DatasetNSCLC_collapsed_to_symbols.NSCLC.cls
#SEN_versus_RES.NSCLC.cls
#SEN_versus_RES_repos
PhenotypeNSCLC.cls#SEN_versus_RES_repos
Upregulated in class0
GeneSetAZD5438_LINCS
Enrichment Score (ES)-0.24168979
Normalized Enrichment Score (NES)-0.97436386
Nominal p-value0.5434243
FDR q-value1.0
FWER p-Value1.0
Table: GSEA Results Summary



Fig 1: Enrichment plot: AZD5438_LINCS   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEGENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1RIPK4RIPK4
Entrez,  Source
receptor-interacting serine-threonine kinase 4950.5440.0317No
2MAPK13MAPK13
Entrez,  Source
mitogen-activated protein kinase 131100.5250.0682No
3DDR1DDR1
Entrez,  Source
discoidin domain receptor family, member 12120.4040.0893No
4PRKCDPRKCD
Entrez,  Source
protein kinase C, delta3060.3370.1063No
5MST43180.3310.1291No
6SYKSYK
Entrez,  Source
spleen tyrosine kinase4710.2680.1367No
7METMET
Entrez,  Source
met proto-oncogene (hepatocyte growth factor receptor)4990.2590.1531No
8IKBKBIKBKB
Entrez,  Source
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta5530.2450.1666No
9CDK146590.2220.1744No
10EPHB6EPHB6
Entrez,  Source
EPH receptor B67010.2150.1867No
11CDK187600.2040.1968No
12TAOK3TAOK3
Entrez,  Source
TAO kinase 39710.1700.1929No
13MAPK10MAPK10
Entrez,  Source
mitogen-activated protein kinase 1010690.1570.1967No
14TNIKTNIK
Entrez,  Source
TRAF2 and NCK interacting kinase11970.1450.1974No
15DYRK2DYRK2
Entrez,  Source
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 212300.1420.2051No
16GAKGAK
Entrez,  Source
cyclin G associated kinase13400.1330.2063No
17STK3STK3
Entrez,  Source
serine/threonine kinase 3 (STE20 homolog, yeast)15530.1200.1986No
18STK17BSTK17B
Entrez,  Source
serine/threonine kinase 17b (apoptosis-inducing)15540.1190.2071No
19INSRINSR
Entrez,  Source
insulin receptor16640.1140.2069No
20PIP4K2C16760.1140.2142No
21MAP3K9MAP3K9
Entrez,  Source
mitogen-activated protein kinase kinase kinase 916990.1120.2206No
22NTRK2NTRK2
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 217040.1120.2283No
23CSNK1DCSNK1D
Entrez,  Source
casein kinase 1, delta18510.1050.2246No
24RIOK3RIOK3
Entrez,  Source
RIO kinase 3 (yeast)19420.1010.2249No
25AAK1AAK1
Entrez,  Source
AP2 associated kinase 122120.0920.2109No
26MAP3K11MAP3K11
Entrez,  Source
mitogen-activated protein kinase kinase kinase 1122950.0890.2110No
27CLK3CLK3
Entrez,  Source
CDC-like kinase 323490.0870.2132No
28JAK3JAK3
Entrez,  Source
Janus kinase 3 (a protein tyrosine kinase, leukocyte)24440.0840.2120No
29MERTKMERTK
Entrez,  Source
c-mer proto-oncogene tyrosine kinase25220.0820.2120No
30TAOK1TAOK1
Entrez,  Source
TAO kinase 125520.0820.2157No
31EPHA3EPHA3
Entrez,  Source
EPH receptor A328700.0740.1966No
32MINK1MINK1
Entrez,  Source
misshapen-like kinase 1 (zebrafish)30800.0690.1855No
33FLT3FLT3
Entrez,  Source
fms-related tyrosine kinase 334030.0630.1653No
34CSF1RCSF1R
Entrez,  Source
colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog34540.0620.1659No
35CSNK1A1CSNK1A1
Entrez,  Source
casein kinase 1, alpha 136980.0580.1514No
36MARK2MARK2
Entrez,  Source
MAP/microtubule affinity-regulating kinase 238340.0550.1450No
37PRKD2PRKD2
Entrez,  Source
protein kinase D239000.0540.1439No
38CDKL5CDKL5
Entrez,  Source
cyclin-dependent kinase-like 543450.0470.1132No
39AURKCAURKC
Entrez,  Source
aurora kinase C44130.0460.1114No
40CDKL2CDKL2
Entrez,  Source
cyclin-dependent kinase-like 2 (CDC2-related kinase)45480.0440.1043No
41NEK7NEK7
Entrez,  Source
NIMA (never in mitosis gene a)-related kinase 748770.0390.0819No
42MAKMAK
Entrez,  Source
male germ cell-associated kinase51320.0350.0650No
43ACVR1ACVR1
Entrez,  Source
activin A receptor, type I52300.0340.0600No
44PIK3CGPIK3CG
Entrez,  Source
phosphoinositide-3-kinase, catalytic, gamma polypeptide53290.0330.0548No
45STK24STK24
Entrez,  Source
serine/threonine kinase 24 (STE20 homolog, yeast)55870.0290.0372No
46STK16STK16
Entrez,  Source
serine/threonine kinase 1657780.0270.0246No
47SRPK3SRPK3
Entrez,  Source
SFRS protein kinase 358600.0260.0202No
48MAP3K3MAP3K3
Entrez,  Source
mitogen-activated protein kinase kinase kinase 359210.0250.0174No
49CDK1360620.0230.0083No
50IRAK1IRAK1
Entrez,  Source
interleukin-1 receptor-associated kinase 161790.0210.0009No
51CSNK1G2CSNK1G2
Entrez,  Source
casein kinase 1, gamma 263280.018-0.0091No
52AURKAAURKA
Entrez,  Source
aurora kinase A64270.017-0.0154No
53EIF2AK2EIF2AK2
Entrez,  Source
eukaryotic translation initiation factor 2-alpha kinase 264890.016-0.0190No
54PIP4K2B65940.015-0.0259No
55BMPR1BBMPR1B
Entrez,  Source
bone morphogenetic protein receptor, type IB67770.012-0.0390No
56GRK4GRK4
Entrez,  Source
G protein-coupled receptor kinase 467880.012-0.0389No
57MAPK8MAPK8
Entrez,  Source
mitogen-activated protein kinase 868290.011-0.0412No
58MAP4K2MAP4K2
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 268940.010-0.0454No
59MAPK7MAPK7
Entrez,  Source
mitogen-activated protein kinase 769130.010-0.0460No
60CLK4CLK4
Entrez,  Source
CDC-like kinase 469350.010-0.0470No
61BMP2KBMP2K
Entrez,  Source
BMP2 inducible kinase70290.008-0.0535No
62TGFBR2TGFBR2
Entrez,  Source
transforming growth factor, beta receptor II (70/80kDa)71030.007-0.0586No
63CLK2CLK2
Entrez,  Source
CDC-like kinase 271810.005-0.0642No
64GSK3AGSK3A
Entrez,  Source
glycogen synthase kinase 3 alpha73580.002-0.0775No
65CDK5CDK5
Entrez,  Source
cyclin-dependent kinase 574320.001-0.0830No
66PI4KB7697-0.003-0.1030No
67CSNK1ECSNK1E
Entrez,  Source
casein kinase 1, epsilon7742-0.004-0.1061No
68MAP2K3MAP2K3
Entrez,  Source
mitogen-activated protein kinase kinase 37798-0.005-0.1099No
69PDGFRBPDGFRB
Entrez,  Source
platelet-derived growth factor receptor, beta polypeptide7824-0.006-0.1114No
70MAPK9MAPK9
Entrez,  Source
mitogen-activated protein kinase 97830-0.006-0.1114No
71MAP2K1MAP2K1
Entrez,  Source
mitogen-activated protein kinase kinase 17939-0.008-0.1191No
72TAOK2TAOK2
Entrez,  Source
TAO kinase 28059-0.010-0.1275No
73KITKIT
Entrez,  Source
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog8134-0.012-0.1323No
74MAP2K5MAP2K5
Entrez,  Source
mitogen-activated protein kinase kinase 58199-0.013-0.1363No
75DYRK1BDYRK1B
Entrez,  Source
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B8200-0.013-0.1353No
76CDKL3CDKL3
Entrez,  Source
cyclin-dependent kinase-like 38249-0.014-0.1380No
77CDK168353-0.016-0.1447No
78CDK3CDK3
Entrez,  Source
cyclin-dependent kinase 38440-0.018-0.1501No
79STK25STK25
Entrez,  Source
serine/threonine kinase 25 (STE20 homolog, yeast)8561-0.021-0.1578No
80ROCK1ROCK1
Entrez,  Source
Rho-associated, coiled-coil containing protein kinase 18741-0.025-0.1697No
81PIK3CAPIK3CA
Entrez,  Source
phosphoinositide-3-kinase, catalytic, alpha polypeptide8749-0.025-0.1685No
82AURKBAURKB
Entrez,  Source
aurora kinase B8856-0.027-0.1746No
83CDKL1CDKL1
Entrez,  Source
cyclin-dependent kinase-like 1 (CDC2-related kinase)8993-0.031-0.1829No
84CDK11A9060-0.032-0.1856No
85CDK2CDK2
Entrez,  Source
cyclin-dependent kinase 29409-0.040-0.2094No
86TYK2TYK2
Entrez,  Source
tyrosine kinase 29438-0.041-0.2087No
87PAK3PAK3
Entrez,  Source
p21 (CDKN1A)-activated kinase 39490-0.042-0.2095No
88CSNK2A2CSNK2A2
Entrez,  Source
casein kinase 2, alpha prime polypeptide9758-0.049-0.2265No
89HIPK3HIPK3
Entrez,  Source
homeodomain interacting protein kinase 39770-0.050-0.2238No
90PRKD1PRKD1
Entrez,  Source
protein kinase D19827-0.052-0.2244No
91MAP4K4MAP4K4
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 49922-0.055-0.2277No
92TTKTTK
Entrez,  Source
TTK protein kinase9930-0.055-0.2243No
93STK17ASTK17A
Entrez,  Source
serine/threonine kinase 17a (apoptosis-inducing)10017-0.057-0.2268No
94HIPK2HIPK2
Entrez,  Source
homeodomain interacting protein kinase 210151-0.061-0.2327No
95BUB1BUB1
Entrez,  Source
BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast)10160-0.061-0.2289No
96DDR2DDR2
Entrez,  Source
discoidin domain receptor family, member 210235-0.064-0.2300No
97DYRK1ADYRK1A
Entrez,  Source
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A10303-0.066-0.2304No
98CITCIT
Entrez,  Source
citron (rho-interacting, serine/threonine kinase 21)10420-0.070-0.2343No
99ICKICK
Entrez,  Source
intestinal cell (MAK-like) kinase10499-0.073-0.2351No
100PLK4PLK4
Entrez,  Source
polo-like kinase 4 (Drosophila)10581-0.075-0.2359Yes
101JAK1JAK1
Entrez,  Source
Janus kinase 1 (a protein tyrosine kinase)10585-0.076-0.2307Yes
102CAMKK2CAMKK2
Entrez,  Source
calcium/calmodulin-dependent protein kinase kinase 2, beta10729-0.081-0.2359Yes
103TBK1TBK1
Entrez,  Source
TANK-binding kinase 110732-0.082-0.2302Yes
104PIP5K1APIP5K1A
Entrez,  Source
phosphatidylinositol-4-phosphate 5-kinase, type I, alpha10780-0.083-0.2278Yes
105CDK4CDK4
Entrez,  Source
cyclin-dependent kinase 410871-0.087-0.2285Yes
106MTOR10944-0.091-0.2275Yes
107NUAK1NUAK1
Entrez,  Source
NUAK family, SNF1-like kinase, 111032-0.095-0.2274Yes
108GSK3BGSK3B
Entrez,  Source
glycogen synthase kinase 3 beta11131-0.100-0.2277Yes
109CDK7CDK7
Entrez,  Source
cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase)11160-0.101-0.2227Yes
110MYLKMYLK
Entrez,  Source
myosin, light chain kinase11255-0.105-0.2224Yes
111BMPR2BMPR2
Entrez,  Source
bone morphogenetic protein receptor, type II (serine/threonine kinase)11345-0.109-0.2214Yes
112RIPK1RIPK1
Entrez,  Source
receptor (TNFRSF)-interacting serine-threonine kinase 111427-0.113-0.2195Yes
113JAK2JAK2
Entrez,  Source
Janus kinase 2 (a protein tyrosine kinase)11530-0.119-0.2188Yes
114TLK2TLK2
Entrez,  Source
tousled-like kinase 211621-0.124-0.2168Yes
115CDK9CDK9
Entrez,  Source
cyclin-dependent kinase 9 (CDC2-related kinase)11631-0.125-0.2085Yes
116SLKSLK
Entrez,  Source
STE20-like kinase (yeast)11672-0.128-0.2024Yes
117HIPK1HIPK1
Entrez,  Source
homeodomain interacting protein kinase 111798-0.135-0.2023Yes
118MAP2K4MAP2K4
Entrez,  Source
mitogen-activated protein kinase kinase 411811-0.136-0.1935Yes
119CSNK2A1CSNK2A1
Entrez,  Source
casein kinase 2, alpha 1 polypeptide11861-0.139-0.1873Yes
120MAP2K2MAP2K2
Entrez,  Source
mitogen-activated protein kinase kinase 211895-0.142-0.1796Yes
121MAP2K6MAP2K6
Entrez,  Source
mitogen-activated protein kinase kinase 611934-0.144-0.1722Yes
122ROCK2ROCK2
Entrez,  Source
Rho-associated, coiled-coil containing protein kinase 212033-0.152-0.1688Yes
123MAP3K2MAP3K2
Entrez,  Source
mitogen-activated protein kinase kinase kinase 212210-0.168-0.1703Yes
124PKN2PKN2
Entrez,  Source
protein kinase N212286-0.175-0.1635Yes
125MAP3K14MAP3K14
Entrez,  Source
mitogen-activated protein kinase kinase kinase 1412365-0.184-0.1563Yes
126MAP4K3MAP4K3
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 312403-0.189-0.1456Yes
127IRAK3IRAK3
Entrez,  Source
interleukin-1 receptor-associated kinase 312451-0.196-0.1352Yes
128ABL1ABL1
Entrez,  Source
v-abl Abelson murine leukemia viral oncogene homolog 112463-0.197-0.1220Yes
129CSNK1G3CSNK1G3
Entrez,  Source
casein kinase 1, gamma 312464-0.197-0.1078Yes
130RIOK2RIOK2
Entrez,  Source
RIO kinase 2 (yeast)12467-0.198-0.0938Yes
131TLK1TLK1
Entrez,  Source
tousled-like kinase 112558-0.210-0.0857Yes
132CDK1712578-0.213-0.0718Yes
133MAP3K7MAP3K7
Entrez,  Source
mitogen-activated protein kinase kinase kinase 712613-0.221-0.0587Yes
134AXLAXL
Entrez,  Source
AXL receptor tyrosine kinase12789-0.257-0.0537Yes
135CHUKCHUK
Entrez,  Source
conserved helix-loop-helix ubiquitous kinase12978-0.325-0.0448Yes
136PRKD3PRKD3
Entrez,  Source
protein kinase D313008-0.345-0.0224Yes
137SGK113133-0.4980.0038Yes
Table: GSEA details [plain text format]



Fig 2: AZD5438_LINCS   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: AZD5438_LINCS: Random ES distribution   
Gene set null distribution of ES for AZD5438_LINCS