| Dataset | NSCLC_collapsed_to_symbols.NSCLC.cls #SEN_versus_RES.NSCLC.cls #SEN_versus_RES_repos |
| Phenotype | NSCLC.cls#SEN_versus_RES_repos |
| Upregulated in class | 1 |
| GeneSet | TG-101348_KINOME SCAN |
| Enrichment Score (ES) | 0.28870344 |
| Normalized Enrichment Score (NES) | 1.0553937 |
| Nominal p-value | 0.3408 |
| FDR q-value | 0.76474756 |
| FWER p-Value | 1.0 |

| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | DAPK1 | DAPK1 Entrez,  Source | death-associated protein kinase 1 | 88 | 0.557 | 0.0393 | Yes |
| 2 | EPHA1 | EPHA1 Entrez,  Source | EPH receptor A1 | 94 | 0.545 | 0.0840 | Yes |
| 3 | FGFR3 | FGFR3 Entrez,  Source | fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism) | 153 | 0.465 | 0.1180 | Yes |
| 4 | FGFR2 | FGFR2 Entrez,  Source | ffer syndrome, Jackson-Weiss syndrome) | 210 | 0.406 | 0.1472 | Yes |
| 5 | FRK | FRK Entrez,  Source | fyn-related kinase | 296 | 0.343 | 0.1690 | Yes |
| 6 | ROS1 | ROS1 Entrez,  Source | v-ros UR2 sarcoma virus oncogene homolog 1 (avian) | 505 | 0.258 | 0.1744 | Yes |
| 7 | IKBKB | IKBKB Entrez,  Source | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta | 553 | 0.245 | 0.1911 | Yes |
| 8 | MAP3K13 | MAP3K13 Entrez,  Source | mitogen-activated protein kinase kinase kinase 13 | 624 | 0.230 | 0.2047 | Yes |
| 9 | EGFR | EGFR Entrez,  Source | epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) | 625 | 0.230 | 0.2237 | Yes |
| 10 | EPHB6 | EPHB6 Entrez,  Source | EPH receptor B6 | 701 | 0.215 | 0.2358 | Yes |
| 11 | MAPK10 | MAPK10 Entrez,  Source | mitogen-activated protein kinase 10 | 1069 | 0.157 | 0.2207 | Yes |
| 12 | LCK | LCK Entrez,  Source | lymphocyte-specific protein tyrosine kinase | 1310 | 0.136 | 0.2135 | Yes |
| 13 | GAK | GAK Entrez,  Source | cyclin G associated kinase | 1340 | 0.133 | 0.2223 | Yes |
| 14 | TNK1 | TNK1 Entrez,  Source | tyrosine kinase, non-receptor, 1 | 1360 | 0.131 | 0.2317 | Yes |
| 15 | CAMK1D | CAMK1D Entrez,  Source | calcium/calmodulin-dependent protein kinase ID | 1387 | 0.129 | 0.2404 | Yes |
| 16 | STK17B | STK17B Entrez,  Source | serine/threonine kinase 17b (apoptosis-inducing) | 1554 | 0.119 | 0.2376 | Yes |
| 17 | WEE1 | WEE1 Entrez,  Source | WEE1 homolog (S. pombe) | 1639 | 0.115 | 0.2407 | Yes |
| 18 | INSR | INSR Entrez,  Source | insulin receptor | 1664 | 0.114 | 0.2483 | Yes |
| 19 | RPS6KA1 | RPS6KA1 Entrez,  Source | ribosomal protein S6 kinase, 90kDa, polypeptide 1 | 1686 | 0.113 | 0.2560 | Yes |
| 20 | CAMK2A | CAMK2A Entrez,  Source | calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha | 1801 | 0.107 | 0.2561 | Yes |
| 21 | CAMK2G | CAMK2G Entrez,  Source | calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma | 1811 | 0.107 | 0.2642 | Yes |
| 22 | DAPK2 | DAPK2 Entrez,  Source | death-associated protein kinase 2 | 1838 | 0.105 | 0.2709 | Yes |
| 23 | RIOK3 | RIOK3 Entrez,  Source | RIO kinase 3 (yeast) | 1942 | 0.101 | 0.2714 | Yes |
| 24 | LYN | LYN Entrez,  Source | v-yes-1 Yamaguchi sarcoma viral related oncogene homolog | 1974 | 0.100 | 0.2773 | Yes |
| 25 | PTK2B | PTK2B Entrez,  Source | PTK2B protein tyrosine kinase 2 beta | 2042 | 0.098 | 0.2802 | Yes |
| 26 | MARK1 | MARK1 Entrez,  Source | MAP/microtubule affinity-regulating kinase 1 | 2159 | 0.093 | 0.2790 | Yes |
| 27 | AAK1 | AAK1 Entrez,  Source | AP2 associated kinase 1 | 2212 | 0.092 | 0.2827 | Yes |
| 28 | ULK2 | ULK2 Entrez,  Source | unc-51-like kinase 2 (C. elegans) | 2244 | 0.091 | 0.2878 | Yes |
| 29 | TIE1 | TIE1 Entrez,  Source | tyrosine kinase with immunoglobulin-like and EGF-like domains 1 | 2328 | 0.088 | 0.2887 | Yes |
| 30 | JAK3 | JAK3 Entrez,  Source | Janus kinase 3 (a protein tyrosine kinase, leukocyte) | 2444 | 0.084 | 0.2869 | No |
| 31 | MERTK | MERTK Entrez,  Source | c-mer proto-oncogene tyrosine kinase | 2522 | 0.082 | 0.2878 | No |
| 32 | ADCK4 | ADCK4 Entrez,  Source | aarF domain containing kinase 4 | 2715 | 0.077 | 0.2795 | No |
| 33 | TNK2 | TNK2 Entrez,  Source | tyrosine kinase, non-receptor, 2 | 3005 | 0.070 | 0.2632 | No |
| 34 | EIF2AK1 | EIF2AK1 Entrez,  Source | eukaryotic translation initiation factor 2-alpha kinase 1 | 3008 | 0.070 | 0.2689 | No |
| 35 | YES1 | YES1 Entrez,  Source | v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 | 3036 | 0.070 | 0.2726 | No |
| 36 | FLT3 | FLT3 Entrez,  Source | fms-related tyrosine kinase 3 | 3403 | 0.063 | 0.2497 | No |
| 37 | BLK | BLK Entrez,  Source | B lymphoid tyrosine kinase | 3419 | 0.062 | 0.2537 | No |
| 38 | CSF1R | CSF1R Entrez,  Source | colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog | 3454 | 0.062 | 0.2562 | No |
| 39 | ALK | ALK Entrez,  Source | anaplastic lymphoma kinase (Ki-1) | 4073 | 0.051 | 0.2131 | No |
| 40 | MUSK | MUSK Entrez,  Source | muscle, skeletal, receptor tyrosine kinase | 4139 | 0.050 | 0.2123 | No |
| 41 | FGR | FGR Entrez,  Source | Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog | 4193 | 0.049 | 0.2123 | No |
| 42 | AURKC | AURKC Entrez,  Source | aurora kinase C | 4413 | 0.046 | 0.1993 | No |
| 43 | LIMK1 | LIMK1 Entrez,  Source | LIM domain kinase 1 | 4468 | 0.045 | 0.1989 | No |
| 44 | RPS6KA6 | RPS6KA6 Entrez,  Source | ribosomal protein S6 kinase, 90kDa, polypeptide 6 | 4685 | 0.042 | 0.1859 | No |
| 45 | NEK7 | NEK7 Entrez,  Source | NIMA (never in mitosis gene a)-related kinase 7 | 4877 | 0.039 | 0.1745 | No |
| 46 | ULK1 | ULK1 Entrez,  Source | unc-51-like kinase 1 (C. elegans) | 5157 | 0.035 | 0.1560 | No |
| 47 | ACVR1 | ACVR1 Entrez,  Source | activin A receptor, type I | 5230 | 0.034 | 0.1533 | No |
| 48 | BTK | BTK Entrez,  Source | Bruton agammaglobulinemia tyrosine kinase | 5628 | 0.029 | 0.1253 | No |
| 49 | STK16 | STK16 Entrez,  Source | serine/threonine kinase 16 | 5778 | 0.027 | 0.1161 | No |
| 50 | SRPK3 | SRPK3 Entrez,  Source | SFRS protein kinase 3 | 5860 | 0.026 | 0.1121 | No |
| 51 | NTRK1 | NTRK1 Entrez,  Source | neurotrophic tyrosine kinase, receptor, type 1 | 6097 | 0.022 | 0.0958 | No |
| 52 | FES | FES Entrez,  Source | feline sarcoma oncogene | 6126 | 0.022 | 0.0955 | No |
| 53 | IRAK1 | IRAK1 Entrez,  Source | interleukin-1 receptor-associated kinase 1 | 6179 | 0.021 | 0.0932 | No |
| 54 | PHKG1 | PHKG1 Entrez,  Source | phosphorylase kinase, gamma 1 (muscle) | 6245 | 0.020 | 0.0899 | No |
| 55 | DCLK2 | 6462 | 0.016 | 0.0747 | No | ||
| 56 | RET | RET Entrez,  Source | ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease) | 6471 | 0.016 | 0.0754 | No |
| 57 | PIP4K2B | 6594 | 0.015 | 0.0673 | No | ||
| 58 | BMPR1B | BMPR1B Entrez,  Source | bone morphogenetic protein receptor, type IB | 6777 | 0.012 | 0.0544 | No |
| 59 | GRK4 | GRK4 Entrez,  Source | G protein-coupled receptor kinase 4 | 6788 | 0.012 | 0.0546 | No |
| 60 | MAPK8 | MAPK8 Entrez,  Source | mitogen-activated protein kinase 8 | 6829 | 0.011 | 0.0524 | No |
| 61 | MAPK7 | MAPK7 Entrez,  Source | mitogen-activated protein kinase 7 | 6913 | 0.010 | 0.0469 | No |
| 62 | BMP2K | BMP2K Entrez,  Source | BMP2 inducible kinase | 7029 | 0.008 | 0.0388 | No |
| 63 | IKBKE | IKBKE Entrez,  Source | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | 7216 | 0.004 | 0.0249 | No |
| 64 | ITK | ITK Entrez,  Source | IL2-inducible T-cell kinase | 7220 | 0.004 | 0.0250 | No |
| 65 | SIK2 | 7435 | 0.001 | 0.0087 | No | ||
| 66 | SNRK | SNRK Entrez,  Source | SNF related kinase | 7658 | -0.003 | -0.0081 | No |
| 67 | PDGFRB | PDGFRB Entrez,  Source | platelet-derived growth factor receptor, beta polypeptide | 7824 | -0.006 | -0.0202 | No |
| 68 | MAPK9 | MAPK9 Entrez,  Source | mitogen-activated protein kinase 9 | 7830 | -0.006 | -0.0201 | No |
| 69 | MKNK2 | MKNK2 Entrez,  Source | MAP kinase interacting serine/threonine kinase 2 | 7841 | -0.006 | -0.0203 | No |
| 70 | TAOK2 | TAOK2 Entrez,  Source | TAO kinase 2 | 8059 | -0.010 | -0.0361 | No |
| 71 | KIT | KIT Entrez,  Source | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog | 8134 | -0.012 | -0.0408 | No |
| 72 | RPS6KA4 | RPS6KA4 Entrez,  Source | ribosomal protein S6 kinase, 90kDa, polypeptide 4 | 8181 | -0.013 | -0.0433 | No |
| 73 | MAP2K5 | MAP2K5 Entrez,  Source | mitogen-activated protein kinase kinase 5 | 8199 | -0.013 | -0.0435 | No |
| 74 | MARK4 | MARK4 Entrez,  Source | MAP/microtubule affinity-regulating kinase 4 | 8259 | -0.014 | -0.0468 | No |
| 75 | DMPK | DMPK Entrez,  Source | dystrophia myotonica-protein kinase | 8344 | -0.016 | -0.0519 | No |
| 76 | PTK2 | PTK2 Entrez,  Source | PTK2 protein tyrosine kinase 2 | 8356 | -0.016 | -0.0514 | No |
| 77 | AURKB | AURKB Entrez,  Source | aurora kinase B | 8856 | -0.027 | -0.0873 | No |
| 78 | STK11 | STK11 Entrez,  Source | serine/threonine kinase 11 | 9183 | -0.035 | -0.1094 | No |
| 79 | TYK2 | TYK2 Entrez,  Source | tyrosine kinase 2 | 9438 | -0.041 | -0.1255 | No |
| 80 | CSNK2A2 | CSNK2A2 Entrez,  Source | casein kinase 2, alpha prime polypeptide | 9758 | -0.049 | -0.1458 | No |
| 81 | NEK9 | NEK9 Entrez,  Source | NIMA (never in mitosis gene a)- related kinase 9 | 9810 | -0.051 | -0.1455 | No |
| 82 | DCLK1 | 9840 | -0.052 | -0.1435 | No | ||
| 83 | TTK | TTK Entrez,  Source | TTK protein kinase | 9930 | -0.055 | -0.1457 | No |
| 84 | STK17A | STK17A Entrez,  Source | serine/threonine kinase 17a (apoptosis-inducing) | 10017 | -0.057 | -0.1476 | No |
| 85 | HIPK2 | HIPK2 Entrez,  Source | homeodomain interacting protein kinase 2 | 10151 | -0.061 | -0.1528 | No |
| 86 | DDR2 | DDR2 Entrez,  Source | discoidin domain receptor family, member 2 | 10235 | -0.064 | -0.1539 | No |
| 87 | MARK3 | MARK3 Entrez,  Source | MAP/microtubule affinity-regulating kinase 3 | 10374 | -0.068 | -0.1588 | No |
| 88 | CIT | CIT Entrez,  Source | citron (rho-interacting, serine/threonine kinase 21) | 10420 | -0.070 | -0.1565 | No |
| 89 | PLK1 | PLK1 Entrez,  Source | polo-like kinase 1 (Drosophila) | 10440 | -0.071 | -0.1521 | No |
| 90 | PLK4 | PLK4 Entrez,  Source | polo-like kinase 4 (Drosophila) | 10581 | -0.075 | -0.1565 | No |
| 91 | JAK1 | JAK1 Entrez,  Source | Janus kinase 1 (a protein tyrosine kinase) | 10585 | -0.076 | -0.1505 | No |
| 92 | TBK1 | TBK1 Entrez,  Source | TANK-binding kinase 1 | 10732 | -0.082 | -0.1550 | No |
| 93 | SRC | SRC Entrez,  Source | v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | 10776 | -0.083 | -0.1514 | No |
| 94 | PIP5K1A | PIP5K1A Entrez,  Source | phosphatidylinositol-4-phosphate 5-kinase, type I, alpha | 10780 | -0.083 | -0.1447 | No |
| 95 | CDK4 | CDK4 Entrez,  Source | cyclin-dependent kinase 4 | 10871 | -0.087 | -0.1444 | No |
| 96 | NUAK1 | NUAK1 Entrez,  Source | NUAK family, SNF1-like kinase, 1 | 11032 | -0.095 | -0.1488 | No |
| 97 | DAPK3 | DAPK3 Entrez,  Source | death-associated protein kinase 3 | 11066 | -0.096 | -0.1434 | No |
| 98 | SRPK1 | SRPK1 Entrez,  Source | SFRS protein kinase 1 | 11068 | -0.096 | -0.1355 | No |
| 99 | ABL2 | ABL2 Entrez,  Source | v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene) | 11090 | -0.098 | -0.1290 | No |
| 100 | CDK7 | CDK7 Entrez,  Source | cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase) | 11160 | -0.101 | -0.1260 | No |
| 101 | MYLK | MYLK Entrez,  Source | myosin, light chain kinase | 11255 | -0.105 | -0.1245 | No |
| 102 | SRPK2 | SRPK2 Entrez,  Source | SFRS protein kinase 2 | 11496 | -0.117 | -0.1332 | No |
| 103 | JAK2 | JAK2 Entrez,  Source | Janus kinase 2 (a protein tyrosine kinase) | 11530 | -0.119 | -0.1259 | No |
| 104 | SLK | SLK Entrez,  Source | STE20-like kinase (yeast) | 11672 | -0.128 | -0.1262 | No |
| 105 | FYN | FYN Entrez,  Source | FYN oncogene related to SRC, FGR, YES | 11767 | -0.133 | -0.1224 | No |
| 106 | NEK3 | NEK3 Entrez,  Source | NIMA (never in mitosis gene a)-related kinase 3 | 11797 | -0.135 | -0.1134 | No |
| 107 | HIPK1 | HIPK1 Entrez,  Source | homeodomain interacting protein kinase 1 | 11798 | -0.135 | -0.1022 | No |
| 108 | PRPF4B | PRPF4B Entrez,  Source | PRP4 pre-mRNA processing factor 4 homolog B (yeast) | 11856 | -0.139 | -0.0951 | No |
| 109 | CSNK2A1 | CSNK2A1 Entrez,  Source | casein kinase 2, alpha 1 polypeptide | 11861 | -0.139 | -0.0839 | No |
| 110 | MAP3K2 | MAP3K2 Entrez,  Source | mitogen-activated protein kinase kinase kinase 2 | 12210 | -0.168 | -0.0966 | No |
| 111 | SIK1 | 12319 | -0.179 | -0.0901 | No | ||
| 112 | IRAK3 | IRAK3 Entrez,  Source | interleukin-1 receptor-associated kinase 3 | 12451 | -0.196 | -0.0840 | No |
| 113 | ABL1 | ABL1 Entrez,  Source | v-abl Abelson murine leukemia viral oncogene homolog 1 | 12463 | -0.197 | -0.0685 | No |
| 114 | ZAK | ZAK Entrez,  Source | - | 12544 | -0.209 | -0.0574 | No |
| 115 | CDK17 | 12578 | -0.213 | -0.0423 | No | ||
| 116 | AXL | AXL Entrez,  Source | AXL receptor tyrosine kinase | 12789 | -0.257 | -0.0371 | No |
| 117 | CHUK | CHUK Entrez,  Source | conserved helix-loop-helix ubiquitous kinase | 12978 | -0.325 | -0.0246 | No |
| 118 | FGFR1 | FGFR1 Entrez,  Source | fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome) | 13121 | -0.486 | 0.0047 | No |

