DatasetNSCLC_collapsed_to_symbols.NSCLC.cls
#SEN_versus_RES.NSCLC.cls
#SEN_versus_RES_repos
PhenotypeNSCLC.cls#SEN_versus_RES_repos
Upregulated in class1
GeneSetNERATINIB_LINCS
Enrichment Score (ES)0.50443536
Normalized Enrichment Score (NES)1.4224725
Nominal p-value0.07194245
FDR q-value0.6169691
FWER p-Value0.998
Table: GSEA Results Summary



Fig 1: Enrichment plot: NERATINIB_LINCS   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEGENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1ERBB3ERBB3
Entrez,  Source
v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)121.0340.2384Yes
2ERBB2ERBB2
Entrez,  Source
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)1000.5370.3561Yes
3MST43180.3310.4162Yes
4EGFREGFR
Entrez,  Source
epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)6250.2300.4462Yes
5TNIKTNIK
Entrez,  Source
TRAF2 and NCK interacting kinase11970.1450.4364Yes
6LCKLCK
Entrez,  Source
lymphocyte-specific protein tyrosine kinase13100.1360.4593Yes
7GAKGAK
Entrez,  Source
cyclin G associated kinase13400.1330.4879Yes
8STK3STK3
Entrez,  Source
serine/threonine kinase 3 (STE20 homolog, yeast)15530.1200.4995Yes
9ERBB4ERBB4
Entrez,  Source
v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)18130.1070.5044Yes
10MAP3K4MAP3K4
Entrez,  Source
mitogen-activated protein kinase kinase kinase 424890.0830.4724No
11MERTKMERTK
Entrez,  Source
c-mer proto-oncogene tyrosine kinase25220.0820.4890No
12CSKCSK
Entrez,  Source
c-src tyrosine kinase30690.0690.4635No
13MINK1MINK1
Entrez,  Source
misshapen-like kinase 1 (zebrafish)30800.0690.4787No
14BLKBLK
Entrez,  Source
B lymphoid tyrosine kinase34190.0620.4675No
15NEK2NEK2
Entrez,  Source
NIMA (never in mitosis gene a)-related kinase 244830.0450.3971No
16STK24STK24
Entrez,  Source
serine/threonine kinase 24 (STE20 homolog, yeast)55870.0290.3200No
17BTKBTK
Entrez,  Source
Bruton agammaglobulinemia tyrosine kinase56280.0290.3236No
18MAP3K3MAP3K3
Entrez,  Source
mitogen-activated protein kinase kinase kinase 359210.0250.3072No
19MAP4K2MAP4K2
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 268940.0100.2356No
20MAP2K1MAP2K1
Entrez,  Source
mitogen-activated protein kinase kinase 17939-0.0080.1581No
21MAP2K5MAP2K5
Entrez,  Source
mitogen-activated protein kinase kinase 58199-0.0130.1414No
22STK25STK25
Entrez,  Source
serine/threonine kinase 25 (STE20 homolog, yeast)8561-0.0210.1188No
23MAP4K4MAP4K4
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 49922-0.0550.0280No
24STK10STK10
Entrez,  Source
serine/threonine kinase 1011218-0.103-0.0465No
25SLKSLK
Entrez,  Source
STE20-like kinase (yeast)11672-0.128-0.0514No
26MAP4K5MAP4K5
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 511705-0.130-0.0239No
27MAP2K2MAP2K2
Entrez,  Source
mitogen-activated protein kinase kinase 211895-0.142-0.0054No
28MAP4K3MAP4K3
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 312403-0.189-0.0003No
29AXLAXL
Entrez,  Source
AXL receptor tyrosine kinase12789-0.2570.0299No
Table: GSEA details [plain text format]



Fig 2: NERATINIB_LINCS   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: NERATINIB_LINCS: Random ES distribution   
Gene set null distribution of ES for NERATINIB_LINCS