DatasetNSCLC_collapsed_to_symbols.NSCLC.cls
#SEN_versus_RES.NSCLC.cls
#SEN_versus_RES_repos
PhenotypeNSCLC.cls#SEN_versus_RES_repos
Upregulated in class1
GeneSetSKI-606_KINOME SCAN
Enrichment Score (ES)0.30755982
Normalized Enrichment Score (NES)1.1012081
Nominal p-value0.2775974
FDR q-value0.72314095
FWER p-Value1.0
Table: GSEA Results Summary



Fig 1: Enrichment plot: SKI-606_KINOME SCAN   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEGENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1ERBB3ERBB3
Entrez,  Source
v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)121.0340.0930Yes
2DDR1DDR1
Entrez,  Source
discoidin domain receptor family, member 12120.4040.1144Yes
3FRKFRK
Entrez,  Source
fyn-related kinase2960.3430.1393Yes
4MST43180.3310.1677Yes
5SYKSYK
Entrez,  Source
spleen tyrosine kinase4710.2680.1804Yes
6MAP3K13MAP3K13
Entrez,  Source
mitogen-activated protein kinase kinase kinase 136240.2300.1897Yes
7EGFREGFR
Entrez,  Source
epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)6250.2300.2106Yes
8EPHA4EPHA4
Entrez,  Source
EPH receptor A47980.1970.2154Yes
9EPHB2EPHB2
Entrez,  Source
EPH receptor B28680.1850.2269Yes
10TAOK3TAOK3
Entrez,  Source
TAO kinase 39710.1700.2345Yes
11TXKTXK
Entrez,  Source
TXK tyrosine kinase10450.1600.2434Yes
12TNIKTNIK
Entrez,  Source
TRAF2 and NCK interacting kinase11970.1450.2451Yes
13LCKLCK
Entrez,  Source
lymphocyte-specific protein tyrosine kinase13100.1360.2489Yes
14GAKGAK
Entrez,  Source
cyclin G associated kinase13400.1330.2588Yes
15CAMK1DCAMK1D
Entrez,  Source
calcium/calmodulin-dependent protein kinase ID13870.1290.2670Yes
16EPHB3EPHB3
Entrez,  Source
EPH receptor B314260.1270.2756Yes
17NEK11NEK11
Entrez,  Source
NIMA (never in mitosis gene a)- related kinase 1115220.1220.2794Yes
18STK3STK3
Entrez,  Source
serine/threonine kinase 3 (STE20 homolog, yeast)15530.1200.2880Yes
19WEE1WEE1
Entrez,  Source
WEE1 homolog (S. pombe)16390.1150.2919Yes
20ERBB4ERBB4
Entrez,  Source
v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)18130.1070.2884Yes
21CSNK1DCSNK1D
Entrez,  Source
casein kinase 1, delta18510.1050.2951Yes
22LYNLYN
Entrez,  Source
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog19740.1000.2948Yes
23CASKCASK
Entrez,  Source
calcium/calmodulin-dependent serine protein kinase (MAGUK family)20070.0990.3013Yes
24PTK2BPTK2B
Entrez,  Source
PTK2B protein tyrosine kinase 2 beta20420.0980.3076Yes
25ULK2ULK2
Entrez,  Source
unc-51-like kinase 2 (C. elegans)22440.0910.3004No
26CLK3CLK3
Entrez,  Source
CDC-like kinase 323490.0870.3004No
27MAP3K4MAP3K4
Entrez,  Source
mitogen-activated protein kinase kinase kinase 424890.0830.2973No
28MERTKMERTK
Entrez,  Source
c-mer proto-oncogene tyrosine kinase25220.0820.3024No
29MAP4K1MAP4K1
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 128490.0740.2842No
30EPHA3EPHA3
Entrez,  Source
EPH receptor A328700.0740.2893No
31TNK2TNK2
Entrez,  Source
tyrosine kinase, non-receptor, 230050.0700.2855No
32EIF2AK1EIF2AK1
Entrez,  Source
eukaryotic translation initiation factor 2-alpha kinase 130080.0700.2917No
33YES1YES1
Entrez,  Source
v-yes-1 Yamaguchi sarcoma viral oncogene homolog 130360.0700.2960No
34CSKCSK
Entrez,  Source
c-src tyrosine kinase30690.0690.2998No
35MINK1MINK1
Entrez,  Source
misshapen-like kinase 1 (zebrafish)30800.0690.3053No
36FLT3FLT3
Entrez,  Source
fms-related tyrosine kinase 334030.0630.2864No
37BLKBLK
Entrez,  Source
B lymphoid tyrosine kinase34190.0620.2909No
38CSF1RCSF1R
Entrez,  Source
colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog34540.0620.2939No
39CSNK1A1CSNK1A1
Entrez,  Source
casein kinase 1, alpha 136980.0580.2806No
40EPHB4EPHB4
Entrez,  Source
EPH receptor B438790.0540.2717No
41EPHB1EPHB1
Entrez,  Source
EPH receptor B140000.0520.2673No
42ALKALK
Entrez,  Source
anaplastic lymphoma kinase (Ki-1)40730.0510.2665No
43FGRFGR
Entrez,  Source
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog41930.0490.2618No
44BMXBMX
Entrez,  Source
BMX non-receptor tyrosine kinase48260.0400.2171No
45EPHA2EPHA2
Entrez,  Source
EPH receptor A248800.0390.2166No
46TNNI3KTNNI3K
Entrez,  Source
TNNI3 interacting kinase52740.0330.1896No
47MAST1MAST1
Entrez,  Source
microtubule associated serine/threonine kinase 154360.0320.1802No
48EPHA5EPHA5
Entrez,  Source
EPH receptor A554750.0310.1801No
49STK24STK24
Entrez,  Source
serine/threonine kinase 24 (STE20 homolog, yeast)55870.0290.1743No
50BTKBTK
Entrez,  Source
Bruton agammaglobulinemia tyrosine kinase56280.0290.1738No
51MAP3K3MAP3K3
Entrez,  Source
mitogen-activated protein kinase kinase kinase 359210.0250.1538No
52FESFES
Entrez,  Source
feline sarcoma oncogene61260.0220.1401No
53IRAK1IRAK1
Entrez,  Source
interleukin-1 receptor-associated kinase 161790.0210.1380No
54PHKG1PHKG1
Entrez,  Source
phosphorylase kinase, gamma 1 (muscle)62450.0200.1349No
55MAP4K2MAP4K2
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 268940.0100.0862No
56BMP2KBMP2K
Entrez,  Source
BMP2 inducible kinase70290.0080.0767No
57IKBKEIKBKE
Entrez,  Source
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon72160.0040.0629No
58SIK274350.0010.0463No
59SIK37726-0.0040.0245No
60CSNK1ECSNK1E
Entrez,  Source
casein kinase 1, epsilon7742-0.0040.0237No
61PDGFRBPDGFRB
Entrez,  Source
platelet-derived growth factor receptor, beta polypeptide7824-0.0060.0181No
62PKMYT1PKMYT1
Entrez,  Source
protein kinase, membrane associated tyrosine/threonine 17836-0.0060.0178No
63MAP2K1MAP2K1
Entrez,  Source
mitogen-activated protein kinase kinase 17939-0.0080.0107No
64KITKIT
Entrez,  Source
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog8134-0.012-0.0030No
65MAP2K5MAP2K5
Entrez,  Source
mitogen-activated protein kinase kinase 58199-0.013-0.0067No
66DMPKDMPK
Entrez,  Source
dystrophia myotonica-protein kinase8344-0.016-0.0163No
67PTK2PTK2
Entrez,  Source
PTK2 protein tyrosine kinase 28356-0.016-0.0156No
68VRK2VRK2
Entrez,  Source
vaccinia related kinase 28412-0.017-0.0182No
69STK25STK25
Entrez,  Source
serine/threonine kinase 25 (STE20 homolog, yeast)8561-0.021-0.0277No
70ROCK1ROCK1
Entrez,  Source
Rho-associated, coiled-coil containing protein kinase 18741-0.025-0.0391No
71IRAK4IRAK4
Entrez,  Source
interleukin-1 receptor-associated kinase 48996-0.031-0.0558No
72MAP4K4MAP4K4
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 49922-0.055-0.1215No
73HCKHCK
Entrez,  Source
hemopoietic cell kinase9981-0.056-0.1209No
74PLK2PLK2
Entrez,  Source
polo-like kinase 2 (Drosophila)9994-0.057-0.1166No
75CHEK2CHEK2
Entrez,  Source
CHK2 checkpoint homolog (S. pombe)10102-0.059-0.1194No
76DDR2DDR2
Entrez,  Source
discoidin domain receptor family, member 210235-0.064-0.1238No
77RPS6KB1RPS6KB1
Entrez,  Source
ribosomal protein S6 kinase, 70kDa, polypeptide 110717-0.081-0.1532No
78CAMKK2CAMKK2
Entrez,  Source
calcium/calmodulin-dependent protein kinase kinase 2, beta10729-0.081-0.1466No
79TBK1TBK1
Entrez,  Source
TANK-binding kinase 110732-0.082-0.1394No
80SRCSRC
Entrez,  Source
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)10776-0.083-0.1351No
81PRKCQPRKCQ
Entrez,  Source
protein kinase C, theta10961-0.092-0.1409No
82ABL2ABL2
Entrez,  Source
v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)11090-0.098-0.1418No
83STK10STK10
Entrez,  Source
serine/threonine kinase 1011218-0.103-0.1421No
84MYLKMYLK
Entrez,  Source
myosin, light chain kinase11255-0.105-0.1353No
85BMPR2BMPR2
Entrez,  Source
bone morphogenetic protein receptor, type II (serine/threonine kinase)11345-0.109-0.1322No
86FERFER
Entrez,  Source
fer (fps/fes related) tyrosine kinase (phosphoprotein NCP94)11371-0.111-0.1241No
87STK4STK4
Entrez,  Source
serine/threonine kinase 411518-0.118-0.1245No
88TYRO3TYRO3
Entrez,  Source
TYRO3 protein tyrosine kinase11601-0.123-0.1196No
89SLKSLK
Entrez,  Source
STE20-like kinase (yeast)11672-0.128-0.1134No
90MAP4K5MAP4K5
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 511705-0.130-0.1041No
91FYNFYN
Entrez,  Source
FYN oncogene related to SRC, FGR, YES11767-0.133-0.0966No
92HIPK1HIPK1
Entrez,  Source
homeodomain interacting protein kinase 111798-0.135-0.0866No
93MAP2K2MAP2K2
Entrez,  Source
mitogen-activated protein kinase kinase 211895-0.142-0.0811No
94ROCK2ROCK2
Entrez,  Source
Rho-associated, coiled-coil containing protein kinase 212033-0.152-0.0778No
95MAP3K2MAP3K2
Entrez,  Source
mitogen-activated protein kinase kinase kinase 212210-0.168-0.0760No
96SIK112319-0.179-0.0680No
97MAP3K12MAP3K12
Entrez,  Source
mitogen-activated protein kinase kinase kinase 1212384-0.186-0.0560No
98MAP4K3MAP4K3
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 312403-0.189-0.0402No
99ABL1ABL1
Entrez,  Source
v-abl Abelson murine leukemia viral oncogene homolog 112463-0.197-0.0268No
100ZAKZAK
Entrez,  Source
-12544-0.209-0.0139No
101TLK1TLK1
Entrez,  Source
tousled-like kinase 112558-0.2100.0042No
102MAP3K7MAP3K7
Entrez,  Source
mitogen-activated protein kinase kinase kinase 712613-0.2210.0201No
103AXLAXL
Entrez,  Source
AXL receptor tyrosine kinase12789-0.2570.0300No
Table: GSEA details [plain text format]



Fig 2: SKI-606_KINOME SCAN   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: SKI-606_KINOME SCAN: Random ES distribution   
Gene set null distribution of ES for SKI-606_KINOME SCAN