
Entrez,  Source
activin A receptor, type IB43280.0470.1801No
29CDKL5CDKL5
Entrez,  Source
cyclin-dependent kinase-like 543450.0470.1835No
30AURKCAURKC
Entrez,  Source
aurora kinase C44130.0460.1830No
31CDKL2CDKL2
Entrez,  Source
cyclin-dependent kinase-like 2 (CDC2-related kinase)45480.0440.1771No
32RPS6KA6RPS6KA6
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 646850.0420.1709No
33NEK7NEK7
Entrez,  Source
NIMA (never in mitosis gene a)-related kinase 748770.0390.1602No
34FLT4FLT4
Entrez,  Source
fms-related tyrosine kinase 448980.0390.1625No
35ULK1ULK1
Entrez,  Source
unc-51-like kinase 1 (C. elegans)51570.0350.1463No
36ACVR1ACVR1
Entrez,  Source
activin A receptor, type I52300.0340.1441No
37PIK3CGPIK3CG
Entrez,  Source
phosphoinositide-3-kinase, catalytic, gamma polypeptide53290.0330.1399No
38MAPK11MAPK11
Entrez,  Source
mitogen-activated protein kinase 1153920.0320.1384No
39PIK3C2BPIK3C2B
Entrez,  Source
phosphoinositide-3-kinase, class 2, beta polypeptide54150.0320.1399No
40STK16STK16
Entrez,  Source
serine/threonine kinase 1657780.0270.1148No
41IRAK1IRAK1
Entrez,  Source
interleukin-1 receptor-associated kinase 161790.0210.0863No
42PIK3CBPIK3CB
Entrez,  Source
phosphoinositide-3-kinase, catalytic, beta polypeptide62250.0200.0849No
43CSNK1G2CSNK1G2
Entrez,  Source
casein kinase 1, gamma 263280.0180.0789No
44AURKAAURKA
Entrez,  Source
aurora kinase A64270.0170.0731No
45RETRET
Entrez,  Source
ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease)64710.0160.0715No
46BMPR1BBMPR1B
Entrez,  Source
bone morphogenetic protein receptor, type IB67770.0120.0493No
47MAPK8MAPK8
Entrez,  Source
mitogen-activated protein kinase 868290.0110.0465No
48PIP5K1CPIP5K1C
Entrez,  Source
phosphatidylinositol-4-phosphate 5-kinase, type I, gamma68810.0100.0437No
49CLK4CLK4
Entrez,  Source
CDC-like kinase 469350.0100.0405No
50BMP2KBMP2K
Entrez,  Source
BMP2 inducible kinase70290.0080.0342No
51TGFBR2TGFBR2
Entrez,  Source
transforming growth factor, beta receptor II (70/80kDa)71030.0070.0293No
52CLK2CLK2
Entrez,  Source
CDC-like kinase 271810.0050.0239No
53IKBKEIKBKE
Entrez,  Source
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon72160.0040.0218No
54PI4KB7697-0.003-0.0146No
55CSNK1ECSNK1E
Entrez,  Source
casein kinase 1, epsilon7742-0.004-0.0175No
56PDGFRBPDGFRB
Entrez,  Source
platelet-derived growth factor receptor, beta polypeptide7824-0.006-0.0232No
57MAPK9MAPK9
Entrez,  Source
mitogen-activated protein kinase 97830-0.006-0.0229No
58MKNK2MKNK2
Entrez,  Source
MAP kinase interacting serine/threonine kinase 27841-0.006-0.0231No
59MELKMELK
Entrez,  Source
maternal embryonic leucine zipper kinase8047-0.010-0.0378No
60KITKIT
Entrez,  Source
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog8134-0.012-0.0432No
61PIK3CDPIK3CD
Entrez,  Source
phosphoinositide-3-kinase, catalytic, delta polypeptide8176-0.013-0.0451No
62RPS6KA4RPS6KA4
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 48181-0.013-0.0441No
63MAP2K5MAP2K5
Entrez,  Source
mitogen-activated protein kinase kinase 58199-0.013-0.0441No
64DYRK1BDYRK1B
Entrez,  Source
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B8200-0.013-0.0428No
65CDKL3CDKL3
Entrez,  Source
cyclin-dependent kinase-like 38249-0.014-0.0450No
66VRK2VRK2
Entrez,  Source
vaccinia related kinase 28412-0.017-0.0557No
67PIK3CAPIK3CA
Entrez,  Source
phosphoinositide-3-kinase, catalytic, alpha polypeptide8749-0.025-0.0789No
68AURKBAURKB
Entrez,  Source
aurora kinase B8856-0.027-0.0843No
69IRAK4IRAK4
Entrez,  Source
interleukin-1 receptor-associated kinase 48996-0.031-0.0918No
70TYK2TYK2
Entrez,  Source
tyrosine kinase 29438-0.041-0.1215No
71PAK3PAK3
Entrez,  Source
p21 (CDKN1A)-activated kinase 39490-0.042-0.1212No
72CSNK2A2CSNK2A2
Entrez,  Source
casein kinase 2, alpha prime polypeptide9758-0.049-0.1367No
73HIPK3HIPK3
Entrez,  Source
homeodomain interacting protein kinase 39770-0.050-0.1326No
74NEK9NEK9
Entrez,  Source
NIMA (never in mitosis gene a)- related kinase 99810-0.051-0.1306No
75HCKHCK
Entrez,  Source
hemopoietic cell kinase9981-0.056-0.1380No
76PLK2PLK2
Entrez,  Source
polo-like kinase 2 (Drosophila)9994-0.057-0.1333No
77STK17ASTK17A
Entrez,  Source
serine/threonine kinase 17a (apoptosis-inducing)10017-0.057-0.1293No
78HIPK2HIPK2
Entrez,  Source
homeodomain interacting protein kinase 210151-0.061-0.1334No
79ADCK310237-0.064-0.1335No
80DYRK1ADYRK1A
Entrez,  Source
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A10303-0.066-0.1320No
81RPS6KA3RPS6KA3
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 310427-0.070-0.1343No
82PLK4PLK4
Entrez,  Source
polo-like kinase 4 (Drosophila)10581-0.075-0.1385No
83JAK1JAK1
Entrez,  Source
Janus kinase 1 (a protein tyrosine kinase)10585-0.076-0.1312No
84RPS6KB1RPS6KB1
Entrez,  Source
ribosomal protein S6 kinase, 70kDa, polypeptide 110717-0.081-0.1332No
85CAMKK2CAMKK2
Entrez,  Source
calcium/calmodulin-dependent protein kinase kinase 2, beta10729-0.081-0.1260No
86BRSK2BRSK2
Entrez,  Source
BR serine/threonine kinase 210749-0.082-0.1193No
87SRCSRC
Entrez,  Source
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)10776-0.083-0.1130No
88PIP5K1APIP5K1A
Entrez,  Source
phosphatidylinositol-4-phosphate 5-kinase, type I, alpha10780-0.083-0.1049No
89MTOR10944-0.091-0.1083No
90NLKNLK
Entrez,  Source
nemo-like kinase10979-0.093-0.1017No
91DAPK3DAPK3
Entrez,  Source
death-associated protein kinase 311066-0.096-0.0987No
92CDK7CDK7
Entrez,  Source
cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase)11160-0.101-0.0958No
93STK10STK10
Entrez,  Source
serine/threonine kinase 1011218-0.103-0.0898No
94MYLKMYLK
Entrez,  Source
myosin, light chain kinase11255-0.105-0.0822No
95BMPR2BMPR2
Entrez,  Source
bone morphogenetic protein receptor, type II (serine/threonine kinase)11345-0.109-0.0781No
96RIPK2RIPK2
Entrez,  Source
receptor-interacting serine-threonine kinase 211349-0.110-0.0674No
97HIPK1HIPK1
Entrez,  Source
homeodomain interacting protein kinase 111798-0.135-0.0882No
98MAP2K4MAP2K4
Entrez,  Source
mitogen-activated protein kinase kinase 411811-0.136-0.0755No
99CSNK2A1CSNK2A1
Entrez,  Source
casein kinase 2, alpha 1 polypeptide11861-0.139-0.0654No
100BMPR1ABMPR1A
Entrez,  Source
bone morphogenetic protein receptor, type IA12438-0.194-0.0902No
101TGFBR1TGFBR1
Entrez,  Source
transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kDa)12447-0.195-0.0714No
102IRAK3IRAK3
Entrez,  Source
interleukin-1 receptor-associated kinase 312451-0.196-0.0521No
103ABL1ABL1
Entrez,  Source
v-abl Abelson murine leukemia viral oncogene homolog 112463-0.197-0.0333No
104RIOK2RIOK2
Entrez,  Source
RIO kinase 2 (yeast)12467-0.198-0.0139No
105ZAKZAK
Entrez,  Source
-12544-0.2090.0011No
106MAP3K7MAP3K7
Entrez,  Source
mitogen-activated protein kinase kinase kinase 712613-0.2210.0179No
107AXLAXL
Entrez,  Source
AXL receptor tyrosine kinase12789-0.2570.0301No
Table: GSEA details [plain text format]



Fig 2: CP466722_LINCS   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: CP466722_LINCS: Random ES distribution   
Gene set null distribution of ES for CP466722_LINCS