DatasetNSCLC_collapsed_to_symbols.NSCLC.cls
#SEN_versus_RES.NSCLC.cls
#SEN_versus_RES_repos
PhenotypeNSCLC.cls#SEN_versus_RES_repos
Upregulated in class1
GeneSetABT-869_KINOME SCAN
Enrichment Score (ES)0.31244314
Normalized Enrichment Score (NES)0.94501776
Nominal p-value0.55675673
FDR q-value0.87000823
FWER p-Value1.0
Table: GSEA Results Summary



Fig 1: Enrichment plot: ABT-869_KINOME SCAN   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEGENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1DDR1DDR1
Entrez,  Source
discoidin domain receptor family, member 12120.4040.0954Yes
2FRKFRK
Entrez,  Source
fyn-related kinase2960.3430.1839Yes
3METMET
Entrez,  Source
met proto-oncogene (hepatocyte growth factor receptor)4990.2590.2400Yes
4EPHB6EPHB6
Entrez,  Source
EPH receptor B67010.2150.2841Yes
5TAOK3TAOK3
Entrez,  Source
TAO kinase 39710.1700.3106Yes
6EPHA7EPHA7
Entrez,  Source
EPH receptor A714120.1280.3124Yes
7TIE1TIE1
Entrez,  Source
tyrosine kinase with immunoglobulin-like and EGF-like domains 123280.0880.2671No
8MERTKMERTK
Entrez,  Source
c-mer proto-oncogene tyrosine kinase25220.0820.2752No
9TAOK1TAOK1
Entrez,  Source
TAO kinase 125520.0820.2956No
10MAP4K1MAP4K1
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 128490.0740.2935No
11KDRKDR
Entrez,  Source
kinase insert domain receptor (a type III receptor tyrosine kinase)31460.0680.2897No
12FLT3FLT3
Entrez,  Source
fms-related tyrosine kinase 334030.0630.2875No
13CSF1RCSF1R
Entrez,  Source
colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog34540.0620.3008No
14EPHB1EPHB1
Entrez,  Source
EPH receptor B140000.0520.2738No
15MUSKMUSK
Entrez,  Source
muscle, skeletal, receptor tyrosine kinase41390.0500.2771No
16AURKCAURKC
Entrez,  Source
aurora kinase C44130.0460.2691No
17FLT1FLT1
Entrez,  Source
fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)48820.0390.2443No
18FLT4FLT4
Entrez,  Source
fms-related tyrosine kinase 448980.0390.2539No
19MAPK11MAPK11
Entrez,  Source
mitogen-activated protein kinase 1153920.0320.2252No
20CDK1360620.0230.1806No
21RETRET
Entrez,  Source
ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease)64710.0160.1541No
22BMPR1BBMPR1B
Entrez,  Source
bone morphogenetic protein receptor, type IB67770.0120.1342No
23STK32BSTK32B
Entrez,  Source
serine/threonine kinase 32B69190.0100.1261No
24TEKTEK
Entrez,  Source
TEK tyrosine kinase, endothelial (venous malformations, multiple cutaneous and mucosal)70350.0080.1196No
25CDK1972630.0040.1033No
26PDGFRBPDGFRB
Entrez,  Source
platelet-derived growth factor receptor, beta polypeptide7824-0.0060.0623No
27MAPK9MAPK9
Entrez,  Source
mitogen-activated protein kinase 97830-0.0060.0636No
28MKNK2MKNK2
Entrez,  Source
MAP kinase interacting serine/threonine kinase 27841-0.0060.0646No
29KITKIT
Entrez,  Source
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog8134-0.0120.0456No
30LTKLTK
Entrez,  Source
leukocyte tyrosine kinase8158-0.0120.0473No
31NTRK3NTRK3
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 38500-0.0190.0267No
32AURKBAURKB
Entrez,  Source
aurora kinase B8856-0.0270.0073No
33STK10STK10
Entrez,  Source
serine/threonine kinase 1011218-0.103-0.1438No
34SLKSLK
Entrez,  Source
STE20-like kinase (yeast)11672-0.128-0.1430No
35MAP4K5MAP4K5
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 511705-0.130-0.1096No
36ROCK2ROCK2
Entrez,  Source
Rho-associated, coiled-coil containing protein kinase 212033-0.152-0.0925No
37PDGFRAPDGFRA
Entrez,  Source
platelet-derived growth factor receptor, alpha polypeptide12211-0.168-0.0596No
38CDK8CDK8
Entrez,  Source
cyclin-dependent kinase 812650-0.226-0.0306No
39AXLAXL
Entrez,  Source
AXL receptor tyrosine kinase12789-0.2570.0299No
Table: GSEA details [plain text format]



Fig 2: ABT-869_KINOME SCAN   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: ABT-869_KINOME SCAN: Random ES distribution   
Gene set null distribution of ES for ABT-869_KINOME SCAN