DatasetNSCLC_collapsed_to_symbols.NSCLC.cls
#SEN_versus_RES.NSCLC.cls
#SEN_versus_RES_repos
PhenotypeNSCLC.cls#SEN_versus_RES_repos
Upregulated in class0
GeneSetSUNITINIB_KINOME SCAN
Enrichment Score (ES)-0.23575057
Normalized Enrichment Score (NES)-0.96065205
Nominal p-value0.56
FDR q-value0.9094637
FWER p-Value1.0
Table: GSEA Results Summary



Fig 1: Enrichment plot: SUNITINIB_KINOME SCAN   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEGENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1DAPK1DAPK1
Entrez,  Source
death-associated protein kinase 1880.5570.0280No
2FGFR3FGFR3
Entrez,  Source
fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism)1530.4650.0522No
3FGFR2FGFR2
Entrez,  Source
ffer syndrome, Jackson-Weiss syndrome)2100.4060.0732No
4FRKFRK
Entrez,  Source
fyn-related kinase2960.3430.0881No
5MST43180.3310.1071No
6STK39STK39
Entrez,  Source
serine threonine kinase 39 (STE20/SPS1 homolog, yeast)3840.2990.1208No
7RPS6KA2RPS6KA2
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 25900.2370.1199No
8MAP3K13MAP3K13
Entrez,  Source
mitogen-activated protein kinase kinase kinase 136240.2300.1317No
9EGFREGFR
Entrez,  Source
epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)6250.2300.1461No
10CDK146590.2220.1574No
11EPHB6EPHB6
Entrez,  Source
EPH receptor B67010.2150.1677No
12TAOK3TAOK3
Entrez,  Source
TAO kinase 39710.1700.1576No
13TNIKTNIK
Entrez,  Source
TRAF2 and NCK interacting kinase11970.1450.1494No
14DYRK2DYRK2
Entrez,  Source
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 212300.1420.1559No
15LCKLCK
Entrez,  Source
lymphocyte-specific protein tyrosine kinase13100.1360.1583No
16GAKGAK
Entrez,  Source
cyclin G associated kinase13400.1330.1644No
17TNK1TNK1
Entrez,  Source
tyrosine kinase, non-receptor, 113600.1310.1711No
18CAMK1DCAMK1D
Entrez,  Source
calcium/calmodulin-dependent protein kinase ID13870.1290.1772No
19STK3STK3
Entrez,  Source
serine/threonine kinase 3 (STE20 homolog, yeast)15530.1200.1720No
20STK17BSTK17B
Entrez,  Source
serine/threonine kinase 17b (apoptosis-inducing)15540.1190.1794No
21INSRINSR
Entrez,  Source
insulin receptor16640.1140.1782No
22RPS6KA1RPS6KA1
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 116860.1130.1836No
23NTRK2NTRK2
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 217040.1120.1893No
24CAMK2ACAMK2A
Entrez,  Source
calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha18010.1070.1886No
25CAMK2GCAMK2G
Entrez,  Source
calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma18110.1070.1946No
26DAPK2DAPK2
Entrez,  Source
death-associated protein kinase 218380.1050.1992No
27CSNK1DCSNK1D
Entrez,  Source
casein kinase 1, delta18510.1050.2048No
28LYNLYN
Entrez,  Source
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog19740.1000.2017No
29PTK2BPTK2B
Entrez,  Source
PTK2B protein tyrosine kinase 2 beta20420.0980.2026No
30AAK1AAK1
Entrez,  Source
AP2 associated kinase 122120.0920.1954No
31ULK2ULK2
Entrez,  Source
unc-51-like kinase 2 (C. elegans)22440.0910.1987No
32MERTKMERTK
Entrez,  Source
c-mer proto-oncogene tyrosine kinase25220.0820.1826No
33TAOK1TAOK1
Entrez,  Source
TAO kinase 125520.0820.1854No
34RPS6KA5RPS6KA5
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 526100.0800.1861No
35MAP4K1MAP4K1
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 128490.0740.1724No
36STK38STK38
Entrez,  Source
serine/threonine kinase 3828780.0730.1748No
37YES1YES1
Entrez,  Source
v-yes-1 Yamaguchi sarcoma viral oncogene homolog 130360.0700.1671No
38MINK1MINK1
Entrez,  Source
misshapen-like kinase 1 (zebrafish)30800.0690.1682No
39KDRKDR
Entrez,  Source
kinase insert domain receptor (a type III receptor tyrosine kinase)31460.0680.1674No
40FLT3FLT3
Entrez,  Source
fms-related tyrosine kinase 334030.0630.1516No
41BLKBLK
Entrez,  Source
B lymphoid tyrosine kinase34190.0620.1544No
42CSF1RCSF1R
Entrez,  Source
colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog34540.0620.1556No
43CSNK1A1CSNK1A1
Entrez,  Source
casein kinase 1, alpha 136980.0580.1405No
44MARK2MARK2
Entrez,  Source
MAP/microtubule affinity-regulating kinase 238340.0550.1336No
45PRKD2PRKD2
Entrez,  Source
protein kinase D239000.0540.1320No
46EPHB1EPHB1
Entrez,  Source
EPH receptor B140000.0520.1277No
47ALKALK
Entrez,  Source
anaplastic lymphoma kinase (Ki-1)40730.0510.1253No
48MUSKMUSK
Entrez,  Source
muscle, skeletal, receptor tyrosine kinase41390.0500.1235No
49FGRFGR
Entrez,  Source
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog41930.0490.1225No
50AURKCAURKC
Entrez,  Source
aurora kinase C44130.0460.1085No
51CAMK1GCAMK1G
Entrez,  Source
calcium/calmodulin-dependent protein kinase IG45030.0450.1045No
52HUNKHUNK
Entrez,  Source
hormonally upregulated Neu-associated kinase46450.0430.0963No
53PHKG2PHKG2
Entrez,  Source
phosphorylase kinase, gamma 2 (testis)47920.0400.0876No
54FLT1FLT1
Entrez,  Source
fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)48820.0390.0832No
55FLT4FLT4
Entrez,  Source
fms-related tyrosine kinase 448980.0390.0845No
56GRK1GRK1
Entrez,  Source
G protein-coupled receptor kinase 149070.0390.0863No
57ULK1ULK1
Entrez,  Source
unc-51-like kinase 1 (C. elegans)51570.0350.0694No
58INSRRINSRR
Entrez,  Source
insulin receptor-related receptor53320.0330.0581No
59MAST1MAST1
Entrez,  Source
microtubule associated serine/threonine kinase 154360.0320.0521No
60STK24STK24
Entrez,  Source
serine/threonine kinase 24 (STE20 homolog, yeast)55870.0290.0424No
61STK16STK16
Entrez,  Source
serine/threonine kinase 1657780.0270.0295No
62SRPK3SRPK3
Entrez,  Source
SFRS protein kinase 358600.0260.0249No
63PAK7PAK7
Entrez,  Source
p21(CDKN1A)-activated kinase 758810.0250.0250No
64MAP3K3MAP3K3
Entrez,  Source
mitogen-activated protein kinase kinase kinase 359210.0250.0235No
65NTRK1NTRK1
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 160970.0220.0115No
66FESFES
Entrez,  Source
feline sarcoma oncogene61260.0220.0106No
67IRAK1IRAK1
Entrez,  Source
interleukin-1 receptor-associated kinase 161790.0210.0080No
68PHKG1PHKG1
Entrez,  Source
phosphorylase kinase, gamma 1 (muscle)62450.0200.0042No
69CSNK1G2CSNK1G2
Entrez,  Source
casein kinase 1, gamma 263280.018-0.0009No
70CAMK4CAMK4
Entrez,  Source
calcium/calmodulin-dependent protein kinase IV63930.017-0.0048No
71RETRET
Entrez,  Source
ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease)64710.016-0.0097No
72EIF2AK2EIF2AK2
Entrez,  Source
eukaryotic translation initiation factor 2-alpha kinase 264890.016-0.0100No
73PIP4K2B65940.015-0.0170No
74PKN1PKN1
Entrez,  Source
protein kinase N167830.012-0.0307No
75GRK4GRK4
Entrez,  Source
G protein-coupled receptor kinase 467880.012-0.0303No
76MAP4K2MAP4K2
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 268940.010-0.0377No
77CLK4CLK4
Entrez,  Source
CDC-like kinase 469350.010-0.0402No
78BMP2KBMP2K
Entrez,  Source
BMP2 inducible kinase70290.008-0.0469No
79CLK2CLK2
Entrez,  Source
CDC-like kinase 271810.005-0.0581No
80IKBKEIKBKE
Entrez,  Source
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon72160.004-0.0605No
81ITKITK
Entrez,  Source
IL2-inducible T-cell kinase72200.004-0.0604No
82PRKAA2PRKAA2
Entrez,  Source
protein kinase, AMP-activated, alpha 2 catalytic subunit74180.001-0.0755No
83SIK274350.001-0.0766No
84SNRKSNRK
Entrez,  Source
SNF related kinase7658-0.003-0.0935No
85CSNK1ECSNK1E
Entrez,  Source
casein kinase 1, epsilon7742-0.004-0.0996No
86PDGFRBPDGFRB
Entrez,  Source
platelet-derived growth factor receptor, beta polypeptide7824-0.006-0.1055No
87MAP2K1MAP2K1
Entrez,  Source
mitogen-activated protein kinase kinase 17939-0.008-0.1138No
88MELKMELK
Entrez,  Source
maternal embryonic leucine zipper kinase8047-0.010-0.1214No
89KITKIT
Entrez,  Source
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog8134-0.012-0.1272No
90RPS6KA4RPS6KA4
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 48181-0.013-0.1300No
91MAP2K5MAP2K5
Entrez,  Source
mitogen-activated protein kinase kinase 58199-0.013-0.1304No
92CDK168353-0.016-0.1412No
93PTK2PTK2
Entrez,  Source
PTK2 protein tyrosine kinase 28356-0.016-0.1403No
94STK25STK25
Entrez,  Source
serine/threonine kinase 25 (STE20 homolog, yeast)8561-0.021-0.1547No
95CSNK1G1CSNK1G1
Entrez,  Source
casein kinase 1, gamma 18732-0.025-0.1662No
96ROCK1ROCK1
Entrez,  Source
Rho-associated, coiled-coil containing protein kinase 18741-0.025-0.1653No
97AURKBAURKB
Entrez,  Source
aurora kinase B8856-0.027-0.1723No
98IRAK4IRAK4
Entrez,  Source
interleukin-1 receptor-associated kinase 48996-0.031-0.1811No
99STK11STK11
Entrez,  Source
serine/threonine kinase 119183-0.035-0.1932No
100ERN1ERN1
Entrez,  Source
endoplasmic reticulum to nucleus signalling 19341-0.039-0.2028No
101TYK2TYK2
Entrez,  Source
tyrosine kinase 29438-0.041-0.2077No
102PAK3PAK3
Entrez,  Source
p21 (CDKN1A)-activated kinase 39490-0.042-0.2089No
103CSNK2A2CSNK2A2
Entrez,  Source
casein kinase 2, alpha prime polypeptide9758-0.049-0.2264No
104HIPK3HIPK3
Entrez,  Source
homeodomain interacting protein kinase 39770-0.050-0.2241No
105PRKD1PRKD1
Entrez,  Source
protein kinase D19827-0.052-0.2252No
106DCLK19840-0.052-0.2229No
107MAP4K4MAP4K4
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 49922-0.055-0.2257No
108TTKTTK
Entrez,  Source
TTK protein kinase9930-0.055-0.2228No
109HCKHCK
Entrez,  Source
hemopoietic cell kinase9981-0.056-0.2231No
110STK17ASTK17A
Entrez,  Source
serine/threonine kinase 17a (apoptosis-inducing)10017-0.057-0.2223No
111LATS1LATS1
Entrez,  Source
LATS, large tumor suppressor, homolog 1 (Drosophila)10025-0.057-0.2192No
112CHEK2CHEK2
Entrez,  Source
CHK2 checkpoint homolog (S. pombe)10102-0.059-0.2213No
113HIPK2HIPK2
Entrez,  Source
homeodomain interacting protein kinase 210151-0.061-0.2212No
114DYRK1ADYRK1A
Entrez,  Source
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A10303-0.066-0.2287No
115MARK3MARK3
Entrez,  Source
MAP/microtubule affinity-regulating kinase 310374-0.068-0.2298No
116RPS6KA3RPS6KA3
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 310427-0.070-0.2294No
117ICKICK
Entrez,  Source
intestinal cell (MAK-like) kinase10499-0.073-0.2304Yes
118OXSR1OXSR1
Entrez,  Source
oxidative-stress responsive 110514-0.073-0.2269Yes
119PLK4PLK4
Entrez,  Source
polo-like kinase 4 (Drosophila)10581-0.075-0.2272Yes
120JAK1JAK1
Entrez,  Source
Janus kinase 1 (a protein tyrosine kinase)10585-0.076-0.2227Yes
121RPS6KB1RPS6KB1
Entrez,  Source
ribosomal protein S6 kinase, 70kDa, polypeptide 110717-0.081-0.2278Yes
122TBK1TBK1
Entrez,  Source
TANK-binding kinase 110732-0.082-0.2237Yes
123CHEK1CHEK1
Entrez,  Source
CHK1 checkpoint homolog (S. pombe)10792-0.084-0.2230Yes
124PRKAA1PRKAA1
Entrez,  Source
protein kinase, AMP-activated, alpha 1 catalytic subunit10906-0.089-0.2261Yes
125NUAK1NUAK1
Entrez,  Source
NUAK family, SNF1-like kinase, 111032-0.095-0.2298Yes
126DAPK3DAPK3
Entrez,  Source
death-associated protein kinase 311066-0.096-0.2264Yes
127SRPK1SRPK1
Entrez,  Source
SFRS protein kinase 111068-0.096-0.2204Yes
128ABL2ABL2
Entrez,  Source
v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)11090-0.098-0.2159Yes
129CDK7CDK7
Entrez,  Source
cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase)11160-0.101-0.2150Yes
130STK10STK10
Entrez,  Source
serine/threonine kinase 1011218-0.103-0.2129Yes
131MYLKMYLK
Entrez,  Source
myosin, light chain kinase11255-0.105-0.2091Yes
132BMPR2BMPR2
Entrez,  Source
bone morphogenetic protein receptor, type II (serine/threonine kinase)11345-0.109-0.2091Yes
133RIPK1RIPK1
Entrez,  Source
receptor (TNFRSF)-interacting serine-threonine kinase 111427-0.113-0.2082Yes
134STK38LSTK38L
Entrez,  Source
serine/threonine kinase 38 like11441-0.114-0.2021Yes
135SRPK2SRPK2
Entrez,  Source
SFRS protein kinase 211496-0.117-0.1989Yes
136STK4STK4
Entrez,  Source
serine/threonine kinase 411518-0.118-0.1932Yes
137JAK2JAK2
Entrez,  Source
Janus kinase 2 (a protein tyrosine kinase)11530-0.119-0.1866Yes
138TYRO3TYRO3
Entrez,  Source
TYRO3 protein tyrosine kinase11601-0.123-0.1843Yes
139TLK2TLK2
Entrez,  Source
tousled-like kinase 211621-0.124-0.1780Yes
140SLKSLK
Entrez,  Source
STE20-like kinase (yeast)11672-0.128-0.1738Yes
141MAP4K5MAP4K5
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 511705-0.130-0.1682Yes
142FYNFYN
Entrez,  Source
FYN oncogene related to SRC, FGR, YES11767-0.133-0.1646Yes
143HIPK1HIPK1
Entrez,  Source
homeodomain interacting protein kinase 111798-0.135-0.1584Yes
144MAP2K4MAP2K4
Entrez,  Source
mitogen-activated protein kinase kinase 411811-0.136-0.1508Yes
145PRPF4BPRPF4B
Entrez,  Source
PRP4 pre-mRNA processing factor 4 homolog B (yeast)11856-0.139-0.1455Yes
146CSNK2A1CSNK2A1
Entrez,  Source
casein kinase 2, alpha 1 polypeptide11861-0.139-0.1371Yes
147MAP2K2MAP2K2
Entrez,  Source
mitogen-activated protein kinase kinase 211895-0.142-0.1308Yes
148ROCK2ROCK2
Entrez,  Source
Rho-associated, coiled-coil containing protein kinase 212033-0.152-0.1318Yes
149CAMK1CAMK1
Entrez,  Source
calcium/calmodulin-dependent protein kinase I12150-0.162-0.1306Yes
150MAP3K2MAP3K2
Entrez,  Source
mitogen-activated protein kinase kinase kinase 212210-0.168-0.1247Yes
151PDGFRAPDGFRA
Entrez,  Source
platelet-derived growth factor receptor, alpha polypeptide12211-0.168-0.1142Yes
152MAP3K12MAP3K12
Entrez,  Source
mitogen-activated protein kinase kinase kinase 1212384-0.186-0.1157Yes
153MAP4K3MAP4K3
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 312403-0.189-0.1053Yes
154IRAK3IRAK3
Entrez,  Source
interleukin-1 receptor-associated kinase 312451-0.196-0.0967Yes
155ABL1ABL1
Entrez,  Source
v-abl Abelson murine leukemia viral oncogene homolog 112463-0.197-0.0852Yes
156CSNK1G3CSNK1G3
Entrez,  Source
casein kinase 1, gamma 312464-0.197-0.0729Yes
157RIOK2RIOK2
Entrez,  Source
RIO kinase 2 (yeast)12467-0.198-0.0607Yes
158TLK1TLK1
Entrez,  Source
tousled-like kinase 112558-0.210-0.0545Yes
159MAP3K7MAP3K7
Entrez,  Source
mitogen-activated protein kinase kinase kinase 712613-0.221-0.0449Yes
160AXLAXL
Entrez,  Source
AXL receptor tyrosine kinase12789-0.257-0.0423Yes
161CHUKCHUK
Entrez,  Source
conserved helix-loop-helix ubiquitous kinase12978-0.325-0.0364Yes
162PRKD3PRKD3
Entrez,  Source
protein kinase D313008-0.345-0.0171Yes
163FGFR1FGFR1
Entrez,  Source
fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome)13121-0.4860.0047Yes
Table: GSEA details [plain text format]



Fig 2: SUNITINIB_KINOME SCAN   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: SUNITINIB_KINOME SCAN: Random ES distribution   
Gene set null distribution of ES for SUNITINIB_KINOME SCAN