DatasetNSCLC_collapsed_to_symbols.NSCLC.cls
#SEN_versus_RES.NSCLC.cls
#SEN_versus_RES_repos
PhenotypeNSCLC.cls#SEN_versus_RES_repos
Upregulated in class1
GeneSetPD-173955_KINOME SCAN
Enrichment Score (ES)0.39204746
Normalized Enrichment Score (NES)1.404198
Nominal p-value0.030546624
FDR q-value0.6109687
FWER p-Value1.0
Table: GSEA Results Summary



Fig 1: Enrichment plot: PD-173955_KINOME SCAN   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEGENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1ERBB3ERBB3
Entrez,  Source
v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)121.0340.0826Yes
2EPHA1EPHA1
Entrez,  Source
EPH receptor A1940.5450.1205Yes
3PTK6PTK6
Entrez,  Source
PTK6 protein tyrosine kinase 61410.4790.1557Yes
4FGFR3FGFR3
Entrez,  Source
fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism)1530.4650.1924Yes
5FGFR2FGFR2
Entrez,  Source
ffer syndrome, Jackson-Weiss syndrome)2100.4060.2209Yes
6DDR1DDR1
Entrez,  Source
discoidin domain receptor family, member 12120.4040.2534Yes
7FRKFRK
Entrez,  Source
fyn-related kinase2960.3430.2748Yes
8SYKSYK
Entrez,  Source
spleen tyrosine kinase4710.2680.2832Yes
9METMET
Entrez,  Source
met proto-oncogene (hepatocyte growth factor receptor)4990.2590.3020Yes
10EGFREGFR
Entrez,  Source
epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)6250.2300.3110Yes
11EPHB6EPHB6
Entrez,  Source
EPH receptor B67010.2150.3227Yes
12EPHA4EPHA4
Entrez,  Source
EPH receptor A47980.1970.3313Yes
13EPHB2EPHB2
Entrez,  Source
EPH receptor B28680.1850.3410Yes
14TAOK3TAOK3
Entrez,  Source
TAO kinase 39710.1700.3469Yes
15TXKTXK
Entrez,  Source
TXK tyrosine kinase10450.1600.3542Yes
16TNIKTNIK
Entrez,  Source
TRAF2 and NCK interacting kinase11970.1450.3544Yes
17LCKLCK
Entrez,  Source
lymphocyte-specific protein tyrosine kinase13100.1360.3568Yes
18GAKGAK
Entrez,  Source
cyclin G associated kinase13400.1330.3654Yes
19TNK1TNK1
Entrez,  Source
tyrosine kinase, non-receptor, 113600.1310.3745Yes
20EPHB3EPHB3
Entrez,  Source
EPH receptor B314260.1270.3798Yes
21WEE1WEE1
Entrez,  Source
WEE1 homolog (S. pombe)16390.1150.3730Yes
22PIP4K2C16760.1140.3794Yes
23MAP3K9MAP3K9
Entrez,  Source
mitogen-activated protein kinase kinase kinase 916990.1120.3868Yes
24ERBB4ERBB4
Entrez,  Source
v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)18130.1070.3867Yes
25TESK1TESK1
Entrez,  Source
testis-specific kinase 118550.1050.3920Yes
26LYNLYN
Entrez,  Source
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog19740.1000.3911No
27MAP3K11MAP3K11
Entrez,  Source
mitogen-activated protein kinase kinase kinase 1122950.0890.3738No
28JAK3JAK3
Entrez,  Source
Janus kinase 3 (a protein tyrosine kinase, leukocyte)24440.0840.3693No
29MAP3K4MAP3K4
Entrez,  Source
mitogen-activated protein kinase kinase kinase 424890.0830.3727No
30TAOK1TAOK1
Entrez,  Source
TAO kinase 125520.0820.3745No
31ADCK4ADCK4
Entrez,  Source
aarF domain containing kinase 427150.0770.3684No
32LIMK2LIMK2
Entrez,  Source
LIM domain kinase 227990.0760.3682No
33MAP4K1MAP4K1
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 128490.0740.3704No
34EPHA3EPHA3
Entrez,  Source
EPH receptor A328700.0740.3748No
35TNK2TNK2
Entrez,  Source
tyrosine kinase, non-receptor, 230050.0700.3703No
36YES1YES1
Entrez,  Source
v-yes-1 Yamaguchi sarcoma viral oncogene homolog 130360.0700.3736No
37CSKCSK
Entrez,  Source
c-src tyrosine kinase30690.0690.3767No
38MINK1MINK1
Entrez,  Source
misshapen-like kinase 1 (zebrafish)30800.0690.3816No
39KDRKDR
Entrez,  Source
kinase insert domain receptor (a type III receptor tyrosine kinase)31460.0680.3821No
40FLT3FLT3
Entrez,  Source
fms-related tyrosine kinase 334030.0630.3675No
41BLKBLK
Entrez,  Source
B lymphoid tyrosine kinase34190.0620.3714No
42CSF1RCSF1R
Entrez,  Source
colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog34540.0620.3738No
43ACVRL1ACVRL1
Entrez,  Source
activin A receptor type II-like 137150.0570.3586No
44BRAFBRAF
Entrez,  Source
v-raf murine sarcoma viral oncogene homolog B137720.0560.3588No
45EPHB4EPHB4
Entrez,  Source
EPH receptor B438790.0540.3551No
46EPHB1EPHB1
Entrez,  Source
EPH receptor B140000.0520.3502No
47FGRFGR
Entrez,  Source
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog41930.0490.3395No
48ACVR1BACVR1B
Entrez,  Source
activin A receptor, type IB43280.0470.3330No
49LIMK1LIMK1
Entrez,  Source
LIM domain kinase 144680.0450.3261No
50NEK2NEK2
Entrez,  Source
NIMA (never in mitosis gene a)-related kinase 244830.0450.3286No
51FGFR4FGFR4
Entrez,  Source
fibroblast growth factor receptor 447150.0410.3143No
52BMXBMX
Entrez,  Source
BMX non-receptor tyrosine kinase48260.0400.3091No
53EPHA2EPHA2
Entrez,  Source
EPH receptor A248800.0390.3082No
54FLT1FLT1
Entrez,  Source
fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)48820.0390.3113No
55FLT4FLT4
Entrez,  Source
fms-related tyrosine kinase 448980.0390.3133No
56ACVR1ACVR1
Entrez,  Source
activin A receptor, type I52300.0340.2908No
57TNNI3KTNNI3K
Entrez,  Source
TNNI3 interacting kinase52740.0330.2902No
58TECTEC
Entrez,  Source
tec protein tyrosine kinase53790.0320.2848No
59MAPK11MAPK11
Entrez,  Source
mitogen-activated protein kinase 1153920.0320.2865No
60EPHA5EPHA5
Entrez,  Source
EPH receptor A554750.0310.2827No
61BTKBTK
Entrez,  Source
Bruton agammaglobulinemia tyrosine kinase56280.0290.2734No
62MAP3K3MAP3K3
Entrez,  Source
mitogen-activated protein kinase kinase kinase 359210.0250.2531No
63FESFES
Entrez,  Source
feline sarcoma oncogene61260.0220.2393No
64RETRET
Entrez,  Source
ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease)64710.0160.2143No
65MAPK14MAPK14
Entrez,  Source
mitogen-activated protein kinase 1464920.0160.2140No
66BMPR1BBMPR1B
Entrez,  Source
bone morphogenetic protein receptor, type IB67770.0120.1933No
67TEKTEK
Entrez,  Source
TEK tyrosine kinase, endothelial (venous malformations, multiple cutaneous and mucosal)70350.0080.1743No
68TGFBR2TGFBR2
Entrez,  Source
transforming growth factor, beta receptor II (70/80kDa)71030.0070.1697No
69ACVR2BACVR2B
Entrez,  Source
activin A receptor, type IIB73820.0020.1486No
70SIK274350.0010.1447No
71SIK37726-0.0040.1228No
72PDGFRBPDGFRB
Entrez,  Source
platelet-derived growth factor receptor, beta polypeptide7824-0.0060.1159No
73PKMYT1PKMYT1
Entrez,  Source
protein kinase, membrane associated tyrosine/threonine 17836-0.0060.1156No
74MAP2K1MAP2K1
Entrez,  Source
mitogen-activated protein kinase kinase 17939-0.0080.1084No
75RAF1RAF1
Entrez,  Source
v-raf-1 murine leukemia viral oncogene homolog 18015-0.0090.1034No
76TAOK2TAOK2
Entrez,  Source
TAO kinase 28059-0.0100.1009No
77KITKIT
Entrez,  Source
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog8134-0.0120.0962No
78MAP2K5MAP2K5
Entrez,  Source
mitogen-activated protein kinase kinase 58199-0.0130.0924No
79ACVR2AACVR2A
Entrez,  Source
activin A receptor, type IIA9293-0.0380.0119No
80TYK2TYK2
Entrez,  Source
tyrosine kinase 29438-0.0410.0042No
81MAP4K4MAP4K4
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 49922-0.055-0.0284No
82HCKHCK
Entrez,  Source
hemopoietic cell kinase9981-0.056-0.0283No
83DDR2DDR2
Entrez,  Source
discoidin domain receptor family, member 210235-0.064-0.0425No
84ADCK310237-0.064-0.0374No
85MARK3MARK3
Entrez,  Source
MAP/microtubule affinity-regulating kinase 310374-0.068-0.0423No
86JAK1JAK1
Entrez,  Source
Janus kinase 1 (a protein tyrosine kinase)10585-0.076-0.0523No
87SRCSRC
Entrez,  Source
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)10776-0.083-0.0601No
88NLKNLK
Entrez,  Source
nemo-like kinase10979-0.093-0.0680No
89ABL2ABL2
Entrez,  Source
v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)11090-0.098-0.0686No
90MYLKMYLK
Entrez,  Source
myosin, light chain kinase11255-0.105-0.0726No
91RIPK2RIPK2
Entrez,  Source
receptor-interacting serine-threonine kinase 211349-0.110-0.0709No
92JAK2JAK2
Entrez,  Source
Janus kinase 2 (a protein tyrosine kinase)11530-0.119-0.0751No
93TYRO3TYRO3
Entrez,  Source
TYRO3 protein tyrosine kinase11601-0.123-0.0704No
94MAP4K5MAP4K5
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 511705-0.130-0.0678No
95FYNFYN
Entrez,  Source
FYN oncogene related to SRC, FGR, YES11767-0.133-0.0618No
96MAP2K4MAP2K4
Entrez,  Source
mitogen-activated protein kinase kinase 411811-0.136-0.0540No
97MAP3K2MAP3K2
Entrez,  Source
mitogen-activated protein kinase kinase kinase 212210-0.168-0.0709No
98PDGFRAPDGFRA
Entrez,  Source
platelet-derived growth factor receptor, alpha polypeptide12211-0.168-0.0573No
99MAPK6MAPK6
Entrez,  Source
mitogen-activated protein kinase 612214-0.168-0.0439No
100SIK112319-0.179-0.0374No
101MAP4K3MAP4K3
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 312403-0.189-0.0285No
102BMPR1ABMPR1A
Entrez,  Source
bone morphogenetic protein receptor, type IA12438-0.194-0.0154No
103ABL1ABL1
Entrez,  Source
v-abl Abelson murine leukemia viral oncogene homolog 112463-0.197-0.0013No
104ZAKZAK
Entrez,  Source
-12544-0.2090.0094No
105FGFR1FGFR1
Entrez,  Source
fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome)13121-0.4860.0047No
Table: GSEA details [plain text format]



Fig 2: PD-173955_KINOME SCAN   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: PD-173955_KINOME SCAN: Random ES distribution   
Gene set null distribution of ES for PD-173955_KINOME SCAN