DatasetNSCLC_collapsed_to_symbols.NSCLC.cls
#SEN_versus_RES.NSCLC.cls
#SEN_versus_RES_repos
PhenotypeNSCLC.cls#SEN_versus_RES_repos
Upregulated in class1
GeneSetK252A_MRC
Enrichment Score (ES)0.3268906
Normalized Enrichment Score (NES)1.1821753
Nominal p-value0.17687075
FDR q-value0.630116
FWER p-Value1.0
Table: GSEA Results Summary



Fig 1: Enrichment plot: K252A_MRC   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEGENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1DAPK1DAPK1
Entrez,  Source
death-associated protein kinase 1880.5570.0456Yes
2MAPK13MAPK13
Entrez,  Source
mitogen-activated protein kinase 131100.5250.0935Yes
3PTK6PTK6
Entrez,  Source
PTK6 protein tyrosine kinase 61410.4790.1362Yes
4PAK6PAK6
Entrez,  Source
p21(CDKN1A)-activated kinase 61580.4590.1782Yes
5PRKCZPRKCZ
Entrez,  Source
protein kinase C, zeta1690.4470.2194Yes
6MST43180.3310.2392Yes
7SYKSYK
Entrez,  Source
spleen tyrosine kinase4710.2680.2528Yes
8IKBKBIKBKB
Entrez,  Source
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta5530.2450.2697Yes
9EPHA4EPHA4
Entrez,  Source
EPH receptor A47980.1970.2696Yes
10EPHB2EPHB2
Entrez,  Source
EPH receptor B28680.1850.2818Yes
11MAPK10MAPK10
Entrez,  Source
mitogen-activated protein kinase 1010690.1570.2813Yes
12DYRK2DYRK2
Entrez,  Source
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 212300.1420.2824Yes
13LCKLCK
Entrez,  Source
lymphocyte-specific protein tyrosine kinase13100.1360.2892Yes
14MAPKAPK3MAPKAPK3
Entrez,  Source
mitogen-activated protein kinase-activated protein kinase 315480.1200.2824Yes
15STK3STK3
Entrez,  Source
serine/threonine kinase 3 (STE20 homolog, yeast)15530.1200.2933Yes
16INSRINSR
Entrez,  Source
insulin receptor16640.1140.2956Yes
17RPS6KA1RPS6KA1
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 116860.1130.3046Yes
18MAP3K9MAP3K9
Entrez,  Source
mitogen-activated protein kinase kinase kinase 916990.1120.3143Yes
19MAPK3MAPK3
Entrez,  Source
mitogen-activated protein kinase 317660.1090.3195Yes
20ERBB4ERBB4
Entrez,  Source
v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)18130.1070.3260Yes
21EIF2AK3EIF2AK3
Entrez,  Source
eukaryotic translation initiation factor 2-alpha kinase 319510.1010.3250Yes
22MAP3K5MAP3K5
Entrez,  Source
mitogen-activated protein kinase kinase kinase 521470.0940.3190Yes
23MARK1MARK1
Entrez,  Source
MAP/microtubule affinity-regulating kinase 121590.0930.3269Yes
24MAP3K11MAP3K11
Entrez,  Source
mitogen-activated protein kinase kinase kinase 1122950.0890.3249No
25TAOK1TAOK1
Entrez,  Source
TAO kinase 125520.0820.3131No
26RPS6KA5RPS6KA5
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 526100.0800.3163No
27PIM2PIM2
Entrez,  Source
pim-2 oncogene29560.0710.2966No
28YES1YES1
Entrez,  Source
v-yes-1 Yamaguchi sarcoma viral oncogene homolog 130360.0700.2971No
29MINK1MINK1
Entrez,  Source
misshapen-like kinase 1 (zebrafish)30800.0690.3003No
30PIM1PIM1
Entrez,  Source
pim-1 oncogene41360.0500.2244No
31MAP3K1MAP3K1
Entrez,  Source
mitogen-activated protein kinase kinase kinase 142810.0480.2180No
32EPHA2EPHA2
Entrez,  Source
EPH receptor A248800.0390.1759No
33FLT1FLT1
Entrez,  Source
fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)48820.0390.1795No
34PAK4PAK4
Entrez,  Source
p21(CDKN1A)-activated kinase 450140.0370.1730No
35INSRRINSRR
Entrez,  Source
insulin receptor-related receptor53320.0330.1519No
36BTKBTK
Entrez,  Source
Bruton agammaglobulinemia tyrosine kinase56280.0290.1321No
37STK16STK16
Entrez,  Source
serine/threonine kinase 1657780.0270.1232No
38PAK7PAK7
Entrez,  Source
p21(CDKN1A)-activated kinase 758810.0250.1178No
39MAPK1MAPK1
Entrez,  Source
mitogen-activated protein kinase 159940.0240.1115No
40NTRK1NTRK1
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 160970.0220.1057No
41IRAK1IRAK1
Entrez,  Source
interleukin-1 receptor-associated kinase 161790.0210.1015No
42AURKAAURKA
Entrez,  Source
aurora kinase A64270.0170.0842No
43MAPK8MAPK8
Entrez,  Source
mitogen-activated protein kinase 868290.0110.0546No
44MAP4K2MAP4K2
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 268940.0100.0507No
45TEKTEK
Entrez,  Source
TEK tyrosine kinase, endothelial (venous malformations, multiple cutaneous and mucosal)70350.0080.0407No
46CLK2CLK2
Entrez,  Source
CDC-like kinase 271810.0050.0301No
47IKBKEIKBKE
Entrez,  Source
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon72160.0040.0280No
48AKT1AKT1
Entrez,  Source
v-akt murine thymoma viral oncogene homolog 173870.0020.0151No
49PRKAA2PRKAA2
Entrez,  Source
protein kinase, AMP-activated, alpha 2 catalytic subunit74180.0010.0129No
50MAPK9MAPK9
Entrez,  Source
mitogen-activated protein kinase 97830-0.006-0.0179No
51MKNK2MKNK2
Entrez,  Source
MAP kinase interacting serine/threonine kinase 27841-0.006-0.0181No
52MAP2K1MAP2K1
Entrez,  Source
mitogen-activated protein kinase kinase 17939-0.008-0.0247No
53IGF1RIGF1R
Entrez,  Source
insulin-like growth factor 1 receptor7959-0.008-0.0254No
54MELKMELK
Entrez,  Source
maternal embryonic leucine zipper kinase8047-0.010-0.0311No
55PRKACAPRKACA
Entrez,  Source
protein kinase, cAMP-dependent, catalytic, alpha8112-0.011-0.0349No
56MARK4MARK4
Entrez,  Source
MAP/microtubule affinity-regulating kinase 48259-0.014-0.0448No
57PDK1PDK1
Entrez,  Source
pyruvate dehydrogenase kinase, isozyme 18449-0.018-0.0575No
58AURKBAURKB
Entrez,  Source
aurora kinase B8856-0.027-0.0859No
59ZAP70ZAP70
Entrez,  Source
zeta-chain (TCR) associated protein kinase 70kDa8954-0.030-0.0905No
60IRAK4IRAK4
Entrez,  Source
interleukin-1 receptor-associated kinase 48996-0.031-0.0908No
61PHKA2PHKA2
Entrez,  Source
phosphorylase kinase, alpha 2 (liver)9057-0.032-0.0924No
62STK11STK11
Entrez,  Source
serine/threonine kinase 119183-0.035-0.0987No
63MAPKAPK2MAPKAPK2
Entrez,  Source
mitogen-activated protein kinase-activated protein kinase 29187-0.035-0.0956No
64CDK2CDK2
Entrez,  Source
cyclin-dependent kinase 29409-0.040-0.1087No
65HIPK3HIPK3
Entrez,  Source
homeodomain interacting protein kinase 39770-0.050-0.1315No
66PRKD1PRKD1
Entrez,  Source
protein kinase D19827-0.052-0.1310No
67CHEK2CHEK2
Entrez,  Source
CHK2 checkpoint homolog (S. pombe)10102-0.059-0.1463No
68HIPK2HIPK2
Entrez,  Source
homeodomain interacting protein kinase 210151-0.061-0.1443No
69DYRK1ADYRK1A
Entrez,  Source
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A10303-0.066-0.1496No
70MARK3MARK3
Entrez,  Source
MAP/microtubule affinity-regulating kinase 310374-0.068-0.1486No
71RPS6KA3RPS6KA3
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 310427-0.070-0.1459No
72OXSR1OXSR1
Entrez,  Source
oxidative-stress responsive 110514-0.073-0.1456No
73RPS6KB1RPS6KB1
Entrez,  Source
ribosomal protein S6 kinase, 70kDa, polypeptide 110717-0.081-0.1534No
74CAMKK2CAMKK2
Entrez,  Source
calcium/calmodulin-dependent protein kinase kinase 2, beta10729-0.081-0.1466No
75TBK1TBK1
Entrez,  Source
TANK-binding kinase 110732-0.082-0.1391No
76BRSK2BRSK2
Entrez,  Source
BR serine/threonine kinase 210749-0.082-0.1326No
77SRCSRC
Entrez,  Source
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)10776-0.083-0.1268No
78CHEK1CHEK1
Entrez,  Source
CHK1 checkpoint homolog (S. pombe)10792-0.084-0.1200No
79PAK2PAK2
Entrez,  Source
p21 (CDKN1A)-activated kinase 210809-0.085-0.1133No
80MAPKAPK5MAPKAPK5
Entrez,  Source
mitogen-activated protein kinase-activated protein kinase 510962-0.092-0.1163No
81NUAK1NUAK1
Entrez,  Source
NUAK family, SNF1-like kinase, 111032-0.095-0.1126No
82GSK3BGSK3B
Entrez,  Source
glycogen synthase kinase 3 beta11131-0.100-0.1107No
83MYLKMYLK
Entrez,  Source
myosin, light chain kinase11255-0.105-0.1103No
84RIPK2RIPK2
Entrez,  Source
receptor-interacting serine-threonine kinase 211349-0.110-0.1071No
85JAK2JAK2
Entrez,  Source
Janus kinase 2 (a protein tyrosine kinase)11530-0.119-0.1097No
86HIPK1HIPK1
Entrez,  Source
homeodomain interacting protein kinase 111798-0.135-0.1173No
87MAP2K2MAP2K2
Entrez,  Source
mitogen-activated protein kinase kinase 211895-0.142-0.1113No
88PRKCAPRKCA
Entrez,  Source
protein kinase C, alpha11975-0.147-0.1035No
89ROCK2ROCK2
Entrez,  Source
Rho-associated, coiled-coil containing protein kinase 212033-0.152-0.0936No
90CAMK1CAMK1
Entrez,  Source
calcium/calmodulin-dependent protein kinase I12150-0.162-0.0872No
91DYRK3DYRK3
Entrez,  Source
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 312238-0.171-0.0778No
92PKN2PKN2
Entrez,  Source
protein kinase N212286-0.175-0.0649No
93TLK1TLK1
Entrez,  Source
tousled-like kinase 112558-0.210-0.0658No
94MAP3K7MAP3K7
Entrez,  Source
mitogen-activated protein kinase kinase kinase 712613-0.221-0.0492No
95FGFR1FGFR1
Entrez,  Source
fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome)13121-0.486-0.0422No
96SGK113133-0.4980.0037No
Table: GSEA details [plain text format]



Fig 2: K252A_MRC   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: K252A_MRC: Random ES distribution   
Gene set null distribution of ES for K252A_MRC