DatasetNSCLC_collapsed_to_symbols.NSCLC.cls
#SEN_versus_RES.NSCLC.cls
#SEN_versus_RES_repos
PhenotypeNSCLC.cls#SEN_versus_RES_repos
Upregulated in class1
GeneSetPAZOPANIB_FDA
Enrichment Score (ES)0.3376279
Normalized Enrichment Score (NES)1.0503721
Nominal p-value0.36572438
FDR q-value0.7596237
FWER p-Value1.0
Table: GSEA Results Summary



Fig 1: Enrichment plot: PAZOPANIB_FDA   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEGENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1FGFR3FGFR3
Entrez,  Source
fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism)1530.4650.0668Yes
2FGFR2FGFR2
Entrez,  Source
ffer syndrome, Jackson-Weiss syndrome)2100.4060.1309Yes
3DDR1DDR1
Entrez,  Source
discoidin domain receptor family, member 12120.4040.1989Yes
4FRKFRK
Entrez,  Source
fyn-related kinase2960.3430.2505Yes
5ROS1ROS1
Entrez,  Source
v-ros UR2 sarcoma virus oncogene homolog 1 (avian)5050.2580.2781Yes
6EPHB6EPHB6
Entrez,  Source
EPH receptor B67010.2150.2995Yes
7TAOK3TAOK3
Entrez,  Source
TAO kinase 39710.1700.3077Yes
8TNIKTNIK
Entrez,  Source
TRAF2 and NCK interacting kinase11970.1450.3151Yes
9GAKGAK
Entrez,  Source
cyclin G associated kinase13400.1330.3267Yes
10PIP4K2C16760.1140.3204Yes
11MAP3K9MAP3K9
Entrez,  Source
mitogen-activated protein kinase kinase kinase 916990.1120.3376Yes
12MAP3K11MAP3K11
Entrez,  Source
mitogen-activated protein kinase kinase kinase 1122950.0890.3073No
13TIE1TIE1
Entrez,  Source
tyrosine kinase with immunoglobulin-like and EGF-like domains 123280.0880.3197No
14TAOK1TAOK1
Entrez,  Source
TAO kinase 125520.0820.3165No
15LIMK2LIMK2
Entrez,  Source
LIM domain kinase 227990.0760.3106No
16MAP4K1MAP4K1
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 128490.0740.3193No
17KDRKDR
Entrez,  Source
kinase insert domain receptor (a type III receptor tyrosine kinase)31460.0680.3082No
18FLT3FLT3
Entrez,  Source
fms-related tyrosine kinase 334030.0630.2993No
19CSF1RCSF1R
Entrez,  Source
colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog34540.0620.3059No
20BRAFBRAF
Entrez,  Source
v-raf murine sarcoma viral oncogene homolog B137720.0560.2912No
21AURKCAURKC
Entrez,  Source
aurora kinase C44130.0460.2502No
22LIMK1LIMK1
Entrez,  Source
LIM domain kinase 144680.0450.2538No
23NEK2NEK2
Entrez,  Source
NIMA (never in mitosis gene a)-related kinase 244830.0450.2603No
24FLT1FLT1
Entrez,  Source
fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)48820.0390.2366No
25FLT4FLT4
Entrez,  Source
fms-related tyrosine kinase 448980.0390.2420No
26STK16STK16
Entrez,  Source
serine/threonine kinase 1657780.0270.1796No
27RETRET
Entrez,  Source
ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease)64710.0160.1297No
28BMPR1BBMPR1B
Entrez,  Source
bone morphogenetic protein receptor, type IB67770.0120.1085No
29PI4KB7697-0.0030.0391No
30PDGFRBPDGFRB
Entrez,  Source
platelet-derived growth factor receptor, beta polypeptide7824-0.0060.0305No
31RAF1RAF1
Entrez,  Source
v-raf-1 murine leukemia viral oncogene homolog 18015-0.0090.0175No
32KITKIT
Entrez,  Source
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog8134-0.0120.0105No
33MAP2K5MAP2K5
Entrez,  Source
mitogen-activated protein kinase kinase 58199-0.0130.0079No
34TTKTTK
Entrez,  Source
TTK protein kinase9930-0.055-0.1146No
35DDR2DDR2
Entrez,  Source
discoidin domain receptor family, member 210235-0.064-0.1270No
36PLK4PLK4
Entrez,  Source
polo-like kinase 4 (Drosophila)10581-0.075-0.1406No
37STK10STK10
Entrez,  Source
serine/threonine kinase 1011218-0.103-0.1715No
38RIPK2RIPK2
Entrez,  Source
receptor-interacting serine-threonine kinase 211349-0.110-0.1629No
39RIPK1RIPK1
Entrez,  Source
receptor (TNFRSF)-interacting serine-threonine kinase 111427-0.113-0.1497No
40SLKSLK
Entrez,  Source
STE20-like kinase (yeast)11672-0.128-0.1467No
41MAP2K4MAP2K4
Entrez,  Source
mitogen-activated protein kinase kinase 411811-0.136-0.1342No
42MAP3K2MAP3K2
Entrez,  Source
mitogen-activated protein kinase kinase kinase 212210-0.168-0.1362No
43PDGFRAPDGFRA
Entrez,  Source
platelet-derived growth factor receptor, alpha polypeptide12211-0.168-0.1079No
44IRAK3IRAK3
Entrez,  Source
interleukin-1 receptor-associated kinase 312451-0.196-0.0931No
45ABL1ABL1
Entrez,  Source
v-abl Abelson murine leukemia viral oncogene homolog 112463-0.197-0.0607No
46RIOK2RIOK2
Entrez,  Source
RIO kinase 2 (yeast)12467-0.198-0.0276No
47FGFR1FGFR1
Entrez,  Source
fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome)13121-0.4860.0046No
Table: GSEA details [plain text format]



Fig 2: PAZOPANIB_FDA   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: PAZOPANIB_FDA: Random ES distribution   
Gene set null distribution of ES for PAZOPANIB_FDA