DatasetNSCLC_collapsed_to_symbols.NSCLC.cls
#SEN_versus_RES.NSCLC.cls
#SEN_versus_RES_repos
PhenotypeNSCLC.cls#SEN_versus_RES_repos
Upregulated in class1
GeneSetWH-4-023_LINCS
Enrichment Score (ES)0.39869812
Normalized Enrichment Score (NES)1.4845226
Nominal p-value0.010050251
FDR q-value1.0
FWER p-Value0.993
Table: GSEA Results Summary



Fig 1: Enrichment plot: WH-4-023_LINCS   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEGENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1ERBB3ERBB3
Entrez,  Source
v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)121.0340.0714Yes
2EPHA1EPHA1
Entrez,  Source
EPH receptor A1940.5450.1034Yes
3ERBB2ERBB2
Entrez,  Source
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)1000.5370.1406Yes
4PTK6PTK6
Entrez,  Source
PTK6 protein tyrosine kinase 61410.4790.1710Yes
5FGFR3FGFR3
Entrez,  Source
fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism)1530.4650.2027Yes
6FGFR2FGFR2
Entrez,  Source
ffer syndrome, Jackson-Weiss syndrome)2100.4060.2267Yes
7DDR1DDR1
Entrez,  Source
discoidin domain receptor family, member 12120.4040.2549Yes
8FRKFRK
Entrez,  Source
fyn-related kinase2960.3430.2725Yes
9PRKCDPRKCD
Entrez,  Source
protein kinase C, delta3060.3370.2954Yes
10SYKSYK
Entrez,  Source
spleen tyrosine kinase4710.2680.3016Yes
11METMET
Entrez,  Source
met proto-oncogene (hepatocyte growth factor receptor)4990.2590.3176Yes
12ROS1ROS1
Entrez,  Source
v-ros UR2 sarcoma virus oncogene homolog 1 (avian)5050.2580.3352Yes
13EGFREGFR
Entrez,  Source
epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)6250.2300.3422Yes
14PAK1PAK1
Entrez,  Source
p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast)6740.2190.3539Yes
15EPHB6EPHB6
Entrez,  Source
EPH receptor B67010.2150.3669Yes
16EPHA4EPHA4
Entrez,  Source
EPH receptor A47980.1970.3734Yes
17EPHB2EPHB2
Entrez,  Source
EPH receptor B28680.1850.3810Yes
18TAOK3TAOK3
Entrez,  Source
TAO kinase 39710.1700.3851Yes
19TXKTXK
Entrez,  Source
TXK tyrosine kinase10450.1600.3907Yes
20LCKLCK
Entrez,  Source
lymphocyte-specific protein tyrosine kinase13100.1360.3800Yes
21GAKGAK
Entrez,  Source
cyclin G associated kinase13400.1330.3871Yes
22TNK1TNK1
Entrez,  Source
tyrosine kinase, non-receptor, 113600.1310.3948Yes
23EPHB3EPHB3
Entrez,  Source
EPH receptor B314260.1270.3987Yes
24MAP3K9MAP3K9
Entrez,  Source
mitogen-activated protein kinase kinase kinase 916990.1120.3857No
25ERBB4ERBB4
Entrez,  Source
v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)18130.1070.3845No
26TESK1TESK1
Entrez,  Source
testis-specific kinase 118550.1050.3887No
27RIOK3RIOK3
Entrez,  Source
RIO kinase 3 (yeast)19420.1010.3892No
28LYNLYN
Entrez,  Source
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog19740.1000.3938No
29PTK2BPTK2B
Entrez,  Source
PTK2B protein tyrosine kinase 2 beta20420.0980.3955No
30AAK1AAK1
Entrez,  Source
AP2 associated kinase 122120.0920.3890No
31MAP3K11MAP3K11
Entrez,  Source
mitogen-activated protein kinase kinase kinase 1122950.0890.3889No
32TIE1TIE1
Entrez,  Source
tyrosine kinase with immunoglobulin-like and EGF-like domains 123280.0880.3926No
33JAK3JAK3
Entrez,  Source
Janus kinase 3 (a protein tyrosine kinase, leukocyte)24440.0840.3897No
34TAOK1TAOK1
Entrez,  Source
TAO kinase 125520.0820.3872No
35LIMK2LIMK2
Entrez,  Source
LIM domain kinase 227990.0760.3737No
36MAP4K1MAP4K1
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 128490.0740.3751No
37EPHA3EPHA3
Entrez,  Source
EPH receptor A328700.0740.3787No
38TNK2TNK2
Entrez,  Source
tyrosine kinase, non-receptor, 230050.0700.3734No
39YES1YES1
Entrez,  Source
v-yes-1 Yamaguchi sarcoma viral oncogene homolog 130360.0700.3760No
40CSKCSK
Entrez,  Source
c-src tyrosine kinase30690.0690.3784No
41MINK1MINK1
Entrez,  Source
misshapen-like kinase 1 (zebrafish)30800.0690.3824No
42KDRKDR
Entrez,  Source
kinase insert domain receptor (a type III receptor tyrosine kinase)31460.0680.3822No
43FLT3FLT3
Entrez,  Source
fms-related tyrosine kinase 334030.0630.3670No
44BLKBLK
Entrez,  Source
B lymphoid tyrosine kinase34190.0620.3702No
45CSF1RCSF1R
Entrez,  Source
colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog34540.0620.3719No
46ACVRL1ACVRL1
Entrez,  Source
activin A receptor type II-like 137150.0570.3560No
47EPHB4EPHB4
Entrez,  Source
EPH receptor B438790.0540.3473No
48PRKD2PRKD2
Entrez,  Source
protein kinase D239000.0540.3495No
49EPHB1EPHB1
Entrez,  Source
EPH receptor B140000.0520.3456No
50ALKALK
Entrez,  Source
anaplastic lymphoma kinase (Ki-1)40730.0510.3437No
51FGRFGR
Entrez,  Source
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog41930.0490.3380No
52ACVR1BACVR1B
Entrez,  Source
activin A receptor, type IB43280.0470.3311No
53AURKCAURKC
Entrez,  Source
aurora kinase C44130.0460.3279No
54LIMK1LIMK1
Entrez,  Source
LIM domain kinase 144680.0450.3269No
55CDKL2CDKL2
Entrez,  Source
cyclin-dependent kinase-like 2 (CDC2-related kinase)45480.0440.3239No
56HUNKHUNK
Entrez,  Source
hormonally upregulated Neu-associated kinase46450.0430.3195No
57FGFR4FGFR4
Entrez,  Source
fibroblast growth factor receptor 447150.0410.3172No
58BMXBMX
Entrez,  Source
BMX non-receptor tyrosine kinase48260.0400.3115No
59EPHA2EPHA2
Entrez,  Source
EPH receptor A248800.0390.3102No
60FLT1FLT1
Entrez,  Source
fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)48820.0390.3129No
61ACVR1ACVR1
Entrez,  Source
activin A receptor, type I52300.0340.2887No
62TNNI3KTNNI3K
Entrez,  Source
TNNI3 interacting kinase52740.0330.2877No
63TECTEC
Entrez,  Source
tec protein tyrosine kinase53790.0320.2820No
64MAPK11MAPK11
Entrez,  Source
mitogen-activated protein kinase 1153920.0320.2833No
65PIK3C2BPIK3C2B
Entrez,  Source
phosphoinositide-3-kinase, class 2, beta polypeptide54150.0320.2839No
66EPHA5EPHA5
Entrez,  Source
EPH receptor A554750.0310.2815No
67BTKBTK
Entrez,  Source
Bruton agammaglobulinemia tyrosine kinase56280.0290.2719No
68STK16STK16
Entrez,  Source
serine/threonine kinase 1657780.0270.2624No
69SRPK3SRPK3
Entrez,  Source
SFRS protein kinase 358600.0260.2580No
70MAP3K3MAP3K3
Entrez,  Source
mitogen-activated protein kinase kinase kinase 359210.0250.2551No
71FESFES
Entrez,  Source
feline sarcoma oncogene61260.0220.2410No
72PHKG1PHKG1
Entrez,  Source
phosphorylase kinase, gamma 1 (muscle)62450.0200.2333No
73AURKAAURKA
Entrez,  Source
aurora kinase A64270.0170.2207No
74RETRET
Entrez,  Source
ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease)64710.0160.2185No
75PIP4K2B65940.0150.2102No
76BMPR1BBMPR1B
Entrez,  Source
bone morphogenetic protein receptor, type IB67770.0120.1971No
77PKN1PKN1
Entrez,  Source
protein kinase N167830.0120.1975No
78GRK4GRK4
Entrez,  Source
G protein-coupled receptor kinase 467880.0120.1981No
79MAP4K2MAP4K2
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 268940.0100.1907No
80STK32BSTK32B
Entrez,  Source
serine/threonine kinase 32B69190.0100.1896No
81BMP2KBMP2K
Entrez,  Source
BMP2 inducible kinase70290.0080.1818No
82TEKTEK
Entrez,  Source
TEK tyrosine kinase, endothelial (venous malformations, multiple cutaneous and mucosal)70350.0080.1820No
83ACVR2BACVR2B
Entrez,  Source
activin A receptor, type IIB73820.0020.1556No
84PRKAA2PRKAA2
Entrez,  Source
protein kinase, AMP-activated, alpha 2 catalytic subunit74180.0010.1530No
85SIK274350.0010.1518No
86PDGFRBPDGFRB
Entrez,  Source
platelet-derived growth factor receptor, beta polypeptide7824-0.0060.1225No
87MAPK9MAPK9
Entrez,  Source
mitogen-activated protein kinase 97830-0.0060.1226No
88TAOK2TAOK2
Entrez,  Source
TAO kinase 28059-0.0100.1058No
89PRKACAPRKACA
Entrez,  Source
protein kinase, cAMP-dependent, catalytic, alpha8112-0.0110.1026No
90KITKIT
Entrez,  Source
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog8134-0.0120.1018No
91LTKLTK
Entrez,  Source
leukocyte tyrosine kinase8158-0.0120.1009No
92MAP2K5MAP2K5
Entrez,  Source
mitogen-activated protein kinase kinase 58199-0.0130.0988No
93CDKL3CDKL3
Entrez,  Source
cyclin-dependent kinase-like 38249-0.0140.0960No
94DMPKDMPK
Entrez,  Source
dystrophia myotonica-protein kinase8344-0.0160.0899No
95ACVR2AACVR2A
Entrez,  Source
activin A receptor, type IIA9293-0.0380.0200No
96PAK3PAK3
Entrez,  Source
p21 (CDKN1A)-activated kinase 39490-0.0420.0079No
97PRKD1PRKD1
Entrez,  Source
protein kinase D19827-0.052-0.0142No
98MAP4K4MAP4K4
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 49922-0.055-0.0176No
99HCKHCK
Entrez,  Source
hemopoietic cell kinase9981-0.056-0.0181No
100DDR2DDR2
Entrez,  Source
discoidin domain receptor family, member 210235-0.064-0.0330No
101MARK3MARK3
Entrez,  Source
MAP/microtubule affinity-regulating kinase 310374-0.068-0.0388No
102CITCIT
Entrez,  Source
citron (rho-interacting, serine/threonine kinase 21)10420-0.070-0.0374No
103SRCSRC
Entrez,  Source
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)10776-0.083-0.0587No
104PIP5K1APIP5K1A
Entrez,  Source
phosphatidylinositol-4-phosphate 5-kinase, type I, alpha10780-0.083-0.0531No
105CDK4CDK4
Entrez,  Source
cyclin-dependent kinase 410871-0.087-0.0539No
106NLKNLK
Entrez,  Source
nemo-like kinase10979-0.093-0.0556No
107ABL2ABL2
Entrez,  Source
v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)11090-0.098-0.0572No
108PRKACBPRKACB
Entrez,  Source
protein kinase, cAMP-dependent, catalytic, beta11179-0.102-0.0568No
109STK10STK10
Entrez,  Source
serine/threonine kinase 1011218-0.103-0.0525No
110RIPK2RIPK2
Entrez,  Source
receptor-interacting serine-threonine kinase 211349-0.110-0.0548No
111FERFER
Entrez,  Source
fer (fps/fes related) tyrosine kinase (phosphoprotein NCP94)11371-0.111-0.0487No
112SLKSLK
Entrez,  Source
STE20-like kinase (yeast)11672-0.128-0.0627No
113MAP4K5MAP4K5
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 511705-0.130-0.0561No
114FYNFYN
Entrez,  Source
FYN oncogene related to SRC, FGR, YES11767-0.133-0.0515No
115CDC42BPBCDC42BPB
Entrez,  Source
CDC42 binding protein kinase beta (DMPK-like)12053-0.154-0.0625No
116MAP3K2MAP3K2
Entrez,  Source
mitogen-activated protein kinase kinase kinase 212210-0.168-0.0627No
117PDGFRAPDGFRA
Entrez,  Source
platelet-derived growth factor receptor, alpha polypeptide12211-0.168-0.0510No
118SIK112319-0.179-0.0467No
119MAP4K3MAP4K3
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 312403-0.189-0.0398No
120BMPR1ABMPR1A
Entrez,  Source
bone morphogenetic protein receptor, type IA12438-0.194-0.0289No
121TGFBR1TGFBR1
Entrez,  Source
transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kDa)12447-0.195-0.0158No
122ABL1ABL1
Entrez,  Source
v-abl Abelson murine leukemia viral oncogene homolog 112463-0.197-0.0032No
123PRKD3PRKD3
Entrez,  Source
protein kinase D313008-0.345-0.0207No
124FGFR1FGFR1
Entrez,  Source
fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome)13121-0.4860.0047No
Table: GSEA details [plain text format]



Fig 2: WH-4-023_LINCS   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: WH-4-023_LINCS: Random ES distribution   
Gene set null distribution of ES for WH-4-023_LINCS