| Dataset | NSCLC_collapsed_to_symbols.NSCLC.cls #SEN_versus_RES.NSCLC.cls #SEN_versus_RES_repos |
| Phenotype | NSCLC.cls#SEN_versus_RES_repos |
| Upregulated in class | 1 |
| GeneSet | CP466722_LINCS |
| Enrichment Score (ES) | 0.2849662 |
| Normalized Enrichment Score (NES) | 1.0335896 |
| Nominal p-value | 0.38980263 |
| FDR q-value | 0.7270519 |
| FWER p-Value | 1.0 |

| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | ERBB3 | ERBB3 Entrez,  Source | v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) | 12 | 1.034 | 0.1020 | Yes |
| 2 | DAPK1 | DAPK1 Entrez,  Source | death-associated protein kinase 1 | 88 | 0.557 | 0.1517 | Yes |
| 3 | EPHA1 | EPHA1 Entrez,  Source | EPH receptor A1 | 94 | 0.545 | 0.2056 | Yes |
| 4 | RIPK4 | RIPK4 Entrez,  Source | receptor-interacting serine-threonine kinase 4 | 95 | 0.544 | 0.2597 | Yes |
| 5 | EPHB6 | EPHB6 Entrez,  Source | EPH receptor B6 | 701 | 0.215 | 0.2348 | Yes |
| 6 | MAPK10 | MAPK10 Entrez,  Source | mitogen-activated protein kinase 10 | 1069 | 0.157 | 0.2224 | Yes |
| 7 | DYRK2 | DYRK2 Entrez,  Source | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 | 1230 | 0.142 | 0.2243 | Yes |
| 8 | LCK | LCK Entrez,  Source | lymphocyte-specific protein tyrosine kinase | 1310 | 0.136 | 0.2318 | Yes |
| 9 | GAK | GAK Entrez,  Source | cyclin G associated kinase | 1340 | 0.133 | 0.2429 | Yes |
| 10 | TNK1 | TNK1 Entrez,  Source | tyrosine kinase, non-receptor, 1 | 1360 | 0.131 | 0.2545 | Yes |
| 11 | PIK3C2G | PIK3C2G Entrez,  Source | phosphoinositide-3-kinase, class 2, gamma polypeptide | 1498 | 0.123 | 0.2563 | Yes |
| 12 | STK17B | STK17B Entrez,  Source | serine/threonine kinase 17b (apoptosis-inducing) | 1554 | 0.119 | 0.2640 | Yes |
| 13 | PIP4K2C | 1676 | 0.114 | 0.2660 | Yes | ||
| 14 | RPS6KA1 | RPS6KA1 Entrez,  Source | ribosomal protein S6 kinase, 90kDa, polypeptide 1 | 1686 | 0.113 | 0.2765 | Yes |
| 15 | DAPK2 | DAPK2 Entrez,  Source | death-associated protein kinase 2 | 1838 | 0.105 | 0.2755 | Yes |
| 16 | CSNK1D | CSNK1D Entrez,  Source | casein kinase 1, delta | 1851 | 0.105 | 0.2850 | Yes |
| 17 | AAK1 | AAK1 Entrez,  Source | AP2 associated kinase 1 | 2212 | 0.092 | 0.2666 | No |
| 18 | ULK2 | ULK2 Entrez,  Source | unc-51-like kinase 2 (C. elegans) | 2244 | 0.091 | 0.2733 | No |
| 19 | CLK3 | CLK3 Entrez,  Source | CDC-like kinase 3 | 2349 | 0.087 | 0.2740 | No |
| 20 | TAOK1 | TAOK1 Entrez,  Source | TAO kinase 1 | 2552 | 0.082 | 0.2667 | No |
| 21 | ADCK4 | ADCK4 Entrez,  Source | aarF domain containing kinase 4 | 2715 | 0.077 | 0.2620 | No |
| 22 | EPHA3 | EPHA3 Entrez,  Source | EPH receptor A3 | 2870 | 0.074 | 0.2576 | No |
| 23 | FLT3 | FLT3 Entrez,  Source | fms-related tyrosine kinase 3 | 3403 | 0.063 | 0.2231 | No |
| 24 | BLK | BLK Entrez,  Source | B lymphoid tyrosine kinase | 3419 | 0.062 | 0.2281 | No |
| 25 | CSNK1A1 | CSNK1A1 Entrez,  Source | casein kinase 1, alpha 1 | 3698 | 0.058 | 0.2126 | No |
| 26 | ACVRL1 | ACVRL1 Entrez,  Source | activin A receptor type II-like 1 | 3715 | 0.057 | 0.2171 | No |
| 27 | PIM1 | PIM1 Entrez,  Source | pim-1 oncogene | 4136 | 0.050 | 0.1899 | No |
| 28 | ACVR1B | ACVR1B Entrez,  Source | activin A receptor, type IB | 4328 | 0.047 | 0.1801 | No |
| 29 | CDKL5 | CDKL5 Entrez,  Source | cyclin-dependent kinase-like 5 | 4345 | 0.047 | 0.1835 | No |
| 30 | AURKC | AURKC Entrez,  Source | aurora kinase C | 4413 | 0.046 | 0.1830 | No |
| 31 | CDKL2 | CDKL2 Entrez,  Source | cyclin-dependent kinase-like 2 (CDC2-related kinase) | 4548 | 0.044 | 0.1771 | No |
| 32 | RPS6KA6 | RPS6KA6 Entrez,  Source | ribosomal protein S6 kinase, 90kDa, polypeptide 6 | 4685 | 0.042 | 0.1709 | No |
| 33 | NEK7 | NEK7 Entrez,  Source | NIMA (never in mitosis gene a)-related kinase 7 | 4877 | 0.039 | 0.1602 | No |
| 34 | FLT4 | FLT4 Entrez,  Source | fms-related tyrosine kinase 4 | 4898 | 0.039 | 0.1625 | No |
| 35 | ULK1 | ULK1 Entrez,  Source | unc-51-like kinase 1 (C. elegans) | 5157 | 0.035 | 0.1463 | No |
| 36 | ACVR1 | ACVR1 Entrez,  Source | activin A receptor, type I | 5230 | 0.034 | 0.1441 | No |
| 37 | PIK3CG | PIK3CG Entrez,  Source | phosphoinositide-3-kinase, catalytic, gamma polypeptide | 5329 | 0.033 | 0.1399 | No |
| 38 | MAPK11 | MAPK11 Entrez,  Source | mitogen-activated protein kinase 11 | 5392 | 0.032 | 0.1384 | No |
| 39 | PIK3C2B | PIK3C2B Entrez,  Source | phosphoinositide-3-kinase, class 2, beta polypeptide | 5415 | 0.032 | 0.1399 | No |
| 40 | STK16 | STK16 Entrez,  Source | serine/threonine kinase 16 | 5778 | 0.027 | 0.1148 | No |
| 41 | IRAK1 | IRAK1 Entrez,  Source | interleukin-1 receptor-associated kinase 1 | 6179 | 0.021 | 0.0863 | No |
| 42 | PIK3CB | PIK3CB Entrez,  Source | phosphoinositide-3-kinase, catalytic, beta polypeptide | 6225 | 0.020 | 0.0849 | No |
| 43 | CSNK1G2 | CSNK1G2 Entrez,  Source | casein kinase 1, gamma 2 | 6328 | 0.018 | 0.0789 | No |
| 44 | AURKA | AURKA Entrez,  Source | aurora kinase A | 6427 | 0.017 | 0.0731 | No |
| 45 | RET | RET Entrez,  Source | ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease) | 6471 | 0.016 | 0.0715 | No |
| 46 | BMPR1B | BMPR1B Entrez,  Source | bone morphogenetic protein receptor, type IB | 6777 | 0.012 | 0.0493 | No |
| 47 | MAPK8 | MAPK8 Entrez,  Source | mitogen-activated protein kinase 8 | 6829 | 0.011 | 0.0465 | No |
| 48 | PIP5K1C | PIP5K1C Entrez,  Source | phosphatidylinositol-4-phosphate 5-kinase, type I, gamma | 6881 | 0.010 | 0.0437 | No |
| 49 | CLK4 | CLK4 Entrez,  Source | CDC-like kinase 4 | 6935 | 0.010 | 0.0405 | No |
| 50 | BMP2K | BMP2K Entrez,  Source | BMP2 inducible kinase | 7029 | 0.008 | 0.0342 | No |
| 51 | TGFBR2 | TGFBR2 Entrez,  Source | transforming growth factor, beta receptor II (70/80kDa) | 7103 | 0.007 | 0.0293 | No |
| 52 | CLK2 | CLK2 Entrez,  Source | CDC-like kinase 2 | 7181 | 0.005 | 0.0239 | No |
| 53 | IKBKE | IKBKE Entrez,  Source | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | 7216 | 0.004 | 0.0218 | No |
| 54 | PI4KB | 7697 | -0.003 | -0.0146 | No | ||
| 55 | CSNK1E | CSNK1E Entrez,  Source | casein kinase 1, epsilon | 7742 | -0.004 | -0.0175 | No |
| 56 | PDGFRB | PDGFRB Entrez,  Source | platelet-derived growth factor receptor, beta polypeptide | 7824 | -0.006 | -0.0232 | No |
| 57 | MAPK9 | MAPK9 Entrez,  Source | mitogen-activated protein kinase 9 | 7830 | -0.006 | -0.0229 | No |
| 58 | MKNK2 | MKNK2 Entrez,  Source | MAP kinase interacting serine/threonine kinase 2 | 7841 | -0.006 | -0.0231 | No |
| 59 | MELK | MELK Entrez,  Source | maternal embryonic leucine zipper kinase | 8047 | -0.010 | -0.0378 | No |
| 60 | KIT | KIT Entrez,  Source | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog | 8134 | -0.012 | -0.0432 | No |
| 61 | PIK3CD | PIK3CD Entrez,  Source | phosphoinositide-3-kinase, catalytic, delta polypeptide | 8176 | -0.013 | -0.0451 | No |
| 62 | RPS6KA4 | RPS6KA4 Entrez,  Source | ribosomal protein S6 kinase, 90kDa, polypeptide 4 | 8181 | -0.013 | -0.0441 | No |
| 63 | MAP2K5 | MAP2K5 Entrez,  Source | mitogen-activated protein kinase kinase 5 | 8199 | -0.013 | -0.0441 | No |
| 64 | DYRK1B | DYRK1B Entrez,  Source | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B | 8200 | -0.013 | -0.0428 | No |
| 65 | CDKL3 | CDKL3 Entrez,  Source | cyclin-dependent kinase-like 3 | 8249 | -0.014 | -0.0450 | No |
| 66 | VRK2 | VRK2 Entrez,  Source | vaccinia related kinase 2 | 8412 | -0.017 | -0.0557 | No |
| 67 | PIK3CA | PIK3CA Entrez,  Source | phosphoinositide-3-kinase, catalytic, alpha polypeptide | 8749 | -0.025 | -0.0789 | No |
| 68 | AURKB | AURKB Entrez,  Source | aurora kinase B | 8856 | -0.027 | -0.0843 | No |
| 69 | IRAK4 | IRAK4 Entrez,  Source | interleukin-1 receptor-associated kinase 4 | 8996 | -0.031 | -0.0918 | No |
| 70 | TYK2 | TYK2 Entrez,  Source | tyrosine kinase 2 | 9438 | -0.041 | -0.1215 | No |
| 71 | PAK3 | PAK3 Entrez,  Source | p21 (CDKN1A)-activated kinase 3 | 9490 | -0.042 | -0.1212 | No |
| 72 | CSNK2A2 | CSNK2A2 Entrez,  Source | casein kinase 2, alpha prime polypeptide | 9758 | -0.049 | -0.1367 | No |
| 73 | HIPK3 | HIPK3 Entrez,  Source | homeodomain interacting protein kinase 3 | 9770 | -0.050 | -0.1326 | No |
| 74 | NEK9 | NEK9 Entrez,  Source | NIMA (never in mitosis gene a)- related kinase 9 | 9810 | -0.051 | -0.1306 | No |
| 75 | HCK | HCK Entrez,  Source | hemopoietic cell kinase | 9981 | -0.056 | -0.1380 | No |
| 76 | PLK2 | PLK2 Entrez,  Source | polo-like kinase 2 (Drosophila) | 9994 | -0.057 | -0.1333 | No |
| 77 | STK17A | STK17A Entrez,  Source | serine/threonine kinase 17a (apoptosis-inducing) | 10017 | -0.057 | -0.1293 | No |
| 78 | HIPK2 | HIPK2 Entrez,  Source | homeodomain interacting protein kinase 2 | 10151 | -0.061 | -0.1334 | No |
| 79 | ADCK3 | 10237 | -0.064 | -0.1335 | No | ||
| 80 | DYRK1A | DYRK1A Entrez,  Source | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 10303 | -0.066 | -0.1320 | No |
| 81 | RPS6KA3 | RPS6KA3 Entrez,  Source | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | 10427 | -0.070 | -0.1343 | No |
| 82 | PLK4 | PLK4 Entrez,  Source | polo-like kinase 4 (Drosophila) | 10581 | -0.075 | -0.1385 | No |
| 83 | JAK1 | JAK1 Entrez,  Source | Janus kinase 1 (a protein tyrosine kinase) | 10585 | -0.076 | -0.1312 | No |
| 84 | RPS6KB1 | RPS6KB1 Entrez,  Source | ribosomal protein S6 kinase, 70kDa, polypeptide 1 | 10717 | -0.081 | -0.1332 | No |
| 85 | CAMKK2 | CAMKK2 Entrez,  Source | calcium/calmodulin-dependent protein kinase kinase 2, beta | 10729 | -0.081 | -0.1260 | No |
| 86 | BRSK2 | BRSK2 Entrez,  Source | BR serine/threonine kinase 2 | 10749 | -0.082 | -0.1193 | No |
| 87 | SRC | SRC Entrez,  Source | v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | 10776 | -0.083 | -0.1130 | No |
| 88 | PIP5K1A | PIP5K1A Entrez,  Source | phosphatidylinositol-4-phosphate 5-kinase, type I, alpha | 10780 | -0.083 | -0.1049 | No |
| 89 | MTOR | 10944 | -0.091 | -0.1083 | No | ||
| 90 | NLK | NLK Entrez,  Source | nemo-like kinase | 10979 | -0.093 | -0.1017 | No |
| 91 | DAPK3 | DAPK3 Entrez,  Source | death-associated protein kinase 3 | 11066 | -0.096 | -0.0987 | No |
| 92 | CDK7 | CDK7 Entrez,  Source | cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase) | 11160 | -0.101 | -0.0958 | No |
| 93 | STK10 | STK10 Entrez,  Source | serine/threonine kinase 10 | 11218 | -0.103 | -0.0898 | No |
| 94 | MYLK | MYLK Entrez,  Source | myosin, light chain kinase | 11255 | -0.105 | -0.0822 | No |
| 95 | BMPR2 | BMPR2 Entrez,  Source | bone morphogenetic protein receptor, type II (serine/threonine kinase) | 11345 | -0.109 | -0.0781 | No |
| 96 | RIPK2 | RIPK2 Entrez,  Source | receptor-interacting serine-threonine kinase 2 | 11349 | -0.110 | -0.0674 | No |
| 97 | HIPK1 | HIPK1 Entrez,  Source | homeodomain interacting protein kinase 1 | 11798 | -0.135 | -0.0882 | No |
| 98 | MAP2K4 | MAP2K4 Entrez,  Source | mitogen-activated protein kinase kinase 4 | 11811 | -0.136 | -0.0755 | No |
| 99 | CSNK2A1 | CSNK2A1 Entrez,  Source | casein kinase 2, alpha 1 polypeptide | 11861 | -0.139 | -0.0654 | No |
| 100 | BMPR1A | BMPR1A Entrez,  Source | bone morphogenetic protein receptor, type IA | 12438 | -0.194 | -0.0902 | No |
| 101 | TGFBR1 | TGFBR1 Entrez,  Source | transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kDa) | 12447 | -0.195 | -0.0714 | No |
| 102 | IRAK3 | IRAK3 Entrez,  Source | interleukin-1 receptor-associated kinase 3 | 12451 | -0.196 | -0.0521 | No |
| 103 | ABL1 | ABL1 Entrez,  Source | v-abl Abelson murine leukemia viral oncogene homolog 1 | 12463 | -0.197 | -0.0333 | No |
| 104 | RIOK2 | RIOK2 Entrez,  Source | RIO kinase 2 (yeast) | 12467 | -0.198 | -0.0139 | No |
| 105 | ZAK | ZAK Entrez,  Source | - | 12544 | -0.209 | 0.0011 | No |
| 106 | MAP3K7 | MAP3K7 Entrez,  Source | mitogen-activated protein kinase kinase kinase 7 | 12613 | -0.221 | 0.0179 | No |
| 107 | AXL | AXL Entrez,  Source | AXL receptor tyrosine kinase | 12789 | -0.257 | 0.0301 | No |

