DatasetNSCLC_collapsed_to_symbols.NSCLC.cls
#SEN_versus_RES.NSCLC.cls
#SEN_versus_RES_repos
PhenotypeNSCLC.cls#SEN_versus_RES_repos
Upregulated in class1
GeneSetKW-2449_KINOME SCAN
Enrichment Score (ES)0.2846569
Normalized Enrichment Score (NES)1.095225
Nominal p-value0.24921136
FDR q-value0.73039263
FWER p-Value1.0
Table: GSEA Results Summary



Fig 1: Enrichment plot: KW-2449_KINOME SCAN   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEGENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1MST1RMST1R
Entrez,  Source
macrophage stimulating 1 receptor (c-met-related tyrosine kinase)540.6360.0328Yes
2DAPK1DAPK1
Entrez,  Source
death-associated protein kinase 1880.5570.0627Yes
3EPHA1EPHA1
Entrez,  Source
EPH receptor A1940.5450.0940Yes
4RIPK4RIPK4
Entrez,  Source
receptor-interacting serine-threonine kinase 4950.5440.1256Yes
5FGFR3FGFR3
Entrez,  Source
fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism)1530.4650.1483Yes
6FGFR2FGFR2
Entrez,  Source
ffer syndrome, Jackson-Weiss syndrome)2100.4060.1676Yes
7STK39STK39
Entrez,  Source
serine threonine kinase 39 (STE20/SPS1 homolog, yeast)3840.2990.1717Yes
8SYKSYK
Entrez,  Source
spleen tyrosine kinase4710.2680.1807Yes
9METMET
Entrez,  Source
met proto-oncogene (hepatocyte growth factor receptor)4990.2590.1936Yes
10IKBKBIKBKB
Entrez,  Source
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta5530.2450.2038Yes
11RPS6KA2RPS6KA2
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 25900.2370.2148Yes
12MAP3K13MAP3K13
Entrez,  Source
mitogen-activated protein kinase kinase kinase 136240.2300.2256Yes
13EGFREGFR
Entrez,  Source
epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)6250.2300.2390Yes
14CDK146590.2220.2494Yes
15EPHB6EPHB6
Entrez,  Source
EPH receptor B67010.2150.2587Yes
16TAOK3TAOK3
Entrez,  Source
TAO kinase 39710.1700.2479Yes
17TXKTXK
Entrez,  Source
TXK tyrosine kinase10450.1600.2516Yes
18MAPK10MAPK10
Entrez,  Source
mitogen-activated protein kinase 1010690.1570.2590Yes
19TNIKTNIK
Entrez,  Source
TRAF2 and NCK interacting kinase11970.1450.2577Yes
20DYRK2DYRK2
Entrez,  Source
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 212300.1420.2635Yes
21GAKGAK
Entrez,  Source
cyclin G associated kinase13400.1330.2629Yes
22TNK1TNK1
Entrez,  Source
tyrosine kinase, non-receptor, 113600.1310.2690Yes
23CAMK1DCAMK1D
Entrez,  Source
calcium/calmodulin-dependent protein kinase ID13870.1290.2746Yes
24EPHA7EPHA7
Entrez,  Source
EPH receptor A714120.1280.2802Yes
25STK17BSTK17B
Entrez,  Source
serine/threonine kinase 17b (apoptosis-inducing)15540.1190.2763Yes
26INSRINSR
Entrez,  Source
insulin receptor16640.1140.2745Yes
27MAP3K9MAP3K9
Entrez,  Source
mitogen-activated protein kinase kinase kinase 916990.1120.2785Yes
28NTRK2NTRK2
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 217040.1120.2847Yes
29RIOK3RIOK3
Entrez,  Source
RIO kinase 3 (yeast)19420.1010.2723No
30PTK2BPTK2B
Entrez,  Source
PTK2B protein tyrosine kinase 2 beta20420.0980.2704No
31MARK1MARK1
Entrez,  Source
MAP/microtubule affinity-regulating kinase 121590.0930.2669No
32AAK1AAK1
Entrez,  Source
AP2 associated kinase 122120.0920.2683No
33ULK2ULK2
Entrez,  Source
unc-51-like kinase 2 (C. elegans)22440.0910.2712No
34MAP3K11MAP3K11
Entrez,  Source
mitogen-activated protein kinase kinase kinase 1122950.0890.2725No
35TIE1TIE1
Entrez,  Source
tyrosine kinase with immunoglobulin-like and EGF-like domains 123280.0880.2752No
36JAK3JAK3
Entrez,  Source
Janus kinase 3 (a protein tyrosine kinase, leukocyte)24440.0840.2712No
37MERTKMERTK
Entrez,  Source
c-mer proto-oncogene tyrosine kinase25220.0820.2701No
38MAP4K1MAP4K1
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 128490.0740.2494No
39EPHA3EPHA3
Entrez,  Source
EPH receptor A328700.0740.2521No
40STK38STK38
Entrez,  Source
serine/threonine kinase 3828780.0730.2559No
41YES1YES1
Entrez,  Source
v-yes-1 Yamaguchi sarcoma viral oncogene homolog 130360.0700.2479No
42MINK1MINK1
Entrez,  Source
misshapen-like kinase 1 (zebrafish)30800.0690.2486No
43KDRKDR
Entrez,  Source
kinase insert domain receptor (a type III receptor tyrosine kinase)31460.0680.2475No
44FLT3FLT3
Entrez,  Source
fms-related tyrosine kinase 334030.0630.2315No
45CSF1RCSF1R
Entrez,  Source
colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog34540.0620.2312No
46MYO3AMYO3A
Entrez,  Source
myosin IIIA37350.0570.2130No
47MARK2MARK2
Entrez,  Source
MAP/microtubule affinity-regulating kinase 238340.0550.2087No
48PRKG2PRKG2
Entrez,  Source
protein kinase, cGMP-dependent, type II40210.0520.1974No
49ALKALK
Entrez,  Source
anaplastic lymphoma kinase (Ki-1)40730.0510.1965No
50MUSKMUSK
Entrez,  Source
muscle, skeletal, receptor tyrosine kinase41390.0500.1944No
51FGRFGR
Entrez,  Source
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog41930.0490.1932No
52AURKCAURKC
Entrez,  Source
aurora kinase C44130.0460.1791No
53HUNKHUNK
Entrez,  Source
hormonally upregulated Neu-associated kinase46450.0430.1638No
54RPS6KA6RPS6KA6
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 646850.0420.1632No
55PHKG2PHKG2
Entrez,  Source
phosphorylase kinase, gamma 2 (testis)47920.0400.1574No
56NEK7NEK7
Entrez,  Source
NIMA (never in mitosis gene a)-related kinase 748770.0390.1533No
57FLT1FLT1
Entrez,  Source
fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)48820.0390.1552No
58ULK1ULK1
Entrez,  Source
unc-51-like kinase 1 (C. elegans)51570.0350.1362No
59ACVR1ACVR1
Entrez,  Source
activin A receptor, type I52300.0340.1327No
60INSRRINSRR
Entrez,  Source
insulin receptor-related receptor53320.0330.1268No
61PDPK1PDPK1
Entrez,  Source
3-phosphoinositide dependent protein kinase-155490.0300.1120No
62BTKBTK
Entrez,  Source
Bruton agammaglobulinemia tyrosine kinase56280.0290.1077No
63STK16STK16
Entrez,  Source
serine/threonine kinase 1657780.0270.0978No
64SRPK3SRPK3
Entrez,  Source
SFRS protein kinase 358600.0260.0931No
65PAK7PAK7
Entrez,  Source
p21(CDKN1A)-activated kinase 758810.0250.0930No
66MAP3K3MAP3K3
Entrez,  Source
mitogen-activated protein kinase kinase kinase 359210.0250.0914No
67NTRK1NTRK1
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 160970.0220.0793No
68FESFES
Entrez,  Source
feline sarcoma oncogene61260.0220.0784No
69IRAK1IRAK1
Entrez,  Source
interleukin-1 receptor-associated kinase 161790.0210.0756No
70PHKG1PHKG1
Entrez,  Source
phosphorylase kinase, gamma 1 (muscle)62450.0200.0718No
71CSNK1G2CSNK1G2
Entrez,  Source
casein kinase 1, gamma 263280.0180.0665No
72AURKAAURKA
Entrez,  Source
aurora kinase A64270.0170.0600No
73RETRET
Entrez,  Source
ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease)64710.0160.0576No
74PIP4K2B65940.0150.0491No
75BMPR1BBMPR1B
Entrez,  Source
bone morphogenetic protein receptor, type IB67770.0120.0358No
76PKN1PKN1
Entrez,  Source
protein kinase N167830.0120.0362No
77GRK4GRK4
Entrez,  Source
G protein-coupled receptor kinase 467880.0120.0365No
78MAPK8MAPK8
Entrez,  Source
mitogen-activated protein kinase 868290.0110.0341No
79MAP4K2MAP4K2
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 268940.0100.0298No
80CLK4CLK4
Entrez,  Source
CDC-like kinase 469350.0100.0273No
81BMP2KBMP2K
Entrez,  Source
BMP2 inducible kinase70290.0080.0206No
82CLK2CLK2
Entrez,  Source
CDC-like kinase 271810.0050.0093No
83IKBKEIKBKE
Entrez,  Source
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon72160.0040.0069No
84ITKITK
Entrez,  Source
IL2-inducible T-cell kinase72200.0040.0070No
85ACVR2BACVR2B
Entrez,  Source
activin A receptor, type IIB73820.002-0.0053No
86PRKAA2PRKAA2
Entrez,  Source
protein kinase, AMP-activated, alpha 2 catalytic subunit74180.001-0.0079No
87SIK274350.001-0.0091No
88CSNK1ECSNK1E
Entrez,  Source
casein kinase 1, epsilon7742-0.004-0.0324No
89MAP2K3MAP2K3
Entrez,  Source
mitogen-activated protein kinase kinase 37798-0.005-0.0363No
90PDGFRBPDGFRB
Entrez,  Source
platelet-derived growth factor receptor, beta polypeptide7824-0.006-0.0378No
91MAPK9MAPK9
Entrez,  Source
mitogen-activated protein kinase 97830-0.006-0.0379No
92MAP2K1MAP2K1
Entrez,  Source
mitogen-activated protein kinase kinase 17939-0.008-0.0457No
93IGF1RIGF1R
Entrez,  Source
insulin-like growth factor 1 receptor7959-0.008-0.0467No
94MELKMELK
Entrez,  Source
maternal embryonic leucine zipper kinase8047-0.010-0.0528No
95KITKIT
Entrez,  Source
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog8134-0.012-0.0587No
96LTKLTK
Entrez,  Source
leukocyte tyrosine kinase8158-0.012-0.0598No
97MAP2K5MAP2K5
Entrez,  Source
mitogen-activated protein kinase kinase 58199-0.013-0.0621No
98DYRK1BDYRK1B
Entrez,  Source
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B8200-0.013-0.0613No
99MARK4MARK4
Entrez,  Source
MAP/microtubule affinity-regulating kinase 48259-0.014-0.0649No
100CDK168353-0.016-0.0711No
101NTRK3NTRK3
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 38500-0.019-0.0812No
102ROCK1ROCK1
Entrez,  Source
Rho-associated, coiled-coil containing protein kinase 18741-0.025-0.0982No
103AURKBAURKB
Entrez,  Source
aurora kinase B8856-0.027-0.1054No
104ZAP70ZAP70
Entrez,  Source
zeta-chain (TCR) associated protein kinase 70kDa8954-0.030-0.1111No
105IRAK4IRAK4
Entrez,  Source
interleukin-1 receptor-associated kinase 48996-0.031-0.1125No
106STK11STK11
Entrez,  Source
serine/threonine kinase 119183-0.035-0.1247No
107ACVR2AACVR2A
Entrez,  Source
activin A receptor, type IIA9293-0.038-0.1309No
108TYK2TYK2
Entrez,  Source
tyrosine kinase 29438-0.041-0.1396No
109PAK3PAK3
Entrez,  Source
p21 (CDKN1A)-activated kinase 39490-0.042-0.1411No
110CSNK2A2CSNK2A2
Entrez,  Source
casein kinase 2, alpha prime polypeptide9758-0.049-0.1587No
111HIPK3HIPK3
Entrez,  Source
homeodomain interacting protein kinase 39770-0.050-0.1567No
112NEK9NEK9
Entrez,  Source
NIMA (never in mitosis gene a)- related kinase 99810-0.051-0.1567No
113MAP4K4MAP4K4
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 49922-0.055-0.1621No
114TTKTTK
Entrez,  Source
TTK protein kinase9930-0.055-0.1594No
115STK17ASTK17A
Entrez,  Source
serine/threonine kinase 17a (apoptosis-inducing)10017-0.057-0.1627No
116CHEK2CHEK2
Entrez,  Source
CHK2 checkpoint homolog (S. pombe)10102-0.059-0.1657No
117HIPK2HIPK2
Entrez,  Source
homeodomain interacting protein kinase 210151-0.061-0.1659No
118DYRK1ADYRK1A
Entrez,  Source
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A10303-0.066-0.1736No
119CITCIT
Entrez,  Source
citron (rho-interacting, serine/threonine kinase 21)10420-0.070-0.1785No
120RPS6KA3RPS6KA3
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 310427-0.070-0.1748No
121PLK4PLK4
Entrez,  Source
polo-like kinase 4 (Drosophila)10581-0.075-0.1822No
122JAK1JAK1
Entrez,  Source
Janus kinase 1 (a protein tyrosine kinase)10585-0.076-0.1780No
123RPS6KB1RPS6KB1
Entrez,  Source
ribosomal protein S6 kinase, 70kDa, polypeptide 110717-0.081-0.1834No
124CAMKK2CAMKK2
Entrez,  Source
calcium/calmodulin-dependent protein kinase kinase 2, beta10729-0.081-0.1795No
125TBK1TBK1
Entrez,  Source
TANK-binding kinase 110732-0.082-0.1749No
126PIP5K1APIP5K1A
Entrez,  Source
phosphatidylinositol-4-phosphate 5-kinase, type I, alpha10780-0.083-0.1737No
127CHEK1CHEK1
Entrez,  Source
CHK1 checkpoint homolog (S. pombe)10792-0.084-0.1697No
128CDK4CDK4
Entrez,  Source
cyclin-dependent kinase 410871-0.087-0.1706No
129PRKAA1PRKAA1
Entrez,  Source
protein kinase, AMP-activated, alpha 1 catalytic subunit10906-0.089-0.1680No
130DAPK3DAPK3
Entrez,  Source
death-associated protein kinase 311066-0.096-0.1746No
131SRPK1SRPK1
Entrez,  Source
SFRS protein kinase 111068-0.096-0.1691No
132ABL2ABL2
Entrez,  Source
v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)11090-0.098-0.1651No
133CDK7CDK7
Entrez,  Source
cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase)11160-0.101-0.1645No
134STK10STK10
Entrez,  Source
serine/threonine kinase 1011218-0.103-0.1629No
135MYLKMYLK
Entrez,  Source
myosin, light chain kinase11255-0.105-0.1595No
136BMPR2BMPR2
Entrez,  Source
bone morphogenetic protein receptor, type II (serine/threonine kinase)11345-0.109-0.1600No
137RIPK1RIPK1
Entrez,  Source
receptor (TNFRSF)-interacting serine-threonine kinase 111427-0.113-0.1596No
138SRPK2SRPK2
Entrez,  Source
SFRS protein kinase 211496-0.117-0.1581No
139STK4STK4
Entrez,  Source
serine/threonine kinase 411518-0.118-0.1528No
140JAK2JAK2
Entrez,  Source
Janus kinase 2 (a protein tyrosine kinase)11530-0.119-0.1468No
141SLKSLK
Entrez,  Source
STE20-like kinase (yeast)11672-0.128-0.1502No
142MAP4K5MAP4K5
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 511705-0.130-0.1451No
143FYNFYN
Entrez,  Source
FYN oncogene related to SRC, FGR, YES11767-0.133-0.1420No
144NEK3NEK3
Entrez,  Source
NIMA (never in mitosis gene a)-related kinase 311797-0.135-0.1364No
145HIPK1HIPK1
Entrez,  Source
homeodomain interacting protein kinase 111798-0.135-0.1285No
146MAP2K4MAP2K4
Entrez,  Source
mitogen-activated protein kinase kinase 411811-0.136-0.1215No
147PRPF4BPRPF4B
Entrez,  Source
PRP4 pre-mRNA processing factor 4 homolog B (yeast)11856-0.139-0.1168No
148MAP2K2MAP2K2
Entrez,  Source
mitogen-activated protein kinase kinase 211895-0.142-0.1115No
149MAP2K6MAP2K6
Entrez,  Source
mitogen-activated protein kinase kinase 611934-0.144-0.1060No
150ROCK2ROCK2
Entrez,  Source
Rho-associated, coiled-coil containing protein kinase 212033-0.152-0.1047No
151MAP3K2MAP3K2
Entrez,  Source
mitogen-activated protein kinase kinase kinase 212210-0.168-0.1085No
152PDGFRAPDGFRA
Entrez,  Source
platelet-derived growth factor receptor, alpha polypeptide12211-0.168-0.0987No
153PKN2PKN2
Entrez,  Source
protein kinase N212286-0.175-0.0942No
154SIK112319-0.179-0.0863No
155MAP3K12MAP3K12
Entrez,  Source
mitogen-activated protein kinase kinase kinase 1212384-0.186-0.0803No
156MAP4K3MAP4K3
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 312403-0.189-0.0708No
157IRAK3IRAK3
Entrez,  Source
interleukin-1 receptor-associated kinase 312451-0.196-0.0630No
158ABL1ABL1
Entrez,  Source
v-abl Abelson murine leukemia viral oncogene homolog 112463-0.197-0.0524No
159ZAKZAK
Entrez,  Source
-12544-0.209-0.0464No
160MAP3K7MAP3K7
Entrez,  Source
mitogen-activated protein kinase kinase kinase 712613-0.221-0.0387No
161AXLAXL
Entrez,  Source
AXL receptor tyrosine kinase12789-0.257-0.0373No
162CHUKCHUK
Entrez,  Source
conserved helix-loop-helix ubiquitous kinase12978-0.325-0.0328No
163PRKD3PRKD3
Entrez,  Source
protein kinase D313008-0.345-0.0150No
164FGFR1FGFR1
Entrez,  Source
fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome)13121-0.4860.0047No
Table: GSEA details [plain text format]



Fig 2: KW-2449_KINOME SCAN   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: KW-2449_KINOME SCAN: Random ES distribution   
Gene set null distribution of ES for KW-2449_KINOME SCAN