DatasetNSCLC_collapsed_to_symbols.NSCLC.cls
#SEN_versus_RES.NSCLC.cls
#SEN_versus_RES_repos
PhenotypeNSCLC.cls#SEN_versus_RES_repos
Upregulated in class1
GeneSetCRIZOTINIB_FDA
Enrichment Score (ES)0.31997606
Normalized Enrichment Score (NES)1.1878242
Nominal p-value0.1579832
FDR q-value0.6368124
FWER p-Value1.0
Table: GSEA Results Summary



Fig 1: Enrichment plot: CRIZOTINIB_FDA   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEGENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1MST1RMST1R
Entrez,  Source
macrophage stimulating 1 receptor (c-met-related tyrosine kinase)540.6360.0446Yes
2EPHA1EPHA1
Entrez,  Source
EPH receptor A1940.5450.0834Yes
3RIPK4RIPK4
Entrez,  Source
receptor-interacting serine-threonine kinase 4950.5440.1251Yes
4DDR1DDR1
Entrez,  Source
discoidin domain receptor family, member 12120.4040.1472Yes
5FRKFRK
Entrez,  Source
fyn-related kinase2960.3430.1671Yes
6MST43180.3310.1909Yes
7SYKSYK
Entrez,  Source
spleen tyrosine kinase4710.2680.1998Yes
8METMET
Entrez,  Source
met proto-oncogene (hepatocyte growth factor receptor)4990.2590.2175Yes
9ROS1ROS1
Entrez,  Source
v-ros UR2 sarcoma virus oncogene homolog 1 (avian)5050.2580.2369Yes
10IKBKBIKBKB
Entrez,  Source
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta5530.2450.2521Yes
11MAP3K13MAP3K13
Entrez,  Source
mitogen-activated protein kinase kinase kinase 136240.2300.2644Yes
12EPHB6EPHB6
Entrez,  Source
EPH receptor B67010.2150.2750Yes
13EPHA4EPHA4
Entrez,  Source
EPH receptor A47980.1970.2828Yes
14TAOK3TAOK3
Entrez,  Source
TAO kinase 39710.1700.2826Yes
15TXKTXK
Entrez,  Source
TXK tyrosine kinase10450.1600.2893Yes
16DYRK2DYRK2
Entrez,  Source
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 212300.1420.2861Yes
17LCKLCK
Entrez,  Source
lymphocyte-specific protein tyrosine kinase13100.1360.2905Yes
18TNK1TNK1
Entrez,  Source
tyrosine kinase, non-receptor, 113600.1310.2968Yes
19EPHA7EPHA7
Entrez,  Source
EPH receptor A714120.1280.3027Yes
20STK3STK3
Entrez,  Source
serine/threonine kinase 3 (STE20 homolog, yeast)15530.1200.3011Yes
21INSRINSR
Entrez,  Source
insulin receptor16640.1140.3014Yes
22NTRK2NTRK2
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 217040.1120.3070Yes
23TESK1TESK1
Entrez,  Source
testis-specific kinase 118550.1050.3036Yes
24RIOK3RIOK3
Entrez,  Source
RIO kinase 3 (yeast)19420.1010.3047Yes
25LYNLYN
Entrez,  Source
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog19740.1000.3100Yes
26CASKCASK
Entrez,  Source
calcium/calmodulin-dependent serine protein kinase (MAGUK family)20070.0990.3151Yes
27PTK2BPTK2B
Entrez,  Source
PTK2B protein tyrosine kinase 2 beta20420.0980.3200Yes
28ULK2ULK2
Entrez,  Source
unc-51-like kinase 2 (C. elegans)22440.0910.3115No
29TIE1TIE1
Entrez,  Source
tyrosine kinase with immunoglobulin-like and EGF-like domains 123280.0880.3119No
30JAK3JAK3
Entrez,  Source
Janus kinase 3 (a protein tyrosine kinase, leukocyte)24440.0840.3096No
31MERTKMERTK
Entrez,  Source
c-mer proto-oncogene tyrosine kinase25220.0820.3100No
32TAOK1TAOK1
Entrez,  Source
TAO kinase 125520.0820.3141No
33ADCK4ADCK4
Entrez,  Source
aarF domain containing kinase 427150.0770.3076No
34LIMK2LIMK2
Entrez,  Source
LIM domain kinase 227990.0760.3070No
35MAP4K1MAP4K1
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 128490.0740.3090No
36EPHA3EPHA3
Entrez,  Source
EPH receptor A328700.0740.3131No
37TNK2TNK2
Entrez,  Source
tyrosine kinase, non-receptor, 230050.0700.3082No
38YES1YES1
Entrez,  Source
v-yes-1 Yamaguchi sarcoma viral oncogene homolog 130360.0700.3113No
39FLT3FLT3
Entrez,  Source
fms-related tyrosine kinase 334030.0630.2880No
40BLKBLK
Entrez,  Source
B lymphoid tyrosine kinase34190.0620.2916No
41CSF1RCSF1R
Entrez,  Source
colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog34540.0620.2938No
42EPHB4EPHB4
Entrez,  Source
EPH receptor B438790.0540.2655No
43PRKD2PRKD2
Entrez,  Source
protein kinase D239000.0540.2681No
44EPHB1EPHB1
Entrez,  Source
EPH receptor B140000.0520.2645No
45ALKALK
Entrez,  Source
anaplastic lymphoma kinase (Ki-1)40730.0510.2629No
46MUSKMUSK
Entrez,  Source
muscle, skeletal, receptor tyrosine kinase41390.0500.2618No
47FGRFGR
Entrez,  Source
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog41930.0490.2615No
48MAP3K1MAP3K1
Entrez,  Source
mitogen-activated protein kinase kinase kinase 142810.0480.2585No
49ACVR1BACVR1B
Entrez,  Source
activin A receptor, type IB43280.0470.2586No
50AURKCAURKC
Entrez,  Source
aurora kinase C44130.0460.2557No
51LIMK1LIMK1
Entrez,  Source
LIM domain kinase 144680.0450.2550No
52CDKL2CDKL2
Entrez,  Source
cyclin-dependent kinase-like 2 (CDC2-related kinase)45480.0440.2524No
53NEK7NEK7
Entrez,  Source
NIMA (never in mitosis gene a)-related kinase 748770.0390.2302No
54EPHA2EPHA2
Entrez,  Source
EPH receptor A248800.0390.2331No
55ULK1ULK1
Entrez,  Source
unc-51-like kinase 1 (C. elegans)51570.0350.2146No
56ACVR1ACVR1
Entrez,  Source
activin A receptor, type I52300.0340.2117No
57TNNI3KTNNI3K
Entrez,  Source
TNNI3 interacting kinase52740.0330.2110No
58INSRRINSRR
Entrez,  Source
insulin receptor-related receptor53320.0330.2092No
59EPHA5EPHA5
Entrez,  Source
EPH receptor A554750.0310.2007No
60SRPK3SRPK3
Entrez,  Source
SFRS protein kinase 358600.0260.1732No
61MAP3K3MAP3K3
Entrez,  Source
mitogen-activated protein kinase kinase kinase 359210.0250.1705No
62NTRK1NTRK1
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 160970.0220.1588No
63FESFES
Entrez,  Source
feline sarcoma oncogene61260.0220.1583No
64IRAK1IRAK1
Entrez,  Source
interleukin-1 receptor-associated kinase 161790.0210.1560No
65AURKAAURKA
Entrez,  Source
aurora kinase A64270.0170.1383No
66DCLK264620.0160.1370No
67PIP4K2B65940.0150.1281No
68BMPR1BBMPR1B
Entrez,  Source
bone morphogenetic protein receptor, type IB67770.0120.1151No
69GRK4GRK4
Entrez,  Source
G protein-coupled receptor kinase 467880.0120.1152No
70MAP4K2MAP4K2
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 268940.0100.1079No
71MAPK7MAPK7
Entrez,  Source
mitogen-activated protein kinase 769130.0100.1073No
72BMP2KBMP2K
Entrez,  Source
BMP2 inducible kinase70290.0080.0991No
73TEKTEK
Entrez,  Source
TEK tyrosine kinase, endothelial (venous malformations, multiple cutaneous and mucosal)70350.0080.0993No
74IKBKEIKBKE
Entrez,  Source
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon72160.0040.0859No
75SIK274350.0010.0693No
76MKNK2MKNK2
Entrez,  Source
MAP kinase interacting serine/threonine kinase 27841-0.0060.0387No
77IGF1RIGF1R
Entrez,  Source
insulin-like growth factor 1 receptor7959-0.0080.0304No
78TAOK2TAOK2
Entrez,  Source
TAO kinase 28059-0.0100.0236No
79KITKIT
Entrez,  Source
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog8134-0.0120.0188No
80LTKLTK
Entrez,  Source
leukocyte tyrosine kinase8158-0.0120.0180No
81DMPKDMPK
Entrez,  Source
dystrophia myotonica-protein kinase8344-0.0160.0051No
82PTK2PTK2
Entrez,  Source
PTK2 protein tyrosine kinase 28356-0.0160.0055No
83NTRK3NTRK3
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 38500-0.019-0.0040No
84ROCK1ROCK1
Entrez,  Source
Rho-associated, coiled-coil containing protein kinase 18741-0.025-0.0204No
85AURKBAURKB
Entrez,  Source
aurora kinase B8856-0.027-0.0271No
86CDK11A9060-0.032-0.0402No
87TYK2TYK2
Entrez,  Source
tyrosine kinase 29438-0.041-0.0659No
88PAK3PAK3
Entrez,  Source
p21 (CDKN1A)-activated kinase 39490-0.042-0.0666No
89NEK9NEK9
Entrez,  Source
NIMA (never in mitosis gene a)- related kinase 99810-0.051-0.0871No
90PRKD1PRKD1
Entrez,  Source
protein kinase D19827-0.052-0.0844No
91DCLK19840-0.052-0.0813No
92DDR2DDR2
Entrez,  Source
discoidin domain receptor family, member 210235-0.064-0.1066No
93MARK3MARK3
Entrez,  Source
MAP/microtubule affinity-regulating kinase 310374-0.068-0.1120No
94PLK4PLK4
Entrez,  Source
polo-like kinase 4 (Drosophila)10581-0.075-0.1220No
95JAK1JAK1
Entrez,  Source
Janus kinase 1 (a protein tyrosine kinase)10585-0.076-0.1164No
96RPS6KB1RPS6KB1
Entrez,  Source
ribosomal protein S6 kinase, 70kDa, polypeptide 110717-0.081-0.1203No
97CAMKK2CAMKK2
Entrez,  Source
calcium/calmodulin-dependent protein kinase kinase 2, beta10729-0.081-0.1149No
98TBK1TBK1
Entrez,  Source
TANK-binding kinase 110732-0.082-0.1088No
99SRCSRC
Entrez,  Source
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)10776-0.083-0.1057No
100PIP5K1APIP5K1A
Entrez,  Source
phosphatidylinositol-4-phosphate 5-kinase, type I, alpha10780-0.083-0.0995No
101PRKAA1PRKAA1
Entrez,  Source
protein kinase, AMP-activated, alpha 1 catalytic subunit10906-0.089-0.1023No
102NUAK1NUAK1
Entrez,  Source
NUAK family, SNF1-like kinase, 111032-0.095-0.1046No
103ABL2ABL2
Entrez,  Source
v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)11090-0.098-0.1015No
104CDK7CDK7
Entrez,  Source
cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase)11160-0.101-0.0991No
105STK10STK10
Entrez,  Source
serine/threonine kinase 1011218-0.103-0.0955No
106RIPK2RIPK2
Entrez,  Source
receptor-interacting serine-threonine kinase 211349-0.110-0.0970No
107FERFER
Entrez,  Source
fer (fps/fes related) tyrosine kinase (phosphoprotein NCP94)11371-0.111-0.0902No
108RIPK1RIPK1
Entrez,  Source
receptor (TNFRSF)-interacting serine-threonine kinase 111427-0.113-0.0857No
109STK4STK4
Entrez,  Source
serine/threonine kinase 411518-0.118-0.0836No
110JAK2JAK2
Entrez,  Source
Janus kinase 2 (a protein tyrosine kinase)11530-0.119-0.0753No
111TYRO3TYRO3
Entrez,  Source
TYRO3 protein tyrosine kinase11601-0.123-0.0712No
112SLKSLK
Entrez,  Source
STE20-like kinase (yeast)11672-0.128-0.0668No
113MAP4K5MAP4K5
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 511705-0.130-0.0593No
114FYNFYN
Entrez,  Source
FYN oncogene related to SRC, FGR, YES11767-0.133-0.0538No
115ROCK2ROCK2
Entrez,  Source
Rho-associated, coiled-coil containing protein kinase 212033-0.152-0.0624No
116MAP3K2MAP3K2
Entrez,  Source
mitogen-activated protein kinase kinase kinase 212210-0.168-0.0630No
117MAP3K12MAP3K12
Entrez,  Source
mitogen-activated protein kinase kinase kinase 1212384-0.186-0.0620No
118MAP4K3MAP4K3
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 312403-0.189-0.0489No
119TGFBR1TGFBR1
Entrez,  Source
transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kDa)12447-0.195-0.0372No
120IRAK3IRAK3
Entrez,  Source
interleukin-1 receptor-associated kinase 312451-0.196-0.0225No
121ABL1ABL1
Entrez,  Source
v-abl Abelson murine leukemia viral oncogene homolog 112463-0.197-0.0082No
122MAP3K7MAP3K7
Entrez,  Source
mitogen-activated protein kinase kinase kinase 712613-0.221-0.0027No
123AXLAXL
Entrez,  Source
AXL receptor tyrosine kinase12789-0.2570.0036No
124PRKD3PRKD3
Entrez,  Source
protein kinase D313008-0.3450.0133No
Table: GSEA details [plain text format]



Fig 2: CRIZOTINIB_FDA   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: CRIZOTINIB_FDA: Random ES distribution   
Gene set null distribution of ES for CRIZOTINIB_FDA