DatasetNSCLC_collapsed_to_symbols.NSCLC.cls
#SEN_versus_RES.NSCLC.cls
#SEN_versus_RES_repos
PhenotypeNSCLC.cls#SEN_versus_RES_repos
Upregulated in class1
GeneSetBOSUTINIB_FDA
Enrichment Score (ES)0.33448195
Normalized Enrichment Score (NES)1.2419492
Nominal p-value0.10696921
FDR q-value0.63008153
FWER p-Value1.0
Table: GSEA Results Summary



Fig 1: Enrichment plot: BOSUTINIB_FDA   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEGENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1ERBB3ERBB3
Entrez,  Source
v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)121.0340.0775Yes
2ERBB2ERBB2
Entrez,  Source
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)1000.5370.1116Yes
3DDR1DDR1
Entrez,  Source
discoidin domain receptor family, member 12120.4040.1337Yes
4FRKFRK
Entrez,  Source
fyn-related kinase2960.3430.1533Yes
5PRKCDPRKCD
Entrez,  Source
protein kinase C, delta3060.3370.1781Yes
6MST43180.3310.2024Yes
7SYKSYK
Entrez,  Source
spleen tyrosine kinase4710.2680.2111Yes
8MAP3K13MAP3K13
Entrez,  Source
mitogen-activated protein kinase kinase kinase 136240.2300.2169Yes
9EGFREGFR
Entrez,  Source
epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)6250.2300.2343Yes
10PAK1PAK1
Entrez,  Source
p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast)6740.2190.2472Yes
11EPHA4EPHA4
Entrez,  Source
EPH receptor A47980.1970.2528Yes
12EPHB2EPHB2
Entrez,  Source
EPH receptor B28680.1850.2616Yes
13TAOK3TAOK3
Entrez,  Source
TAO kinase 39710.1700.2666Yes
14TXKTXK
Entrez,  Source
TXK tyrosine kinase10450.1600.2731Yes
15TNIKTNIK
Entrez,  Source
TRAF2 and NCK interacting kinase11970.1450.2726Yes
16LCKLCK
Entrez,  Source
lymphocyte-specific protein tyrosine kinase13100.1360.2743Yes
17GAKGAK
Entrez,  Source
cyclin G associated kinase13400.1330.2822Yes
18CAMK1DCAMK1D
Entrez,  Source
calcium/calmodulin-dependent protein kinase ID13870.1290.2885Yes
19EPHB3EPHB3
Entrez,  Source
EPH receptor B314260.1270.2952Yes
20NEK11NEK11
Entrez,  Source
NIMA (never in mitosis gene a)- related kinase 1115220.1220.2971Yes
21STK3STK3
Entrez,  Source
serine/threonine kinase 3 (STE20 homolog, yeast)15530.1200.3039Yes
22WEE1WEE1
Entrez,  Source
WEE1 homolog (S. pombe)16390.1150.3062Yes
23MAP3K9MAP3K9
Entrez,  Source
mitogen-activated protein kinase kinase kinase 916990.1120.3102Yes
24ERBB4ERBB4
Entrez,  Source
v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)18130.1070.3096Yes
25CSNK1DCSNK1D
Entrez,  Source
casein kinase 1, delta18510.1050.3147Yes
26RIOK3RIOK3
Entrez,  Source
RIO kinase 3 (yeast)19420.1010.3155Yes
27LYNLYN
Entrez,  Source
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog19740.1000.3206Yes
28CASKCASK
Entrez,  Source
calcium/calmodulin-dependent serine protein kinase (MAGUK family)20070.0990.3257Yes
29PTK2BPTK2B
Entrez,  Source
PTK2B protein tyrosine kinase 2 beta20420.0980.3305Yes
30AAK1AAK1
Entrez,  Source
AP2 associated kinase 122120.0920.3245Yes
31ULK2ULK2
Entrez,  Source
unc-51-like kinase 2 (C. elegans)22440.0910.3290Yes
32MAP3K11MAP3K11
Entrez,  Source
mitogen-activated protein kinase kinase kinase 1122950.0890.3319Yes
33CLK3CLK3
Entrez,  Source
CDC-like kinase 323490.0870.3345Yes
34MAP3K4MAP3K4
Entrez,  Source
mitogen-activated protein kinase kinase kinase 424890.0830.3301No
35MERTKMERTK
Entrez,  Source
c-mer proto-oncogene tyrosine kinase25220.0820.3339No
36MAP4K1MAP4K1
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 128490.0740.3146No
37EPHA3EPHA3
Entrez,  Source
EPH receptor A328700.0740.3186No
38TNK2TNK2
Entrez,  Source
tyrosine kinase, non-receptor, 230050.0700.3137No
39EIF2AK1EIF2AK1
Entrez,  Source
eukaryotic translation initiation factor 2-alpha kinase 130080.0700.3189No
40YES1YES1
Entrez,  Source
v-yes-1 Yamaguchi sarcoma viral oncogene homolog 130360.0700.3221No
41CSKCSK
Entrez,  Source
c-src tyrosine kinase30690.0690.3249No
42MINK1MINK1
Entrez,  Source
misshapen-like kinase 1 (zebrafish)30800.0690.3294No
43FLT3FLT3
Entrez,  Source
fms-related tyrosine kinase 334030.0630.3095No
44BLKBLK
Entrez,  Source
B lymphoid tyrosine kinase34190.0620.3130No
45CSF1RCSF1R
Entrez,  Source
colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog34540.0620.3151No
46CSNK1A1CSNK1A1
Entrez,  Source
casein kinase 1, alpha 136980.0580.3009No
47EPHB4EPHB4
Entrez,  Source
EPH receptor B438790.0540.2912No
48EPHB1EPHB1
Entrez,  Source
EPH receptor B140000.0520.2860No
49ALKALK
Entrez,  Source
anaplastic lymphoma kinase (Ki-1)40730.0510.2844No
50FGRFGR
Entrez,  Source
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog41930.0490.2790No
51NEK2NEK2
Entrez,  Source
NIMA (never in mitosis gene a)-related kinase 244830.0450.2603No
52BMXBMX
Entrez,  Source
BMX non-receptor tyrosine kinase48260.0400.2371No
53EPHA2EPHA2
Entrez,  Source
EPH receptor A248800.0390.2360No
54TNNI3KTNNI3K
Entrez,  Source
TNNI3 interacting kinase52740.0330.2085No
55MAST1MAST1
Entrez,  Source
microtubule associated serine/threonine kinase 154360.0320.1985No
56EPHA5EPHA5
Entrez,  Source
EPH receptor A554750.0310.1980No
57MAPK4MAPK4
Entrez,  Source
mitogen-activated protein kinase 455850.0290.1918No
58STK24STK24
Entrez,  Source
serine/threonine kinase 24 (STE20 homolog, yeast)55870.0290.1940No
59BTKBTK
Entrez,  Source
Bruton agammaglobulinemia tyrosine kinase56280.0290.1931No
60SRPK3SRPK3
Entrez,  Source
SFRS protein kinase 358600.0260.1774No
61MAP3K3MAP3K3
Entrez,  Source
mitogen-activated protein kinase kinase kinase 359210.0250.1747No
62NTRK1NTRK1
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 160970.0220.1629No
63FESFES
Entrez,  Source
feline sarcoma oncogene61260.0220.1624No
64IRAK1IRAK1
Entrez,  Source
interleukin-1 receptor-associated kinase 161790.0210.1600No
65PHKG1PHKG1
Entrez,  Source
phosphorylase kinase, gamma 1 (muscle)62450.0200.1566No
66RETRET
Entrez,  Source
ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease)64710.0160.1406No
67PIP4K2B65940.0150.1323No
68GRK4GRK4
Entrez,  Source
G protein-coupled receptor kinase 467880.0120.1185No
69MAP4K2MAP4K2
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 268940.0100.1112No
70BMP2KBMP2K
Entrez,  Source
BMP2 inducible kinase70290.0080.1015No
71IKBKEIKBKE
Entrez,  Source
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon72160.0040.0876No
72SIK274350.0010.0710No
73SIK37726-0.0040.0491No
74CSNK1ECSNK1E
Entrez,  Source
casein kinase 1, epsilon7742-0.0040.0483No
75PDGFRBPDGFRB
Entrez,  Source
platelet-derived growth factor receptor, beta polypeptide7824-0.0060.0425No
76PKMYT1PKMYT1
Entrez,  Source
protein kinase, membrane associated tyrosine/threonine 17836-0.0060.0421No
77MAP2K1MAP2K1
Entrez,  Source
mitogen-activated protein kinase kinase 17939-0.0080.0349No
78KITKIT
Entrez,  Source
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog8134-0.0120.0210No
79MAP2K5MAP2K5
Entrez,  Source
mitogen-activated protein kinase kinase 58199-0.0130.0171No
80DMPKDMPK
Entrez,  Source
dystrophia myotonica-protein kinase8344-0.0160.0073No
81PTK2PTK2
Entrez,  Source
PTK2 protein tyrosine kinase 28356-0.0160.0077No
82VRK2VRK2
Entrez,  Source
vaccinia related kinase 28412-0.0170.0048No
83STK25STK25
Entrez,  Source
serine/threonine kinase 25 (STE20 homolog, yeast)8561-0.021-0.0050No
84ROCK1ROCK1
Entrez,  Source
Rho-associated, coiled-coil containing protein kinase 18741-0.025-0.0168No
85IRAK4IRAK4
Entrez,  Source
interleukin-1 receptor-associated kinase 48996-0.031-0.0339No
86PHKA2PHKA2
Entrez,  Source
phosphorylase kinase, alpha 2 (liver)9057-0.032-0.0361No
87PAK3PAK3
Entrez,  Source
p21 (CDKN1A)-activated kinase 39490-0.042-0.0660No
88MAP4K4MAP4K4
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 49922-0.055-0.0949No
89HCKHCK
Entrez,  Source
hemopoietic cell kinase9981-0.056-0.0950No
90PLK2PLK2
Entrez,  Source
polo-like kinase 2 (Drosophila)9994-0.057-0.0917No
91CHEK2CHEK2
Entrez,  Source
CHK2 checkpoint homolog (S. pombe)10102-0.059-0.0954No
92DDR2DDR2
Entrez,  Source
discoidin domain receptor family, member 210235-0.064-0.1007No
93CITCIT
Entrez,  Source
citron (rho-interacting, serine/threonine kinase 21)10420-0.070-0.1095No
94RPS6KB1RPS6KB1
Entrez,  Source
ribosomal protein S6 kinase, 70kDa, polypeptide 110717-0.081-0.1260No
95CAMKK2CAMKK2
Entrez,  Source
calcium/calmodulin-dependent protein kinase kinase 2, beta10729-0.081-0.1207No
96TBK1TBK1
Entrez,  Source
TANK-binding kinase 110732-0.082-0.1146No
97SRCSRC
Entrez,  Source
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)10776-0.083-0.1116No
98PRKCQPRKCQ
Entrez,  Source
protein kinase C, theta10961-0.092-0.1187No
99NUAK1NUAK1
Entrez,  Source
NUAK family, SNF1-like kinase, 111032-0.095-0.1169No
100ABL2ABL2
Entrez,  Source
v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)11090-0.098-0.1139No
101STK10STK10
Entrez,  Source
serine/threonine kinase 1011218-0.103-0.1158No
102MYLKMYLK
Entrez,  Source
myosin, light chain kinase11255-0.105-0.1106No
103BMPR2BMPR2
Entrez,  Source
bone morphogenetic protein receptor, type II (serine/threonine kinase)11345-0.109-0.1091No
104FERFER
Entrez,  Source
fer (fps/fes related) tyrosine kinase (phosphoprotein NCP94)11371-0.111-0.1027No
105STK4STK4
Entrez,  Source
serine/threonine kinase 411518-0.118-0.1049No
106JAK2JAK2
Entrez,  Source
Janus kinase 2 (a protein tyrosine kinase)11530-0.119-0.0967No
107TYRO3TYRO3
Entrez,  Source
TYRO3 protein tyrosine kinase11601-0.123-0.0928No
108SLKSLK
Entrez,  Source
STE20-like kinase (yeast)11672-0.128-0.0884No
109MAP4K5MAP4K5
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 511705-0.130-0.0811No
110FYNFYN
Entrez,  Source
FYN oncogene related to SRC, FGR, YES11767-0.133-0.0756No
111HIPK1HIPK1
Entrez,  Source
homeodomain interacting protein kinase 111798-0.135-0.0677No
112MAP2K2MAP2K2
Entrez,  Source
mitogen-activated protein kinase kinase 211895-0.142-0.0643No
113ROCK2ROCK2
Entrez,  Source
Rho-associated, coiled-coil containing protein kinase 212033-0.152-0.0632No
114MAP3K2MAP3K2
Entrez,  Source
mitogen-activated protein kinase kinase kinase 212210-0.168-0.0640No
115MAPK6MAPK6
Entrez,  Source
mitogen-activated protein kinase 612214-0.168-0.0515No
116SIK112319-0.179-0.0459No
117MAP3K12MAP3K12
Entrez,  Source
mitogen-activated protein kinase kinase kinase 1212384-0.186-0.0366No
118MAP4K3MAP4K3
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 312403-0.189-0.0237No
119ABL1ABL1
Entrez,  Source
v-abl Abelson murine leukemia viral oncogene homolog 112463-0.197-0.0133No
120ZAKZAK
Entrez,  Source
-12544-0.209-0.0035No
121TLK1TLK1
Entrez,  Source
tousled-like kinase 112558-0.2100.0114No
122MAP3K7MAP3K7
Entrez,  Source
mitogen-activated protein kinase kinase kinase 712613-0.2210.0240No
123AXLAXL
Entrez,  Source
AXL receptor tyrosine kinase12789-0.2570.0301No
Table: GSEA details [plain text format]



Fig 2: BOSUTINIB_FDA   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: BOSUTINIB_FDA: Random ES distribution   
Gene set null distribution of ES for BOSUTINIB_FDA