DatasetNSCLC_collapsed_to_symbols.NSCLC.cls
#SEN_versus_RES.NSCLC.cls
#SEN_versus_RES_repos
PhenotypeNSCLC.cls#SEN_versus_RES_repos
Upregulated in class1
GeneSetTAE-684_KINOME SCAN
Enrichment Score (ES)0.3250894
Normalized Enrichment Score (NES)1.2439471
Nominal p-value0.092675634
FDR q-value0.6396544
FWER p-Value1.0
Table: GSEA Results Summary



Fig 1: Enrichment plot: TAE-684_KINOME SCAN   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEGENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1MST1RMST1R
Entrez,  Source
macrophage stimulating 1 receptor (c-met-related tyrosine kinase)540.6360.0299Yes
2EPHA1EPHA1
Entrez,  Source
EPH receptor A1940.5450.0562Yes
3ERBB2ERBB2
Entrez,  Source
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)1000.5370.0846Yes
4PTK6PTK6
Entrez,  Source
PTK6 protein tyrosine kinase 61410.4790.1072Yes
5FGFR3FGFR3
Entrez,  Source
fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism)1530.4650.1312Yes
6FGFR2FGFR2
Entrez,  Source
ffer syndrome, Jackson-Weiss syndrome)2100.4060.1487Yes
7DDR1DDR1
Entrez,  Source
discoidin domain receptor family, member 12120.4040.1702Yes
8FRKFRK
Entrez,  Source
fyn-related kinase2960.3430.1822Yes
9MST43180.3310.1983Yes
10STK39STK39
Entrez,  Source
serine threonine kinase 39 (STE20/SPS1 homolog, yeast)3840.2990.2094Yes
11METMET
Entrez,  Source
met proto-oncogene (hepatocyte growth factor receptor)4990.2590.2144Yes
12ROS1ROS1
Entrez,  Source
v-ros UR2 sarcoma virus oncogene homolog 1 (avian)5050.2580.2279Yes
13RPS6KA2RPS6KA2
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 25900.2370.2341Yes
14MAP3K13MAP3K13
Entrez,  Source
mitogen-activated protein kinase kinase kinase 136240.2300.2439Yes
15EGFREGFR
Entrez,  Source
epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)6250.2300.2562Yes
16PAK1PAK1
Entrez,  Source
p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast)6740.2190.2643Yes
17EPHB6EPHB6
Entrez,  Source
EPH receptor B67010.2150.2738Yes
18EPHA4EPHA4
Entrez,  Source
EPH receptor A47980.1970.2770Yes
19TAOK3TAOK3
Entrez,  Source
TAO kinase 39710.1700.2728Yes
20TXKTXK
Entrez,  Source
TXK tyrosine kinase10450.1600.2758Yes
21MAPK10MAPK10
Entrez,  Source
mitogen-activated protein kinase 1010690.1570.2824Yes
22LCKLCK
Entrez,  Source
lymphocyte-specific protein tyrosine kinase13100.1360.2713Yes
23GAKGAK
Entrez,  Source
cyclin G associated kinase13400.1330.2762Yes
24TNK1TNK1
Entrez,  Source
tyrosine kinase, non-receptor, 113600.1310.2817Yes
25CAMK1DCAMK1D
Entrez,  Source
calcium/calmodulin-dependent protein kinase ID13870.1290.2867Yes
26EPHA7EPHA7
Entrez,  Source
EPH receptor A714120.1280.2917Yes
27STK3STK3
Entrez,  Source
serine/threonine kinase 3 (STE20 homolog, yeast)15530.1200.2873Yes
28INSRINSR
Entrez,  Source
insulin receptor16640.1140.2850Yes
29RPS6KA1RPS6KA1
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 116860.1130.2894Yes
30MAP3K9MAP3K9
Entrez,  Source
mitogen-activated protein kinase kinase kinase 916990.1120.2945Yes
31NTRK2NTRK2
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 217040.1120.3002Yes
32MAPK3MAPK3
Entrez,  Source
mitogen-activated protein kinase 317660.1090.3013Yes
33CAMK2ACAMK2A
Entrez,  Source
calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha18010.1070.3044Yes
34CAMK2GCAMK2G
Entrez,  Source
calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma18110.1070.3095Yes
35ERBB4ERBB4
Entrez,  Source
v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)18130.1070.3151Yes
36DAPK2DAPK2
Entrez,  Source
death-associated protein kinase 218380.1050.3189Yes
37LYNLYN
Entrez,  Source
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog19740.1000.3139Yes
38CASKCASK
Entrez,  Source
calcium/calmodulin-dependent serine protein kinase (MAGUK family)20070.0990.3167Yes
39PTK2BPTK2B
Entrez,  Source
PTK2B protein tyrosine kinase 2 beta20420.0980.3193Yes
40MARK1MARK1
Entrez,  Source
MAP/microtubule affinity-regulating kinase 121590.0930.3154Yes
41AAK1AAK1
Entrez,  Source
AP2 associated kinase 122120.0920.3163Yes
42ULK2ULK2
Entrez,  Source
unc-51-like kinase 2 (C. elegans)22440.0910.3188Yes
43MAP3K11MAP3K11
Entrez,  Source
mitogen-activated protein kinase kinase kinase 1122950.0890.3197Yes
44TIE1TIE1
Entrez,  Source
tyrosine kinase with immunoglobulin-like and EGF-like domains 123280.0880.3220Yes
45CLK3CLK3
Entrez,  Source
CDC-like kinase 323490.0870.3251Yes
46JAK3JAK3
Entrez,  Source
Janus kinase 3 (a protein tyrosine kinase, leukocyte)24440.0840.3224No
47MERTKMERTK
Entrez,  Source
c-mer proto-oncogene tyrosine kinase25220.0820.3209No
48TAOK1TAOK1
Entrez,  Source
TAO kinase 125520.0820.3230No
49ADCK4ADCK4
Entrez,  Source
aarF domain containing kinase 427150.0770.3147No
50MAP4K1MAP4K1
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 128490.0740.3085No
51STK38STK38
Entrez,  Source
serine/threonine kinase 3828780.0730.3102No
52TNK2TNK2
Entrez,  Source
tyrosine kinase, non-receptor, 230050.0700.3043No
53YES1YES1
Entrez,  Source
v-yes-1 Yamaguchi sarcoma viral oncogene homolog 130360.0700.3058No
54MINK1MINK1
Entrez,  Source
misshapen-like kinase 1 (zebrafish)30800.0690.3061No
55KDRKDR
Entrez,  Source
kinase insert domain receptor (a type III receptor tyrosine kinase)31460.0680.3048No
56FLT3FLT3
Entrez,  Source
fms-related tyrosine kinase 334030.0630.2884No
57BLKBLK
Entrez,  Source
B lymphoid tyrosine kinase34190.0620.2906No
58TSSK1B34450.0620.2920No
59CSF1RCSF1R
Entrez,  Source
colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog34540.0620.2947No
60ACVRL1ACVRL1
Entrez,  Source
activin A receptor type II-like 137150.0570.2778No
61MYO3AMYO3A
Entrez,  Source
myosin IIIA37350.0570.2794No
62MARK2MARK2
Entrez,  Source
MAP/microtubule affinity-regulating kinase 238340.0550.2748No
63EPHB4EPHB4
Entrez,  Source
EPH receptor B438790.0540.2743No
64PRKD2PRKD2
Entrez,  Source
protein kinase D239000.0540.2757No
65EPHB1EPHB1
Entrez,  Source
EPH receptor B140000.0520.2708No
66PRKG2PRKG2
Entrez,  Source
protein kinase, cGMP-dependent, type II40210.0520.2721No
67ALKALK
Entrez,  Source
anaplastic lymphoma kinase (Ki-1)40730.0510.2709No
68MUSKMUSK
Entrez,  Source
muscle, skeletal, receptor tyrosine kinase41390.0500.2686No
69FGRFGR
Entrez,  Source
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog41930.0490.2672No
70ACVR1BACVR1B
Entrez,  Source
activin A receptor, type IB43280.0470.2594No
71AURKCAURKC
Entrez,  Source
aurora kinase C44130.0460.2554No
72HUNKHUNK
Entrez,  Source
hormonally upregulated Neu-associated kinase46450.0430.2399No
73RPS6KA6RPS6KA6
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 646850.0420.2392No
74FGFR4FGFR4
Entrez,  Source
fibroblast growth factor receptor 447150.0410.2392No
75PHKG2PHKG2
Entrez,  Source
phosphorylase kinase, gamma 2 (testis)47920.0400.2355No
76EPHA2EPHA2
Entrez,  Source
EPH receptor A248800.0390.2309No
77FLT1FLT1
Entrez,  Source
fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)48820.0390.2329No
78FLT4FLT4
Entrez,  Source
fms-related tyrosine kinase 448980.0390.2338No
79GRK1GRK1
Entrez,  Source
G protein-coupled receptor kinase 149070.0390.2353No
80PRKG1PRKG1
Entrez,  Source
protein kinase, cGMP-dependent, type I49360.0380.2352No
81ULK1ULK1
Entrez,  Source
unc-51-like kinase 1 (C. elegans)51570.0350.2201No
82ACVR1ACVR1
Entrez,  Source
activin A receptor, type I52300.0340.2164No
83INSRRINSRR
Entrez,  Source
insulin receptor-related receptor53320.0330.2104No
84TECTEC
Entrez,  Source
tec protein tyrosine kinase53790.0320.2086No
85BTKBTK
Entrez,  Source
Bruton agammaglobulinemia tyrosine kinase56280.0290.1911No
86STK16STK16
Entrez,  Source
serine/threonine kinase 1657780.0270.1811No
87PAK7PAK7
Entrez,  Source
p21(CDKN1A)-activated kinase 758810.0250.1746No
88MAP3K3MAP3K3
Entrez,  Source
mitogen-activated protein kinase kinase kinase 359210.0250.1729No
89MAPK1MAPK1
Entrez,  Source
mitogen-activated protein kinase 159940.0240.1686No
90NTRK1NTRK1
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 160970.0220.1620No
91FESFES
Entrez,  Source
feline sarcoma oncogene61260.0220.1610No
92IRAK1IRAK1
Entrez,  Source
interleukin-1 receptor-associated kinase 161790.0210.1581No
93PHKG1PHKG1
Entrez,  Source
phosphorylase kinase, gamma 1 (muscle)62450.0200.1542No
94CAMK4CAMK4
Entrez,  Source
calcium/calmodulin-dependent protein kinase IV63930.0170.1438No
95AURKAAURKA
Entrez,  Source
aurora kinase A64270.0170.1421No
96DCLK264620.0160.1404No
97RETRET
Entrez,  Source
ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease)64710.0160.1407No
98PLK3PLK3
Entrez,  Source
polo-like kinase 3 (Drosophila)67550.0120.1196No
99BMPR1BBMPR1B
Entrez,  Source
bone morphogenetic protein receptor, type IB67770.0120.1186No
100PKN1PKN1
Entrez,  Source
protein kinase N167830.0120.1189No
101MAPK8MAPK8
Entrez,  Source
mitogen-activated protein kinase 868290.0110.1160No
102MAP4K2MAP4K2
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 268940.0100.1116No
103MAPK7MAPK7
Entrez,  Source
mitogen-activated protein kinase 769130.0100.1107No
104STK32BSTK32B
Entrez,  Source
serine/threonine kinase 32B69190.0100.1109No
105CLK4CLK4
Entrez,  Source
CDC-like kinase 469350.0100.1102No
106TEKTEK
Entrez,  Source
TEK tyrosine kinase, endothelial (venous malformations, multiple cutaneous and mucosal)70350.0080.1030No
107TGFBR2TGFBR2
Entrez,  Source
transforming growth factor, beta receptor II (70/80kDa)71030.0070.0982No
108CLK2CLK2
Entrez,  Source
CDC-like kinase 271810.0050.0926No
109ITKITK
Entrez,  Source
IL2-inducible T-cell kinase72200.0040.0899No
110PRKAA2PRKAA2
Entrez,  Source
protein kinase, AMP-activated, alpha 2 catalytic subunit74180.0010.0748No
111SIK274350.0010.0736No
112SNRKSNRK
Entrez,  Source
SNF related kinase7658-0.0030.0567No
113PI4KB7697-0.0030.0539No
114MAP2K3MAP2K3
Entrez,  Source
mitogen-activated protein kinase kinase 37798-0.0050.0465No
115PDGFRBPDGFRB
Entrez,  Source
platelet-derived growth factor receptor, beta polypeptide7824-0.0060.0449No
116MAPK9MAPK9
Entrez,  Source
mitogen-activated protein kinase 97830-0.0060.0449No
117MKNK2MKNK2
Entrez,  Source
MAP kinase interacting serine/threonine kinase 27841-0.0060.0444No
118MAP2K1MAP2K1
Entrez,  Source
mitogen-activated protein kinase kinase 17939-0.0080.0374No
119IGF1RIGF1R
Entrez,  Source
insulin-like growth factor 1 receptor7959-0.0080.0364No
120MELKMELK
Entrez,  Source
maternal embryonic leucine zipper kinase8047-0.0100.0302No
121TAOK2TAOK2
Entrez,  Source
TAO kinase 28059-0.0100.0299No
122KITKIT
Entrez,  Source
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog8134-0.0120.0249No
123LTKLTK
Entrez,  Source
leukocyte tyrosine kinase8158-0.0120.0237No
124MAP2K5MAP2K5
Entrez,  Source
mitogen-activated protein kinase kinase 58199-0.0130.0214No
125MARK4MARK4
Entrez,  Source
MAP/microtubule affinity-regulating kinase 48259-0.0140.0176No
126CDK168353-0.0160.0113No
127PTK2PTK2
Entrez,  Source
PTK2 protein tyrosine kinase 28356-0.0160.0120No
128ROCK1ROCK1
Entrez,  Source
Rho-associated, coiled-coil containing protein kinase 18741-0.025-0.0162No
129AURKBAURKB
Entrez,  Source
aurora kinase B8856-0.027-0.0235No
130IRAK4IRAK4
Entrez,  Source
interleukin-1 receptor-associated kinase 48996-0.031-0.0325No
131ERN1ERN1
Entrez,  Source
endoplasmic reticulum to nucleus signalling 19341-0.039-0.0569No
132TYK2TYK2
Entrez,  Source
tyrosine kinase 29438-0.041-0.0621No
133PAK3PAK3
Entrez,  Source
p21 (CDKN1A)-activated kinase 39490-0.042-0.0638No
134NEK9NEK9
Entrez,  Source
NIMA (never in mitosis gene a)- related kinase 99810-0.051-0.0856No
135PRKD1PRKD1
Entrez,  Source
protein kinase D19827-0.052-0.0840No
136DCLK19840-0.052-0.0822No
137MAP4K4MAP4K4
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 49922-0.055-0.0855No
138TTKTTK
Entrez,  Source
TTK protein kinase9930-0.055-0.0831No
139HCKHCK
Entrez,  Source
hemopoietic cell kinase9981-0.056-0.0839No
140CHEK2CHEK2
Entrez,  Source
CHK2 checkpoint homolog (S. pombe)10102-0.059-0.0900No
141MARK3MARK3
Entrez,  Source
MAP/microtubule affinity-regulating kinase 310374-0.068-0.1072No
142RPS6KA3RPS6KA3
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 310427-0.070-0.1074No
143PLK1PLK1
Entrez,  Source
polo-like kinase 1 (Drosophila)10440-0.071-0.1045No
144OXSR1OXSR1
Entrez,  Source
oxidative-stress responsive 110514-0.073-0.1062No
145PLK4PLK4
Entrez,  Source
polo-like kinase 4 (Drosophila)10581-0.075-0.1073No
146JAK1JAK1
Entrez,  Source
Janus kinase 1 (a protein tyrosine kinase)10585-0.076-0.1035No
147CAMKK2CAMKK2
Entrez,  Source
calcium/calmodulin-dependent protein kinase kinase 2, beta10729-0.081-0.1101No
148TBK1TBK1
Entrez,  Source
TANK-binding kinase 110732-0.082-0.1059No
149BRSK2BRSK2
Entrez,  Source
BR serine/threonine kinase 210749-0.082-0.1027No
150SRCSRC
Entrez,  Source
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)10776-0.083-0.1003No
151CHEK1CHEK1
Entrez,  Source
CHK1 checkpoint homolog (S. pombe)10792-0.084-0.0969No
152CDK4CDK4
Entrez,  Source
cyclin-dependent kinase 410871-0.087-0.0982No
153PRKAA1PRKAA1
Entrez,  Source
protein kinase, AMP-activated, alpha 1 catalytic subunit10906-0.089-0.0961No
154NUAK1NUAK1
Entrez,  Source
NUAK family, SNF1-like kinase, 111032-0.095-0.1006No
155ABL2ABL2
Entrez,  Source
v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)11090-0.098-0.0998No
156CDK7CDK7
Entrez,  Source
cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase)11160-0.101-0.0997No
157STK10STK10
Entrez,  Source
serine/threonine kinase 1011218-0.103-0.0985No
158MYLKMYLK
Entrez,  Source
myosin, light chain kinase11255-0.105-0.0957No
159FERFER
Entrez,  Source
fer (fps/fes related) tyrosine kinase (phosphoprotein NCP94)11371-0.111-0.0986No
160STK38LSTK38L
Entrez,  Source
serine/threonine kinase 38 like11441-0.114-0.0978No
161STK4STK4
Entrez,  Source
serine/threonine kinase 411518-0.118-0.0973No
162JAK2JAK2
Entrez,  Source
Janus kinase 2 (a protein tyrosine kinase)11530-0.119-0.0918No
163SLKSLK
Entrez,  Source
STE20-like kinase (yeast)11672-0.128-0.0958No
164MAP4K5MAP4K5
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 511705-0.130-0.0913No
165MAP2K4MAP2K4
Entrez,  Source
mitogen-activated protein kinase kinase 411811-0.136-0.0921No
166MAP2K2MAP2K2
Entrez,  Source
mitogen-activated protein kinase kinase 211895-0.142-0.0909No
167ROCK2ROCK2
Entrez,  Source
Rho-associated, coiled-coil containing protein kinase 212033-0.152-0.0933No
168MAP3K2MAP3K2
Entrez,  Source
mitogen-activated protein kinase kinase kinase 212210-0.168-0.0978No
169PDGFRAPDGFRA
Entrez,  Source
platelet-derived growth factor receptor, alpha polypeptide12211-0.168-0.0888No
170PKN2PKN2
Entrez,  Source
protein kinase N212286-0.175-0.0851No
171SIK112319-0.179-0.0780No
172MAP3K12MAP3K12
Entrez,  Source
mitogen-activated protein kinase kinase kinase 1212384-0.186-0.0730No
173MAP4K3MAP4K3
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 312403-0.189-0.0642No
174BMPR1ABMPR1A
Entrez,  Source
bone morphogenetic protein receptor, type IA12438-0.194-0.0564No
175TGFBR1TGFBR1
Entrez,  Source
transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kDa)12447-0.195-0.0466No
176IRAK3IRAK3
Entrez,  Source
interleukin-1 receptor-associated kinase 312451-0.196-0.0363No
177ABL1ABL1
Entrez,  Source
v-abl Abelson murine leukemia viral oncogene homolog 112463-0.197-0.0266No
178CDK1712578-0.213-0.0240No
179MAP3K7MAP3K7
Entrez,  Source
mitogen-activated protein kinase kinase kinase 712613-0.221-0.0147No
180AXLAXL
Entrez,  Source
AXL receptor tyrosine kinase12789-0.257-0.0144No
181PRKD3PRKD3
Entrez,  Source
protein kinase D313008-0.345-0.0127No
182FGFR1FGFR1
Entrez,  Source
fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome)13121-0.4860.0047No
Table: GSEA details [plain text format]



Fig 2: TAE-684_KINOME SCAN   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: TAE-684_KINOME SCAN: Random ES distribution   
Gene set null distribution of ES for TAE-684_KINOME SCAN