DatasetNSCLC_collapsed_to_symbols.NSCLC.cls
#SEN_versus_RES.NSCLC.cls
#SEN_versus_RES_repos
PhenotypeNSCLC.cls#SEN_versus_RES_repos
Upregulated in class1
GeneSetSTAUROSPORINE_MRC
Enrichment Score (ES)0.29194865
Normalized Enrichment Score (NES)0.99864733
Nominal p-value0.4357262
FDR q-value0.7887501
FWER p-Value1.0
Table: GSEA Results Summary



Fig 1: Enrichment plot: STAUROSPORINE_MRC   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEGENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1DAPK1DAPK1
Entrez,  Source
death-associated protein kinase 1880.5570.0521Yes
2MAPK13MAPK13
Entrez,  Source
mitogen-activated protein kinase 131100.5250.1061Yes
3PTK6PTK6
Entrez,  Source
PTK6 protein tyrosine kinase 61410.4790.1544Yes
4PAK6PAK6
Entrez,  Source
p21(CDKN1A)-activated kinase 61580.4590.2017Yes
5PRKCZPRKCZ
Entrez,  Source
protein kinase C, zeta1690.4470.2481Yes
6SYKSYK
Entrez,  Source
spleen tyrosine kinase4710.2680.2535Yes
7IKBKBIKBKB
Entrez,  Source
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta5530.2450.2732Yes
8EPHB2EPHB2
Entrez,  Source
EPH receptor B28680.1850.2688Yes
9MAPK10MAPK10
Entrez,  Source
mitogen-activated protein kinase 1010690.1570.2702Yes
10DYRK2DYRK2
Entrez,  Source
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 212300.1420.2730Yes
11LCKLCK
Entrez,  Source
lymphocyte-specific protein tyrosine kinase13100.1360.2814Yes
12EPHB3EPHB3
Entrez,  Source
EPH receptor B314260.1270.2860Yes
13INSRINSR
Entrez,  Source
insulin receptor16640.1140.2800Yes
14RPS6KA1RPS6KA1
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 116860.1130.2903Yes
15ERBB4ERBB4
Entrez,  Source
v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)18130.1070.2919Yes
16MAP3K5MAP3K5
Entrez,  Source
mitogen-activated protein kinase kinase kinase 521470.0940.2765No
17MAP3K11MAP3K11
Entrez,  Source
mitogen-activated protein kinase kinase kinase 1122950.0890.2747No
18TAOK1TAOK1
Entrez,  Source
TAO kinase 125520.0820.2638No
19RPS6KA5RPS6KA5
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 526100.0800.2679No
20PIM2PIM2
Entrez,  Source
pim-2 oncogene29560.0710.2491No
21YES1YES1
Entrez,  Source
v-yes-1 Yamaguchi sarcoma viral oncogene homolog 130360.0700.2504No
22EPHB4EPHB4
Entrez,  Source
EPH receptor B438790.0540.1919No
23PIM1PIM1
Entrez,  Source
pim-1 oncogene41360.0500.1777No
24NEK2NEK2
Entrez,  Source
NIMA (never in mitosis gene a)-related kinase 244830.0450.1561No
25EPHA2EPHA2
Entrez,  Source
EPH receptor A248800.0390.1300No
26FLT1FLT1
Entrez,  Source
fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)48820.0390.1340No
27PAK4PAK4
Entrez,  Source
p21(CDKN1A)-activated kinase 450140.0370.1279No
28INSRRINSRR
Entrez,  Source
insulin receptor-related receptor53320.0330.1072No
29PAK7PAK7
Entrez,  Source
p21(CDKN1A)-activated kinase 758810.0250.0681No
30NTRK1NTRK1
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 160970.0220.0540No
31IRAK1IRAK1
Entrez,  Source
interleukin-1 receptor-associated kinase 161790.0210.0500No
32AURKAAURKA
Entrez,  Source
aurora kinase A64270.0170.0330No
33MAPK8MAPK8
Entrez,  Source
mitogen-activated protein kinase 868290.0110.0036No
34MAP4K2MAP4K2
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 268940.010-0.0003No
35TEKTEK
Entrez,  Source
TEK tyrosine kinase, endothelial (venous malformations, multiple cutaneous and mucosal)70350.008-0.0101No
36CLK2CLK2
Entrez,  Source
CDC-like kinase 271810.005-0.0206No
37IKBKEIKBKE
Entrez,  Source
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon72160.004-0.0228No
38AKT1AKT1
Entrez,  Source
v-akt murine thymoma viral oncogene homolog 173870.002-0.0355No
39PRKCGPRKCG
Entrez,  Source
protein kinase C, gamma74490.001-0.0401No
40MAP2K1MAP2K1
Entrez,  Source
mitogen-activated protein kinase kinase 17939-0.008-0.0766No
41IGF1RIGF1R
Entrez,  Source
insulin-like growth factor 1 receptor7959-0.008-0.0772No
42PRKACAPRKACA
Entrez,  Source
protein kinase, cAMP-dependent, catalytic, alpha8112-0.011-0.0876No
43MARK4MARK4
Entrez,  Source
MAP/microtubule affinity-regulating kinase 48259-0.014-0.0972No
44ZAP70ZAP70
Entrez,  Source
zeta-chain (TCR) associated protein kinase 70kDa8954-0.030-0.1471No
45IRAK4IRAK4
Entrez,  Source
interleukin-1 receptor-associated kinase 48996-0.031-0.1470No
46STK11STK11
Entrez,  Source
serine/threonine kinase 119183-0.035-0.1575No
47MAPKAPK2MAPKAPK2
Entrez,  Source
mitogen-activated protein kinase-activated protein kinase 29187-0.035-0.1540No
48CDK2CDK2
Entrez,  Source
cyclin-dependent kinase 29409-0.040-0.1666No
49HIPK3HIPK3
Entrez,  Source
homeodomain interacting protein kinase 39770-0.050-0.1888No
50PRKD1PRKD1
Entrez,  Source
protein kinase D19827-0.052-0.1877No
51CHEK2CHEK2
Entrez,  Source
CHK2 checkpoint homolog (S. pombe)10102-0.059-0.2023No
52HIPK2HIPK2
Entrez,  Source
homeodomain interacting protein kinase 210151-0.061-0.1995No
53DYRK1ADYRK1A
Entrez,  Source
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A10303-0.066-0.2041No
54MARK3MARK3
Entrez,  Source
MAP/microtubule affinity-regulating kinase 310374-0.068-0.2022No
55RPS6KA3RPS6KA3
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 310427-0.070-0.1988No
56OXSR1OXSR1
Entrez,  Source
oxidative-stress responsive 110514-0.073-0.1976No
57RPS6KB1RPS6KB1
Entrez,  Source
ribosomal protein S6 kinase, 70kDa, polypeptide 110717-0.081-0.2045No
58CAMKK2CAMKK2
Entrez,  Source
calcium/calmodulin-dependent protein kinase kinase 2, beta10729-0.081-0.1967No
59TBK1TBK1
Entrez,  Source
TANK-binding kinase 110732-0.082-0.1883No
60BRSK2BRSK2
Entrez,  Source
BR serine/threonine kinase 210749-0.082-0.1808No
61SRCSRC
Entrez,  Source
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)10776-0.083-0.1740No
62PAK2PAK2
Entrez,  Source
p21 (CDKN1A)-activated kinase 210809-0.085-0.1675No
63MAPKAPK5MAPKAPK5
Entrez,  Source
mitogen-activated protein kinase-activated protein kinase 510962-0.092-0.1694No
64NUAK1NUAK1
Entrez,  Source
NUAK family, SNF1-like kinase, 111032-0.095-0.1647No
65SRPK1SRPK1
Entrez,  Source
SFRS protein kinase 111068-0.096-0.1571No
66GSK3BGSK3B
Entrez,  Source
glycogen synthase kinase 3 beta11131-0.100-0.1513No
67MYLKMYLK
Entrez,  Source
myosin, light chain kinase11255-0.105-0.1496No
68JAK2JAK2
Entrez,  Source
Janus kinase 2 (a protein tyrosine kinase)11530-0.119-0.1580No
69MAP2K2MAP2K2
Entrez,  Source
mitogen-activated protein kinase kinase 211895-0.142-0.1708No
70PRKCAPRKCA
Entrez,  Source
protein kinase C, alpha11975-0.147-0.1613No
71CAMK1CAMK1
Entrez,  Source
calcium/calmodulin-dependent protein kinase I12150-0.162-0.1574No
72DYRK3DYRK3
Entrez,  Source
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 312238-0.171-0.1461No
73PKN2PKN2
Entrez,  Source
protein kinase N212286-0.175-0.1311No
74ABL1ABL1
Entrez,  Source
v-abl Abelson murine leukemia viral oncogene homolog 112463-0.197-0.1237No
75TLK1TLK1
Entrez,  Source
tousled-like kinase 112558-0.210-0.1087No
76MAP3K7MAP3K7
Entrez,  Source
mitogen-activated protein kinase kinase kinase 712613-0.221-0.0895No
77AKT2AKT2
Entrez,  Source
v-akt murine thymoma viral oncogene homolog 212829-0.271-0.0772No
78FGFR1FGFR1
Entrez,  Source
fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome)13121-0.486-0.0480No
79SGK113133-0.4980.0037No
Table: GSEA details [plain text format]



Fig 2: STAUROSPORINE_MRC   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: STAUROSPORINE_MRC: Random ES distribution   
Gene set null distribution of ES for STAUROSPORINE_MRC