DatasetNSCLC_collapsed_to_symbols.NSCLC.cls
#SEN_versus_RES.NSCLC.cls
#SEN_versus_RES_repos
PhenotypeNSCLC.cls#SEN_versus_RES_repos
Upregulated in class1
GeneSetHKI-272_KINOME SCAN
Enrichment Score (ES)0.38235503
Normalized Enrichment Score (NES)1.2284871
Nominal p-value0.15044248
FDR q-value0.6409715
FWER p-Value1.0
Table: GSEA Results Summary



Fig 1: Enrichment plot: HKI-272_KINOME SCAN   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEGENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1ERBB3ERBB3
Entrez,  Source
v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)121.0340.1612Yes
2ERBB2ERBB2
Entrez,  Source
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)1000.5370.2387Yes
3MST43180.3310.2740Yes
4MAP3K13MAP3K13
Entrez,  Source
mitogen-activated protein kinase kinase kinase 136240.2300.2869Yes
5EGFREGFR
Entrez,  Source
epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)6250.2300.3229Yes
6PAK1PAK1
Entrez,  Source
p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast)6740.2190.3536Yes
7TNIKTNIK
Entrez,  Source
TRAF2 and NCK interacting kinase11970.1450.3366Yes
8LCKLCK
Entrez,  Source
lymphocyte-specific protein tyrosine kinase13100.1360.3494Yes
9GAKGAK
Entrez,  Source
cyclin G associated kinase13400.1330.3680Yes
10STK3STK3
Entrez,  Source
serine/threonine kinase 3 (STE20 homolog, yeast)15530.1200.3706Yes
11ERBB4ERBB4
Entrez,  Source
v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)18130.1070.3676Yes
12LYNLYN
Entrez,  Source
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog19740.1000.3710Yes
13TIE1TIE1
Entrez,  Source
tyrosine kinase with immunoglobulin-like and EGF-like domains 123280.0880.3579Yes
14MAP3K4MAP3K4
Entrez,  Source
mitogen-activated protein kinase kinase kinase 424890.0830.3588Yes
15MERTKMERTK
Entrez,  Source
c-mer proto-oncogene tyrosine kinase25220.0820.3692Yes
16MAP4K1MAP4K1
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 128490.0740.3560Yes
17TNK2TNK2
Entrez,  Source
tyrosine kinase, non-receptor, 230050.0700.3552Yes
18YES1YES1
Entrez,  Source
v-yes-1 Yamaguchi sarcoma viral oncogene homolog 130360.0700.3639Yes
19CSKCSK
Entrez,  Source
c-src tyrosine kinase30690.0690.3723Yes
20MINK1MINK1
Entrez,  Source
misshapen-like kinase 1 (zebrafish)30800.0690.3824Yes
21BLKBLK
Entrez,  Source
B lymphoid tyrosine kinase34190.0620.3664No
22CSF1RCSF1R
Entrez,  Source
colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog34540.0620.3735No
23NEK2NEK2
Entrez,  Source
NIMA (never in mitosis gene a)-related kinase 244830.0450.3022No
24STK24STK24
Entrez,  Source
serine/threonine kinase 24 (STE20 homolog, yeast)55870.0290.2229No
25BTKBTK
Entrez,  Source
Bruton agammaglobulinemia tyrosine kinase56280.0290.2243No
26MAP3K3MAP3K3
Entrez,  Source
mitogen-activated protein kinase kinase kinase 359210.0250.2060No
27FESFES
Entrez,  Source
feline sarcoma oncogene61260.0220.1938No
28MAP4K2MAP4K2
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 268940.0100.1370No
29CSNK1ECSNK1E
Entrez,  Source
casein kinase 1, epsilon7742-0.0040.0732No
30MAP2K1MAP2K1
Entrez,  Source
mitogen-activated protein kinase kinase 17939-0.0080.0595No
31MAP2K5MAP2K5
Entrez,  Source
mitogen-activated protein kinase kinase 58199-0.0130.0418No
32STK25STK25
Entrez,  Source
serine/threonine kinase 25 (STE20 homolog, yeast)8561-0.0210.0176No
33PRKD1PRKD1
Entrez,  Source
protein kinase D19827-0.052-0.0707No
34MAP2K7MAP2K7
Entrez,  Source
mitogen-activated protein kinase kinase 79831-0.052-0.0628No
35MAP4K4MAP4K4
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 49922-0.055-0.0611No
36HCKHCK
Entrez,  Source
hemopoietic cell kinase9981-0.056-0.0567No
37STK17ASTK17A
Entrez,  Source
serine/threonine kinase 17a (apoptosis-inducing)10017-0.057-0.0504No
38CHEK2CHEK2
Entrez,  Source
CHK2 checkpoint homolog (S. pombe)10102-0.059-0.0475No
39PAK2PAK2
Entrez,  Source
p21 (CDKN1A)-activated kinase 210809-0.085-0.0880No
40STK10STK10
Entrez,  Source
serine/threonine kinase 1011218-0.103-0.1029No
41FERFER
Entrez,  Source
fer (fps/fes related) tyrosine kinase (phosphoprotein NCP94)11371-0.111-0.0971No
42STK4STK4
Entrez,  Source
serine/threonine kinase 411518-0.118-0.0898No
43SLKSLK
Entrez,  Source
STE20-like kinase (yeast)11672-0.128-0.0815No
44MAP4K5MAP4K5
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 511705-0.130-0.0636No
45MAP2K2MAP2K2
Entrez,  Source
mitogen-activated protein kinase kinase 211895-0.142-0.0557No
46MAP3K2MAP3K2
Entrez,  Source
mitogen-activated protein kinase kinase kinase 212210-0.168-0.0534No
47SIK112319-0.179-0.0336No
48MAP3K12MAP3K12
Entrez,  Source
mitogen-activated protein kinase kinase kinase 1212384-0.186-0.0092No
49MAP4K3MAP4K3
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 312403-0.1890.0190No
50AXLAXL
Entrez,  Source
AXL receptor tyrosine kinase12789-0.2570.0299No
Table: GSEA details [plain text format]



Fig 2: HKI-272_KINOME SCAN   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HKI-272_KINOME SCAN: Random ES distribution   
Gene set null distribution of ES for HKI-272_KINOME SCAN