DatasetNSCLC_collapsed_to_symbols.NSCLC.cls
#SEN_versus_RES.NSCLC.cls
#SEN_versus_RES_repos
PhenotypeNSCLC.cls#SEN_versus_RES_repos
Upregulated in class0
GeneSetJNJ-28312141_KINOME SCAN
Enrichment Score (ES)-0.25844923
Normalized Enrichment Score (NES)-0.9724735
Nominal p-value0.511335
FDR q-value0.99067503
FWER p-Value1.0
Table: GSEA Results Summary



Fig 1: Enrichment plot: JNJ-28312141_KINOME SCAN   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEGENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1DDR1DDR1
Entrez,  Source
discoidin domain receptor family, member 12120.4040.0359No
2METMET
Entrez,  Source
met proto-oncogene (hepatocyte growth factor receptor)4990.2590.0475No
3MAP3K13MAP3K13
Entrez,  Source
mitogen-activated protein kinase kinase kinase 136240.2300.0677No
4EGFREGFR
Entrez,  Source
epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)6250.2300.0974No
5MAPK10MAPK10
Entrez,  Source
mitogen-activated protein kinase 1010690.1570.0839No
6TNIKTNIK
Entrez,  Source
TRAF2 and NCK interacting kinase11970.1450.0930No
7LCKLCK
Entrez,  Source
lymphocyte-specific protein tyrosine kinase13100.1360.1020No
8GAKGAK
Entrez,  Source
cyclin G associated kinase13400.1330.1169No
9STK3STK3
Entrez,  Source
serine/threonine kinase 3 (STE20 homolog, yeast)15530.1200.1162No
10INSRINSR
Entrez,  Source
insulin receptor16640.1140.1225No
11NTRK2NTRK2
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 217040.1120.1340No
12PTK2BPTK2B
Entrez,  Source
PTK2B protein tyrosine kinase 2 beta20420.0980.1209No
13AAK1AAK1
Entrez,  Source
AP2 associated kinase 122120.0920.1198No
14ULK2ULK2
Entrez,  Source
unc-51-like kinase 2 (C. elegans)22440.0910.1292No
15JAK3JAK3
Entrez,  Source
Janus kinase 3 (a protein tyrosine kinase, leukocyte)24440.0840.1249No
16MERTKMERTK
Entrez,  Source
c-mer proto-oncogene tyrosine kinase25220.0820.1297No
17MAP4K1MAP4K1
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 128490.0740.1143No
18PIM2PIM2
Entrez,  Source
pim-2 oncogene29560.0710.1154No
19TNK2TNK2
Entrez,  Source
tyrosine kinase, non-receptor, 230050.0700.1209No
20YES1YES1
Entrez,  Source
v-yes-1 Yamaguchi sarcoma viral oncogene homolog 130360.0700.1276No
21MINK1MINK1
Entrez,  Source
misshapen-like kinase 1 (zebrafish)30800.0690.1332No
22KDRKDR
Entrez,  Source
kinase insert domain receptor (a type III receptor tyrosine kinase)31460.0680.1370No
23FLT3FLT3
Entrez,  Source
fms-related tyrosine kinase 334030.0630.1255No
24BLKBLK
Entrez,  Source
B lymphoid tyrosine kinase34190.0620.1324No
25CSF1RCSF1R
Entrez,  Source
colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog34540.0620.1378No
26PRKD2PRKD2
Entrez,  Source
protein kinase D239000.0540.1108No
27ALKALK
Entrez,  Source
anaplastic lymphoma kinase (Ki-1)40730.0510.1042No
28FGRFGR
Entrez,  Source
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog41930.0490.1015No
29ACVR1BACVR1B
Entrez,  Source
activin A receptor, type IB43280.0470.0974No
30BMXBMX
Entrez,  Source
BMX non-receptor tyrosine kinase48260.0400.0646No
31FLT1FLT1
Entrez,  Source
fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)48820.0390.0654No
32FLT4FLT4
Entrez,  Source
fms-related tyrosine kinase 448980.0390.0693No
33ACVR1ACVR1
Entrez,  Source
activin A receptor, type I52300.0340.0484No
34BTKBTK
Entrez,  Source
Bruton agammaglobulinemia tyrosine kinase56280.0290.0218No
35STK16STK16
Entrez,  Source
serine/threonine kinase 1657780.0270.0139No
36PAK7PAK7
Entrez,  Source
p21(CDKN1A)-activated kinase 758810.0250.0094No
37MAP3K3MAP3K3
Entrez,  Source
mitogen-activated protein kinase kinase kinase 359210.0250.0096No
38NTRK1NTRK1
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 160970.022-0.0009No
39IRAK1IRAK1
Entrez,  Source
interleukin-1 receptor-associated kinase 161790.021-0.0044No
40PHKG1PHKG1
Entrez,  Source
phosphorylase kinase, gamma 1 (muscle)62450.020-0.0068No
41RETRET
Entrez,  Source
ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease)64710.016-0.0219No
42BMPR1BBMPR1B
Entrez,  Source
bone morphogenetic protein receptor, type IB67770.012-0.0436No
43MAPK8MAPK8
Entrez,  Source
mitogen-activated protein kinase 868290.011-0.0461No
44MAP4K2MAP4K2
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 268940.010-0.0497No
45BMP2KBMP2K
Entrez,  Source
BMP2 inducible kinase70290.008-0.0589No
46CLK2CLK2
Entrez,  Source
CDC-like kinase 271810.005-0.0697No
47ITKITK
Entrez,  Source
IL2-inducible T-cell kinase72200.004-0.0721No
48GSK3AGSK3A
Entrez,  Source
glycogen synthase kinase 3 alpha73580.002-0.0823No
49PRKAA2PRKAA2
Entrez,  Source
protein kinase, AMP-activated, alpha 2 catalytic subunit74180.001-0.0866No
50SIK274350.001-0.0877No
51MAP2K3MAP2K3
Entrez,  Source
mitogen-activated protein kinase kinase 37798-0.005-0.1147No
52PDGFRBPDGFRB
Entrez,  Source
platelet-derived growth factor receptor, beta polypeptide7824-0.006-0.1158No
53MAP2K1MAP2K1
Entrez,  Source
mitogen-activated protein kinase kinase 17939-0.008-0.1235No
54KITKIT
Entrez,  Source
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog8134-0.012-0.1368No
55MAP2K5MAP2K5
Entrez,  Source
mitogen-activated protein kinase kinase 58199-0.013-0.1400No
56NTRK3NTRK3
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 38500-0.019-0.1604No
57IRAK4IRAK4
Entrez,  Source
interleukin-1 receptor-associated kinase 48996-0.031-0.1943No
58TYK2TYK2
Entrez,  Source
tyrosine kinase 29438-0.041-0.2227No
59PAK3PAK3
Entrez,  Source
p21 (CDKN1A)-activated kinase 39490-0.042-0.2211No
60PRKD1PRKD1
Entrez,  Source
protein kinase D19827-0.052-0.2401No
61MAP4K4MAP4K4
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 49922-0.055-0.2402No
62TTKTTK
Entrez,  Source
TTK protein kinase9930-0.055-0.2337No
63STK17ASTK17A
Entrez,  Source
serine/threonine kinase 17a (apoptosis-inducing)10017-0.057-0.2329No
64DDR2DDR2
Entrez,  Source
discoidin domain receptor family, member 210235-0.064-0.2413No
65RPS6KA3RPS6KA3
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 310427-0.070-0.2468No
66PLK4PLK4
Entrez,  Source
polo-like kinase 4 (Drosophila)10581-0.075-0.2487Yes
67JAK1JAK1
Entrez,  Source
Janus kinase 1 (a protein tyrosine kinase)10585-0.076-0.2392Yes
68TBK1TBK1
Entrez,  Source
TANK-binding kinase 110732-0.082-0.2398Yes
69PIP5K1APIP5K1A
Entrez,  Source
phosphatidylinositol-4-phosphate 5-kinase, type I, alpha10780-0.083-0.2326Yes
70CHEK1CHEK1
Entrez,  Source
CHK1 checkpoint homolog (S. pombe)10792-0.084-0.2226Yes
71PRKAA1PRKAA1
Entrez,  Source
protein kinase, AMP-activated, alpha 1 catalytic subunit10906-0.089-0.2198Yes
72GSK3BGSK3B
Entrez,  Source
glycogen synthase kinase 3 beta11131-0.100-0.2240Yes
73MYLKMYLK
Entrez,  Source
myosin, light chain kinase11255-0.105-0.2199Yes
74BMPR2BMPR2
Entrez,  Source
bone morphogenetic protein receptor, type II (serine/threonine kinase)11345-0.109-0.2125Yes
75FERFER
Entrez,  Source
fer (fps/fes related) tyrosine kinase (phosphoprotein NCP94)11371-0.111-0.2002Yes
76RIPK1RIPK1
Entrez,  Source
receptor (TNFRSF)-interacting serine-threonine kinase 111427-0.113-0.1897Yes
77STK4STK4
Entrez,  Source
serine/threonine kinase 411518-0.118-0.1814Yes
78JAK2JAK2
Entrez,  Source
Janus kinase 2 (a protein tyrosine kinase)11530-0.119-0.1669Yes
79SLKSLK
Entrez,  Source
STE20-like kinase (yeast)11672-0.128-0.1612Yes
80MAP4K5MAP4K5
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 511705-0.130-0.1469Yes
81FYNFYN
Entrez,  Source
FYN oncogene related to SRC, FGR, YES11767-0.133-0.1344Yes
82MAP2K2MAP2K2
Entrez,  Source
mitogen-activated protein kinase kinase 211895-0.142-0.1257Yes
83MAP3K2MAP3K2
Entrez,  Source
mitogen-activated protein kinase kinase kinase 212210-0.168-0.1280Yes
84PDGFRAPDGFRA
Entrez,  Source
platelet-derived growth factor receptor, alpha polypeptide12211-0.168-0.1064Yes
85MAP3K12MAP3K12
Entrez,  Source
mitogen-activated protein kinase kinase kinase 1212384-0.186-0.0954Yes
86MAP4K3MAP4K3
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 312403-0.189-0.0724Yes
87ABL1ABL1
Entrez,  Source
v-abl Abelson murine leukemia viral oncogene homolog 112463-0.197-0.0515Yes
88MAP3K7MAP3K7
Entrez,  Source
mitogen-activated protein kinase kinase kinase 712613-0.221-0.0344Yes
89AXLAXL
Entrez,  Source
AXL receptor tyrosine kinase12789-0.257-0.0146Yes
90PRKD3PRKD3
Entrez,  Source
protein kinase D313008-0.3450.0133Yes
Table: GSEA details [plain text format]



Fig 2: JNJ-28312141_KINOME SCAN   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: JNJ-28312141_KINOME SCAN: Random ES distribution   
Gene set null distribution of ES for JNJ-28312141_KINOME SCAN