DatasetNSCLC_collapsed_to_symbols.NSCLC.cls
#SEN_versus_RES.NSCLC.cls
#SEN_versus_RES_repos
PhenotypeNSCLC.cls#SEN_versus_RES_repos
Upregulated in class1
GeneSetAST-487_KINOME SCAN
Enrichment Score (ES)0.28663054
Normalized Enrichment Score (NES)1.0554385
Nominal p-value0.3338843
FDR q-value0.7747157
FWER p-Value1.0
Table: GSEA Results Summary



Fig 1: Enrichment plot: AST-487_KINOME SCAN   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEGENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1MST1RMST1R
Entrez,  Source
macrophage stimulating 1 receptor (c-met-related tyrosine kinase)540.6360.0419Yes
2RIPK4RIPK4
Entrez,  Source
receptor-interacting serine-threonine kinase 4950.5440.0783Yes
3MAPK13MAPK13
Entrez,  Source
mitogen-activated protein kinase 131100.5250.1153Yes
4DDR1DDR1
Entrez,  Source
discoidin domain receptor family, member 12120.4040.1368Yes
5FRKFRK
Entrez,  Source
fyn-related kinase2960.3430.1553Yes
6SYKSYK
Entrez,  Source
spleen tyrosine kinase4710.2680.1614Yes
7METMET
Entrez,  Source
met proto-oncogene (hepatocyte growth factor receptor)4990.2590.1780Yes
8IKBKBIKBKB
Entrez,  Source
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta5530.2450.1917Yes
9MAP3K13MAP3K13
Entrez,  Source
mitogen-activated protein kinase kinase kinase 136240.2300.2030Yes
10EGFREGFR
Entrez,  Source
epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)6250.2300.2197Yes
11CDK146590.2220.2333Yes
12CDK187600.2040.2404Yes
13EPHA4EPHA4
Entrez,  Source
EPH receptor A47980.1970.2518Yes
14EPHB2EPHB2
Entrez,  Source
EPH receptor B28680.1850.2600Yes
15TAOK3TAOK3
Entrez,  Source
TAO kinase 39710.1700.2645Yes
16MAPK10MAPK10
Entrez,  Source
mitogen-activated protein kinase 1010690.1570.2684Yes
17TNIKTNIK
Entrez,  Source
TRAF2 and NCK interacting kinase11970.1450.2692Yes
18DYRK2DYRK2
Entrez,  Source
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 212300.1420.2771Yes
19LCKLCK
Entrez,  Source
lymphocyte-specific protein tyrosine kinase13100.1360.2809Yes
20TNK1TNK1
Entrez,  Source
tyrosine kinase, non-receptor, 113600.1310.2866Yes
21STK3STK3
Entrez,  Source
serine/threonine kinase 3 (STE20 homolog, yeast)15530.1200.2806No
22NTRK2NTRK2
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 217040.1120.2772No
23LYNLYN
Entrez,  Source
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog19740.1000.2638No
24PTK2BPTK2B
Entrez,  Source
PTK2B protein tyrosine kinase 2 beta20420.0980.2658No
25ULK2ULK2
Entrez,  Source
unc-51-like kinase 2 (C. elegans)22440.0910.2569No
26TIE1TIE1
Entrez,  Source
tyrosine kinase with immunoglobulin-like and EGF-like domains 123280.0880.2569No
27JAK3JAK3
Entrez,  Source
Janus kinase 3 (a protein tyrosine kinase, leukocyte)24440.0840.2542No
28MERTKMERTK
Entrez,  Source
c-mer proto-oncogene tyrosine kinase25220.0820.2543No
29TAOK1TAOK1
Entrez,  Source
TAO kinase 125520.0820.2580No
30RPS6KA5RPS6KA5
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 526100.0800.2595No
31MAP4K1MAP4K1
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 128490.0740.2466No
32EPHA3EPHA3
Entrez,  Source
EPH receptor A328700.0740.2504No
33MKNK1MKNK1
Entrez,  Source
MAP kinase interacting serine/threonine kinase 129070.0730.2529No
34YES1YES1
Entrez,  Source
v-yes-1 Yamaguchi sarcoma viral oncogene homolog 130360.0700.2481No
35MINK1MINK1
Entrez,  Source
misshapen-like kinase 1 (zebrafish)30800.0690.2499No
36KDRKDR
Entrez,  Source
kinase insert domain receptor (a type III receptor tyrosine kinase)31460.0680.2498No
37FLT3FLT3
Entrez,  Source
fms-related tyrosine kinase 334030.0630.2347No
38BLKBLK
Entrez,  Source
B lymphoid tyrosine kinase34190.0620.2381No
39CSF1RCSF1R
Entrez,  Source
colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog34540.0620.2399No
40MYO3AMYO3A
Entrez,  Source
myosin IIIA37350.0570.2226No
41BRAFBRAF
Entrez,  Source
v-raf murine sarcoma viral oncogene homolog B137720.0560.2239No
42PRKD2PRKD2
Entrez,  Source
protein kinase D239000.0540.2181No
43EPHB1EPHB1
Entrez,  Source
EPH receptor B140000.0520.2143No
44MUSKMUSK
Entrez,  Source
muscle, skeletal, receptor tyrosine kinase41390.0500.2074No
45FGRFGR
Entrez,  Source
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog41930.0490.2069No
46CDKL5CDKL5
Entrez,  Source
cyclin-dependent kinase-like 543450.0470.1987No
47AURKCAURKC
Entrez,  Source
aurora kinase C44130.0460.1969No
48LIMK1LIMK1
Entrez,  Source
LIM domain kinase 144680.0450.1960No
49CDKL2CDKL2
Entrez,  Source
cyclin-dependent kinase-like 2 (CDC2-related kinase)45480.0440.1932No
50EPHA2EPHA2
Entrez,  Source
EPH receptor A248800.0390.1707No
51FLT1FLT1
Entrez,  Source
fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)48820.0390.1734No
52FLT4FLT4
Entrez,  Source
fms-related tyrosine kinase 448980.0390.1751No
53MAKMAK
Entrez,  Source
male germ cell-associated kinase51320.0350.1598No
54TNNI3KTNNI3K
Entrez,  Source
TNNI3 interacting kinase52740.0330.1514No
55MAPK11MAPK11
Entrez,  Source
mitogen-activated protein kinase 1153920.0320.1448No
56EPHA5EPHA5
Entrez,  Source
EPH receptor A554750.0310.1407No
57CDK1360620.0230.0975No
58NTRK1NTRK1
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 160970.0220.0965No
59FESFES
Entrez,  Source
feline sarcoma oncogene61260.0220.0959No
60IRAK1IRAK1
Entrez,  Source
interleukin-1 receptor-associated kinase 161790.0210.0934No
61CSNK1G2CSNK1G2
Entrez,  Source
casein kinase 1, gamma 263280.0180.0834No
62RETRET
Entrez,  Source
ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease)64710.0160.0737No
63MAPK14MAPK14
Entrez,  Source
mitogen-activated protein kinase 1464920.0160.0734No
64MAPK8MAPK8
Entrez,  Source
mitogen-activated protein kinase 868290.0110.0484No
65MAP4K2MAP4K2
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 268940.0100.0442No
66CLK4CLK4
Entrez,  Source
CDC-like kinase 469350.0100.0419No
67TEKTEK
Entrez,  Source
TEK tyrosine kinase, endothelial (venous malformations, multiple cutaneous and mucosal)70350.0080.0349No
68TGFBR2TGFBR2
Entrez,  Source
transforming growth factor, beta receptor II (70/80kDa)71030.0070.0302No
69ITKITK
Entrez,  Source
IL2-inducible T-cell kinase72200.0040.0216No
70CDK1972630.0040.0187No
71CDK5CDK5
Entrez,  Source
cyclin-dependent kinase 574320.0010.0059No
72PDGFRBPDGFRB
Entrez,  Source
platelet-derived growth factor receptor, beta polypeptide7824-0.006-0.0236No
73MAPK9MAPK9
Entrez,  Source
mitogen-activated protein kinase 97830-0.006-0.0236No
74MKNK2MKNK2
Entrez,  Source
MAP kinase interacting serine/threonine kinase 27841-0.006-0.0239No
75RAF1RAF1
Entrez,  Source
v-raf-1 murine leukemia viral oncogene homolog 18015-0.009-0.0365No
76MELKMELK
Entrez,  Source
maternal embryonic leucine zipper kinase8047-0.010-0.0381No
77TAOK2TAOK2
Entrez,  Source
TAO kinase 28059-0.010-0.0383No
78KITKIT
Entrez,  Source
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog8134-0.012-0.0431No
79LTKLTK
Entrez,  Source
leukocyte tyrosine kinase8158-0.012-0.0440No
80MAP2K5MAP2K5
Entrez,  Source
mitogen-activated protein kinase kinase 58199-0.013-0.0461No
81CDKL3CDKL3
Entrez,  Source
cyclin-dependent kinase-like 38249-0.014-0.0488No
82CDK168353-0.016-0.0555No
83CDK3CDK3
Entrez,  Source
cyclin-dependent kinase 38440-0.018-0.0608No
84NTRK3NTRK3
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 38500-0.019-0.0639No
85CSNK1G1CSNK1G1
Entrez,  Source
casein kinase 1, gamma 18732-0.025-0.0798No
86CDKL1CDKL1
Entrez,  Source
cyclin-dependent kinase-like 1 (CDC2-related kinase)8993-0.031-0.0975No
87NEK4NEK4
Entrez,  Source
NIMA (never in mitosis gene a)-related kinase 49362-0.039-0.1229No
88CDK2CDK2
Entrez,  Source
cyclin-dependent kinase 29409-0.040-0.1235No
89HIPK3HIPK3
Entrez,  Source
homeodomain interacting protein kinase 39770-0.050-0.1475No
90MAP2K7MAP2K7
Entrez,  Source
mitogen-activated protein kinase kinase 79831-0.052-0.1483No
91MAP4K4MAP4K4
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 49922-0.055-0.1513No
92TTKTTK
Entrez,  Source
TTK protein kinase9930-0.055-0.1478No
93HCKHCK
Entrez,  Source
hemopoietic cell kinase9981-0.056-0.1476No
94LATS1LATS1
Entrez,  Source
LATS, large tumor suppressor, homolog 1 (Drosophila)10025-0.057-0.1467No
95CHEK2CHEK2
Entrez,  Source
CHK2 checkpoint homolog (S. pombe)10102-0.059-0.1483No
96HIPK2HIPK2
Entrez,  Source
homeodomain interacting protein kinase 210151-0.061-0.1475No
97DDR2DDR2
Entrez,  Source
discoidin domain receptor family, member 210235-0.064-0.1493No
98CITCIT
Entrez,  Source
citron (rho-interacting, serine/threonine kinase 21)10420-0.070-0.1583No
99JAK1JAK1
Entrez,  Source
Janus kinase 1 (a protein tyrosine kinase)10585-0.076-0.1654No
100RPS6KB1RPS6KB1
Entrez,  Source
ribosomal protein S6 kinase, 70kDa, polypeptide 110717-0.081-0.1696No
101CAMKK2CAMKK2
Entrez,  Source
calcium/calmodulin-dependent protein kinase kinase 2, beta10729-0.081-0.1645No
102SRCSRC
Entrez,  Source
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)10776-0.083-0.1620No
103CDK4CDK4
Entrez,  Source
cyclin-dependent kinase 410871-0.087-0.1629No
104NLKNLK
Entrez,  Source
nemo-like kinase10979-0.093-0.1644No
105ABL2ABL2
Entrez,  Source
v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)11090-0.098-0.1658No
106CDK7CDK7
Entrez,  Source
cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase)11160-0.101-0.1638No
107PRKACBPRKACB
Entrez,  Source
protein kinase, cAMP-dependent, catalytic, beta11179-0.102-0.1578No
108STK10STK10
Entrez,  Source
serine/threonine kinase 1011218-0.103-0.1532No
109FERFER
Entrez,  Source
fer (fps/fes related) tyrosine kinase (phosphoprotein NCP94)11371-0.111-0.1568No
110RIPK1RIPK1
Entrez,  Source
receptor (TNFRSF)-interacting serine-threonine kinase 111427-0.113-0.1528No
111JAK2JAK2
Entrez,  Source
Janus kinase 2 (a protein tyrosine kinase)11530-0.119-0.1520No
112CDK9CDK9
Entrez,  Source
cyclin-dependent kinase 9 (CDC2-related kinase)11631-0.125-0.1506No
113SLKSLK
Entrez,  Source
STE20-like kinase (yeast)11672-0.128-0.1444No
114MAP4K5MAP4K5
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 511705-0.130-0.1375No
115FYNFYN
Entrez,  Source
FYN oncogene related to SRC, FGR, YES11767-0.133-0.1325No
116HIPK1HIPK1
Entrez,  Source
homeodomain interacting protein kinase 111798-0.135-0.1250No
117MAP2K4MAP2K4
Entrez,  Source
mitogen-activated protein kinase kinase 411811-0.136-0.1160No
118ROCK2ROCK2
Entrez,  Source
Rho-associated, coiled-coil containing protein kinase 212033-0.152-0.1220No
119PDGFRAPDGFRA
Entrez,  Source
platelet-derived growth factor receptor, alpha polypeptide12211-0.168-0.1234No
120MAP4K3MAP4K3
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 312403-0.189-0.1243No
121ABL1ABL1
Entrez,  Source
v-abl Abelson murine leukemia viral oncogene homolog 112463-0.197-0.1145No
122CSNK1G3CSNK1G3
Entrez,  Source
casein kinase 1, gamma 312464-0.197-0.1002No
123RIOK2RIOK2
Entrez,  Source
RIO kinase 2 (yeast)12467-0.198-0.0861No
124ZAKZAK
Entrez,  Source
-12544-0.209-0.0767No
125CDK1712578-0.213-0.0638No
126MAP3K7MAP3K7
Entrez,  Source
mitogen-activated protein kinase kinase kinase 712613-0.221-0.0504No
127CDK8CDK8
Entrez,  Source
cyclin-dependent kinase 812650-0.226-0.0369No
128AXLAXL
Entrez,  Source
AXL receptor tyrosine kinase12789-0.257-0.0288No
129CHUKCHUK
Entrez,  Source
conserved helix-loop-helix ubiquitous kinase12978-0.325-0.0197No
130FGFR1FGFR1
Entrez,  Source
fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome)13121-0.4860.0047No
Table: GSEA details [plain text format]



Fig 2: AST-487_KINOME SCAN   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: AST-487_KINOME SCAN: Random ES distribution   
Gene set null distribution of ES for AST-487_KINOME SCAN