| Dataset | NSCLC_collapsed_to_symbols.NSCLC.cls #SEN_versus_RES.NSCLC.cls #SEN_versus_RES_repos |
| Phenotype | NSCLC.cls#SEN_versus_RES_repos |
| Upregulated in class | 1 |
| GeneSet | BOSUTINIB_FDA |
| Enrichment Score (ES) | 0.33448195 |
| Normalized Enrichment Score (NES) | 1.2419492 |
| Nominal p-value | 0.10696921 |
| FDR q-value | 0.63008153 |
| FWER p-Value | 1.0 |

| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | ERBB3 | ERBB3 Entrez,  Source | v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) | 12 | 1.034 | 0.0775 | Yes |
| 2 | ERBB2 | ERBB2 Entrez,  Source | v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) | 100 | 0.537 | 0.1116 | Yes |
| 3 | DDR1 | DDR1 Entrez,  Source | discoidin domain receptor family, member 1 | 212 | 0.404 | 0.1337 | Yes |
| 4 | FRK | FRK Entrez,  Source | fyn-related kinase | 296 | 0.343 | 0.1533 | Yes |
| 5 | PRKCD | PRKCD Entrez,  Source | protein kinase C, delta | 306 | 0.337 | 0.1781 | Yes |
| 6 | MST4 | 318 | 0.331 | 0.2024 | Yes | ||
| 7 | SYK | SYK Entrez,  Source | spleen tyrosine kinase | 471 | 0.268 | 0.2111 | Yes |
| 8 | MAP3K13 | MAP3K13 Entrez,  Source | mitogen-activated protein kinase kinase kinase 13 | 624 | 0.230 | 0.2169 | Yes |
| 9 | EGFR | EGFR Entrez,  Source | epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) | 625 | 0.230 | 0.2343 | Yes |
| 10 | PAK1 | PAK1 Entrez,  Source | p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast) | 674 | 0.219 | 0.2472 | Yes |
| 11 | EPHA4 | EPHA4 Entrez,  Source | EPH receptor A4 | 798 | 0.197 | 0.2528 | Yes |
| 12 | EPHB2 | EPHB2 Entrez,  Source | EPH receptor B2 | 868 | 0.185 | 0.2616 | Yes |
| 13 | TAOK3 | TAOK3 Entrez,  Source | TAO kinase 3 | 971 | 0.170 | 0.2666 | Yes |
| 14 | TXK | TXK Entrez,  Source | TXK tyrosine kinase | 1045 | 0.160 | 0.2731 | Yes |
| 15 | TNIK | TNIK Entrez,  Source | TRAF2 and NCK interacting kinase | 1197 | 0.145 | 0.2726 | Yes |
| 16 | LCK | LCK Entrez,  Source | lymphocyte-specific protein tyrosine kinase | 1310 | 0.136 | 0.2743 | Yes |
| 17 | GAK | GAK Entrez,  Source | cyclin G associated kinase | 1340 | 0.133 | 0.2822 | Yes |
| 18 | CAMK1D | CAMK1D Entrez,  Source | calcium/calmodulin-dependent protein kinase ID | 1387 | 0.129 | 0.2885 | Yes |
| 19 | EPHB3 | EPHB3 Entrez,  Source | EPH receptor B3 | 1426 | 0.127 | 0.2952 | Yes |
| 20 | NEK11 | NEK11 Entrez,  Source | NIMA (never in mitosis gene a)- related kinase 11 | 1522 | 0.122 | 0.2971 | Yes |
| 21 | STK3 | STK3 Entrez,  Source | serine/threonine kinase 3 (STE20 homolog, yeast) | 1553 | 0.120 | 0.3039 | Yes |
| 22 | WEE1 | WEE1 Entrez,  Source | WEE1 homolog (S. pombe) | 1639 | 0.115 | 0.3062 | Yes |
| 23 | MAP3K9 | MAP3K9 Entrez,  Source | mitogen-activated protein kinase kinase kinase 9 | 1699 | 0.112 | 0.3102 | Yes |
| 24 | ERBB4 | ERBB4 Entrez,  Source | v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) | 1813 | 0.107 | 0.3096 | Yes |
| 25 | CSNK1D | CSNK1D Entrez,  Source | casein kinase 1, delta | 1851 | 0.105 | 0.3147 | Yes |
| 26 | RIOK3 | RIOK3 Entrez,  Source | RIO kinase 3 (yeast) | 1942 | 0.101 | 0.3155 | Yes |
| 27 | LYN | LYN Entrez,  Source | v-yes-1 Yamaguchi sarcoma viral related oncogene homolog | 1974 | 0.100 | 0.3206 | Yes |
| 28 | CASK | CASK Entrez,  Source | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | 2007 | 0.099 | 0.3257 | Yes |
| 29 | PTK2B | PTK2B Entrez,  Source | PTK2B protein tyrosine kinase 2 beta | 2042 | 0.098 | 0.3305 | Yes |
| 30 | AAK1 | AAK1 Entrez,  Source | AP2 associated kinase 1 | 2212 | 0.092 | 0.3245 | Yes |
| 31 | ULK2 | ULK2 Entrez,  Source | unc-51-like kinase 2 (C. elegans) | 2244 | 0.091 | 0.3290 | Yes |
| 32 | MAP3K11 | MAP3K11 Entrez,  Source | mitogen-activated protein kinase kinase kinase 11 | 2295 | 0.089 | 0.3319 | Yes |
| 33 | CLK3 | CLK3 Entrez,  Source | CDC-like kinase 3 | 2349 | 0.087 | 0.3345 | Yes |
| 34 | MAP3K4 | MAP3K4 Entrez,  Source | mitogen-activated protein kinase kinase kinase 4 | 2489 | 0.083 | 0.3301 | No |
| 35 | MERTK | MERTK Entrez,  Source | c-mer proto-oncogene tyrosine kinase | 2522 | 0.082 | 0.3339 | No |
| 36 | MAP4K1 | MAP4K1 Entrez,  Source | mitogen-activated protein kinase kinase kinase kinase 1 | 2849 | 0.074 | 0.3146 | No |
| 37 | EPHA3 | EPHA3 Entrez,  Source | EPH receptor A3 | 2870 | 0.074 | 0.3186 | No |
| 38 | TNK2 | TNK2 Entrez,  Source | tyrosine kinase, non-receptor, 2 | 3005 | 0.070 | 0.3137 | No |
| 39 | EIF2AK1 | EIF2AK1 Entrez,  Source | eukaryotic translation initiation factor 2-alpha kinase 1 | 3008 | 0.070 | 0.3189 | No |
| 40 | YES1 | YES1 Entrez,  Source | v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 | 3036 | 0.070 | 0.3221 | No |
| 41 | CSK | CSK Entrez,  Source | c-src tyrosine kinase | 3069 | 0.069 | 0.3249 | No |
| 42 | MINK1 | MINK1 Entrez,  Source | misshapen-like kinase 1 (zebrafish) | 3080 | 0.069 | 0.3294 | No |
| 43 | FLT3 | FLT3 Entrez,  Source | fms-related tyrosine kinase 3 | 3403 | 0.063 | 0.3095 | No |
| 44 | BLK | BLK Entrez,  Source | B lymphoid tyrosine kinase | 3419 | 0.062 | 0.3130 | No |
| 45 | CSF1R | CSF1R Entrez,  Source | colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog | 3454 | 0.062 | 0.3151 | No |
| 46 | CSNK1A1 | CSNK1A1 Entrez,  Source | casein kinase 1, alpha 1 | 3698 | 0.058 | 0.3009 | No |
| 47 | EPHB4 | EPHB4 Entrez,  Source | EPH receptor B4 | 3879 | 0.054 | 0.2912 | No |
| 48 | EPHB1 | EPHB1 Entrez,  Source | EPH receptor B1 | 4000 | 0.052 | 0.2860 | No |
| 49 | ALK | ALK Entrez,  Source | anaplastic lymphoma kinase (Ki-1) | 4073 | 0.051 | 0.2844 | No |
| 50 | FGR | FGR Entrez,  Source | Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog | 4193 | 0.049 | 0.2790 | No |
| 51 | NEK2 | NEK2 Entrez,  Source | NIMA (never in mitosis gene a)-related kinase 2 | 4483 | 0.045 | 0.2603 | No |
| 52 | BMX | BMX Entrez,  Source | BMX non-receptor tyrosine kinase | 4826 | 0.040 | 0.2371 | No |
| 53 | EPHA2 | EPHA2 Entrez,  Source | EPH receptor A2 | 4880 | 0.039 | 0.2360 | No |
| 54 | TNNI3K | TNNI3K Entrez,  Source | TNNI3 interacting kinase | 5274 | 0.033 | 0.2085 | No |
| 55 | MAST1 | MAST1 Entrez,  Source | microtubule associated serine/threonine kinase 1 | 5436 | 0.032 | 0.1985 | No |
| 56 | EPHA5 | EPHA5 Entrez,  Source | EPH receptor A5 | 5475 | 0.031 | 0.1980 | No |
| 57 | MAPK4 | MAPK4 Entrez,  Source | mitogen-activated protein kinase 4 | 5585 | 0.029 | 0.1918 | No |
| 58 | STK24 | STK24 Entrez,  Source | serine/threonine kinase 24 (STE20 homolog, yeast) | 5587 | 0.029 | 0.1940 | No |
| 59 | BTK | BTK Entrez,  Source | Bruton agammaglobulinemia tyrosine kinase | 5628 | 0.029 | 0.1931 | No |
| 60 | SRPK3 | SRPK3 Entrez,  Source | SFRS protein kinase 3 | 5860 | 0.026 | 0.1774 | No |
| 61 | MAP3K3 | MAP3K3 Entrez,  Source | mitogen-activated protein kinase kinase kinase 3 | 5921 | 0.025 | 0.1747 | No |
| 62 | NTRK1 | NTRK1 Entrez,  Source | neurotrophic tyrosine kinase, receptor, type 1 | 6097 | 0.022 | 0.1629 | No |
| 63 | FES | FES Entrez,  Source | feline sarcoma oncogene | 6126 | 0.022 | 0.1624 | No |
| 64 | IRAK1 | IRAK1 Entrez,  Source | interleukin-1 receptor-associated kinase 1 | 6179 | 0.021 | 0.1600 | No |
| 65 | PHKG1 | PHKG1 Entrez,  Source | phosphorylase kinase, gamma 1 (muscle) | 6245 | 0.020 | 0.1566 | No |
| 66 | RET | RET Entrez,  Source | ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease) | 6471 | 0.016 | 0.1406 | No |
| 67 | PIP4K2B | 6594 | 0.015 | 0.1323 | No | ||
| 68 | GRK4 | GRK4 Entrez,  Source | G protein-coupled receptor kinase 4 | 6788 | 0.012 | 0.1185 | No |
| 69 | MAP4K2 | MAP4K2 Entrez,  Source | mitogen-activated protein kinase kinase kinase kinase 2 | 6894 | 0.010 | 0.1112 | No |
| 70 | BMP2K | BMP2K Entrez,  Source | BMP2 inducible kinase | 7029 | 0.008 | 0.1015 | No |
| 71 | IKBKE | IKBKE Entrez,  Source | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | 7216 | 0.004 | 0.0876 | No |
| 72 | SIK2 | 7435 | 0.001 | 0.0710 | No | ||
| 73 | SIK3 | 7726 | -0.004 | 0.0491 | No | ||
| 74 | CSNK1E | CSNK1E Entrez,  Source | casein kinase 1, epsilon | 7742 | -0.004 | 0.0483 | No |
| 75 | PDGFRB | PDGFRB Entrez,  Source | platelet-derived growth factor receptor, beta polypeptide | 7824 | -0.006 | 0.0425 | No |
| 76 | PKMYT1 | PKMYT1 Entrez,  Source | protein kinase, membrane associated tyrosine/threonine 1 | 7836 | -0.006 | 0.0421 | No |
| 77 | MAP2K1 | MAP2K1 Entrez,  Source | mitogen-activated protein kinase kinase 1 | 7939 | -0.008 | 0.0349 | No |
| 78 | KIT | KIT Entrez,  Source | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog | 8134 | -0.012 | 0.0210 | No |
| 79 | MAP2K5 | MAP2K5 Entrez,  Source | mitogen-activated protein kinase kinase 5 | 8199 | -0.013 | 0.0171 | No |
| 80 | DMPK | DMPK Entrez,  Source | dystrophia myotonica-protein kinase | 8344 | -0.016 | 0.0073 | No |
| 81 | PTK2 | PTK2 Entrez,  Source | PTK2 protein tyrosine kinase 2 | 8356 | -0.016 | 0.0077 | No |
| 82 | VRK2 | VRK2 Entrez,  Source | vaccinia related kinase 2 | 8412 | -0.017 | 0.0048 | No |
| 83 | STK25 | STK25 Entrez,  Source | serine/threonine kinase 25 (STE20 homolog, yeast) | 8561 | -0.021 | -0.0050 | No |
| 84 | ROCK1 | ROCK1 Entrez,  Source | Rho-associated, coiled-coil containing protein kinase 1 | 8741 | -0.025 | -0.0168 | No |
| 85 | IRAK4 | IRAK4 Entrez,  Source | interleukin-1 receptor-associated kinase 4 | 8996 | -0.031 | -0.0339 | No |
| 86 | PHKA2 | PHKA2 Entrez,  Source | phosphorylase kinase, alpha 2 (liver) | 9057 | -0.032 | -0.0361 | No |
| 87 | PAK3 | PAK3 Entrez,  Source | p21 (CDKN1A)-activated kinase 3 | 9490 | -0.042 | -0.0660 | No |
| 88 | MAP4K4 | MAP4K4 Entrez,  Source | mitogen-activated protein kinase kinase kinase kinase 4 | 9922 | -0.055 | -0.0949 | No |
| 89 | HCK | HCK Entrez,  Source | hemopoietic cell kinase | 9981 | -0.056 | -0.0950 | No |
| 90 | PLK2 | PLK2 Entrez,  Source | polo-like kinase 2 (Drosophila) | 9994 | -0.057 | -0.0917 | No |
| 91 | CHEK2 | CHEK2 Entrez,  Source | CHK2 checkpoint homolog (S. pombe) | 10102 | -0.059 | -0.0954 | No |
| 92 | DDR2 | DDR2 Entrez,  Source | discoidin domain receptor family, member 2 | 10235 | -0.064 | -0.1007 | No |
| 93 | CIT | CIT Entrez,  Source | citron (rho-interacting, serine/threonine kinase 21) | 10420 | -0.070 | -0.1095 | No |
| 94 | RPS6KB1 | RPS6KB1 Entrez,  Source | ribosomal protein S6 kinase, 70kDa, polypeptide 1 | 10717 | -0.081 | -0.1260 | No |
| 95 | CAMKK2 | CAMKK2 Entrez,  Source | calcium/calmodulin-dependent protein kinase kinase 2, beta | 10729 | -0.081 | -0.1207 | No |
| 96 | TBK1 | TBK1 Entrez,  Source | TANK-binding kinase 1 | 10732 | -0.082 | -0.1146 | No |
| 97 | SRC | SRC Entrez,  Source | v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | 10776 | -0.083 | -0.1116 | No |
| 98 | PRKCQ | PRKCQ Entrez,  Source | protein kinase C, theta | 10961 | -0.092 | -0.1187 | No |
| 99 | NUAK1 | NUAK1 Entrez,  Source | NUAK family, SNF1-like kinase, 1 | 11032 | -0.095 | -0.1169 | No |
| 100 | ABL2 | ABL2 Entrez,  Source | v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene) | 11090 | -0.098 | -0.1139 | No |
| 101 | STK10 | STK10 Entrez,  Source | serine/threonine kinase 10 | 11218 | -0.103 | -0.1158 | No |
| 102 | MYLK | MYLK Entrez,  Source | myosin, light chain kinase | 11255 | -0.105 | -0.1106 | No |
| 103 | BMPR2 | BMPR2 Entrez,  Source | bone morphogenetic protein receptor, type II (serine/threonine kinase) | 11345 | -0.109 | -0.1091 | No |
| 104 | FER | FER Entrez,  Source | fer (fps/fes related) tyrosine kinase (phosphoprotein NCP94) | 11371 | -0.111 | -0.1027 | No |
| 105 | STK4 | STK4 Entrez,  Source | serine/threonine kinase 4 | 11518 | -0.118 | -0.1049 | No |
| 106 | JAK2 | JAK2 Entrez,  Source | Janus kinase 2 (a protein tyrosine kinase) | 11530 | -0.119 | -0.0967 | No |
| 107 | TYRO3 | TYRO3 Entrez,  Source | TYRO3 protein tyrosine kinase | 11601 | -0.123 | -0.0928 | No |
| 108 | SLK | SLK Entrez,  Source | STE20-like kinase (yeast) | 11672 | -0.128 | -0.0884 | No |
| 109 | MAP4K5 | MAP4K5 Entrez,  Source | mitogen-activated protein kinase kinase kinase kinase 5 | 11705 | -0.130 | -0.0811 | No |
| 110 | FYN | FYN Entrez,  Source | FYN oncogene related to SRC, FGR, YES | 11767 | -0.133 | -0.0756 | No |
| 111 | HIPK1 | HIPK1 Entrez,  Source | homeodomain interacting protein kinase 1 | 11798 | -0.135 | -0.0677 | No |
| 112 | MAP2K2 | MAP2K2 Entrez,  Source | mitogen-activated protein kinase kinase 2 | 11895 | -0.142 | -0.0643 | No |
| 113 | ROCK2 | ROCK2 Entrez,  Source | Rho-associated, coiled-coil containing protein kinase 2 | 12033 | -0.152 | -0.0632 | No |
| 114 | MAP3K2 | MAP3K2 Entrez,  Source | mitogen-activated protein kinase kinase kinase 2 | 12210 | -0.168 | -0.0640 | No |
| 115 | MAPK6 | MAPK6 Entrez,  Source | mitogen-activated protein kinase 6 | 12214 | -0.168 | -0.0515 | No |
| 116 | SIK1 | 12319 | -0.179 | -0.0459 | No | ||
| 117 | MAP3K12 | MAP3K12 Entrez,  Source | mitogen-activated protein kinase kinase kinase 12 | 12384 | -0.186 | -0.0366 | No |
| 118 | MAP4K3 | MAP4K3 Entrez,  Source | mitogen-activated protein kinase kinase kinase kinase 3 | 12403 | -0.189 | -0.0237 | No |
| 119 | ABL1 | ABL1 Entrez,  Source | v-abl Abelson murine leukemia viral oncogene homolog 1 | 12463 | -0.197 | -0.0133 | No |
| 120 | ZAK | ZAK Entrez,  Source | - | 12544 | -0.209 | -0.0035 | No |
| 121 | TLK1 | TLK1 Entrez,  Source | tousled-like kinase 1 | 12558 | -0.210 | 0.0114 | No |
| 122 | MAP3K7 | MAP3K7 Entrez,  Source | mitogen-activated protein kinase kinase kinase 7 | 12613 | -0.221 | 0.0240 | No |
| 123 | AXL | AXL Entrez,  Source | AXL receptor tyrosine kinase | 12789 | -0.257 | 0.0301 | No |

