DatasetNSCLC_collapsed_to_symbols.NSCLC.cls
#SEN_versus_RES.NSCLC.cls
#SEN_versus_RES_repos
PhenotypeNSCLC.cls#SEN_versus_RES_repos
Upregulated in class0
GeneSetPKR INHIBITOR_MRC
Enrichment Score (ES)-0.2962925
Normalized Enrichment Score (NES)-1.1166985
Nominal p-value0.23294118
FDR q-value0.85352516
FWER p-Value1.0
Table: GSEA Results Summary



Fig 1: Enrichment plot: PKR INHIBITOR_MRC   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEGENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1DAPK1DAPK1
Entrez,  Source
death-associated protein kinase 1880.5570.0623No
2MST43180.3310.0858No
3IKBKBIKBKB
Entrez,  Source
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta5530.2450.0983No
4MAPK10MAPK10
Entrez,  Source
mitogen-activated protein kinase 1010690.1570.0784No
5DYRK2DYRK2
Entrez,  Source
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 212300.1420.0839No
6LCKLCK
Entrez,  Source
lymphocyte-specific protein tyrosine kinase13100.1360.0947No
7STK3STK3
Entrez,  Source
serine/threonine kinase 3 (STE20 homolog, yeast)15530.1200.0910No
8INSRINSR
Entrez,  Source
insulin receptor16640.1140.0967No
9RPS6KA1RPS6KA1
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 116860.1130.1091No
10MAP3K9MAP3K9
Entrez,  Source
mitogen-activated protein kinase kinase kinase 916990.1120.1221No
11MAPK3MAPK3
Entrez,  Source
mitogen-activated protein kinase 317660.1090.1306No
12CSNK1DCSNK1D
Entrez,  Source
casein kinase 1, delta18510.1050.1371No
13MAP3K5MAP3K5
Entrez,  Source
mitogen-activated protein kinase kinase kinase 521470.0940.1262No
14MARK1MARK1
Entrez,  Source
MAP/microtubule affinity-regulating kinase 121590.0930.1370No
15ULK2ULK2
Entrez,  Source
unc-51-like kinase 2 (C. elegans)22440.0910.1418No
16MAP3K11MAP3K11
Entrez,  Source
mitogen-activated protein kinase kinase kinase 1122950.0890.1490No
17TAOK1TAOK1
Entrez,  Source
TAO kinase 125520.0820.1396No
18RPS6KA5RPS6KA5
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 526100.0800.1452No
19MKNK1MKNK1
Entrez,  Source
MAP kinase interacting serine/threonine kinase 129070.0730.1316No
20PIM2PIM2
Entrez,  Source
pim-2 oncogene29560.0710.1368No
21MINK1MINK1
Entrez,  Source
misshapen-like kinase 1 (zebrafish)30800.0690.1359No
22TSSK1B34450.0620.1158No
23MARK2MARK2
Entrez,  Source
MAP/microtubule affinity-regulating kinase 238340.0550.0930No
24PIM1PIM1
Entrez,  Source
pim-1 oncogene41360.0500.0762No
25FLT1FLT1
Entrez,  Source
fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)48820.0390.0242No
26PAK4PAK4
Entrez,  Source
p21(CDKN1A)-activated kinase 450140.0370.0188No
27ULK1ULK1
Entrez,  Source
unc-51-like kinase 1 (C. elegans)51570.0350.0123No
28INSRRINSRR
Entrez,  Source
insulin receptor-related receptor53320.0330.0031No
29STK24STK24
Entrez,  Source
serine/threonine kinase 24 (STE20 homolog, yeast)55870.029-0.0127No
30BTKBTK
Entrez,  Source
Bruton agammaglobulinemia tyrosine kinase56280.029-0.0122No
31MAPK1MAPK1
Entrez,  Source
mitogen-activated protein kinase 159940.024-0.0371No
32NTRK1NTRK1
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 160970.022-0.0422No
33IRAK1IRAK1
Entrez,  Source
interleukin-1 receptor-associated kinase 161790.021-0.0458No
34AURKAAURKA
Entrez,  Source
aurora kinase A64270.017-0.0625No
35MAPK8MAPK8
Entrez,  Source
mitogen-activated protein kinase 868290.011-0.0918No
36MAP4K2MAP4K2
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 268940.010-0.0954No
37MAPK7MAPK7
Entrez,  Source
mitogen-activated protein kinase 769130.010-0.0956No
38CLK2CLK2
Entrez,  Source
CDC-like kinase 271810.005-0.1154No
39IKBKEIKBKE
Entrez,  Source
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon72160.004-0.1174No
40PRKAA2PRKAA2
Entrez,  Source
protein kinase, AMP-activated, alpha 2 catalytic subunit74180.001-0.1326No
41SIK274350.001-0.1337No
42SIK37726-0.004-0.1554No
43MAPK9MAPK9
Entrez,  Source
mitogen-activated protein kinase 97830-0.006-0.1625No
44MKNK2MKNK2
Entrez,  Source
MAP kinase interacting serine/threonine kinase 27841-0.006-0.1625No
45MAP2K1MAP2K1
Entrez,  Source
mitogen-activated protein kinase kinase 17939-0.008-0.1689No
46IGF1RIGF1R
Entrez,  Source
insulin-like growth factor 1 receptor7959-0.008-0.1693No
47MELKMELK
Entrez,  Source
maternal embryonic leucine zipper kinase8047-0.010-0.1747No
48PRKACAPRKACA
Entrez,  Source
protein kinase, cAMP-dependent, catalytic, alpha8112-0.011-0.1782No
49MARK4MARK4
Entrez,  Source
MAP/microtubule affinity-regulating kinase 48259-0.014-0.1876No
50PDK1PDK1
Entrez,  Source
pyruvate dehydrogenase kinase, isozyme 18449-0.018-0.1998No
51AURKBAURKB
Entrez,  Source
aurora kinase B8856-0.027-0.2274No
52IRAK4IRAK4
Entrez,  Source
interleukin-1 receptor-associated kinase 48996-0.031-0.2342No
53PHKA2PHKA2
Entrez,  Source
phosphorylase kinase, alpha 2 (liver)9057-0.032-0.2348No
54CDK2CDK2
Entrez,  Source
cyclin-dependent kinase 29409-0.040-0.2566No
55HIPK3HIPK3
Entrez,  Source
homeodomain interacting protein kinase 39770-0.050-0.2780No
56PRKD1PRKD1
Entrez,  Source
protein kinase D19827-0.052-0.2759No
57TTKTTK
Entrez,  Source
TTK protein kinase9930-0.055-0.2769No
58CHEK2CHEK2
Entrez,  Source
CHK2 checkpoint homolog (S. pombe)10102-0.059-0.2826No
59HIPK2HIPK2
Entrez,  Source
homeodomain interacting protein kinase 210151-0.061-0.2787No
60DYRK1ADYRK1A
Entrez,  Source
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A10303-0.066-0.2821No
61MARK3MARK3
Entrez,  Source
MAP/microtubule affinity-regulating kinase 310374-0.068-0.2790No
62RPS6KA3RPS6KA3
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 310427-0.070-0.2742No
63RPS6KB1RPS6KB1
Entrez,  Source
ribosomal protein S6 kinase, 70kDa, polypeptide 110717-0.081-0.2863Yes
64CAMKK2CAMKK2
Entrez,  Source
calcium/calmodulin-dependent protein kinase kinase 2, beta10729-0.081-0.2770Yes
65TBK1TBK1
Entrez,  Source
TANK-binding kinase 110732-0.082-0.2671Yes
66BRSK2BRSK2
Entrez,  Source
BR serine/threonine kinase 210749-0.082-0.2582Yes
67SRCSRC
Entrez,  Source
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)10776-0.083-0.2498Yes
68CHEK1CHEK1
Entrez,  Source
CHK1 checkpoint homolog (S. pombe)10792-0.084-0.2406Yes
69NUAK1NUAK1
Entrez,  Source
NUAK family, SNF1-like kinase, 111032-0.095-0.2471Yes
70GSK3BGSK3B
Entrez,  Source
glycogen synthase kinase 3 beta11131-0.100-0.2422Yes
71MYLKMYLK
Entrez,  Source
myosin, light chain kinase11255-0.105-0.2386Yes
72RIPK2RIPK2
Entrez,  Source
receptor-interacting serine-threonine kinase 211349-0.110-0.2321Yes
73JAK2JAK2
Entrez,  Source
Janus kinase 2 (a protein tyrosine kinase)11530-0.119-0.2311Yes
74CDK9CDK9
Entrez,  Source
cyclin-dependent kinase 9 (CDC2-related kinase)11631-0.125-0.2233Yes
75MAP4K5MAP4K5
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 511705-0.130-0.2128Yes
76HIPK1HIPK1
Entrez,  Source
homeodomain interacting protein kinase 111798-0.135-0.2030Yes
77CSNK2A1CSNK2A1
Entrez,  Source
casein kinase 2, alpha 1 polypeptide11861-0.139-0.1905Yes
78MAP2K2MAP2K2
Entrez,  Source
mitogen-activated protein kinase kinase 211895-0.142-0.1754Yes
79MAP2K6MAP2K6
Entrez,  Source
mitogen-activated protein kinase kinase 611934-0.144-0.1604Yes
80ROCK2ROCK2
Entrez,  Source
Rho-associated, coiled-coil containing protein kinase 212033-0.152-0.1491Yes
81PDGFRAPDGFRA
Entrez,  Source
platelet-derived growth factor receptor, alpha polypeptide12211-0.168-0.1418Yes
82DYRK3DYRK3
Entrez,  Source
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 312238-0.171-0.1226Yes
83PKN2PKN2
Entrez,  Source
protein kinase N212286-0.175-0.1045Yes
84MAP4K3MAP4K3
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 312403-0.189-0.0900Yes
85MAP3K7MAP3K7
Entrez,  Source
mitogen-activated protein kinase kinase kinase 712613-0.221-0.0786Yes
86FGFR1FGFR1
Entrez,  Source
fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome)13121-0.486-0.0571Yes
87SGK113133-0.4980.0037Yes
Table: GSEA details [plain text format]



Fig 2: PKR INHIBITOR_MRC   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: PKR INHIBITOR_MRC: Random ES distribution   
Gene set null distribution of ES for PKR INHIBITOR_MRC