| Dataset | NSCLC_collapsed_to_symbols.NSCLC.cls #SEN_versus_RES.NSCLC.cls #SEN_versus_RES_repos |
| Phenotype | NSCLC.cls#SEN_versus_RES_repos |
| Upregulated in class | 0 |
| GeneSet | GSK-690693_KINOME SCAN |
| Enrichment Score (ES) | -0.28701413 |
| Normalized Enrichment Score (NES) | -0.9325891 |
| Nominal p-value | 0.5707434 |
| FDR q-value | 0.91259176 |
| FWER p-Value | 1.0 |

| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | PAK6 | PAK6 Entrez,  Source | p21(CDKN1A)-activated kinase 6 | 158 | 0.459 | 0.0990 | Yes |
| 2 | PRKCD | PRKCD Entrez,  Source | protein kinase C, delta | 306 | 0.337 | 0.1692 | Yes |
| 3 | PRKCH | PRKCH Entrez,  Source | protein kinase C, eta | 356 | 0.309 | 0.2402 | Yes |
| 4 | PAK1 | PAK1 Entrez,  Source | p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast) | 674 | 0.219 | 0.2690 | Yes |
| 5 | TAOK1 | TAOK1 Entrez,  Source | TAO kinase 1 | 2552 | 0.082 | 0.1459 | No |
| 6 | RPS6KA5 | RPS6KA5 Entrez,  Source | ribosomal protein S6 kinase, 90kDa, polypeptide 5 | 2610 | 0.080 | 0.1610 | No |
| 7 | PIM2 | PIM2 Entrez,  Source | pim-2 oncogene | 2956 | 0.071 | 0.1520 | No |
| 8 | MARK2 | MARK2 Entrez,  Source | MAP/microtubule affinity-regulating kinase 2 | 3834 | 0.055 | 0.0985 | No |
| 9 | PRKG2 | PRKG2 Entrez,  Source | protein kinase, cGMP-dependent, type II | 4021 | 0.052 | 0.0969 | No |
| 10 | PIM1 | PIM1 Entrez,  Source | pim-1 oncogene | 4136 | 0.050 | 0.1004 | No |
| 11 | GRK1 | GRK1 Entrez,  Source | G protein-coupled receptor kinase 1 | 4907 | 0.039 | 0.0512 | No |
| 12 | PRKG1 | PRKG1 Entrez,  Source | protein kinase, cGMP-dependent, type I | 4936 | 0.038 | 0.0583 | No |
| 13 | PAK4 | PAK4 Entrez,  Source | p21(CDKN1A)-activated kinase 4 | 5014 | 0.037 | 0.0614 | No |
| 14 | PAK7 | PAK7 Entrez,  Source | p21(CDKN1A)-activated kinase 7 | 5881 | 0.025 | 0.0017 | No |
| 15 | MAP3K3 | MAP3K3 Entrez,  Source | mitogen-activated protein kinase kinase kinase 3 | 5921 | 0.025 | 0.0047 | No |
| 16 | PRKX | PRKX Entrez,  Source | protein kinase, X-linked | 5993 | 0.024 | 0.0051 | No |
| 17 | CAMK4 | CAMK4 Entrez,  Source | calcium/calmodulin-dependent protein kinase IV | 6393 | 0.017 | -0.0211 | No |
| 18 | PKN1 | PKN1 Entrez,  Source | protein kinase N1 | 6783 | 0.012 | -0.0478 | No |
| 19 | CLK2 | CLK2 Entrez,  Source | CDC-like kinase 2 | 7181 | 0.005 | -0.0768 | No |
| 20 | AKT1 | AKT1 Entrez,  Source | v-akt murine thymoma viral oncogene homolog 1 | 7387 | 0.002 | -0.0920 | No |
| 21 | MELK | MELK Entrez,  Source | maternal embryonic leucine zipper kinase | 8047 | -0.010 | -0.1397 | No |
| 22 | PRKACA | PRKACA Entrez,  Source | protein kinase, cAMP-dependent, catalytic, alpha | 8112 | -0.011 | -0.1419 | No |
| 23 | KIT | KIT Entrez,  Source | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog | 8134 | -0.012 | -0.1407 | No |
| 24 | RPS6KA4 | RPS6KA4 Entrez,  Source | ribosomal protein S6 kinase, 90kDa, polypeptide 4 | 8181 | -0.013 | -0.1411 | No |
| 25 | PRKCI | PRKCI Entrez,  Source | protein kinase C, iota | 8226 | -0.014 | -0.1411 | No |
| 26 | ROCK1 | ROCK1 Entrez,  Source | Rho-associated, coiled-coil containing protein kinase 1 | 8741 | -0.025 | -0.1742 | No |
| 27 | HIPK3 | HIPK3 Entrez,  Source | homeodomain interacting protein kinase 3 | 9770 | -0.050 | -0.2404 | No |
| 28 | HIPK2 | HIPK2 Entrez,  Source | homeodomain interacting protein kinase 2 | 10151 | -0.061 | -0.2546 | No |
| 29 | CIT | CIT Entrez,  Source | citron (rho-interacting, serine/threonine kinase 21) | 10420 | -0.070 | -0.2581 | No |
| 30 | PRKCE | PRKCE Entrez,  Source | protein kinase C, epsilon | 10801 | -0.084 | -0.2666 | No |
| 31 | PAK2 | PAK2 Entrez,  Source | p21 (CDKN1A)-activated kinase 2 | 10809 | -0.085 | -0.2467 | No |
| 32 | PRKCQ | PRKCQ Entrez,  Source | protein kinase C, theta | 10961 | -0.092 | -0.2360 | No |
| 33 | NUAK1 | NUAK1 Entrez,  Source | NUAK family, SNF1-like kinase, 1 | 11032 | -0.095 | -0.2184 | No |
| 34 | DAPK3 | DAPK3 Entrez,  Source | death-associated protein kinase 3 | 11066 | -0.096 | -0.1976 | No |
| 35 | GSK3B | GSK3B Entrez,  Source | glycogen synthase kinase 3 beta | 11131 | -0.100 | -0.1784 | No |
| 36 | PRKACB | PRKACB Entrez,  Source | protein kinase, cAMP-dependent, catalytic, beta | 11179 | -0.102 | -0.1573 | No |
| 37 | HIPK1 | HIPK1 Entrez,  Source | homeodomain interacting protein kinase 1 | 11798 | -0.135 | -0.1716 | No |
| 38 | ROCK2 | ROCK2 Entrez,  Source | Rho-associated, coiled-coil containing protein kinase 2 | 12033 | -0.152 | -0.1526 | No |
| 39 | MAP3K2 | MAP3K2 Entrez,  Source | mitogen-activated protein kinase kinase kinase 2 | 12210 | -0.168 | -0.1255 | No |
| 40 | AKT3 | AKT3 Entrez,  Source | v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) | 12533 | -0.207 | -0.0998 | No |
| 41 | AKT2 | AKT2 Entrez,  Source | v-akt murine thymoma viral oncogene homolog 2 | 12829 | -0.271 | -0.0566 | No |
| 42 | PRKD3 | PRKD3 Entrez,  Source | protein kinase D3 | 13008 | -0.345 | 0.0132 | No |

