DatasetNSCLC_collapsed_to_symbols.NSCLC.cls
#SEN_versus_RES.NSCLC.cls
#SEN_versus_RES_repos
PhenotypeNSCLC.cls#SEN_versus_RES_repos
Upregulated in class1
GeneSetSORAFENIB_FDA
Enrichment Score (ES)0.28974375
Normalized Enrichment Score (NES)0.95029706
Nominal p-value0.5468227
FDR q-value0.87316215
FWER p-Value1.0
Table: GSEA Results Summary



Fig 1: Enrichment plot: SORAFENIB_FDA   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEGENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1MAPK13MAPK13
Entrez,  Source
mitogen-activated protein kinase 131100.5250.0752Yes
2FGFR2FGFR2
Entrez,  Source
ffer syndrome, Jackson-Weiss syndrome)2100.4060.1321Yes
3DDR1DDR1
Entrez,  Source
discoidin domain receptor family, member 12120.4040.1962Yes
4FRKFRK
Entrez,  Source
fyn-related kinase2960.3430.2445Yes
5CDK146590.2220.2522Yes
6EPHB6EPHB6
Entrez,  Source
EPH receptor B67010.2150.2832Yes
7TAOK3TAOK3
Entrez,  Source
TAO kinase 39710.1700.2897Yes
8LCKLCK
Entrez,  Source
lymphocyte-specific protein tyrosine kinase13100.1360.2856No
9NTRK2NTRK2
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 217040.1120.2735No
10TIE1TIE1
Entrez,  Source
tyrosine kinase with immunoglobulin-like and EGF-like domains 123280.0880.2400No
11MERTKMERTK
Entrez,  Source
c-mer proto-oncogene tyrosine kinase25220.0820.2384No
12EPHA3EPHA3
Entrez,  Source
EPH receptor A328700.0740.2237No
13MKNK1MKNK1
Entrez,  Source
MAP kinase interacting serine/threonine kinase 129070.0730.2325No
14KDRKDR
Entrez,  Source
kinase insert domain receptor (a type III receptor tyrosine kinase)31460.0680.2251No
15FLT3FLT3
Entrez,  Source
fms-related tyrosine kinase 334030.0630.2156No
16CSF1RCSF1R
Entrez,  Source
colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog34540.0620.2216No
17BRAFBRAF
Entrez,  Source
v-raf murine sarcoma viral oncogene homolog B137720.0560.2064No
18MUSKMUSK
Entrez,  Source
muscle, skeletal, receptor tyrosine kinase41390.0500.1865No
19AURKCAURKC
Entrez,  Source
aurora kinase C44130.0460.1730No
20CDKL2CDKL2
Entrez,  Source
cyclin-dependent kinase-like 2 (CDC2-related kinase)45480.0440.1698No
21FLT1FLT1
Entrez,  Source
fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)48820.0390.1506No
22FLT4FLT4
Entrez,  Source
fms-related tyrosine kinase 448980.0390.1557No
23TNNI3KTNNI3K
Entrez,  Source
TNNI3 interacting kinase52740.0330.1324No
24MAPK11MAPK11
Entrez,  Source
mitogen-activated protein kinase 1153920.0320.1286No
25RETRET
Entrez,  Source
ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease)64710.0160.0491No
26MAPK14MAPK14
Entrez,  Source
mitogen-activated protein kinase 1464920.0160.0501No
27TEKTEK
Entrez,  Source
TEK tyrosine kinase, endothelial (venous malformations, multiple cutaneous and mucosal)70350.0080.0101No
28CDK1972630.004-0.0066No
29PDGFRBPDGFRB
Entrez,  Source
platelet-derived growth factor receptor, beta polypeptide7824-0.006-0.0483No
30MKNK2MKNK2
Entrez,  Source
MAP kinase interacting serine/threonine kinase 27841-0.006-0.0485No
31RAF1RAF1
Entrez,  Source
v-raf-1 murine leukemia viral oncogene homolog 18015-0.009-0.0602No
32TAOK2TAOK2
Entrez,  Source
TAO kinase 28059-0.010-0.0619No
33KITKIT
Entrez,  Source
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog8134-0.012-0.0657No
34MAP2K5MAP2K5
Entrez,  Source
mitogen-activated protein kinase kinase 58199-0.013-0.0685No
35CDKL3CDKL3
Entrez,  Source
cyclin-dependent kinase-like 38249-0.014-0.0700No
36NTRK3NTRK3
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 38500-0.019-0.0859No
37AURKBAURKB
Entrez,  Source
aurora kinase B8856-0.027-0.1086No
38HIPK3HIPK3
Entrez,  Source
homeodomain interacting protein kinase 39770-0.050-0.1702No
39TTKTTK
Entrez,  Source
TTK protein kinase9930-0.055-0.1737No
40HIPK2HIPK2
Entrez,  Source
homeodomain interacting protein kinase 210151-0.061-0.1807No
41DDR2DDR2
Entrez,  Source
discoidin domain receptor family, member 210235-0.064-0.1770No
42ARAFARAF
Entrez,  Source
v-raf murine sarcoma 3611 viral oncogene homolog10275-0.065-0.1696No
43NLKNLK
Entrez,  Source
nemo-like kinase10979-0.093-0.2084No
44CDK7CDK7
Entrez,  Source
cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase)11160-0.101-0.2061No
45STK10STK10
Entrez,  Source
serine/threonine kinase 1011218-0.103-0.1940No
46SLKSLK
Entrez,  Source
STE20-like kinase (yeast)11672-0.128-0.2082No
47MAP4K5MAP4K5
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 511705-0.130-0.1900No
48HIPK1HIPK1
Entrez,  Source
homeodomain interacting protein kinase 111798-0.135-0.1755No
49PDGFRAPDGFRA
Entrez,  Source
platelet-derived growth factor receptor, alpha polypeptide12211-0.168-0.1802No
50ABL1ABL1
Entrez,  Source
v-abl Abelson murine leukemia viral oncogene homolog 112463-0.197-0.1680No
51ZAKZAK
Entrez,  Source
-12544-0.209-0.1408No
52MAP3K7MAP3K7
Entrez,  Source
mitogen-activated protein kinase kinase kinase 712613-0.221-0.1109No
53CDK8CDK8
Entrez,  Source
cyclin-dependent kinase 812650-0.226-0.0778No
54AXLAXL
Entrez,  Source
AXL receptor tyrosine kinase12789-0.257-0.0474No
55FGFR1FGFR1
Entrez,  Source
fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome)13121-0.4860.0046No
Table: GSEA details [plain text format]



Fig 2: SORAFENIB_FDA   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: SORAFENIB_FDA: Random ES distribution   
Gene set null distribution of ES for SORAFENIB_FDA