DatasetNSCLC_collapsed_to_symbols.NSCLC.cls
#SEN_versus_RES.NSCLC.cls
#SEN_versus_RES_repos
PhenotypeNSCLC.cls#SEN_versus_RES_repos
Upregulated in class1
GeneSetBOSUTINIB_LINCS
Enrichment Score (ES)0.41692895
Normalized Enrichment Score (NES)1.4036812
Nominal p-value0.048986487
FDR q-value0.57902825
FWER p-Value1.0
Table: GSEA Results Summary



Fig 1: Enrichment plot: BOSUTINIB_LINCS   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEGENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1ERBB3ERBB3
Entrez,  Source
v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)121.0340.1263Yes
2ERBB2ERBB2
Entrez,  Source
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)1000.5370.1858Yes
3FRKFRK
Entrez,  Source
fyn-related kinase2960.3430.2131Yes
4PRKCDPRKCD
Entrez,  Source
protein kinase C, delta3060.3370.2538Yes
5MST43180.3310.2937Yes
6SYKSYK
Entrez,  Source
spleen tyrosine kinase4710.2680.3151Yes
7EGFREGFR
Entrez,  Source
epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)6250.2300.3317Yes
8PAK1PAK1
Entrez,  Source
p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast)6740.2190.3550Yes
9TNIKTNIK
Entrez,  Source
TRAF2 and NCK interacting kinase11970.1450.3331Yes
10LCKLCK
Entrez,  Source
lymphocyte-specific protein tyrosine kinase13100.1360.3412Yes
11GAKGAK
Entrez,  Source
cyclin G associated kinase13400.1330.3554Yes
12CAMK1DCAMK1D
Entrez,  Source
calcium/calmodulin-dependent protein kinase ID13870.1290.3678Yes
13STK3STK3
Entrez,  Source
serine/threonine kinase 3 (STE20 homolog, yeast)15530.1200.3699Yes
14WEE1WEE1
Entrez,  Source
WEE1 homolog (S. pombe)16390.1150.3776Yes
15MAP3K9MAP3K9
Entrez,  Source
mitogen-activated protein kinase kinase kinase 916990.1120.3869Yes
16ERBB4ERBB4
Entrez,  Source
v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)18130.1070.3914Yes
17CSNK1DCSNK1D
Entrez,  Source
casein kinase 1, delta18510.1050.4015Yes
18RIOK3RIOK3
Entrez,  Source
RIO kinase 3 (yeast)19420.1010.4070Yes
19LYNLYN
Entrez,  Source
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog19740.1000.4169Yes
20AAK1AAK1
Entrez,  Source
AP2 associated kinase 122120.0920.4102No
21MAP3K11MAP3K11
Entrez,  Source
mitogen-activated protein kinase kinase kinase 1122950.0890.4149No
22MAP3K4MAP3K4
Entrez,  Source
mitogen-activated protein kinase kinase kinase 424890.0830.4104No
23EPHA3EPHA3
Entrez,  Source
EPH receptor A328700.0740.3905No
24EIF2AK1EIF2AK1
Entrez,  Source
eukaryotic translation initiation factor 2-alpha kinase 130080.0700.3887No
25YES1YES1
Entrez,  Source
v-yes-1 Yamaguchi sarcoma viral oncogene homolog 130360.0700.3952No
26CSKCSK
Entrez,  Source
c-src tyrosine kinase30690.0690.4013No
27MINK1MINK1
Entrez,  Source
misshapen-like kinase 1 (zebrafish)30800.0690.4090No
28BLKBLK
Entrez,  Source
B lymphoid tyrosine kinase34190.0620.3909No
29CSF1RCSF1R
Entrez,  Source
colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog34540.0620.3959No
30CSNK1A1CSNK1A1
Entrez,  Source
casein kinase 1, alpha 136980.0580.3844No
31FGRFGR
Entrez,  Source
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog41930.0490.3528No
32NEK2NEK2
Entrez,  Source
NIMA (never in mitosis gene a)-related kinase 244830.0450.3363No
33EPHA2EPHA2
Entrez,  Source
EPH receptor A248800.0390.3109No
34MAPK4MAPK4
Entrez,  Source
mitogen-activated protein kinase 455850.0290.2609No
35STK24STK24
Entrez,  Source
serine/threonine kinase 24 (STE20 homolog, yeast)55870.0290.2644No
36BTKBTK
Entrez,  Source
Bruton agammaglobulinemia tyrosine kinase56280.0290.2649No
37SRPK3SRPK3
Entrez,  Source
SFRS protein kinase 358600.0260.2504No
38MAP3K3MAP3K3
Entrez,  Source
mitogen-activated protein kinase kinase kinase 359210.0250.2489No
39FESFES
Entrez,  Source
feline sarcoma oncogene61260.0220.2360No
40RETRET
Entrez,  Source
ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease)64710.0160.2118No
41PIP4K2B65940.0150.2043No
42GRK4GRK4
Entrez,  Source
G protein-coupled receptor kinase 467880.0120.1910No
43MAP4K2MAP4K2
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 268940.0100.1843No
44BMP2KBMP2K
Entrez,  Source
BMP2 inducible kinase70290.0080.1750No
45SIK274350.0010.1443No
46SIK37726-0.0040.1226No
47CSNK1ECSNK1E
Entrez,  Source
casein kinase 1, epsilon7742-0.0040.1220No
48MAP2K1MAP2K1
Entrez,  Source
mitogen-activated protein kinase kinase 17939-0.0080.1080No
49MAP2K5MAP2K5
Entrez,  Source
mitogen-activated protein kinase kinase 58199-0.0130.0899No
50DMPKDMPK
Entrez,  Source
dystrophia myotonica-protein kinase8344-0.0160.0809No
51VRK2VRK2
Entrez,  Source
vaccinia related kinase 28412-0.0170.0780No
52STK25STK25
Entrez,  Source
serine/threonine kinase 25 (STE20 homolog, yeast)8561-0.0210.0692No
53MAP4K4MAP4K4
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 49922-0.055-0.0278No
54HCKHCK
Entrez,  Source
hemopoietic cell kinase9981-0.056-0.0253No
55CITCIT
Entrez,  Source
citron (rho-interacting, serine/threonine kinase 21)10420-0.070-0.0501No
56SRCSRC
Entrez,  Source
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)10776-0.083-0.0669No
57ABL2ABL2
Entrez,  Source
v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)11090-0.098-0.0788No
58STK10STK10
Entrez,  Source
serine/threonine kinase 1011218-0.103-0.0758No
59BMPR2BMPR2
Entrez,  Source
bone morphogenetic protein receptor, type II (serine/threonine kinase)11345-0.109-0.0719No
60JAK2JAK2
Entrez,  Source
Janus kinase 2 (a protein tyrosine kinase)11530-0.119-0.0713No
61SLKSLK
Entrez,  Source
STE20-like kinase (yeast)11672-0.128-0.0664No
62MAP4K5MAP4K5
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 511705-0.130-0.0529No
63MAP2K2MAP2K2
Entrez,  Source
mitogen-activated protein kinase kinase 211895-0.142-0.0499No
64MAP3K2MAP3K2
Entrez,  Source
mitogen-activated protein kinase kinase kinase 212210-0.168-0.0532No
65MAPK6MAPK6
Entrez,  Source
mitogen-activated protein kinase 612214-0.168-0.0327No
66MAP4K3MAP4K3
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 312403-0.189-0.0238No
67ABL1ABL1
Entrez,  Source
v-abl Abelson murine leukemia viral oncogene homolog 112463-0.197-0.0040No
68MAP3K7MAP3K7
Entrez,  Source
mitogen-activated protein kinase kinase kinase 712613-0.2210.0117No
69AXLAXL
Entrez,  Source
AXL receptor tyrosine kinase12789-0.2570.0300No
Table: GSEA details [plain text format]



Fig 2: BOSUTINIB_LINCS   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: BOSUTINIB_LINCS: Random ES distribution   
Gene set null distribution of ES for BOSUTINIB_LINCS