DatasetNSCLC_collapsed_to_symbols.NSCLC.cls
#SEN_versus_RES.NSCLC.cls
#SEN_versus_RES_repos
PhenotypeNSCLC.cls#SEN_versus_RES_repos
Upregulated in class1
GeneSetBMS-536924,KIN001-126_LINCS
Enrichment Score (ES)0.3200414
Normalized Enrichment Score (NES)1.1882448
Nominal p-value0.15422077
FDR q-value0.6476636
FWER p-Value1.0
Table: GSEA Results Summary



Fig 1: Enrichment plot: BMS-536924,KIN001-126_LINCS   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEGENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1DAPK1DAPK1
Entrez,  Source
death-associated protein kinase 1880.5570.0359Yes
2FGFR3FGFR3
Entrez,  Source
fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism)1530.4650.0666Yes
3PAK6PAK6
Entrez,  Source
p21(CDKN1A)-activated kinase 61580.4590.1014Yes
4FGFR2FGFR2
Entrez,  Source
ffer syndrome, Jackson-Weiss syndrome)2100.4060.1285Yes
5DDR1DDR1
Entrez,  Source
discoidin domain receptor family, member 12120.4040.1593Yes
6FRKFRK
Entrez,  Source
fyn-related kinase2960.3430.1793Yes
7MST43180.3310.2030Yes
8SYKSYK
Entrez,  Source
spleen tyrosine kinase4710.2680.2118Yes
9METMET
Entrez,  Source
met proto-oncogene (hepatocyte growth factor receptor)4990.2590.2296Yes
10ROS1ROS1
Entrez,  Source
v-ros UR2 sarcoma virus oncogene homolog 1 (avian)5050.2580.2489Yes
11EGFREGFR
Entrez,  Source
epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)6250.2300.2574Yes
12TXKTXK
Entrez,  Source
TXK tyrosine kinase10450.1600.2375Yes
13TNIKTNIK
Entrez,  Source
TRAF2 and NCK interacting kinase11970.1450.2371Yes
14LCKLCK
Entrez,  Source
lymphocyte-specific protein tyrosine kinase13100.1360.2389Yes
15GAKGAK
Entrez,  Source
cyclin G associated kinase13400.1330.2469Yes
16TNK1TNK1
Entrez,  Source
tyrosine kinase, non-receptor, 113600.1310.2555Yes
17EPHA7EPHA7
Entrez,  Source
EPH receptor A714120.1280.2614Yes
18SLC12A7SLC12A7
Entrez,  Source
solute carrier family 12 (potassium/chloride transporters), member 715430.1200.2606Yes
19STK3STK3
Entrez,  Source
serine/threonine kinase 3 (STE20 homolog, yeast)15530.1200.2691Yes
20STK17BSTK17B
Entrez,  Source
serine/threonine kinase 17b (apoptosis-inducing)15540.1190.2782Yes
21INSRINSR
Entrez,  Source
insulin receptor16640.1140.2786Yes
22RPS6KA1RPS6KA1
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 116860.1130.2856Yes
23MAP3K9MAP3K9
Entrez,  Source
mitogen-activated protein kinase kinase kinase 916990.1120.2933Yes
24NTRK2NTRK2
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 217040.1120.3016Yes
25DAPK2DAPK2
Entrez,  Source
death-associated protein kinase 218380.1050.2995Yes
26RIOK3RIOK3
Entrez,  Source
RIO kinase 3 (yeast)19420.1010.2993Yes
27LYNLYN
Entrez,  Source
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog19740.1000.3046Yes
28PTK2BPTK2B
Entrez,  Source
PTK2B protein tyrosine kinase 2 beta20420.0980.3069Yes
29MARK1MARK1
Entrez,  Source
MAP/microtubule affinity-regulating kinase 121590.0930.3052Yes
30AAK1AAK1
Entrez,  Source
AP2 associated kinase 122120.0920.3082Yes
31ULK2ULK2
Entrez,  Source
unc-51-like kinase 2 (C. elegans)22440.0910.3128Yes
32MAP3K11MAP3K11
Entrez,  Source
mitogen-activated protein kinase kinase kinase 1122950.0890.3158Yes
33TIE1TIE1
Entrez,  Source
tyrosine kinase with immunoglobulin-like and EGF-like domains 123280.0880.3200Yes
34JAK3JAK3
Entrez,  Source
Janus kinase 3 (a protein tyrosine kinase, leukocyte)24440.0840.3177No
35MERTKMERTK
Entrez,  Source
c-mer proto-oncogene tyrosine kinase25220.0820.3181No
36MAP4K1MAP4K1
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 128490.0740.2988No
37EPHA3EPHA3
Entrez,  Source
EPH receptor A328700.0740.3029No
38TNK2TNK2
Entrez,  Source
tyrosine kinase, non-receptor, 230050.0700.2980No
39YES1YES1
Entrez,  Source
v-yes-1 Yamaguchi sarcoma viral oncogene homolog 130360.0700.3011No
40CSKCSK
Entrez,  Source
c-src tyrosine kinase30690.0690.3039No
41MINK1MINK1
Entrez,  Source
misshapen-like kinase 1 (zebrafish)30800.0690.3084No
42FLT3FLT3
Entrez,  Source
fms-related tyrosine kinase 334030.0630.2886No
43BLKBLK
Entrez,  Source
B lymphoid tyrosine kinase34190.0620.2922No
44CSF1RCSF1R
Entrez,  Source
colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog34540.0620.2943No
45ACVRL1ACVRL1
Entrez,  Source
activin A receptor type II-like 137150.0570.2788No
46MARK2MARK2
Entrez,  Source
MAP/microtubule affinity-regulating kinase 238340.0550.2739No
47PRKG2PRKG2
Entrez,  Source
protein kinase, cGMP-dependent, type II40210.0520.2637No
48ALKALK
Entrez,  Source
anaplastic lymphoma kinase (Ki-1)40730.0510.2637No
49FGRFGR
Entrez,  Source
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog41930.0490.2583No
50AURKCAURKC
Entrez,  Source
aurora kinase C44130.0460.2451No
51RPS6KA6RPS6KA6
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 646850.0420.2275No
52FGFR4FGFR4
Entrez,  Source
fibroblast growth factor receptor 447150.0410.2285No
53PHKG2PHKG2
Entrez,  Source
phosphorylase kinase, gamma 2 (testis)47920.0400.2258No
54NEK7NEK7
Entrez,  Source
NIMA (never in mitosis gene a)-related kinase 748770.0390.2223No
55FLT1FLT1
Entrez,  Source
fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)48820.0390.2250No
56FLT4FLT4
Entrez,  Source
fms-related tyrosine kinase 448980.0390.2268No
57PRKG1PRKG1
Entrez,  Source
protein kinase, cGMP-dependent, type I49360.0380.2269No
58PAK4PAK4
Entrez,  Source
p21(CDKN1A)-activated kinase 450140.0370.2239No
59ACVR1ACVR1
Entrez,  Source
activin A receptor, type I52300.0340.2100No
60INSRRINSRR
Entrez,  Source
insulin receptor-related receptor53320.0330.2048No
61TECTEC
Entrez,  Source
tec protein tyrosine kinase53790.0320.2037No
62EPHA5EPHA5
Entrez,  Source
EPH receptor A554750.0310.1988No
63STK24STK24
Entrez,  Source
serine/threonine kinase 24 (STE20 homolog, yeast)55870.0290.1926No
64BTKBTK
Entrez,  Source
Bruton agammaglobulinemia tyrosine kinase56280.0290.1917No
65STK16STK16
Entrez,  Source
serine/threonine kinase 1657780.0270.1824No
66SRPK3SRPK3
Entrez,  Source
SFRS protein kinase 358600.0260.1781No
67PAK7PAK7
Entrez,  Source
p21(CDKN1A)-activated kinase 758810.0250.1785No
68MAP3K3MAP3K3
Entrez,  Source
mitogen-activated protein kinase kinase kinase 359210.0250.1775No
69NTRK1NTRK1
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 160970.0220.1657No
70PHKG1PHKG1
Entrez,  Source
phosphorylase kinase, gamma 1 (muscle)62450.0200.1560No
71RETRET
Entrez,  Source
ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease)64710.0160.1400No
72MAP3K10MAP3K10
Entrez,  Source
mitogen-activated protein kinase kinase kinase 1065490.0150.1353No
73PIP4K2B65940.0150.1330No
74PKN1PKN1
Entrez,  Source
protein kinase N167830.0120.1196No
75MAP4K2MAP4K2
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 268940.0100.1119No
76CLK4CLK4
Entrez,  Source
CDC-like kinase 469350.0100.1096No
77BMP2KBMP2K
Entrez,  Source
BMP2 inducible kinase70290.0080.1030No
78CLK2CLK2
Entrez,  Source
CDC-like kinase 271810.0050.0919No
79IKBKEIKBKE
Entrez,  Source
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon72160.0040.0896No
80ITKITK
Entrez,  Source
IL2-inducible T-cell kinase72200.0040.0897No
81PRKAA2PRKAA2
Entrez,  Source
protein kinase, AMP-activated, alpha 2 catalytic subunit74180.0010.0747No
82MAP2K3MAP2K3
Entrez,  Source
mitogen-activated protein kinase kinase 37798-0.0050.0461No
83PDGFRBPDGFRB
Entrez,  Source
platelet-derived growth factor receptor, beta polypeptide7824-0.0060.0446No
84MAP2K1MAP2K1
Entrez,  Source
mitogen-activated protein kinase kinase 17939-0.0080.0365No
85IGF1RIGF1R
Entrez,  Source
insulin-like growth factor 1 receptor7959-0.0080.0357No
86MELKMELK
Entrez,  Source
maternal embryonic leucine zipper kinase8047-0.0100.0298No
87KITKIT
Entrez,  Source
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog8134-0.0120.0241No
88LTKLTK
Entrez,  Source
leukocyte tyrosine kinase8158-0.0120.0233No
89PTK2PTK2
Entrez,  Source
PTK2 protein tyrosine kinase 28356-0.0160.0094No
90NTRK3NTRK3
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 38500-0.019-0.0000No
91AURKBAURKB
Entrez,  Source
aurora kinase B8856-0.027-0.0251No
92STK11STK11
Entrez,  Source
serine/threonine kinase 119183-0.035-0.0474No
93TYK2TYK2
Entrez,  Source
tyrosine kinase 29438-0.041-0.0638No
94PAK3PAK3
Entrez,  Source
p21 (CDKN1A)-activated kinase 39490-0.042-0.0644No
95NEK9NEK9
Entrez,  Source
NIMA (never in mitosis gene a)- related kinase 99810-0.051-0.0850No
96MAP4K4MAP4K4
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 49922-0.055-0.0893No
97HCKHCK
Entrez,  Source
hemopoietic cell kinase9981-0.056-0.0895No
98STK17ASTK17A
Entrez,  Source
serine/threonine kinase 17a (apoptosis-inducing)10017-0.057-0.0878No
99MARK3MARK3
Entrez,  Source
MAP/microtubule affinity-regulating kinase 310374-0.068-0.1098No
100PLK4PLK4
Entrez,  Source
polo-like kinase 4 (Drosophila)10581-0.075-0.1199No
101JAK1JAK1
Entrez,  Source
Janus kinase 1 (a protein tyrosine kinase)10585-0.076-0.1143No
102SRCSRC
Entrez,  Source
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)10776-0.083-0.1225No
103PIP5K1APIP5K1A
Entrez,  Source
phosphatidylinositol-4-phosphate 5-kinase, type I, alpha10780-0.083-0.1163No
104PRKAA1PRKAA1
Entrez,  Source
protein kinase, AMP-activated, alpha 1 catalytic subunit10906-0.089-0.1191No
105NUAK1NUAK1
Entrez,  Source
NUAK family, SNF1-like kinase, 111032-0.095-0.1214No
106DAPK3DAPK3
Entrez,  Source
death-associated protein kinase 311066-0.096-0.1166No
107SRPK1SRPK1
Entrez,  Source
SFRS protein kinase 111068-0.096-0.1093No
108ABL2ABL2
Entrez,  Source
v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)11090-0.098-0.1034No
109MYLKMYLK
Entrez,  Source
myosin, light chain kinase11255-0.105-0.1080No
110BMPR2BMPR2
Entrez,  Source
bone morphogenetic protein receptor, type II (serine/threonine kinase)11345-0.109-0.1064No
111FERFER
Entrez,  Source
fer (fps/fes related) tyrosine kinase (phosphoprotein NCP94)11371-0.111-0.0999No
112STK4STK4
Entrez,  Source
serine/threonine kinase 411518-0.118-0.1020No
113JAK2JAK2
Entrez,  Source
Janus kinase 2 (a protein tyrosine kinase)11530-0.119-0.0938No
114SLKSLK
Entrez,  Source
STE20-like kinase (yeast)11672-0.128-0.0948No
115MAP4K5MAP4K5
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 511705-0.130-0.0874No
116FYNFYN
Entrez,  Source
FYN oncogene related to SRC, FGR, YES11767-0.133-0.0818No
117CSNK2A1CSNK2A1
Entrez,  Source
casein kinase 2, alpha 1 polypeptide11861-0.139-0.0783No
118MAP2K2MAP2K2
Entrez,  Source
mitogen-activated protein kinase kinase 211895-0.142-0.0700No
119CDC42BPACDC42BPA
Entrez,  Source
CDC42 binding protein kinase alpha (DMPK-like)11941-0.145-0.0623No
120CDC42BPBCDC42BPB
Entrez,  Source
CDC42 binding protein kinase beta (DMPK-like)12053-0.154-0.0591No
121CAMK1CAMK1
Entrez,  Source
calcium/calmodulin-dependent protein kinase I12150-0.162-0.0540No
122MAP3K12MAP3K12
Entrez,  Source
mitogen-activated protein kinase kinase kinase 1212384-0.186-0.0576No
123MAP4K3MAP4K3
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 312403-0.189-0.0445No
124IRAK3IRAK3
Entrez,  Source
interleukin-1 receptor-associated kinase 312451-0.196-0.0331No
125ABL1ABL1
Entrez,  Source
v-abl Abelson murine leukemia viral oncogene homolog 112463-0.197-0.0189No
126MAP3K7MAP3K7
Entrez,  Source
mitogen-activated protein kinase kinase kinase 712613-0.221-0.0134No
127AXLAXL
Entrez,  Source
AXL receptor tyrosine kinase12789-0.257-0.0072No
128FGFR1FGFR1
Entrez,  Source
fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome)13121-0.4860.0047No
Table: GSEA details [plain text format]



Fig 2: BMS-536924,KIN001-126_LINCS   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: BMS-536924,KIN001-126_LINCS: Random ES distribution   
Gene set null distribution of ES for BMS-536924,KIN001-126_LINCS