DatasetNSCLC_collapsed_to_symbols.NSCLC.cls
#SEN_versus_RES.NSCLC.cls
#SEN_versus_RES_repos
PhenotypeNSCLC.cls#SEN_versus_RES_repos
Upregulated in class1
GeneSetBX-912_LINCS
Enrichment Score (ES)0.26113945
Normalized Enrichment Score (NES)1.0079098
Nominal p-value0.42563292
FDR q-value0.78068876
FWER p-Value1.0
Table: GSEA Results Summary



Fig 1: Enrichment plot: BX-912_LINCS   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEGENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1DAPK1DAPK1
Entrez,  Source
death-associated protein kinase 1880.5570.0236Yes
2RIPK4RIPK4
Entrez,  Source
receptor-interacting serine-threonine kinase 4950.5440.0529Yes
3MAPK13MAPK13
Entrez,  Source
mitogen-activated protein kinase 131100.5250.0805Yes
4FGFR3FGFR3
Entrez,  Source
fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism)1530.4650.1027Yes
5PAK6PAK6
Entrez,  Source
p21(CDKN1A)-activated kinase 61580.4590.1275Yes
6FGFR2FGFR2
Entrez,  Source
ffer syndrome, Jackson-Weiss syndrome)2100.4060.1457Yes
7PRKCDPRKCD
Entrez,  Source
protein kinase C, delta3060.3370.1568Yes
8MST43180.3310.1740Yes
9SYKSYK
Entrez,  Source
spleen tyrosine kinase4710.2680.1769Yes
10METMET
Entrez,  Source
met proto-oncogene (hepatocyte growth factor receptor)4990.2590.1890Yes
11IKBKBIKBKB
Entrez,  Source
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta5530.2450.1983Yes
12RPS6KA2RPS6KA2
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 25900.2370.2085Yes
13MAP3K13MAP3K13
Entrez,  Source
mitogen-activated protein kinase kinase kinase 136240.2300.2185Yes
14EGFREGFR
Entrez,  Source
epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)6250.2300.2311Yes
15EPHB6EPHB6
Entrez,  Source
EPH receptor B67010.2150.2371Yes
16TAOK3TAOK3
Entrez,  Source
TAO kinase 39710.1700.2256Yes
17MAPK10MAPK10
Entrez,  Source
mitogen-activated protein kinase 1010690.1570.2268Yes
18TNIKTNIK
Entrez,  Source
TRAF2 and NCK interacting kinase11970.1450.2249Yes
19DYRK2DYRK2
Entrez,  Source
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 212300.1420.2302Yes
20LCKLCK
Entrez,  Source
lymphocyte-specific protein tyrosine kinase13100.1360.2316Yes
21GAKGAK
Entrez,  Source
cyclin G associated kinase13400.1330.2366Yes
22TNK1TNK1
Entrez,  Source
tyrosine kinase, non-receptor, 113600.1310.2423Yes
23CAMK1DCAMK1D
Entrez,  Source
calcium/calmodulin-dependent protein kinase ID13870.1290.2474Yes
24STK3STK3
Entrez,  Source
serine/threonine kinase 3 (STE20 homolog, yeast)15530.1200.2412Yes
25STK17BSTK17B
Entrez,  Source
serine/threonine kinase 17b (apoptosis-inducing)15540.1190.2478Yes
26PIP4K2C16760.1140.2446Yes
27RPS6KA1RPS6KA1
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 116860.1130.2501Yes
28MAP3K9MAP3K9
Entrez,  Source
mitogen-activated protein kinase kinase kinase 916990.1120.2553Yes
29NTRK2NTRK2
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 217040.1120.2611Yes
30RIOK3RIOK3
Entrez,  Source
RIO kinase 3 (yeast)19420.1010.2484No
31PTK2BPTK2B
Entrez,  Source
PTK2B protein tyrosine kinase 2 beta20420.0980.2461No
32MARK1MARK1
Entrez,  Source
MAP/microtubule affinity-regulating kinase 121590.0930.2423No
33AAK1AAK1
Entrez,  Source
AP2 associated kinase 122120.0920.2433No
34ULK2ULK2
Entrez,  Source
unc-51-like kinase 2 (C. elegans)22440.0910.2459No
35MAP3K11MAP3K11
Entrez,  Source
mitogen-activated protein kinase kinase kinase 1122950.0890.2469No
36TIE1TIE1
Entrez,  Source
tyrosine kinase with immunoglobulin-like and EGF-like domains 123280.0880.2493No
37JAK3JAK3
Entrez,  Source
Janus kinase 3 (a protein tyrosine kinase, leukocyte)24440.0840.2450No
38MERTKMERTK
Entrez,  Source
c-mer proto-oncogene tyrosine kinase25220.0820.2436No
39TAOK1TAOK1
Entrez,  Source
TAO kinase 125520.0820.2459No
40MAP4K1MAP4K1
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 128490.0740.2271No
41MINK1MINK1
Entrez,  Source
misshapen-like kinase 1 (zebrafish)30800.0690.2132No
42KDRKDR
Entrez,  Source
kinase insert domain receptor (a type III receptor tyrosine kinase)31460.0680.2119No
43FLT3FLT3
Entrez,  Source
fms-related tyrosine kinase 334030.0630.1956No
44BLKBLK
Entrez,  Source
B lymphoid tyrosine kinase34190.0620.1979No
45CSF1RCSF1R
Entrez,  Source
colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog34540.0620.1986No
46MARK2MARK2
Entrez,  Source
MAP/microtubule affinity-regulating kinase 238340.0550.1725No
47PRKD2PRKD2
Entrez,  Source
protein kinase D239000.0540.1704No
48PRKG2PRKG2
Entrez,  Source
protein kinase, cGMP-dependent, type II40210.0520.1640No
49ALKALK
Entrez,  Source
anaplastic lymphoma kinase (Ki-1)40730.0510.1629No
50MUSKMUSK
Entrez,  Source
muscle, skeletal, receptor tyrosine kinase41390.0500.1606No
51FGRFGR
Entrez,  Source
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog41930.0490.1593No
52CDKL5CDKL5
Entrez,  Source
cyclin-dependent kinase-like 543450.0470.1502No
53AURKCAURKC
Entrez,  Source
aurora kinase C44130.0460.1476No
54NEK2NEK2
Entrez,  Source
NIMA (never in mitosis gene a)-related kinase 244830.0450.1447No
55CDKL2CDKL2
Entrez,  Source
cyclin-dependent kinase-like 2 (CDC2-related kinase)45480.0440.1422No
56RPS6KA6RPS6KA6
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 646850.0420.1340No
57FGFR4FGFR4
Entrez,  Source
fibroblast growth factor receptor 447150.0410.1341No
58PHKG2PHKG2
Entrez,  Source
phosphorylase kinase, gamma 2 (testis)47920.0400.1304No
59BMXBMX
Entrez,  Source
BMX non-receptor tyrosine kinase48260.0400.1301No
60NEK7NEK7
Entrez,  Source
NIMA (never in mitosis gene a)-related kinase 748770.0390.1283No
61FLT1FLT1
Entrez,  Source
fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)48820.0390.1302No
62FLT4FLT4
Entrez,  Source
fms-related tyrosine kinase 448980.0390.1311No
63PAK4PAK4
Entrez,  Source
p21(CDKN1A)-activated kinase 450140.0370.1243No
64ULK1ULK1
Entrez,  Source
unc-51-like kinase 1 (C. elegans)51570.0350.1153No
65INSRRINSRR
Entrez,  Source
insulin receptor-related receptor53320.0330.1037No
66PDPK1PDPK1
Entrez,  Source
3-phosphoinositide dependent protein kinase-155490.0300.0887No
67MAPK4MAPK4
Entrez,  Source
mitogen-activated protein kinase 455850.0290.0877No
68STK24STK24
Entrez,  Source
serine/threonine kinase 24 (STE20 homolog, yeast)55870.0290.0892No
69BTKBTK
Entrez,  Source
Bruton agammaglobulinemia tyrosine kinase56280.0290.0877No
70STK16STK16
Entrez,  Source
serine/threonine kinase 1657780.0270.0777No
71SRPK3SRPK3
Entrez,  Source
SFRS protein kinase 358600.0260.0729No
72PAK7PAK7
Entrez,  Source
p21(CDKN1A)-activated kinase 758810.0250.0727No
73MAP3K3MAP3K3
Entrez,  Source
mitogen-activated protein kinase kinase kinase 359210.0250.0711No
74PRKXPRKX
Entrez,  Source
protein kinase, X-linked59930.0240.0669No
75CDK1360620.0230.0629No
76NTRK1NTRK1
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 160970.0220.0615No
77IRAK1IRAK1
Entrez,  Source
interleukin-1 receptor-associated kinase 161790.0210.0564No
78PHKG1PHKG1
Entrez,  Source
phosphorylase kinase, gamma 1 (muscle)62450.0200.0525No
79AURKAAURKA
Entrez,  Source
aurora kinase A64270.0170.0395No
80RETRET
Entrez,  Source
ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease)64710.0160.0371No
81MAP3K10MAP3K10
Entrez,  Source
mitogen-activated protein kinase kinase kinase 1065490.0150.0320No
82PIP4K2B65940.0150.0294No
83BMPR1BBMPR1B
Entrez,  Source
bone morphogenetic protein receptor, type IB67770.0120.0160No
84PKN1PKN1
Entrez,  Source
protein kinase N167830.0120.0163No
85GRK4GRK4
Entrez,  Source
G protein-coupled receptor kinase 467880.0120.0167No
86MAPK8MAPK8
Entrez,  Source
mitogen-activated protein kinase 868290.0110.0142No
87MAP4K2MAP4K2
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 268940.0100.0098No
88BMP2KBMP2K
Entrez,  Source
BMP2 inducible kinase70290.008-0.0001No
89TEKTEK
Entrez,  Source
TEK tyrosine kinase, endothelial (venous malformations, multiple cutaneous and mucosal)70350.008-0.0000No
90CLK2CLK2
Entrez,  Source
CDC-like kinase 271810.005-0.0109No
91IKBKEIKBKE
Entrez,  Source
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon72160.004-0.0133No
92ITKITK
Entrez,  Source
IL2-inducible T-cell kinase72200.004-0.0133No
93ACVR2BACVR2B
Entrez,  Source
activin A receptor, type IIB73820.002-0.0255No
94PRKAA2PRKAA2
Entrez,  Source
protein kinase, AMP-activated, alpha 2 catalytic subunit74180.001-0.0282No
95SIK274350.001-0.0294No
96SIK37726-0.004-0.0515No
97PDGFRBPDGFRB
Entrez,  Source
platelet-derived growth factor receptor, beta polypeptide7824-0.006-0.0586No
98MAPK9MAPK9
Entrez,  Source
mitogen-activated protein kinase 97830-0.006-0.0586No
99MKNK2MKNK2
Entrez,  Source
MAP kinase interacting serine/threonine kinase 27841-0.006-0.0591No
100MAP2K1MAP2K1
Entrez,  Source
mitogen-activated protein kinase kinase 17939-0.008-0.0661No
101MELKMELK
Entrez,  Source
maternal embryonic leucine zipper kinase8047-0.010-0.0738No
102TAOK2TAOK2
Entrez,  Source
TAO kinase 28059-0.010-0.0741No
103PRKACAPRKACA
Entrez,  Source
protein kinase, cAMP-dependent, catalytic, alpha8112-0.011-0.0775No
104KITKIT
Entrez,  Source
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog8134-0.012-0.0785No
105RPS6KA4RPS6KA4
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 48181-0.013-0.0813No
106MAP2K5MAP2K5
Entrez,  Source
mitogen-activated protein kinase kinase 58199-0.013-0.0819No
107MARK4MARK4
Entrez,  Source
MAP/microtubule affinity-regulating kinase 48259-0.014-0.0856No
108DMPKDMPK
Entrez,  Source
dystrophia myotonica-protein kinase8344-0.016-0.0912No
109PTK2PTK2
Entrez,  Source
PTK2 protein tyrosine kinase 28356-0.016-0.0912No
110VRK2VRK2
Entrez,  Source
vaccinia related kinase 28412-0.017-0.0945No
111NTRK3NTRK3
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 38500-0.019-0.1001No
112ROCK1ROCK1
Entrez,  Source
Rho-associated, coiled-coil containing protein kinase 18741-0.025-0.1172No
113AURKBAURKB
Entrez,  Source
aurora kinase B8856-0.027-0.1245No
114ZAP70ZAP70
Entrez,  Source
zeta-chain (TCR) associated protein kinase 70kDa8954-0.030-0.1303No
115CDKL1CDKL1
Entrez,  Source
cyclin-dependent kinase-like 1 (CDC2-related kinase)8993-0.031-0.1316No
116IRAK4IRAK4
Entrez,  Source
interleukin-1 receptor-associated kinase 48996-0.031-0.1301No
117STK11STK11
Entrez,  Source
serine/threonine kinase 119183-0.035-0.1425No
118ACVR2AACVR2A
Entrez,  Source
activin A receptor, type IIA9293-0.038-0.1488No
119NEK4NEK4
Entrez,  Source
NIMA (never in mitosis gene a)-related kinase 49362-0.039-0.1519No
120TYK2TYK2
Entrez,  Source
tyrosine kinase 29438-0.041-0.1554No
121PAK3PAK3
Entrez,  Source
p21 (CDKN1A)-activated kinase 39490-0.042-0.1570No
122CSNK2A2CSNK2A2
Entrez,  Source
casein kinase 2, alpha prime polypeptide9758-0.049-0.1749No
123HIPK3HIPK3
Entrez,  Source
homeodomain interacting protein kinase 39770-0.050-0.1730No
124NEK9NEK9
Entrez,  Source
NIMA (never in mitosis gene a)- related kinase 99810-0.051-0.1733No
125PRKD1PRKD1
Entrez,  Source
protein kinase D19827-0.052-0.1717No
126MAP4K4MAP4K4
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 49922-0.055-0.1759No
127TTKTTK
Entrez,  Source
TTK protein kinase9930-0.055-0.1735No
128PLK2PLK2
Entrez,  Source
polo-like kinase 2 (Drosophila)9994-0.057-0.1752No
129STK17ASTK17A
Entrez,  Source
serine/threonine kinase 17a (apoptosis-inducing)10017-0.057-0.1738No
130HIPK2HIPK2
Entrez,  Source
homeodomain interacting protein kinase 210151-0.061-0.1807No
131DYRK1ADYRK1A
Entrez,  Source
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A10303-0.066-0.1887No
132MARK3MARK3
Entrez,  Source
MAP/microtubule affinity-regulating kinase 310374-0.068-0.1904No
133CITCIT
Entrez,  Source
citron (rho-interacting, serine/threonine kinase 21)10420-0.070-0.1900No
134RPS6KA3RPS6KA3
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 310427-0.070-0.1866No
135ICKICK
Entrez,  Source
intestinal cell (MAK-like) kinase10499-0.073-0.1881No
136PLK4PLK4
Entrez,  Source
polo-like kinase 4 (Drosophila)10581-0.075-0.1903No
137JAK1JAK1
Entrez,  Source
Janus kinase 1 (a protein tyrosine kinase)10585-0.076-0.1864No
138RPS6KB1RPS6KB1
Entrez,  Source
ribosomal protein S6 kinase, 70kDa, polypeptide 110717-0.081-0.1920No
139CAMKK2CAMKK2
Entrez,  Source
calcium/calmodulin-dependent protein kinase kinase 2, beta10729-0.081-0.1884No
140TBK1TBK1
Entrez,  Source
TANK-binding kinase 110732-0.082-0.1841No
141BRSK2BRSK2
Entrez,  Source
BR serine/threonine kinase 210749-0.082-0.1809No
142SRCSRC
Entrez,  Source
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)10776-0.083-0.1783No
143PIP5K1APIP5K1A
Entrez,  Source
phosphatidylinositol-4-phosphate 5-kinase, type I, alpha10780-0.083-0.1740No
144CHEK1CHEK1
Entrez,  Source
CHK1 checkpoint homolog (S. pombe)10792-0.084-0.1703No
145PRKCEPRKCE
Entrez,  Source
protein kinase C, epsilon10801-0.084-0.1663No
146CDK4CDK4
Entrez,  Source
cyclin-dependent kinase 410871-0.087-0.1668No
147PRKAA1PRKAA1
Entrez,  Source
protein kinase, AMP-activated, alpha 1 catalytic subunit10906-0.089-0.1646No
148PRKCQPRKCQ
Entrez,  Source
protein kinase C, theta10961-0.092-0.1637No
149NUAK1NUAK1
Entrez,  Source
NUAK family, SNF1-like kinase, 111032-0.095-0.1639No
150DAPK3DAPK3
Entrez,  Source
death-associated protein kinase 311066-0.096-0.1612No
151SRPK1SRPK1
Entrez,  Source
SFRS protein kinase 111068-0.096-0.1560No
152ABL2ABL2
Entrez,  Source
v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)11090-0.098-0.1523No
153CDK7CDK7
Entrez,  Source
cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase)11160-0.101-0.1521No
154PRKACBPRKACB
Entrez,  Source
protein kinase, cAMP-dependent, catalytic, beta11179-0.102-0.1479No
155STK10STK10
Entrez,  Source
serine/threonine kinase 1011218-0.103-0.1452No
156MYLKMYLK
Entrez,  Source
myosin, light chain kinase11255-0.105-0.1423No
157BMPR2BMPR2
Entrez,  Source
bone morphogenetic protein receptor, type II (serine/threonine kinase)11345-0.109-0.1431No
158SRPK2SRPK2
Entrez,  Source
SFRS protein kinase 211496-0.117-0.1483No
159STK4STK4
Entrez,  Source
serine/threonine kinase 411518-0.118-0.1435No
160JAK2JAK2
Entrez,  Source
Janus kinase 2 (a protein tyrosine kinase)11530-0.119-0.1378No
161SLKSLK
Entrez,  Source
STE20-like kinase (yeast)11672-0.128-0.1417No
162MAP4K5MAP4K5
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 511705-0.130-0.1371No
163FYNFYN
Entrez,  Source
FYN oncogene related to SRC, FGR, YES11767-0.133-0.1345No
164NEK3NEK3
Entrez,  Source
NIMA (never in mitosis gene a)-related kinase 311797-0.135-0.1293No
165HIPK1HIPK1
Entrez,  Source
homeodomain interacting protein kinase 111798-0.135-0.1219No
166MAP2K4MAP2K4
Entrez,  Source
mitogen-activated protein kinase kinase 411811-0.136-0.1154No
167PRPF4BPRPF4B
Entrez,  Source
PRP4 pre-mRNA processing factor 4 homolog B (yeast)11856-0.139-0.1112No
168CSNK2A1CSNK2A1
Entrez,  Source
casein kinase 2, alpha 1 polypeptide11861-0.139-0.1039No
169MAP2K2MAP2K2
Entrez,  Source
mitogen-activated protein kinase kinase 211895-0.142-0.0987No
170ROCK2ROCK2
Entrez,  Source
Rho-associated, coiled-coil containing protein kinase 212033-0.152-0.1009No
171CAMK1CAMK1
Entrez,  Source
calcium/calmodulin-dependent protein kinase I12150-0.162-0.1010No
172MAP3K2MAP3K2
Entrez,  Source
mitogen-activated protein kinase kinase kinase 212210-0.168-0.0964No
173PDGFRAPDGFRA
Entrez,  Source
platelet-derived growth factor receptor, alpha polypeptide12211-0.168-0.0872No
174MAPK6MAPK6
Entrez,  Source
mitogen-activated protein kinase 612214-0.168-0.0781No
175PKN2PKN2
Entrez,  Source
protein kinase N212286-0.175-0.0740No
176SIK112319-0.179-0.0667No
177MAP4K3MAP4K3
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 312403-0.189-0.0628No
178IRAK3IRAK3
Entrez,  Source
interleukin-1 receptor-associated kinase 312451-0.196-0.0557No
179ABL1ABL1
Entrez,  Source
v-abl Abelson murine leukemia viral oncogene homolog 112463-0.197-0.0458No
180ZAKZAK
Entrez,  Source
-12544-0.209-0.0405No
181MAP3K7MAP3K7
Entrez,  Source
mitogen-activated protein kinase kinase kinase 712613-0.221-0.0337No
182AXLAXL
Entrez,  Source
AXL receptor tyrosine kinase12789-0.257-0.0331No
183CHUKCHUK
Entrez,  Source
conserved helix-loop-helix ubiquitous kinase12978-0.325-0.0298No
184PRKD3PRKD3
Entrez,  Source
protein kinase D313008-0.345-0.0132No
185FGFR1FGFR1
Entrez,  Source
fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome)13121-0.4860.0047No
Table: GSEA details [plain text format]



Fig 2: BX-912_LINCS   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: BX-912_LINCS: Random ES distribution   
Gene set null distribution of ES for BX-912_LINCS