DatasetNSCLC_collapsed_to_symbols.NSCLC.cls
#SEN_versus_RES.NSCLC.cls
#SEN_versus_RES_repos
PhenotypeNSCLC.cls#SEN_versus_RES_repos
Upregulated in class1
GeneSetHG-9-91-01_LINCS
Enrichment Score (ES)0.3907817
Normalized Enrichment Score (NES)1.4609526
Nominal p-value0.017886179
FDR q-value0.7181096
FWER p-Value0.998
Table: GSEA Results Summary



Fig 1: Enrichment plot: HG-9-91-01_LINCS   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEGENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1ERBB3ERBB3
Entrez,  Source
v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)121.0340.0649Yes
2EPHA1EPHA1
Entrez,  Source
EPH receptor A1940.5450.0933Yes
3ERBB2ERBB2
Entrez,  Source
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)1000.5370.1271Yes
4PTK6PTK6
Entrez,  Source
PTK6 protein tyrosine kinase 61410.4790.1545Yes
5FGFR3FGFR3
Entrez,  Source
fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism)1530.4650.1833Yes
6PAK6PAK6
Entrez,  Source
p21(CDKN1A)-activated kinase 61580.4590.2122Yes
7FGFR2FGFR2
Entrez,  Source
ffer syndrome, Jackson-Weiss syndrome)2100.4060.2340Yes
8DDR1DDR1
Entrez,  Source
discoidin domain receptor family, member 12120.4040.2596Yes
9FRKFRK
Entrez,  Source
fyn-related kinase2960.3430.2751Yes
10MST43180.3310.2945Yes
11METMET
Entrez,  Source
met proto-oncogene (hepatocyte growth factor receptor)4990.2590.2972Yes
12RPS6KA2RPS6KA2
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 25900.2370.3053Yes
13EGFREGFR
Entrez,  Source
epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)6250.2300.3174Yes
14PAK1PAK1
Entrez,  Source
p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast)6740.2190.3276Yes
15EPHB6EPHB6
Entrez,  Source
EPH receptor B67010.2150.3393Yes
16EPHA4EPHA4
Entrez,  Source
EPH receptor A47980.1970.3445Yes
17EPHB2EPHB2
Entrez,  Source
EPH receptor B28680.1850.3510Yes
18TAOK3TAOK3
Entrez,  Source
TAO kinase 39710.1700.3540Yes
19TXKTXK
Entrez,  Source
TXK tyrosine kinase10450.1600.3585Yes
20MAPK10MAPK10
Entrez,  Source
mitogen-activated protein kinase 1010690.1570.3668Yes
21TNIKTNIK
Entrez,  Source
TRAF2 and NCK interacting kinase11970.1450.3663Yes
22LCKLCK
Entrez,  Source
lymphocyte-specific protein tyrosine kinase13100.1360.3663Yes
23GAKGAK
Entrez,  Source
cyclin G associated kinase13400.1330.3726Yes
24TNK1TNK1
Entrez,  Source
tyrosine kinase, non-receptor, 113600.1310.3795Yes
25EPHA7EPHA7
Entrez,  Source
EPH receptor A714120.1280.3837Yes
26EPHB3EPHB3
Entrez,  Source
EPH receptor B314260.1270.3908Yes
27RPS6KA1RPS6KA1
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 116860.1130.3781No
28ERBB4ERBB4
Entrez,  Source
v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)18130.1070.3752No
29TESK1TESK1
Entrez,  Source
testis-specific kinase 118550.1050.3787No
30LYNLYN
Entrez,  Source
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog19740.1000.3760No
31PTK2BPTK2B
Entrez,  Source
PTK2B protein tyrosine kinase 2 beta20420.0980.3771No
32MARK1MARK1
Entrez,  Source
MAP/microtubule affinity-regulating kinase 121590.0930.3741No
33ULK2ULK2
Entrez,  Source
unc-51-like kinase 2 (C. elegans)22440.0910.3735No
34JAK3JAK3
Entrez,  Source
Janus kinase 3 (a protein tyrosine kinase, leukocyte)24440.0840.3636No
35TAOK1TAOK1
Entrez,  Source
TAO kinase 125520.0820.3606No
36ADCK4ADCK4
Entrez,  Source
aarF domain containing kinase 427150.0770.3531No
37LIMK2LIMK2
Entrez,  Source
LIM domain kinase 227990.0760.3516No
38MAP4K1MAP4K1
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 128490.0740.3525No
39EPHA3EPHA3
Entrez,  Source
EPH receptor A328700.0740.3557No
40TNK2TNK2
Entrez,  Source
tyrosine kinase, non-receptor, 230050.0700.3499No
41YES1YES1
Entrez,  Source
v-yes-1 Yamaguchi sarcoma viral oncogene homolog 130360.0700.3520No
42CSKCSK
Entrez,  Source
c-src tyrosine kinase30690.0690.3539No
43MINK1MINK1
Entrez,  Source
misshapen-like kinase 1 (zebrafish)30800.0690.3576No
44KDRKDR
Entrez,  Source
kinase insert domain receptor (a type III receptor tyrosine kinase)31460.0680.3569No
45BLKBLK
Entrez,  Source
B lymphoid tyrosine kinase34190.0620.3400No
46CSF1RCSF1R
Entrez,  Source
colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog34540.0620.3413No
47ACVRL1ACVRL1
Entrez,  Source
activin A receptor type II-like 137150.0570.3250No
48MYO3AMYO3A
Entrez,  Source
myosin IIIA37350.0570.3272No
49BRAFBRAF
Entrez,  Source
v-raf murine sarcoma viral oncogene homolog B137720.0560.3280No
50MARK2MARK2
Entrez,  Source
MAP/microtubule affinity-regulating kinase 238340.0550.3268No
51EPHB4EPHB4
Entrez,  Source
EPH receptor B438790.0540.3269No
52PRKD2PRKD2
Entrez,  Source
protein kinase D239000.0540.3288No
53EPHB1EPHB1
Entrez,  Source
EPH receptor B140000.0520.3246No
54ALKALK
Entrez,  Source
anaplastic lymphoma kinase (Ki-1)40730.0510.3223No
55FGRFGR
Entrez,  Source
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog41930.0490.3163No
56ACVR1BACVR1B
Entrez,  Source
activin A receptor, type IB43280.0470.3090No
57LIMK1LIMK1
Entrez,  Source
LIM domain kinase 144680.0450.3013No
58HUNKHUNK
Entrez,  Source
hormonally upregulated Neu-associated kinase46450.0430.2905No
59RPS6KA6RPS6KA6
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 646850.0420.2902No
60FGFR4FGFR4
Entrez,  Source
fibroblast growth factor receptor 447150.0410.2906No
61BMXBMX
Entrez,  Source
BMX non-receptor tyrosine kinase48260.0400.2847No
62EPHA2EPHA2
Entrez,  Source
EPH receptor A248800.0390.2831No
63FLT1FLT1
Entrez,  Source
fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)48820.0390.2855No
64ULK1ULK1
Entrez,  Source
unc-51-like kinase 1 (C. elegans)51570.0350.2667No
65ACVR1ACVR1
Entrez,  Source
activin A receptor, type I52300.0340.2634No
66TNNI3KTNNI3K
Entrez,  Source
TNNI3 interacting kinase52740.0330.2622No
67MAPK11MAPK11
Entrez,  Source
mitogen-activated protein kinase 1153920.0320.2553No
68PIK3C2BPIK3C2B
Entrez,  Source
phosphoinositide-3-kinase, class 2, beta polypeptide54150.0320.2556No
69EPHA5EPHA5
Entrez,  Source
EPH receptor A554750.0310.2531No
70STK24STK24
Entrez,  Source
serine/threonine kinase 24 (STE20 homolog, yeast)55870.0290.2464No
71BTKBTK
Entrez,  Source
Bruton agammaglobulinemia tyrosine kinase56280.0290.2452No
72STK16STK16
Entrez,  Source
serine/threonine kinase 1657780.0270.2355No
73PAK7PAK7
Entrez,  Source
p21(CDKN1A)-activated kinase 758810.0250.2293No
74MAP3K3MAP3K3
Entrez,  Source
mitogen-activated protein kinase kinase kinase 359210.0250.2279No
75FESFES
Entrez,  Source
feline sarcoma oncogene61260.0220.2136No
76IRAK1IRAK1
Entrez,  Source
interleukin-1 receptor-associated kinase 161790.0210.2110No
77AURKAAURKA
Entrez,  Source
aurora kinase A64270.0170.1931No
78DCLK264620.0160.1915No
79RETRET
Entrez,  Source
ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease)64710.0160.1920No
80MAPK14MAPK14
Entrez,  Source
mitogen-activated protein kinase 1464920.0160.1915No
81MAP3K10MAP3K10
Entrez,  Source
mitogen-activated protein kinase kinase kinase 1065490.0150.1881No
82BMPR1BBMPR1B
Entrez,  Source
bone morphogenetic protein receptor, type IB67770.0120.1715No
83MAPK8MAPK8
Entrez,  Source
mitogen-activated protein kinase 868290.0110.1683No
84MAP4K2MAP4K2
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 268940.0100.1640No
85MAPK7MAPK7
Entrez,  Source
mitogen-activated protein kinase 769130.0100.1633No
86STK32BSTK32B
Entrez,  Source
serine/threonine kinase 32B69190.0100.1635No
87BMP2KBMP2K
Entrez,  Source
BMP2 inducible kinase70290.0080.1557No
88TEKTEK
Entrez,  Source
TEK tyrosine kinase, endothelial (venous malformations, multiple cutaneous and mucosal)70350.0080.1558No
89TGFBR2TGFBR2
Entrez,  Source
transforming growth factor, beta receptor II (70/80kDa)71030.0070.1511No
90ACVR2BACVR2B
Entrez,  Source
activin A receptor, type IIB73820.0020.1299No
91SIK37726-0.0040.1038No
92CSNK1ECSNK1E
Entrez,  Source
casein kinase 1, epsilon7742-0.0040.1030No
93MAP2K3MAP2K3
Entrez,  Source
mitogen-activated protein kinase kinase 37798-0.0050.0991No
94PDGFRBPDGFRB
Entrez,  Source
platelet-derived growth factor receptor, beta polypeptide7824-0.0060.0975No
95MAPK9MAPK9
Entrez,  Source
mitogen-activated protein kinase 97830-0.0060.0975No
96TAOK2TAOK2
Entrez,  Source
TAO kinase 28059-0.0100.0807No
97PRKACAPRKACA
Entrez,  Source
protein kinase, cAMP-dependent, catalytic, alpha8112-0.0110.0774No
98KITKIT
Entrez,  Source
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog8134-0.0120.0766No
99LTKLTK
Entrez,  Source
leukocyte tyrosine kinase8158-0.0120.0756No
100MAP2K5MAP2K5
Entrez,  Source
mitogen-activated protein kinase kinase 58199-0.0130.0734No
101DMPKDMPK
Entrez,  Source
dystrophia myotonica-protein kinase8344-0.0160.0633No
102STK25STK25
Entrez,  Source
serine/threonine kinase 25 (STE20 homolog, yeast)8561-0.0210.0481No
103ACVR2AACVR2A
Entrez,  Source
activin A receptor, type IIA9293-0.038-0.0055No
104PRKD1PRKD1
Entrez,  Source
protein kinase D19827-0.052-0.0431No
105MAP4K4MAP4K4
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 49922-0.055-0.0469No
106TTKTTK
Entrez,  Source
TTK protein kinase9930-0.055-0.0439No
107HCKHCK
Entrez,  Source
hemopoietic cell kinase9981-0.056-0.0442No
108CHEK2CHEK2
Entrez,  Source
CHK2 checkpoint homolog (S. pombe)10102-0.059-0.0496No
109DDR2DDR2
Entrez,  Source
discoidin domain receptor family, member 210235-0.064-0.0557No
110MARK3MARK3
Entrez,  Source
MAP/microtubule affinity-regulating kinase 310374-0.068-0.0619No
111CITCIT
Entrez,  Source
citron (rho-interacting, serine/threonine kinase 21)10420-0.070-0.0609No
112RPS6KA3RPS6KA3
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 310427-0.070-0.0569No
113SRCSRC
Entrez,  Source
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)10776-0.083-0.0783No
114PRKCEPRKCE
Entrez,  Source
protein kinase C, epsilon10801-0.084-0.0747No
115CDK4CDK4
Entrez,  Source
cyclin-dependent kinase 410871-0.087-0.0745No
116ABL2ABL2
Entrez,  Source
v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)11090-0.098-0.0850No
117PRKACBPRKACB
Entrez,  Source
protein kinase, cAMP-dependent, catalytic, beta11179-0.102-0.0853No
118STK10STK10
Entrez,  Source
serine/threonine kinase 1011218-0.103-0.0816No
119RIPK2RIPK2
Entrez,  Source
receptor-interacting serine-threonine kinase 211349-0.110-0.0846No
120SLKSLK
Entrez,  Source
STE20-like kinase (yeast)11672-0.128-0.1011No
121MAP4K5MAP4K5
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 511705-0.130-0.0954No
122FYNFYN
Entrez,  Source
FYN oncogene related to SRC, FGR, YES11767-0.133-0.0916No
123MAP2K4MAP2K4
Entrez,  Source
mitogen-activated protein kinase kinase 411811-0.136-0.0862No
124MAP2K2MAP2K2
Entrez,  Source
mitogen-activated protein kinase kinase 211895-0.142-0.0835No
125CDC42BPACDC42BPA
Entrez,  Source
CDC42 binding protein kinase alpha (DMPK-like)11941-0.145-0.0778No
126CDC42BPBCDC42BPB
Entrez,  Source
CDC42 binding protein kinase beta (DMPK-like)12053-0.154-0.0765No
127MAP3K2MAP3K2
Entrez,  Source
mitogen-activated protein kinase kinase kinase 212210-0.168-0.0778No
128PDGFRAPDGFRA
Entrez,  Source
platelet-derived growth factor receptor, alpha polypeptide12211-0.168-0.0671No
129SIK112319-0.179-0.0639No
130MAP4K3MAP4K3
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 312403-0.189-0.0583No
131BMPR1ABMPR1A
Entrez,  Source
bone morphogenetic protein receptor, type IA12438-0.194-0.0486No
132TGFBR1TGFBR1
Entrez,  Source
transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kDa)12447-0.195-0.0368No
133ABL1ABL1
Entrez,  Source
v-abl Abelson murine leukemia viral oncogene homolog 112463-0.197-0.0254No
134ZAKZAK
Entrez,  Source
-12544-0.209-0.0182No
135MAP3K7MAP3K7
Entrez,  Source
mitogen-activated protein kinase kinase kinase 712613-0.221-0.0094No
136PRKD3PRKD3
Entrez,  Source
protein kinase D313008-0.345-0.0176No
137FGFR1FGFR1
Entrez,  Source
fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome)13121-0.4860.0047No
Table: GSEA details [plain text format]



Fig 2: HG-9-91-01_LINCS   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HG-9-91-01_LINCS: Random ES distribution   
Gene set null distribution of ES for HG-9-91-01_LINCS