DatasetNSCLC_collapsed_to_symbols.NSCLC.cls
#SEN_versus_RES.NSCLC.cls
#SEN_versus_RES_repos
PhenotypeNSCLC.cls#SEN_versus_RES_repos
Upregulated in class1
GeneSetPP-242_KINOME SCAN
Enrichment Score (ES)0.40937793
Normalized Enrichment Score (NES)1.4793651
Nominal p-value0.011551155
FDR q-value0.907732
FWER p-Value0.993
Table: GSEA Results Summary



Fig 1: Enrichment plot: PP-242_KINOME SCAN   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEGENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1ERBB3ERBB3
Entrez,  Source
v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)121.0340.0787Yes
2DAPK1DAPK1
Entrez,  Source
death-associated protein kinase 1880.5570.1159Yes
3EPHA1EPHA1
Entrez,  Source
EPH receptor A1940.5450.1575Yes
4RIPK4RIPK4
Entrez,  Source
receptor-interacting serine-threonine kinase 4950.5440.1994Yes
5PTK6PTK6
Entrez,  Source
PTK6 protein tyrosine kinase 61410.4790.2328Yes
6FGFR3FGFR3
Entrez,  Source
fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism)1530.4650.2678Yes
7FGFR2FGFR2
Entrez,  Source
ffer syndrome, Jackson-Weiss syndrome)2100.4060.2947Yes
8DDR1DDR1
Entrez,  Source
discoidin domain receptor family, member 12120.4040.3257Yes
9FRKFRK
Entrez,  Source
fyn-related kinase2960.3430.3458Yes
10PRKCHPRKCH
Entrez,  Source
protein kinase C, eta3560.3090.3651Yes
11EGFREGFR
Entrez,  Source
epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)6250.2300.3623Yes
12EPHA4EPHA4
Entrez,  Source
EPH receptor A47980.1970.3643Yes
13EPHB2EPHB2
Entrez,  Source
EPH receptor B28680.1850.3733Yes
14TAOK3TAOK3
Entrez,  Source
TAO kinase 39710.1700.3786Yes
15TXKTXK
Entrez,  Source
TXK tyrosine kinase10450.1600.3853Yes
16TNIKTNIK
Entrez,  Source
TRAF2 and NCK interacting kinase11970.1450.3850Yes
17DYRK2DYRK2
Entrez,  Source
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 212300.1420.3935Yes
18LCKLCK
Entrez,  Source
lymphocyte-specific protein tyrosine kinase13100.1360.3979Yes
19GAKGAK
Entrez,  Source
cyclin G associated kinase13400.1330.4059Yes
20PIK3C2GPIK3C2G
Entrez,  Source
phosphoinositide-3-kinase, class 2, gamma polypeptide14980.1230.4034Yes
21PIP4K2C16760.1140.3986Yes
22DAPK2DAPK2
Entrez,  Source
death-associated protein kinase 218380.1050.3944Yes
23CSNK1DCSNK1D
Entrez,  Source
casein kinase 1, delta18510.1050.4016Yes
24TESK1TESK1
Entrez,  Source
testis-specific kinase 118550.1050.4094Yes
25LYNLYN
Entrez,  Source
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog19740.1000.4080No
26JAK3JAK3
Entrez,  Source
Janus kinase 3 (a protein tyrosine kinase, leukocyte)24440.0840.3787No
27TAOK1TAOK1
Entrez,  Source
TAO kinase 125520.0820.3768No
28EPHA3EPHA3
Entrez,  Source
EPH receptor A328700.0740.3582No
29PIM2PIM2
Entrez,  Source
pim-2 oncogene29560.0710.3572No
30YES1YES1
Entrez,  Source
v-yes-1 Yamaguchi sarcoma viral oncogene homolog 130360.0700.3565No
31MINK1MINK1
Entrez,  Source
misshapen-like kinase 1 (zebrafish)30800.0690.3585No
32FLT3FLT3
Entrez,  Source
fms-related tyrosine kinase 334030.0630.3387No
33BLKBLK
Entrez,  Source
B lymphoid tyrosine kinase34190.0620.3424No
34CSNK1A1CSNK1A1
Entrez,  Source
casein kinase 1, alpha 136980.0580.3255No
35ACVRL1ACVRL1
Entrez,  Source
activin A receptor type II-like 137150.0570.3287No
36MYO3AMYO3A
Entrez,  Source
myosin IIIA37350.0570.3316No
37BRAFBRAF
Entrez,  Source
v-raf murine sarcoma viral oncogene homolog B137720.0560.3332No
38PRKG2PRKG2
Entrez,  Source
protein kinase, cGMP-dependent, type II40210.0520.3182No
39FGRFGR
Entrez,  Source
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog41930.0490.3090No
40ACVR1BACVR1B
Entrez,  Source
activin A receptor, type IB43280.0470.3023No
41RPS6KA6RPS6KA6
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 646850.0420.2783No
42PHKG2PHKG2
Entrez,  Source
phosphorylase kinase, gamma 2 (testis)47920.0400.2733No
43BMXBMX
Entrez,  Source
BMX non-receptor tyrosine kinase48260.0400.2739No
44EPHA2EPHA2
Entrez,  Source
EPH receptor A248800.0390.2728No
45FLT4FLT4
Entrez,  Source
fms-related tyrosine kinase 448980.0390.2745No
46GRK1GRK1
Entrez,  Source
G protein-coupled receptor kinase 149070.0390.2769No
47PAK4PAK4
Entrez,  Source
p21(CDKN1A)-activated kinase 450140.0370.2717No
48ACVR1ACVR1
Entrez,  Source
activin A receptor, type I52300.0340.2578No
49TNNI3KTNNI3K
Entrez,  Source
TNNI3 interacting kinase52740.0330.2571No
50PIK3CGPIK3CG
Entrez,  Source
phosphoinositide-3-kinase, catalytic, gamma polypeptide53290.0330.2555No
51PIK3C2BPIK3C2B
Entrez,  Source
phosphoinositide-3-kinase, class 2, beta polypeptide54150.0320.2515No
52PAK7PAK7
Entrez,  Source
p21(CDKN1A)-activated kinase 758810.0250.2179No
53MAP3K3MAP3K3
Entrez,  Source
mitogen-activated protein kinase kinase kinase 359210.0250.2168No
54PIK3CBPIK3CB
Entrez,  Source
phosphoinositide-3-kinase, catalytic, beta polypeptide62250.0200.1952No
55RETRET
Entrez,  Source
ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease)64710.0160.1777No
56BMPR1BBMPR1B
Entrez,  Source
bone morphogenetic protein receptor, type IB67770.0120.1553No
57PIP5K1CPIP5K1C
Entrez,  Source
phosphatidylinositol-4-phosphate 5-kinase, type I, gamma68810.0100.1482No
58MAP4K2MAP4K2
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 268940.0100.1481No
59CLK4CLK4
Entrez,  Source
CDC-like kinase 469350.0100.1457No
60TGFBR2TGFBR2
Entrez,  Source
transforming growth factor, beta receptor II (70/80kDa)71030.0070.1335No
61CLK2CLK2
Entrez,  Source
CDC-like kinase 271810.0050.1280No
62ACVR2BACVR2B
Entrez,  Source
activin A receptor, type IIB73820.0020.1128No
63SIK274350.0010.1089No
64PI4KB7697-0.0030.0892No
65CSNK1ECSNK1E
Entrez,  Source
casein kinase 1, epsilon7742-0.0040.0861No
66MAP2K3MAP2K3
Entrez,  Source
mitogen-activated protein kinase kinase 37798-0.0050.0823No
67PDGFRBPDGFRB
Entrez,  Source
platelet-derived growth factor receptor, beta polypeptide7824-0.0060.0809No
68MKNK2MKNK2
Entrez,  Source
MAP kinase interacting serine/threonine kinase 27841-0.0060.0802No
69MAP2K1MAP2K1
Entrez,  Source
mitogen-activated protein kinase kinase 17939-0.0080.0733No
70MELKMELK
Entrez,  Source
maternal embryonic leucine zipper kinase8047-0.0100.0659No
71TAOK2TAOK2
Entrez,  Source
TAO kinase 28059-0.0100.0658No
72KITKIT
Entrez,  Source
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog8134-0.0120.0611No
73PIK3CDPIK3CD
Entrez,  Source
phosphoinositide-3-kinase, catalytic, delta polypeptide8176-0.0130.0589No
74RPS6KA4RPS6KA4
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 48181-0.0130.0596No
75MAP2K5MAP2K5
Entrez,  Source
mitogen-activated protein kinase kinase 58199-0.0130.0593No
76DMPKDMPK
Entrez,  Source
dystrophia myotonica-protein kinase8344-0.0160.0495No
77PIK3CAPIK3CA
Entrez,  Source
phosphoinositide-3-kinase, catalytic, alpha polypeptide8749-0.0250.0206No
78ACVR2AACVR2A
Entrez,  Source
activin A receptor, type IIA9293-0.038-0.0181No
79TYK2TYK2
Entrez,  Source
tyrosine kinase 29438-0.041-0.0259No
80CSNK2A2CSNK2A2
Entrez,  Source
casein kinase 2, alpha prime polypeptide9758-0.049-0.0466No
81HIPK3HIPK3
Entrez,  Source
homeodomain interacting protein kinase 39770-0.050-0.0436No
82TTKTTK
Entrez,  Source
TTK protein kinase9930-0.055-0.0515No
83HCKHCK
Entrez,  Source
hemopoietic cell kinase9981-0.056-0.0510No
84HIPK2HIPK2
Entrez,  Source
homeodomain interacting protein kinase 210151-0.061-0.0593No
85RPS6KA3RPS6KA3
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 310427-0.070-0.0749No
86PLK4PLK4
Entrez,  Source
polo-like kinase 4 (Drosophila)10581-0.075-0.0808No
87JAK1JAK1
Entrez,  Source
Janus kinase 1 (a protein tyrosine kinase)10585-0.076-0.0752No
88BRSK2BRSK2
Entrez,  Source
BR serine/threonine kinase 210749-0.082-0.0813No
89SRCSRC
Entrez,  Source
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)10776-0.083-0.0769No
90PRKCEPRKCE
Entrez,  Source
protein kinase C, epsilon10801-0.084-0.0723No
91MTOR10944-0.091-0.0761No
92NLKNLK
Entrez,  Source
nemo-like kinase10979-0.093-0.0716No
93DAPK3DAPK3
Entrez,  Source
death-associated protein kinase 311066-0.096-0.0707No
94STK10STK10
Entrez,  Source
serine/threonine kinase 1011218-0.103-0.0743No
95MYLKMYLK
Entrez,  Source
myosin, light chain kinase11255-0.105-0.0690No
96BMPR2BMPR2
Entrez,  Source
bone morphogenetic protein receptor, type II (serine/threonine kinase)11345-0.109-0.0674No
97RIPK2RIPK2
Entrez,  Source
receptor-interacting serine-threonine kinase 211349-0.110-0.0592No
98JAK2JAK2
Entrez,  Source
Janus kinase 2 (a protein tyrosine kinase)11530-0.119-0.0638No
99SLKSLK
Entrez,  Source
STE20-like kinase (yeast)11672-0.128-0.0648No
100FYNFYN
Entrez,  Source
FYN oncogene related to SRC, FGR, YES11767-0.133-0.0617No
101HIPK1HIPK1
Entrez,  Source
homeodomain interacting protein kinase 111798-0.135-0.0536No
102MAP2K4MAP2K4
Entrez,  Source
mitogen-activated protein kinase kinase 411811-0.136-0.0440No
103MAP2K2MAP2K2
Entrez,  Source
mitogen-activated protein kinase kinase 211895-0.142-0.0394No
104MAP3K2MAP3K2
Entrez,  Source
mitogen-activated protein kinase kinase kinase 212210-0.168-0.0505No
105PDGFRAPDGFRA
Entrez,  Source
platelet-derived growth factor receptor, alpha polypeptide12211-0.168-0.0376No
106SIK112319-0.179-0.0320No
107BMPR1ABMPR1A
Entrez,  Source
bone morphogenetic protein receptor, type IA12438-0.194-0.0261No
108TGFBR1TGFBR1
Entrez,  Source
transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kDa)12447-0.195-0.0117No
109IRAK3IRAK3
Entrez,  Source
interleukin-1 receptor-associated kinase 312451-0.1960.0032No
110ABL1ABL1
Entrez,  Source
v-abl Abelson murine leukemia viral oncogene homolog 112463-0.1970.0175No
111FGFR1FGFR1
Entrez,  Source
fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome)13121-0.4860.0047No
Table: GSEA details [plain text format]



Fig 2: PP-242_KINOME SCAN   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: PP-242_KINOME SCAN: Random ES distribution   
Gene set null distribution of ES for PP-242_KINOME SCAN