DatasetNSCLC_collapsed_to_symbols.NSCLC.cls
#SEN_versus_RES.NSCLC.cls
#SEN_versus_RES_repos
PhenotypeNSCLC.cls#SEN_versus_RES_repos
Upregulated in class1
GeneSetWH-4-025_LINCS
Enrichment Score (ES)0.38808447
Normalized Enrichment Score (NES)1.3531567
Nominal p-value0.0659164
FDR q-value0.5902199
FWER p-Value1.0
Table: GSEA Results Summary



Fig 1: Enrichment plot: WH-4-025_LINCS   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEGENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1EPHA1EPHA1
Entrez,  Source
EPH receptor A1940.5450.0515Yes
2PTK6PTK6
Entrez,  Source
PTK6 protein tyrosine kinase 61410.4790.0995Yes
3FGFR3FGFR3
Entrez,  Source
fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism)1530.4650.1487Yes
4FGFR2FGFR2
Entrez,  Source
ffer syndrome, Jackson-Weiss syndrome)2100.4060.1881Yes
5DDR1DDR1
Entrez,  Source
discoidin domain receptor family, member 12120.4040.2314Yes
6FRKFRK
Entrez,  Source
fyn-related kinase2960.3430.2620Yes
7SYKSYK
Entrez,  Source
spleen tyrosine kinase4710.2680.2776Yes
8ROS1ROS1
Entrez,  Source
v-ros UR2 sarcoma virus oncogene homolog 1 (avian)5050.2580.3028Yes
9EGFREGFR
Entrez,  Source
epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)6250.2300.3184Yes
10EPHA4EPHA4
Entrez,  Source
EPH receptor A47980.1970.3265Yes
11EPHB2EPHB2
Entrez,  Source
EPH receptor B28680.1850.3412Yes
12TXKTXK
Entrez,  Source
TXK tyrosine kinase10450.1600.3449Yes
13TNIKTNIK
Entrez,  Source
TRAF2 and NCK interacting kinase11970.1450.3491Yes
14LCKLCK
Entrez,  Source
lymphocyte-specific protein tyrosine kinase13100.1360.3551Yes
15TNK1TNK1
Entrez,  Source
tyrosine kinase, non-receptor, 113600.1310.3655Yes
16EPHA7EPHA7
Entrez,  Source
EPH receptor A714120.1280.3754Yes
17EPHB3EPHB3
Entrez,  Source
EPH receptor B314260.1270.3881Yes
18ERBB4ERBB4
Entrez,  Source
v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)18130.1070.3701No
19TESK1TESK1
Entrez,  Source
testis-specific kinase 118550.1050.3782No
20LYNLYN
Entrez,  Source
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog19740.1000.3799No
21PTK2BPTK2B
Entrez,  Source
PTK2B protein tyrosine kinase 2 beta20420.0980.3853No
22TIE1TIE1
Entrez,  Source
tyrosine kinase with immunoglobulin-like and EGF-like domains 123280.0880.3730No
23JAK3JAK3
Entrez,  Source
Janus kinase 3 (a protein tyrosine kinase, leukocyte)24440.0840.3733No
24MERTKMERTK
Entrez,  Source
c-mer proto-oncogene tyrosine kinase25220.0820.3763No
25LIMK2LIMK2
Entrez,  Source
LIM domain kinase 227990.0760.3634No
26MAP4K1MAP4K1
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 128490.0740.3676No
27EPHA3EPHA3
Entrez,  Source
EPH receptor A328700.0740.3740No
28TNK2TNK2
Entrez,  Source
tyrosine kinase, non-receptor, 230050.0700.3713No
29YES1YES1
Entrez,  Source
v-yes-1 Yamaguchi sarcoma viral oncogene homolog 130360.0700.3766No
30CSKCSK
Entrez,  Source
c-src tyrosine kinase30690.0690.3816No
31KDRKDR
Entrez,  Source
kinase insert domain receptor (a type III receptor tyrosine kinase)31460.0680.3830No
32BLKBLK
Entrez,  Source
B lymphoid tyrosine kinase34190.0620.3690No
33CSF1RCSF1R
Entrez,  Source
colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog34540.0620.3730No
34BRAFBRAF
Entrez,  Source
v-raf murine sarcoma viral oncogene homolog B137720.0560.3549No
35EPHB4EPHB4
Entrez,  Source
EPH receptor B438790.0540.3526No
36EPHB1EPHB1
Entrez,  Source
EPH receptor B140000.0520.3491No
37ALKALK
Entrez,  Source
anaplastic lymphoma kinase (Ki-1)40730.0510.3491No
38FGRFGR
Entrez,  Source
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog41930.0490.3453No
39LIMK1LIMK1
Entrez,  Source
LIM domain kinase 144680.0450.3293No
40FGFR4FGFR4
Entrez,  Source
fibroblast growth factor receptor 447150.0410.3150No
41BMXBMX
Entrez,  Source
BMX non-receptor tyrosine kinase48260.0400.3109No
42EPHA2EPHA2
Entrez,  Source
EPH receptor A248800.0390.3110No
43FLT1FLT1
Entrez,  Source
fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)48820.0390.3152No
44FLT4FLT4
Entrez,  Source
fms-related tyrosine kinase 448980.0390.3182No
45TNNI3KTNNI3K
Entrez,  Source
TNNI3 interacting kinase52740.0330.2932No
46TECTEC
Entrez,  Source
tec protein tyrosine kinase53790.0320.2887No
47MAPK11MAPK11
Entrez,  Source
mitogen-activated protein kinase 1153920.0320.2913No
48EPHA5EPHA5
Entrez,  Source
EPH receptor A554750.0310.2883No
49BTKBTK
Entrez,  Source
Bruton agammaglobulinemia tyrosine kinase56280.0290.2798No
50FESFES
Entrez,  Source
feline sarcoma oncogene61260.0220.2442No
51RETRET
Entrez,  Source
ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease)64710.0160.2197No
52MAPK14MAPK14
Entrez,  Source
mitogen-activated protein kinase 1464920.0160.2199No
53MAPK7MAPK7
Entrez,  Source
mitogen-activated protein kinase 769130.0100.1889No
54TEKTEK
Entrez,  Source
TEK tyrosine kinase, endothelial (venous malformations, multiple cutaneous and mucosal)70350.0080.1805No
55PRKAA2PRKAA2
Entrez,  Source
protein kinase, AMP-activated, alpha 2 catalytic subunit74180.0010.1515No
56SIK274350.0010.1504No
57PDGFRBPDGFRB
Entrez,  Source
platelet-derived growth factor receptor, beta polypeptide7824-0.0060.1214No
58KITKIT
Entrez,  Source
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog8134-0.0120.0991No
59LTKLTK
Entrez,  Source
leukocyte tyrosine kinase8158-0.0120.0986No
60PTK2PTK2
Entrez,  Source
PTK2 protein tyrosine kinase 28356-0.0160.0854No
61NTRK3NTRK3
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 38500-0.0190.0765No
62CDK11A9060-0.0320.0373No
63PAK3PAK3
Entrez,  Source
p21 (CDKN1A)-activated kinase 39490-0.0420.0091No
64MAP4K4MAP4K4
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 49922-0.055-0.0179No
65HCKHCK
Entrez,  Source
hemopoietic cell kinase9981-0.056-0.0163No
66CITCIT
Entrez,  Source
citron (rho-interacting, serine/threonine kinase 21)10420-0.070-0.0422No
67SRCSRC
Entrez,  Source
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)10776-0.083-0.0604No
68PRKAA1PRKAA1
Entrez,  Source
protein kinase, AMP-activated, alpha 1 catalytic subunit10906-0.089-0.0607No
69ABL2ABL2
Entrez,  Source
v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)11090-0.098-0.0641No
70STK10STK10
Entrez,  Source
serine/threonine kinase 1011218-0.103-0.0627No
71RIPK2RIPK2
Entrez,  Source
receptor-interacting serine-threonine kinase 211349-0.110-0.0608No
72FERFER
Entrez,  Source
fer (fps/fes related) tyrosine kinase (phosphoprotein NCP94)11371-0.111-0.0505No
73JAK2JAK2
Entrez,  Source
Janus kinase 2 (a protein tyrosine kinase)11530-0.119-0.0498No
74SLKSLK
Entrez,  Source
STE20-like kinase (yeast)11672-0.128-0.0468No
75MAP4K5MAP4K5
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 511705-0.130-0.0353No
76FYNFYN
Entrez,  Source
FYN oncogene related to SRC, FGR, YES11767-0.133-0.0257No
77PDGFRAPDGFRA
Entrez,  Source
platelet-derived growth factor receptor, alpha polypeptide12211-0.168-0.0414No
78SIK112319-0.179-0.0304No
79ABL1ABL1
Entrez,  Source
v-abl Abelson murine leukemia viral oncogene homolog 112463-0.197-0.0201No
80ZAKZAK
Entrez,  Source
-12544-0.209-0.0037No
81FGFR1FGFR1
Entrez,  Source
fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome)13121-0.4860.0047No
Table: GSEA details [plain text format]



Fig 2: WH-4-025_LINCS   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: WH-4-025_LINCS: Random ES distribution   
Gene set null distribution of ES for WH-4-025_LINCS