DatasetNSCLC_collapsed_to_symbols.NSCLC.cls
#SEN_versus_RES.NSCLC.cls
#SEN_versus_RES_repos
PhenotypeNSCLC.cls#SEN_versus_RES_repos
Upregulated in class1
GeneSetCRIZOTINIB_KINOME SCAN
Enrichment Score (ES)0.29616234
Normalized Enrichment Score (NES)1.0489143
Nominal p-value0.35153583
FDR q-value0.75432783
FWER p-Value1.0
Table: GSEA Results Summary



Fig 1: Enrichment plot: CRIZOTINIB_KINOME SCAN   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEGENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1MST1RMST1R
Entrez,  Source
macrophage stimulating 1 receptor (c-met-related tyrosine kinase)540.6360.0639Yes
2EPHA1EPHA1
Entrez,  Source
EPH receptor A1940.5450.1192Yes
3DDR1DDR1
Entrez,  Source
discoidin domain receptor family, member 12120.4040.1535Yes
4METMET
Entrez,  Source
met proto-oncogene (hepatocyte growth factor receptor)4990.2590.1593Yes
5ROS1ROS1
Entrez,  Source
v-ros UR2 sarcoma virus oncogene homolog 1 (avian)5050.2580.1864Yes
6MAP3K13MAP3K13
Entrez,  Source
mitogen-activated protein kinase kinase kinase 136240.2300.2020Yes
7EPHB6EPHB6
Entrez,  Source
EPH receptor B67010.2150.2192Yes
8EPHA4EPHA4
Entrez,  Source
EPH receptor A47980.1970.2330Yes
9TAOK3TAOK3
Entrez,  Source
TAO kinase 39710.1700.2380Yes
10TXKTXK
Entrez,  Source
TXK tyrosine kinase10450.1600.2495Yes
11LCKLCK
Entrez,  Source
lymphocyte-specific protein tyrosine kinase13100.1360.2439Yes
12TNK1TNK1
Entrez,  Source
tyrosine kinase, non-receptor, 113600.1310.2542Yes
13EPHA7EPHA7
Entrez,  Source
EPH receptor A714120.1280.2640Yes
14STK3STK3
Entrez,  Source
serine/threonine kinase 3 (STE20 homolog, yeast)15530.1200.2660Yes
15INSRINSR
Entrez,  Source
insulin receptor16640.1140.2699Yes
16NTRK2NTRK2
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 217040.1120.2789Yes
17TESK1TESK1
Entrez,  Source
testis-specific kinase 118550.1050.2786Yes
18LYNLYN
Entrez,  Source
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog19740.1000.2802Yes
19CASKCASK
Entrez,  Source
calcium/calmodulin-dependent serine protein kinase (MAGUK family)20070.0990.2883Yes
20PTK2BPTK2B
Entrez,  Source
PTK2B protein tyrosine kinase 2 beta20420.0980.2962Yes
21TIE1TIE1
Entrez,  Source
tyrosine kinase with immunoglobulin-like and EGF-like domains 123280.0880.2838No
22JAK3JAK3
Entrez,  Source
Janus kinase 3 (a protein tyrosine kinase, leukocyte)24440.0840.2840No
23MERTKMERTK
Entrez,  Source
c-mer proto-oncogene tyrosine kinase25220.0820.2870No
24LIMK2LIMK2
Entrez,  Source
LIM domain kinase 227990.0760.2740No
25MAP4K1MAP4K1
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 128490.0740.2782No
26EPHA3EPHA3
Entrez,  Source
EPH receptor A328700.0740.2845No
27TNK2TNK2
Entrez,  Source
tyrosine kinase, non-receptor, 230050.0700.2818No
28YES1YES1
Entrez,  Source
v-yes-1 Yamaguchi sarcoma viral oncogene homolog 130360.0700.2870No
29FLT3FLT3
Entrez,  Source
fms-related tyrosine kinase 334030.0630.2657No
30BLKBLK
Entrez,  Source
B lymphoid tyrosine kinase34190.0620.2712No
31CSF1RCSF1R
Entrez,  Source
colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog34540.0620.2752No
32EPHB4EPHB4
Entrez,  Source
EPH receptor B438790.0540.2486No
33EPHB1EPHB1
Entrez,  Source
EPH receptor B140000.0520.2451No
34ALKALK
Entrez,  Source
anaplastic lymphoma kinase (Ki-1)40730.0510.2450No
35MUSKMUSK
Entrez,  Source
muscle, skeletal, receptor tyrosine kinase41390.0500.2454No
36FGRFGR
Entrez,  Source
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog41930.0490.2467No
37ACVR1BACVR1B
Entrez,  Source
activin A receptor, type IB43280.0470.2415No
38LIMK1LIMK1
Entrez,  Source
LIM domain kinase 144680.0450.2357No
39EPHA2EPHA2
Entrez,  Source
EPH receptor A248800.0390.2085No
40ULK1ULK1
Entrez,  Source
unc-51-like kinase 1 (C. elegans)51570.0350.1911No
41ACVR1ACVR1
Entrez,  Source
activin A receptor, type I52300.0340.1893No
42TNNI3KTNNI3K
Entrez,  Source
TNNI3 interacting kinase52740.0330.1896No
43INSRRINSRR
Entrez,  Source
insulin receptor-related receptor53320.0330.1887No
44EPHA5EPHA5
Entrez,  Source
EPH receptor A554750.0310.1812No
45MAP3K3MAP3K3
Entrez,  Source
mitogen-activated protein kinase kinase kinase 359210.0250.1499No
46NTRK1NTRK1
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 160970.0220.1389No
47FESFES
Entrez,  Source
feline sarcoma oncogene61260.0220.1390No
48IRAK1IRAK1
Entrez,  Source
interleukin-1 receptor-associated kinase 161790.0210.1373No
49AURKAAURKA
Entrez,  Source
aurora kinase A64270.0170.1202No
50DCLK264620.0160.1194No
51BMPR1BBMPR1B
Entrez,  Source
bone morphogenetic protein receptor, type IB67770.0120.0967No
52MAP4K2MAP4K2
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 268940.0100.0889No
53MAPK7MAPK7
Entrez,  Source
mitogen-activated protein kinase 769130.0100.0886No
54BMP2KBMP2K
Entrez,  Source
BMP2 inducible kinase70290.0080.0806No
55TEKTEK
Entrez,  Source
TEK tyrosine kinase, endothelial (venous malformations, multiple cutaneous and mucosal)70350.0080.0811No
56IKBKEIKBKE
Entrez,  Source
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon72160.0040.0678No
57SIK274350.0010.0513No
58IGF1RIGF1R
Entrez,  Source
insulin-like growth factor 1 receptor7959-0.0080.0122No
59TAOK2TAOK2
Entrez,  Source
TAO kinase 28059-0.0100.0057No
60KITKIT
Entrez,  Source
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog8134-0.0120.0013No
61LTKLTK
Entrez,  Source
leukocyte tyrosine kinase8158-0.0120.0009No
62PTK2PTK2
Entrez,  Source
PTK2 protein tyrosine kinase 28356-0.016-0.0124No
63NTRK3NTRK3
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 38500-0.019-0.0213No
64AURKBAURKB
Entrez,  Source
aurora kinase B8856-0.027-0.0455No
65CDK11A9060-0.032-0.0576No
66TYK2TYK2
Entrez,  Source
tyrosine kinase 29438-0.041-0.0820No
67NEK9NEK9
Entrez,  Source
NIMA (never in mitosis gene a)- related kinase 99810-0.051-0.1049No
68PRKD1PRKD1
Entrez,  Source
protein kinase D19827-0.052-0.1006No
69DCLK19840-0.052-0.0960No
70PLK4PLK4
Entrez,  Source
polo-like kinase 4 (Drosophila)10581-0.075-0.1444No
71JAK1JAK1
Entrez,  Source
Janus kinase 1 (a protein tyrosine kinase)10585-0.076-0.1366No
72RPS6KB1RPS6KB1
Entrez,  Source
ribosomal protein S6 kinase, 70kDa, polypeptide 110717-0.081-0.1380No
73TBK1TBK1
Entrez,  Source
TANK-binding kinase 110732-0.082-0.1303No
74SRCSRC
Entrez,  Source
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)10776-0.083-0.1247No
75ABL2ABL2
Entrez,  Source
v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)11090-0.098-0.1382No
76CDK7CDK7
Entrez,  Source
cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase)11160-0.101-0.1327No
77STK10STK10
Entrez,  Source
serine/threonine kinase 1011218-0.103-0.1260No
78RIPK2RIPK2
Entrez,  Source
receptor-interacting serine-threonine kinase 211349-0.110-0.1242No
79FERFER
Entrez,  Source
fer (fps/fes related) tyrosine kinase (phosphoprotein NCP94)11371-0.111-0.1140No
80STK4STK4
Entrez,  Source
serine/threonine kinase 411518-0.118-0.1125No
81JAK2JAK2
Entrez,  Source
Janus kinase 2 (a protein tyrosine kinase)11530-0.119-0.1006No
82TYRO3TYRO3
Entrez,  Source
TYRO3 protein tyrosine kinase11601-0.123-0.0928No
83SLKSLK
Entrez,  Source
STE20-like kinase (yeast)11672-0.128-0.0845No
84MAP4K5MAP4K5
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 511705-0.130-0.0731No
85MAP3K2MAP3K2
Entrez,  Source
mitogen-activated protein kinase kinase kinase 212210-0.168-0.0936No
86MAP3K12MAP3K12
Entrez,  Source
mitogen-activated protein kinase kinase kinase 1212384-0.186-0.0869No
87MAP4K3MAP4K3
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 312403-0.189-0.0681No
88TGFBR1TGFBR1
Entrez,  Source
transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kDa)12447-0.195-0.0505No
89IRAK3IRAK3
Entrez,  Source
interleukin-1 receptor-associated kinase 312451-0.196-0.0298No
90ABL1ABL1
Entrez,  Source
v-abl Abelson murine leukemia viral oncogene homolog 112463-0.197-0.0096No
91AXLAXL
Entrez,  Source
AXL receptor tyrosine kinase12789-0.257-0.0069No
92PRKD3PRKD3
Entrez,  Source
protein kinase D313008-0.3450.0133No
Table: GSEA details [plain text format]



Fig 2: CRIZOTINIB_KINOME SCAN   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: CRIZOTINIB_KINOME SCAN: Random ES distribution   
Gene set null distribution of ES for CRIZOTINIB_KINOME SCAN