Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | NSCLC_collapsed_to_symbols.NSCLC.cls #SEN_versus_RES.NSCLC.cls #SEN_versus_RES_repos |
| Phenotype | NSCLC.cls#SEN_versus_RES_repos |
| Upregulated in class | 0 |
| GeneSet | A-674563_KINOME SCAN |
| Enrichment Score (ES) | -0.23230726 |
| Normalized Enrichment Score (NES) | -0.8267283 |
| Nominal p-value | 0.79802954 |
| FDR q-value | 0.94442 |
| FWER p-Value | 1.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | PAK6 | PAK6 Entrez, Source | p21(CDKN1A)-activated kinase 6 | 158 | 0.459 | 0.0629 | No |
| 2 | PRKCD | PRKCD Entrez, Source | protein kinase C, delta | 306 | 0.337 | 0.1066 | No |
| 3 | PRKCH | PRKCH Entrez, Source | protein kinase C, eta | 356 | 0.309 | 0.1534 | No |
| 4 | CDK14 | 659 | 0.222 | 0.1665 | No | ||
| 5 | TNIK | TNIK Entrez, Source | TRAF2 and NCK interacting kinase | 1197 | 0.145 | 0.1493 | No |
| 6 | DYRK2 | DYRK2 Entrez, Source | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 | 1230 | 0.142 | 0.1701 | No |
| 7 | GAK | GAK Entrez, Source | cyclin G associated kinase | 1340 | 0.133 | 0.1836 | No |
| 8 | CAMK2A | CAMK2A Entrez, Source | calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha | 1801 | 0.107 | 0.1660 | No |
| 9 | CAMK2G | CAMK2G Entrez, Source | calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma | 1811 | 0.107 | 0.1827 | No |
| 10 | CSNK1D | CSNK1D Entrez, Source | casein kinase 1, delta | 1851 | 0.105 | 0.1968 | No |
| 11 | RIOK3 | RIOK3 Entrez, Source | RIO kinase 3 (yeast) | 1942 | 0.101 | 0.2065 | No |
| 12 | AAK1 | AAK1 Entrez, Source | AP2 associated kinase 1 | 2212 | 0.092 | 0.2010 | No |
| 13 | CLK3 | CLK3 Entrez, Source | CDC-like kinase 3 | 2349 | 0.087 | 0.2049 | No |
| 14 | TAOK1 | TAOK1 Entrez, Source | TAO kinase 1 | 2552 | 0.082 | 0.2028 | No |
| 15 | PIM2 | PIM2 Entrez, Source | pim-2 oncogene | 2956 | 0.071 | 0.1838 | No |
| 16 | MINK1 | MINK1 Entrez, Source | misshapen-like kinase 1 (zebrafish) | 3080 | 0.069 | 0.1857 | No |
| 17 | FLT3 | FLT3 Entrez, Source | fms-related tyrosine kinase 3 | 3403 | 0.063 | 0.1713 | No |
| 18 | PRKG2 | PRKG2 Entrez, Source | protein kinase, cGMP-dependent, type II | 4021 | 0.052 | 0.1328 | No |
| 19 | PIM1 | PIM1 Entrez, Source | pim-1 oncogene | 4136 | 0.050 | 0.1323 | No |
| 20 | CAMK2B | CAMK2B Entrez, Source | calcium/calmodulin-dependent protein kinase (CaM kinase) II beta | 4213 | 0.049 | 0.1345 | No |
| 21 | CDKL5 | CDKL5 Entrez, Source | cyclin-dependent kinase-like 5 | 4345 | 0.047 | 0.1322 | No |
| 22 | CDKL2 | CDKL2 Entrez, Source | cyclin-dependent kinase-like 2 (CDC2-related kinase) | 4548 | 0.044 | 0.1240 | No |
| 23 | PRKG1 | PRKG1 Entrez, Source | protein kinase, cGMP-dependent, type I | 4936 | 0.038 | 0.1007 | No |
| 24 | PAK4 | PAK4 Entrez, Source | p21(CDKN1A)-activated kinase 4 | 5014 | 0.037 | 0.1009 | No |
| 25 | PAK7 | PAK7 Entrez, Source | p21(CDKN1A)-activated kinase 7 | 5881 | 0.025 | 0.0391 | No |
| 26 | PRKX | PRKX Entrez, Source | protein kinase, X-linked | 5993 | 0.024 | 0.0345 | No |
| 27 | CSNK1G2 | CSNK1G2 Entrez, Source | casein kinase 1, gamma 2 | 6328 | 0.018 | 0.0120 | No |
| 28 | CAMK4 | CAMK4 Entrez, Source | calcium/calmodulin-dependent protein kinase IV | 6393 | 0.017 | 0.0100 | No |
| 29 | RET | RET Entrez, Source | ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease) | 6471 | 0.016 | 0.0068 | No |
| 30 | PKN1 | PKN1 Entrez, Source | protein kinase N1 | 6783 | 0.012 | -0.0150 | No |
| 31 | CLK4 | CLK4 Entrez, Source | CDC-like kinase 4 | 6935 | 0.010 | -0.0250 | No |
| 32 | BMP2K | BMP2K Entrez, Source | BMP2 inducible kinase | 7029 | 0.008 | -0.0308 | No |
| 33 | CLK2 | CLK2 Entrez, Source | CDC-like kinase 2 | 7181 | 0.005 | -0.0414 | No |
| 34 | AKT1 | AKT1 Entrez, Source | v-akt murine thymoma viral oncogene homolog 1 | 7387 | 0.002 | -0.0568 | No |
| 35 | CSNK1E | CSNK1E Entrez, Source | casein kinase 1, epsilon | 7742 | -0.004 | -0.0830 | No |
| 36 | MELK | MELK Entrez, Source | maternal embryonic leucine zipper kinase | 8047 | -0.010 | -0.1046 | No |
| 37 | PRKACA | PRKACA Entrez, Source | protein kinase, cAMP-dependent, catalytic, alpha | 8112 | -0.011 | -0.1077 | No |
| 38 | KIT | KIT Entrez, Source | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog | 8134 | -0.012 | -0.1073 | No |
| 39 | DYRK1B | DYRK1B Entrez, Source | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B | 8200 | -0.013 | -0.1102 | No |
| 40 | DMPK | DMPK Entrez, Source | dystrophia myotonica-protein kinase | 8344 | -0.016 | -0.1184 | No |
| 41 | CSNK1G1 | CSNK1G1 Entrez, Source | casein kinase 1, gamma 1 | 8732 | -0.025 | -0.1439 | No |
| 42 | ROCK1 | ROCK1 Entrez, Source | Rho-associated, coiled-coil containing protein kinase 1 | 8741 | -0.025 | -0.1405 | No |
| 43 | HIPK3 | HIPK3 Entrez, Source | homeodomain interacting protein kinase 3 | 9770 | -0.050 | -0.2107 | No |
| 44 | MAP4K4 | MAP4K4 Entrez, Source | mitogen-activated protein kinase kinase kinase kinase 4 | 9922 | -0.055 | -0.2134 | No |
| 45 | HIPK2 | HIPK2 Entrez, Source | homeodomain interacting protein kinase 2 | 10151 | -0.061 | -0.2208 | No |
| 46 | DYRK1A | DYRK1A Entrez, Source | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 10303 | -0.066 | -0.2215 | Yes |
| 47 | CIT | CIT Entrez, Source | citron (rho-interacting, serine/threonine kinase 21) | 10420 | -0.070 | -0.2190 | Yes |
| 48 | ICK | ICK Entrez, Source | intestinal cell (MAK-like) kinase | 10499 | -0.073 | -0.2131 | Yes |
| 49 | CAMKK2 | CAMKK2 Entrez, Source | calcium/calmodulin-dependent protein kinase kinase 2, beta | 10729 | -0.081 | -0.2173 | Yes |
| 50 | PIP5K1A | PIP5K1A Entrez, Source | phosphatidylinositol-4-phosphate 5-kinase, type I, alpha | 10780 | -0.083 | -0.2074 | Yes |
| 51 | PRKCE | PRKCE Entrez, Source | protein kinase C, epsilon | 10801 | -0.084 | -0.1952 | Yes |
| 52 | PRKCQ | PRKCQ Entrez, Source | protein kinase C, theta | 10961 | -0.092 | -0.1923 | Yes |
| 53 | SRPK1 | SRPK1 Entrez, Source | SFRS protein kinase 1 | 11068 | -0.096 | -0.1847 | Yes |
| 54 | GSK3B | GSK3B Entrez, Source | glycogen synthase kinase 3 beta | 11131 | -0.100 | -0.1731 | Yes |
| 55 | CDK7 | CDK7 Entrez, Source | cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase) | 11160 | -0.101 | -0.1588 | Yes |
| 56 | PRKACB | PRKACB Entrez, Source | protein kinase, cAMP-dependent, catalytic, beta | 11179 | -0.102 | -0.1435 | Yes |
| 57 | MYLK | MYLK Entrez, Source | myosin, light chain kinase | 11255 | -0.105 | -0.1321 | Yes |
| 58 | CDK9 | CDK9 Entrez, Source | cyclin-dependent kinase 9 (CDC2-related kinase) | 11631 | -0.125 | -0.1403 | Yes |
| 59 | HIPK1 | HIPK1 Entrez, Source | homeodomain interacting protein kinase 1 | 11798 | -0.135 | -0.1308 | Yes |
| 60 | CDC42BPA | CDC42BPA Entrez, Source | CDC42 binding protein kinase alpha (DMPK-like) | 11941 | -0.145 | -0.1180 | Yes |
| 61 | CDC42BPB | CDC42BPB Entrez, Source | CDC42 binding protein kinase beta (DMPK-like) | 12053 | -0.154 | -0.1013 | Yes |
| 62 | PKN2 | PKN2 Entrez, Source | protein kinase N2 | 12286 | -0.175 | -0.0904 | Yes |
| 63 | CSNK1G3 | CSNK1G3 Entrez, Source | casein kinase 1, gamma 3 | 12464 | -0.197 | -0.0717 | Yes |
| 64 | AKT3 | AKT3 Entrez, Source | v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) | 12533 | -0.207 | -0.0430 | Yes |
| 65 | MAP3K7 | MAP3K7 Entrez, Source | mitogen-activated protein kinase kinase kinase 7 | 12613 | -0.221 | -0.0130 | Yes |
| 66 | PRKD3 | PRKD3 Entrez, Source | protein kinase D3 | 13008 | -0.345 | 0.0133 | Yes |
