| Dataset | NSCLC_collapsed_to_symbols.NSCLC.cls #SEN_versus_RES.NSCLC.cls #SEN_versus_RES_repos |
| Phenotype | NSCLC.cls#SEN_versus_RES_repos |
| Upregulated in class | 0 |
| GeneSet | JNK-9L_LINCS |
| Enrichment Score (ES) | -0.3895872 |
| Normalized Enrichment Score (NES) | -1.3276349 |
| Nominal p-value | 0.08274232 |
| FDR q-value | 0.53824574 |
| FWER p-Value | 1.0 |

| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | MET | MET Entrez,  Source | met proto-oncogene (hepatocyte growth factor receptor) | 499 | 0.259 | 0.0191 | No |
| 2 | EPHB6 | EPHB6 Entrez,  Source | EPH receptor B6 | 701 | 0.215 | 0.0513 | No |
| 3 | MAPK10 | MAPK10 Entrez,  Source | mitogen-activated protein kinase 10 | 1069 | 0.157 | 0.0580 | No |
| 4 | PIP4K2C | 1676 | 0.114 | 0.0369 | No | ||
| 5 | RIOK3 | RIOK3 Entrez,  Source | RIO kinase 3 (yeast) | 1942 | 0.101 | 0.0391 | No |
| 6 | AAK1 | AAK1 Entrez,  Source | AP2 associated kinase 1 | 2212 | 0.092 | 0.0389 | No |
| 7 | JAK3 | JAK3 Entrez,  Source | Janus kinase 3 (a protein tyrosine kinase, leukocyte) | 2444 | 0.084 | 0.0399 | No |
| 8 | ADCK4 | ADCK4 Entrez,  Source | aarF domain containing kinase 4 | 2715 | 0.077 | 0.0365 | No |
| 9 | FLT3 | FLT3 Entrez,  Source | fms-related tyrosine kinase 3 | 3403 | 0.063 | -0.0020 | No |
| 10 | CSF1R | CSF1R Entrez,  Source | colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog | 3454 | 0.062 | 0.0078 | No |
| 11 | CDKL5 | CDKL5 Entrez,  Source | cyclin-dependent kinase-like 5 | 4345 | 0.047 | -0.0496 | No |
| 12 | CDKL2 | CDKL2 Entrez,  Source | cyclin-dependent kinase-like 2 (CDC2-related kinase) | 4548 | 0.044 | -0.0553 | No |
| 13 | PIK3CG | PIK3CG Entrez,  Source | phosphoinositide-3-kinase, catalytic, gamma polypeptide | 5329 | 0.033 | -0.1074 | No |
| 14 | MAPK4 | MAPK4 Entrez,  Source | mitogen-activated protein kinase 4 | 5585 | 0.029 | -0.1204 | No |
| 15 | STK16 | STK16 Entrez,  Source | serine/threonine kinase 16 | 5778 | 0.027 | -0.1291 | No |
| 16 | IRAK1 | IRAK1 Entrez,  Source | interleukin-1 receptor-associated kinase 1 | 6179 | 0.021 | -0.1550 | No |
| 17 | PIP4K2B | 6594 | 0.015 | -0.1832 | No | ||
| 18 | MAPK8 | MAPK8 Entrez,  Source | mitogen-activated protein kinase 8 | 6829 | 0.011 | -0.1986 | No |
| 19 | MAP4K2 | MAP4K2 Entrez,  Source | mitogen-activated protein kinase kinase kinase kinase 2 | 6894 | 0.010 | -0.2013 | No |
| 20 | CLK4 | CLK4 Entrez,  Source | CDC-like kinase 4 | 6935 | 0.010 | -0.2022 | No |
| 21 | BMP2K | BMP2K Entrez,  Source | BMP2 inducible kinase | 7029 | 0.008 | -0.2075 | No |
| 22 | CLK2 | CLK2 Entrez,  Source | CDC-like kinase 2 | 7181 | 0.005 | -0.2179 | No |
| 23 | GSK3A | GSK3A Entrez,  Source | glycogen synthase kinase 3 alpha | 7358 | 0.002 | -0.2308 | No |
| 24 | PDGFRB | PDGFRB Entrez,  Source | platelet-derived growth factor receptor, beta polypeptide | 7824 | -0.006 | -0.2650 | No |
| 25 | MAPK9 | MAPK9 Entrez,  Source | mitogen-activated protein kinase 9 | 7830 | -0.006 | -0.2640 | No |
| 26 | KIT | KIT Entrez,  Source | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog | 8134 | -0.012 | -0.2845 | No |
| 27 | MAP2K5 | MAP2K5 Entrez,  Source | mitogen-activated protein kinase kinase 5 | 8199 | -0.013 | -0.2864 | No |
| 28 | DYRK1B | DYRK1B Entrez,  Source | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B | 8200 | -0.013 | -0.2835 | No |
| 29 | CDK16 | 8353 | -0.016 | -0.2915 | No | ||
| 30 | STK11 | STK11 Entrez,  Source | serine/threonine kinase 11 | 9183 | -0.035 | -0.3470 | No |
| 31 | TYK2 | TYK2 Entrez,  Source | tyrosine kinase 2 | 9438 | -0.041 | -0.3573 | No |
| 32 | CSNK2A2 | CSNK2A2 Entrez,  Source | casein kinase 2, alpha prime polypeptide | 9758 | -0.049 | -0.3708 | No |
| 33 | HIPK3 | HIPK3 Entrez,  Source | homeodomain interacting protein kinase 3 | 9770 | -0.050 | -0.3606 | No |
| 34 | HIPK2 | HIPK2 Entrez,  Source | homeodomain interacting protein kinase 2 | 10151 | -0.061 | -0.3761 | Yes |
| 35 | DYRK1A | DYRK1A Entrez,  Source | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 10303 | -0.066 | -0.3731 | Yes |
| 36 | CIT | CIT Entrez,  Source | citron (rho-interacting, serine/threonine kinase 21) | 10420 | -0.070 | -0.3665 | Yes |
| 37 | ICK | ICK Entrez,  Source | intestinal cell (MAK-like) kinase | 10499 | -0.073 | -0.3564 | Yes |
| 38 | JAK1 | JAK1 Entrez,  Source | Janus kinase 1 (a protein tyrosine kinase) | 10585 | -0.076 | -0.3462 | Yes |
| 39 | CDK4 | CDK4 Entrez,  Source | cyclin-dependent kinase 4 | 10871 | -0.087 | -0.3486 | Yes |
| 40 | GSK3B | GSK3B Entrez,  Source | glycogen synthase kinase 3 beta | 11131 | -0.100 | -0.3464 | Yes |
| 41 | CDK7 | CDK7 Entrez,  Source | cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase) | 11160 | -0.101 | -0.3263 | Yes |
| 42 | RIPK1 | RIPK1 Entrez,  Source | receptor (TNFRSF)-interacting serine-threonine kinase 1 | 11427 | -0.113 | -0.3215 | Yes |
| 43 | JAK2 | JAK2 Entrez,  Source | Janus kinase 2 (a protein tyrosine kinase) | 11530 | -0.119 | -0.3030 | Yes |
| 44 | CDK9 | CDK9 Entrez,  Source | cyclin-dependent kinase 9 (CDC2-related kinase) | 11631 | -0.125 | -0.2830 | Yes |
| 45 | SLK | SLK Entrez,  Source | STE20-like kinase (yeast) | 11672 | -0.128 | -0.2579 | Yes |
| 46 | NEK3 | NEK3 Entrez,  Source | NIMA (never in mitosis gene a)-related kinase 3 | 11797 | -0.135 | -0.2374 | Yes |
| 47 | HIPK1 | HIPK1 Entrez,  Source | homeodomain interacting protein kinase 1 | 11798 | -0.135 | -0.2075 | Yes |
| 48 | MAP2K4 | MAP2K4 Entrez,  Source | mitogen-activated protein kinase kinase 4 | 11811 | -0.136 | -0.1783 | Yes |
| 49 | CSNK2A1 | CSNK2A1 Entrez,  Source | casein kinase 2, alpha 1 polypeptide | 11861 | -0.139 | -0.1513 | Yes |
| 50 | PDGFRA | PDGFRA Entrez,  Source | platelet-derived growth factor receptor, alpha polypeptide | 12211 | -0.168 | -0.1408 | Yes |
| 51 | MAPK6 | MAPK6 Entrez,  Source | mitogen-activated protein kinase 6 | 12214 | -0.168 | -0.1038 | Yes |
| 52 | MAP4K3 | MAP4K3 Entrez,  Source | mitogen-activated protein kinase kinase kinase kinase 3 | 12403 | -0.189 | -0.0764 | Yes |
| 53 | IRAK3 | IRAK3 Entrez,  Source | interleukin-1 receptor-associated kinase 3 | 12451 | -0.196 | -0.0368 | Yes |
| 54 | RIOK2 | RIOK2 Entrez,  Source | RIO kinase 2 (yeast) | 12467 | -0.198 | 0.0057 | Yes |
| 55 | MAP3K7 | MAP3K7 Entrez,  Source | mitogen-activated protein kinase kinase kinase 7 | 12613 | -0.221 | 0.0433 | Yes |

