DatasetNSCLC_collapsed_to_symbols.NSCLC.cls
#SEN_versus_RES.NSCLC.cls
#SEN_versus_RES_repos
PhenotypeNSCLC.cls#SEN_versus_RES_repos
Upregulated in class1
GeneSetNVP-TAE684_LINCS
Enrichment Score (ES)0.30410036
Normalized Enrichment Score (NES)1.1694646
Nominal p-value0.13500784
FDR q-value0.64360595
FWER p-Value1.0
Table: GSEA Results Summary



Fig 1: Enrichment plot: NVP-TAE684_LINCS   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEGENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1MST1RMST1R
Entrez,  Source
macrophage stimulating 1 receptor (c-met-related tyrosine kinase)540.6360.0278Yes
2DAPK1DAPK1
Entrez,  Source
death-associated protein kinase 1880.5570.0532Yes
3EPHA1EPHA1
Entrez,  Source
EPH receptor A1940.5450.0802Yes
4ERBB2ERBB2
Entrez,  Source
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)1000.5370.1068Yes
5PTK6PTK6
Entrez,  Source
PTK6 protein tyrosine kinase 61410.4790.1277Yes
6FGFR3FGFR3
Entrez,  Source
fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism)1530.4650.1503Yes
7PAK6PAK6
Entrez,  Source
p21(CDKN1A)-activated kinase 61580.4590.1730Yes
8FGFR2FGFR2
Entrez,  Source
ffer syndrome, Jackson-Weiss syndrome)2100.4060.1894Yes
9DDR1DDR1
Entrez,  Source
discoidin domain receptor family, member 12120.4040.2096Yes
10FRKFRK
Entrez,  Source
fyn-related kinase2960.3430.2205Yes
11SYKSYK
Entrez,  Source
spleen tyrosine kinase4710.2680.2205Yes
12METMET
Entrez,  Source
met proto-oncogene (hepatocyte growth factor receptor)4990.2590.2314Yes
13ROS1ROS1
Entrez,  Source
v-ros UR2 sarcoma virus oncogene homolog 1 (avian)5050.2580.2440Yes
14RPS6KA2RPS6KA2
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 25900.2370.2494Yes
15EGFREGFR
Entrez,  Source
epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)6250.2300.2583Yes
16PAK1PAK1
Entrez,  Source
p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast)6740.2190.2656Yes
17TAOK3TAOK3
Entrez,  Source
TAO kinase 39710.1700.2514Yes
18TXKTXK
Entrez,  Source
TXK tyrosine kinase10450.1600.2538Yes
19MAPK10MAPK10
Entrez,  Source
mitogen-activated protein kinase 1010690.1570.2599Yes
20TNIKTNIK
Entrez,  Source
TRAF2 and NCK interacting kinase11970.1450.2574Yes
21LCKLCK
Entrez,  Source
lymphocyte-specific protein tyrosine kinase13100.1360.2556Yes
22GAKGAK
Entrez,  Source
cyclin G associated kinase13400.1330.2601Yes
23TNK1TNK1
Entrez,  Source
tyrosine kinase, non-receptor, 113600.1310.2652Yes
24CAMK1DCAMK1D
Entrez,  Source
calcium/calmodulin-dependent protein kinase ID13870.1290.2697Yes
25EPHA7EPHA7
Entrez,  Source
EPH receptor A714120.1280.2743Yes
26SLC12A7SLC12A7
Entrez,  Source
solute carrier family 12 (potassium/chloride transporters), member 715430.1200.2703Yes
27STK3STK3
Entrez,  Source
serine/threonine kinase 3 (STE20 homolog, yeast)15530.1200.2756Yes
28INSRINSR
Entrez,  Source
insulin receptor16640.1140.2729Yes
29RPS6KA1RPS6KA1
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 116860.1130.2769Yes
30MAP3K9MAP3K9
Entrez,  Source
mitogen-activated protein kinase kinase kinase 916990.1120.2816Yes
31NTRK2NTRK2
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 217040.1120.2869Yes
32MAPK3MAPK3
Entrez,  Source
mitogen-activated protein kinase 317660.1090.2877Yes
33CAMK2ACAMK2A
Entrez,  Source
calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha18010.1070.2905Yes
34CAMK2GCAMK2G
Entrez,  Source
calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma18110.1070.2951Yes
35ERBB4ERBB4
Entrez,  Source
v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)18130.1070.3004Yes
36DAPK2DAPK2
Entrez,  Source
death-associated protein kinase 218380.1050.3038Yes
37RIOK3RIOK3
Entrez,  Source
RIO kinase 3 (yeast)19420.1010.3010Yes
38LYNLYN
Entrez,  Source
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog19740.1000.3036Yes
39PTK2BPTK2B
Entrez,  Source
PTK2B protein tyrosine kinase 2 beta20420.0980.3034Yes
40MARK1MARK1
Entrez,  Source
MAP/microtubule affinity-regulating kinase 121590.0930.2991Yes
41AAK1AAK1
Entrez,  Source
AP2 associated kinase 122120.0920.2997Yes
42ULK2ULK2
Entrez,  Source
unc-51-like kinase 2 (C. elegans)22440.0910.3019Yes
43TIE1TIE1
Entrez,  Source
tyrosine kinase with immunoglobulin-like and EGF-like domains 123280.0880.2999Yes
44CLK3CLK3
Entrez,  Source
CDC-like kinase 323490.0870.3028Yes
45JAK3JAK3
Entrez,  Source
Janus kinase 3 (a protein tyrosine kinase, leukocyte)24440.0840.2998Yes
46MAP3K4MAP3K4
Entrez,  Source
mitogen-activated protein kinase kinase kinase 424890.0830.3006Yes
47MERTKMERTK
Entrez,  Source
c-mer proto-oncogene tyrosine kinase25220.0820.3022Yes
48TAOK1TAOK1
Entrez,  Source
TAO kinase 125520.0820.3041Yes
49ADCK4ADCK4
Entrez,  Source
aarF domain containing kinase 427150.0770.2955No
50LIMK2LIMK2
Entrez,  Source
LIM domain kinase 227990.0760.2929No
51MAP4K1MAP4K1
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 128490.0740.2929No
52TNK2TNK2
Entrez,  Source
tyrosine kinase, non-receptor, 230050.0700.2845No
53YES1YES1
Entrez,  Source
v-yes-1 Yamaguchi sarcoma viral oncogene homolog 130360.0700.2857No
54CSKCSK
Entrez,  Source
c-src tyrosine kinase30690.0690.2867No
55KDRKDR
Entrez,  Source
kinase insert domain receptor (a type III receptor tyrosine kinase)31460.0680.2842No
56FLT3FLT3
Entrez,  Source
fms-related tyrosine kinase 334030.0630.2677No
57BLKBLK
Entrez,  Source
B lymphoid tyrosine kinase34190.0620.2696No
58TSSK1B34450.0620.2708No
59CSF1RCSF1R
Entrez,  Source
colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog34540.0620.2733No
60ACVRL1ACVRL1
Entrez,  Source
activin A receptor type II-like 137150.0570.2562No
61MYO3AMYO3A
Entrez,  Source
myosin IIIA37350.0570.2575No
62MARK2MARK2
Entrez,  Source
MAP/microtubule affinity-regulating kinase 238340.0550.2528No
63PRKD2PRKD2
Entrez,  Source
protein kinase D239000.0540.2505No
64EPHB1EPHB1
Entrez,  Source
EPH receptor B140000.0520.2455No
65PRKG2PRKG2
Entrez,  Source
protein kinase, cGMP-dependent, type II40210.0520.2466No
66ALKALK
Entrez,  Source
anaplastic lymphoma kinase (Ki-1)40730.0510.2452No
67MUSKMUSK
Entrez,  Source
muscle, skeletal, receptor tyrosine kinase41390.0500.2427No
68FGRFGR
Entrez,  Source
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog41930.0490.2411No
69CAMK2BCAMK2B
Entrez,  Source
calcium/calmodulin-dependent protein kinase (CaM kinase) II beta42130.0490.2421No
70ACVR1BACVR1B
Entrez,  Source
activin A receptor, type IB43280.0470.2357No
71AURKCAURKC
Entrez,  Source
aurora kinase C44130.0460.2315No
72LIMK1LIMK1
Entrez,  Source
LIM domain kinase 144680.0450.2296No
73NEK2NEK2
Entrez,  Source
NIMA (never in mitosis gene a)-related kinase 244830.0450.2308No
74RPS6KA6RPS6KA6
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 646850.0420.2175No
75FGFR4FGFR4
Entrez,  Source
fibroblast growth factor receptor 447150.0410.2173No
76PHKG2PHKG2
Entrez,  Source
phosphorylase kinase, gamma 2 (testis)47920.0400.2135No
77BMXBMX
Entrez,  Source
BMX non-receptor tyrosine kinase48260.0400.2130No
78NEK7NEK7
Entrez,  Source
NIMA (never in mitosis gene a)-related kinase 748770.0390.2111No
79FLT1FLT1
Entrez,  Source
fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)48820.0390.2127No
80FLT4FLT4
Entrez,  Source
fms-related tyrosine kinase 448980.0390.2135No
81PRKG1PRKG1
Entrez,  Source
protein kinase, cGMP-dependent, type I49360.0380.2126No
82PAK4PAK4
Entrez,  Source
p21(CDKN1A)-activated kinase 450140.0370.2085No
83ULK1ULK1
Entrez,  Source
unc-51-like kinase 1 (C. elegans)51570.0350.1994No
84ACVR1ACVR1
Entrez,  Source
activin A receptor, type I52300.0340.1955No
85TNNI3KTNNI3K
Entrez,  Source
TNNI3 interacting kinase52740.0330.1939No
86INSRRINSRR
Entrez,  Source
insulin receptor-related receptor53320.0330.1912No
87TECTEC
Entrez,  Source
tec protein tyrosine kinase53790.0320.1892No
88BTKBTK
Entrez,  Source
Bruton agammaglobulinemia tyrosine kinase56280.0290.1716No
89STK16STK16
Entrez,  Source
serine/threonine kinase 1657780.0270.1615No
90SRPK3SRPK3
Entrez,  Source
SFRS protein kinase 358600.0260.1565No
91PAK7PAK7
Entrez,  Source
p21(CDKN1A)-activated kinase 758810.0250.1563No
92MAP3K3MAP3K3
Entrez,  Source
mitogen-activated protein kinase kinase kinase 359210.0250.1545No
93MAPK1MAPK1
Entrez,  Source
mitogen-activated protein kinase 159940.0240.1501No
94NTRK1NTRK1
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 160970.0220.1434No
95FESFES
Entrez,  Source
feline sarcoma oncogene61260.0220.1423No
96PHKG1PHKG1
Entrez,  Source
phosphorylase kinase, gamma 1 (muscle)62450.0200.1342No
97AURKAAURKA
Entrez,  Source
aurora kinase A64270.0170.1212No
98DCLK264620.0160.1194No
99RETRET
Entrez,  Source
ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease)64710.0160.1196No
100MAP3K10MAP3K10
Entrez,  Source
mitogen-activated protein kinase kinase kinase 1065490.0150.1144No
101PIP4K2B65940.0150.1118No
102PLK3PLK3
Entrez,  Source
polo-like kinase 3 (Drosophila)67550.0120.1001No
103BMPR1BBMPR1B
Entrez,  Source
bone morphogenetic protein receptor, type IB67770.0120.0990No
104PKN1PKN1
Entrez,  Source
protein kinase N167830.0120.0993No
105MAPK8MAPK8
Entrez,  Source
mitogen-activated protein kinase 868290.0110.0964No
106MAP4K2MAP4K2
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 268940.0100.0919No
107MAPK7MAPK7
Entrez,  Source
mitogen-activated protein kinase 769130.0100.0910No
108STK32BSTK32B
Entrez,  Source
serine/threonine kinase 32B69190.0100.0911No
109CLK4CLK4
Entrez,  Source
CDC-like kinase 469350.0100.0905No
110BMP2KBMP2K
Entrez,  Source
BMP2 inducible kinase70290.0080.0837No
111TEKTEK
Entrez,  Source
TEK tyrosine kinase, endothelial (venous malformations, multiple cutaneous and mucosal)70350.0080.0837No
112TGFBR2TGFBR2
Entrez,  Source
transforming growth factor, beta receptor II (70/80kDa)71030.0070.0789No
113CLK2CLK2
Entrez,  Source
CDC-like kinase 271810.0050.0732No
114ITKITK
Entrez,  Source
IL2-inducible T-cell kinase72200.0040.0705No
115PRKAA2PRKAA2
Entrez,  Source
protein kinase, AMP-activated, alpha 2 catalytic subunit74180.0010.0554No
116CDK5CDK5
Entrez,  Source
cyclin-dependent kinase 574320.0010.0545No
117SIK274350.0010.0543No
118MAP2K3MAP2K3
Entrez,  Source
mitogen-activated protein kinase kinase 37798-0.0050.0267No
119PDGFRBPDGFRB
Entrez,  Source
platelet-derived growth factor receptor, beta polypeptide7824-0.0060.0251No
120MAPK9MAPK9
Entrez,  Source
mitogen-activated protein kinase 97830-0.0060.0250No
121MKNK2MKNK2
Entrez,  Source
MAP kinase interacting serine/threonine kinase 27841-0.0060.0246No
122MAP2K1MAP2K1
Entrez,  Source
mitogen-activated protein kinase kinase 17939-0.0080.0175No
123IGF1RIGF1R
Entrez,  Source
insulin-like growth factor 1 receptor7959-0.0080.0165No
124MELKMELK
Entrez,  Source
maternal embryonic leucine zipper kinase8047-0.0100.0103No
125PRKACAPRKACA
Entrez,  Source
protein kinase, cAMP-dependent, catalytic, alpha8112-0.0110.0059No
126KITKIT
Entrez,  Source
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog8134-0.0120.0049No
127LTKLTK
Entrez,  Source
leukocyte tyrosine kinase8158-0.0120.0037No
128RPS6KA4RPS6KA4
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 48181-0.0130.0027No
129MARK4MARK4
Entrez,  Source
MAP/microtubule affinity-regulating kinase 48259-0.014-0.0025No
130DMPKDMPK
Entrez,  Source
dystrophia myotonica-protein kinase8344-0.016-0.0082No
131CDK168353-0.016-0.0080No
132PTK2PTK2
Entrez,  Source
PTK2 protein tyrosine kinase 28356-0.016-0.0073No
133AURKBAURKB
Entrez,  Source
aurora kinase B8856-0.027-0.0444No
134ZAP70ZAP70
Entrez,  Source
zeta-chain (TCR) associated protein kinase 70kDa8954-0.030-0.0504No
135ACVR2AACVR2A
Entrez,  Source
activin A receptor, type IIA9293-0.038-0.0745No
136TYK2TYK2
Entrez,  Source
tyrosine kinase 29438-0.041-0.0835No
137PAK3PAK3
Entrez,  Source
p21 (CDKN1A)-activated kinase 39490-0.042-0.0853No
138NEK9NEK9
Entrez,  Source
NIMA (never in mitosis gene a)- related kinase 99810-0.051-0.1073No
139PRKD1PRKD1
Entrez,  Source
protein kinase D19827-0.052-0.1060No
140DCLK19840-0.052-0.1043No
141MAP4K4MAP4K4
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 49922-0.055-0.1078No
142TTKTTK
Entrez,  Source
TTK protein kinase9930-0.055-0.1056No
143HCKHCK
Entrez,  Source
hemopoietic cell kinase9981-0.056-0.1066No
144STK17ASTK17A
Entrez,  Source
serine/threonine kinase 17a (apoptosis-inducing)10017-0.057-0.1064No
145CHEK2CHEK2
Entrez,  Source
CHK2 checkpoint homolog (S. pombe)10102-0.059-0.1099No
146DDR2DDR2
Entrez,  Source
discoidin domain receptor family, member 210235-0.064-0.1169No
147ADCK310237-0.064-0.1138No
148MARK3MARK3
Entrez,  Source
MAP/microtubule affinity-regulating kinase 310374-0.068-0.1208No
149RPS6KA3RPS6KA3
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 310427-0.070-0.1213No
150PLK1PLK1
Entrez,  Source
polo-like kinase 1 (Drosophila)10440-0.071-0.1187No
151PLK4PLK4
Entrez,  Source
polo-like kinase 4 (Drosophila)10581-0.075-0.1257No
152JAK1JAK1
Entrez,  Source
Janus kinase 1 (a protein tyrosine kinase)10585-0.076-0.1221No
153CAMKK2CAMKK2
Entrez,  Source
calcium/calmodulin-dependent protein kinase kinase 2, beta10729-0.081-0.1290No
154BRSK2BRSK2
Entrez,  Source
BR serine/threonine kinase 210749-0.082-0.1264No
155SRCSRC
Entrez,  Source
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)10776-0.083-0.1242No
156PIP5K1APIP5K1A
Entrez,  Source
phosphatidylinositol-4-phosphate 5-kinase, type I, alpha10780-0.083-0.1202No
157CHEK1CHEK1
Entrez,  Source
CHK1 checkpoint homolog (S. pombe)10792-0.084-0.1169No
158PRKAA1PRKAA1
Entrez,  Source
protein kinase, AMP-activated, alpha 1 catalytic subunit10906-0.089-0.1211No
159PRKCQPRKCQ
Entrez,  Source
protein kinase C, theta10961-0.092-0.1206No
160NUAK1NUAK1
Entrez,  Source
NUAK family, SNF1-like kinase, 111032-0.095-0.1213No
161DAPK3DAPK3
Entrez,  Source
death-associated protein kinase 311066-0.096-0.1190No
162SRPK1SRPK1
Entrez,  Source
SFRS protein kinase 111068-0.096-0.1142No
163ABL2ABL2
Entrez,  Source
v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)11090-0.098-0.1110No
164CDK7CDK7
Entrez,  Source
cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase)11160-0.101-0.1112No
165PRKACBPRKACB
Entrez,  Source
protein kinase, cAMP-dependent, catalytic, beta11179-0.102-0.1075No
166STK10STK10
Entrez,  Source
serine/threonine kinase 1011218-0.103-0.1052No
167MYLKMYLK
Entrez,  Source
myosin, light chain kinase11255-0.105-0.1027No
168FERFER
Entrez,  Source
fer (fps/fes related) tyrosine kinase (phosphoprotein NCP94)11371-0.111-0.1060No
169STK38LSTK38L
Entrez,  Source
serine/threonine kinase 38 like11441-0.114-0.1056No
170SRPK2SRPK2
Entrez,  Source
SFRS protein kinase 211496-0.117-0.1039No
171STK4STK4
Entrez,  Source
serine/threonine kinase 411518-0.118-0.0996No
172JAK2JAK2
Entrez,  Source
Janus kinase 2 (a protein tyrosine kinase)11530-0.119-0.0945No
173SLKSLK
Entrez,  Source
STE20-like kinase (yeast)11672-0.128-0.0989No
174MAP4K5MAP4K5
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 511705-0.130-0.0949No
175FYNFYN
Entrez,  Source
FYN oncogene related to SRC, FGR, YES11767-0.133-0.0929No
176MAP2K4MAP2K4
Entrez,  Source
mitogen-activated protein kinase kinase 411811-0.136-0.0893No
177MAP2K2MAP2K2
Entrez,  Source
mitogen-activated protein kinase kinase 211895-0.142-0.0886No
178ROCK2ROCK2
Entrez,  Source
Rho-associated, coiled-coil containing protein kinase 212033-0.152-0.0915No
179CAMK1CAMK1
Entrez,  Source
calcium/calmodulin-dependent protein kinase I12150-0.162-0.0923No
180PDGFRAPDGFRA
Entrez,  Source
platelet-derived growth factor receptor, alpha polypeptide12211-0.168-0.0885No
181PKN2PKN2
Entrez,  Source
protein kinase N212286-0.175-0.0854No
182SIK112319-0.179-0.0789No
183MAP3K12MAP3K12
Entrez,  Source
mitogen-activated protein kinase kinase kinase 1212384-0.186-0.0745No
184MAP4K3MAP4K3
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 312403-0.189-0.0664No
185BMPR1ABMPR1A
Entrez,  Source
bone morphogenetic protein receptor, type IA12438-0.194-0.0593No
186TGFBR1TGFBR1
Entrez,  Source
transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kDa)12447-0.195-0.0501No
187IRAK3IRAK3
Entrez,  Source
interleukin-1 receptor-associated kinase 312451-0.196-0.0405No
188ABL1ABL1
Entrez,  Source
v-abl Abelson murine leukemia viral oncogene homolog 112463-0.197-0.0314No
189RIOK2RIOK2
Entrez,  Source
RIO kinase 2 (yeast)12467-0.198-0.0217No
190CDK1712578-0.213-0.0195No
191MAP3K7MAP3K7
Entrez,  Source
mitogen-activated protein kinase kinase kinase 712613-0.221-0.0110No
192AXLAXL
Entrez,  Source
AXL receptor tyrosine kinase12789-0.257-0.0116No
193PRKD3PRKD3
Entrez,  Source
protein kinase D313008-0.345-0.0111No
194FGFR1FGFR1
Entrez,  Source
fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome)13121-0.4860.0047No
Table: GSEA details [plain text format]



Fig 2: NVP-TAE684_LINCS   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: NVP-TAE684_LINCS: Random ES distribution   
Gene set null distribution of ES for NVP-TAE684_LINCS