| Dataset | NSCLC_collapsed_to_symbols.NSCLC.cls #SEN_versus_RES.NSCLC.cls #SEN_versus_RES_repos |
| Phenotype | NSCLC.cls#SEN_versus_RES_repos |
| Upregulated in class | 1 |
| GeneSet | SORAFENIB_FDA |
| Enrichment Score (ES) | 0.28974375 |
| Normalized Enrichment Score (NES) | 0.95029706 |
| Nominal p-value | 0.5468227 |
| FDR q-value | 0.87316215 |
| FWER p-Value | 1.0 |

| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | MAPK13 | MAPK13 Entrez,  Source | mitogen-activated protein kinase 13 | 110 | 0.525 | 0.0752 | Yes |
| 2 | FGFR2 | FGFR2 Entrez,  Source | ffer syndrome, Jackson-Weiss syndrome) | 210 | 0.406 | 0.1321 | Yes |
| 3 | DDR1 | DDR1 Entrez,  Source | discoidin domain receptor family, member 1 | 212 | 0.404 | 0.1962 | Yes |
| 4 | FRK | FRK Entrez,  Source | fyn-related kinase | 296 | 0.343 | 0.2445 | Yes |
| 5 | CDK14 | 659 | 0.222 | 0.2522 | Yes | ||
| 6 | EPHB6 | EPHB6 Entrez,  Source | EPH receptor B6 | 701 | 0.215 | 0.2832 | Yes |
| 7 | TAOK3 | TAOK3 Entrez,  Source | TAO kinase 3 | 971 | 0.170 | 0.2897 | Yes |
| 8 | LCK | LCK Entrez,  Source | lymphocyte-specific protein tyrosine kinase | 1310 | 0.136 | 0.2856 | No |
| 9 | NTRK2 | NTRK2 Entrez,  Source | neurotrophic tyrosine kinase, receptor, type 2 | 1704 | 0.112 | 0.2735 | No |
| 10 | TIE1 | TIE1 Entrez,  Source | tyrosine kinase with immunoglobulin-like and EGF-like domains 1 | 2328 | 0.088 | 0.2400 | No |
| 11 | MERTK | MERTK Entrez,  Source | c-mer proto-oncogene tyrosine kinase | 2522 | 0.082 | 0.2384 | No |
| 12 | EPHA3 | EPHA3 Entrez,  Source | EPH receptor A3 | 2870 | 0.074 | 0.2237 | No |
| 13 | MKNK1 | MKNK1 Entrez,  Source | MAP kinase interacting serine/threonine kinase 1 | 2907 | 0.073 | 0.2325 | No |
| 14 | KDR | KDR Entrez,  Source | kinase insert domain receptor (a type III receptor tyrosine kinase) | 3146 | 0.068 | 0.2251 | No |
| 15 | FLT3 | FLT3 Entrez,  Source | fms-related tyrosine kinase 3 | 3403 | 0.063 | 0.2156 | No |
| 16 | CSF1R | CSF1R Entrez,  Source | colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog | 3454 | 0.062 | 0.2216 | No |
| 17 | BRAF | BRAF Entrez,  Source | v-raf murine sarcoma viral oncogene homolog B1 | 3772 | 0.056 | 0.2064 | No |
| 18 | MUSK | MUSK Entrez,  Source | muscle, skeletal, receptor tyrosine kinase | 4139 | 0.050 | 0.1865 | No |
| 19 | AURKC | AURKC Entrez,  Source | aurora kinase C | 4413 | 0.046 | 0.1730 | No |
| 20 | CDKL2 | CDKL2 Entrez,  Source | cyclin-dependent kinase-like 2 (CDC2-related kinase) | 4548 | 0.044 | 0.1698 | No |
| 21 | FLT1 | FLT1 Entrez,  Source | fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) | 4882 | 0.039 | 0.1506 | No |
| 22 | FLT4 | FLT4 Entrez,  Source | fms-related tyrosine kinase 4 | 4898 | 0.039 | 0.1557 | No |
| 23 | TNNI3K | TNNI3K Entrez,  Source | TNNI3 interacting kinase | 5274 | 0.033 | 0.1324 | No |
| 24 | MAPK11 | MAPK11 Entrez,  Source | mitogen-activated protein kinase 11 | 5392 | 0.032 | 0.1286 | No |
| 25 | RET | RET Entrez,  Source | ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease) | 6471 | 0.016 | 0.0491 | No |
| 26 | MAPK14 | MAPK14 Entrez,  Source | mitogen-activated protein kinase 14 | 6492 | 0.016 | 0.0501 | No |
| 27 | TEK | TEK Entrez,  Source | TEK tyrosine kinase, endothelial (venous malformations, multiple cutaneous and mucosal) | 7035 | 0.008 | 0.0101 | No |
| 28 | CDK19 | 7263 | 0.004 | -0.0066 | No | ||
| 29 | PDGFRB | PDGFRB Entrez,  Source | platelet-derived growth factor receptor, beta polypeptide | 7824 | -0.006 | -0.0483 | No |
| 30 | MKNK2 | MKNK2 Entrez,  Source | MAP kinase interacting serine/threonine kinase 2 | 7841 | -0.006 | -0.0485 | No |
| 31 | RAF1 | RAF1 Entrez,  Source | v-raf-1 murine leukemia viral oncogene homolog 1 | 8015 | -0.009 | -0.0602 | No |
| 32 | TAOK2 | TAOK2 Entrez,  Source | TAO kinase 2 | 8059 | -0.010 | -0.0619 | No |
| 33 | KIT | KIT Entrez,  Source | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog | 8134 | -0.012 | -0.0657 | No |
| 34 | MAP2K5 | MAP2K5 Entrez,  Source | mitogen-activated protein kinase kinase 5 | 8199 | -0.013 | -0.0685 | No |
| 35 | CDKL3 | CDKL3 Entrez,  Source | cyclin-dependent kinase-like 3 | 8249 | -0.014 | -0.0700 | No |
| 36 | NTRK3 | NTRK3 Entrez,  Source | neurotrophic tyrosine kinase, receptor, type 3 | 8500 | -0.019 | -0.0859 | No |
| 37 | AURKB | AURKB Entrez,  Source | aurora kinase B | 8856 | -0.027 | -0.1086 | No |
| 38 | HIPK3 | HIPK3 Entrez,  Source | homeodomain interacting protein kinase 3 | 9770 | -0.050 | -0.1702 | No |
| 39 | TTK | TTK Entrez,  Source | TTK protein kinase | 9930 | -0.055 | -0.1737 | No |
| 40 | HIPK2 | HIPK2 Entrez,  Source | homeodomain interacting protein kinase 2 | 10151 | -0.061 | -0.1807 | No |
| 41 | DDR2 | DDR2 Entrez,  Source | discoidin domain receptor family, member 2 | 10235 | -0.064 | -0.1770 | No |
| 42 | ARAF | ARAF Entrez,  Source | v-raf murine sarcoma 3611 viral oncogene homolog | 10275 | -0.065 | -0.1696 | No |
| 43 | NLK | NLK Entrez,  Source | nemo-like kinase | 10979 | -0.093 | -0.2084 | No |
| 44 | CDK7 | CDK7 Entrez,  Source | cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase) | 11160 | -0.101 | -0.2061 | No |
| 45 | STK10 | STK10 Entrez,  Source | serine/threonine kinase 10 | 11218 | -0.103 | -0.1940 | No |
| 46 | SLK | SLK Entrez,  Source | STE20-like kinase (yeast) | 11672 | -0.128 | -0.2082 | No |
| 47 | MAP4K5 | MAP4K5 Entrez,  Source | mitogen-activated protein kinase kinase kinase kinase 5 | 11705 | -0.130 | -0.1900 | No |
| 48 | HIPK1 | HIPK1 Entrez,  Source | homeodomain interacting protein kinase 1 | 11798 | -0.135 | -0.1755 | No |
| 49 | PDGFRA | PDGFRA Entrez,  Source | platelet-derived growth factor receptor, alpha polypeptide | 12211 | -0.168 | -0.1802 | No |
| 50 | ABL1 | ABL1 Entrez,  Source | v-abl Abelson murine leukemia viral oncogene homolog 1 | 12463 | -0.197 | -0.1680 | No |
| 51 | ZAK | ZAK Entrez,  Source | - | 12544 | -0.209 | -0.1408 | No |
| 52 | MAP3K7 | MAP3K7 Entrez,  Source | mitogen-activated protein kinase kinase kinase 7 | 12613 | -0.221 | -0.1109 | No |
| 53 | CDK8 | CDK8 Entrez,  Source | cyclin-dependent kinase 8 | 12650 | -0.226 | -0.0778 | No |
| 54 | AXL | AXL Entrez,  Source | AXL receptor tyrosine kinase | 12789 | -0.257 | -0.0474 | No |
| 55 | FGFR1 | FGFR1 Entrez,  Source | fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome) | 13121 | -0.486 | 0.0046 | No |

