DatasetNSCLC_collapsed_to_symbols.NSCLC.cls
#SEN_versus_RES.NSCLC.cls
#SEN_versus_RES_repos
PhenotypeNSCLC.cls#SEN_versus_RES_repos
Upregulated in class1
GeneSetAZD-2171_KINOME SCAN
Enrichment Score (ES)0.4955129
Normalized Enrichment Score (NES)1.5214767
Nominal p-value0.027075812
FDR q-value1.0
FWER p-Value0.981
Table: GSEA Results Summary



Fig 1: Enrichment plot: AZD-2171_KINOME SCAN   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEGENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1ERBB3ERBB3
Entrez,  Source
v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)121.0340.1458Yes
2PTK6PTK6
Entrez,  Source
PTK6 protein tyrosine kinase 61410.4790.2040Yes
3FGFR3FGFR3
Entrez,  Source
fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism)1530.4650.2692Yes
4FGFR2FGFR2
Entrez,  Source
ffer syndrome, Jackson-Weiss syndrome)2100.4060.3225Yes
5DDR1DDR1
Entrez,  Source
discoidin domain receptor family, member 12120.4040.3797Yes
6FRKFRK
Entrez,  Source
fyn-related kinase2960.3430.4220Yes
7METMET
Entrez,  Source
met proto-oncogene (hepatocyte growth factor receptor)4990.2590.4434Yes
8EGFREGFR
Entrez,  Source
epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)6250.2300.4665Yes
9EPHB6EPHB6
Entrez,  Source
EPH receptor B67010.2150.4913Yes
10TNIKTNIK
Entrez,  Source
TRAF2 and NCK interacting kinase11970.1450.4743Yes
11LCKLCK
Entrez,  Source
lymphocyte-specific protein tyrosine kinase13100.1360.4850Yes
12EPHA7EPHA7
Entrez,  Source
EPH receptor A714120.1280.4955Yes
13LYNLYN
Entrez,  Source
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog19740.1000.4670No
14TIE1TIE1
Entrez,  Source
tyrosine kinase with immunoglobulin-like and EGF-like domains 123280.0880.4526No
15MAP4K1MAP4K1
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 128490.0740.4235No
16YES1YES1
Entrez,  Source
v-yes-1 Yamaguchi sarcoma viral oncogene homolog 130360.0700.4192No
17MINK1MINK1
Entrez,  Source
misshapen-like kinase 1 (zebrafish)30800.0690.4258No
18KDRKDR
Entrez,  Source
kinase insert domain receptor (a type III receptor tyrosine kinase)31460.0680.4304No
19BLKBLK
Entrez,  Source
B lymphoid tyrosine kinase34190.0620.4186No
20CSF1RCSF1R
Entrez,  Source
colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog34540.0620.4247No
21FGFR4FGFR4
Entrez,  Source
fibroblast growth factor receptor 447150.0410.3348No
22FLT1FLT1
Entrez,  Source
fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)48820.0390.3277No
23FLT4FLT4
Entrez,  Source
fms-related tyrosine kinase 448980.0390.3320No
24RETRET
Entrez,  Source
ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease)64710.0160.2147No
25MAP4K2MAP4K2
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 268940.0100.1840No
26TEKTEK
Entrez,  Source
TEK tyrosine kinase, endothelial (venous malformations, multiple cutaneous and mucosal)70350.0080.1745No
27PDGFRBPDGFRB
Entrez,  Source
platelet-derived growth factor receptor, beta polypeptide7824-0.0060.1154No
28KITKIT
Entrez,  Source
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog8134-0.0120.0935No
29ERN1ERN1
Entrez,  Source
endoplasmic reticulum to nucleus signalling 19341-0.0390.0073No
30HCKHCK
Entrez,  Source
hemopoietic cell kinase9981-0.056-0.0334No
31DDR2DDR2
Entrez,  Source
discoidin domain receptor family, member 210235-0.064-0.0436No
32SRCSRC
Entrez,  Source
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)10776-0.083-0.0729No
33ABL2ABL2
Entrez,  Source
v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)11090-0.098-0.0829No
34STK10STK10
Entrez,  Source
serine/threonine kinase 1011218-0.103-0.0779No
35RIPK2RIPK2
Entrez,  Source
receptor-interacting serine-threonine kinase 211349-0.110-0.0722No
36TYRO3TYRO3
Entrez,  Source
TYRO3 protein tyrosine kinase11601-0.123-0.0738No
37SLKSLK
Entrez,  Source
STE20-like kinase (yeast)11672-0.128-0.0610No
38MAP4K5MAP4K5
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 511705-0.130-0.0451No
39PDGFRAPDGFRA
Entrez,  Source
platelet-derived growth factor receptor, alpha polypeptide12211-0.168-0.0597No
40ABL1ABL1
Entrez,  Source
v-abl Abelson murine leukemia viral oncogene homolog 112463-0.197-0.0508No
41AXLAXL
Entrez,  Source
AXL receptor tyrosine kinase12789-0.257-0.0391No
42FGFR1FGFR1
Entrez,  Source
fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome)13121-0.4860.0046No
Table: GSEA details [plain text format]



Fig 2: AZD-2171_KINOME SCAN   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: AZD-2171_KINOME SCAN: Random ES distribution   
Gene set null distribution of ES for AZD-2171_KINOME SCAN