DatasetNSCLC_collapsed_to_symbols.NSCLC.cls
#SEN_versus_RES.NSCLC.cls
#SEN_versus_RES_repos
PhenotypeNSCLC.cls#SEN_versus_RES_repos
Upregulated in class1
GeneSetVANDETANIB_FDA
Enrichment Score (ES)0.45929235
Normalized Enrichment Score (NES)1.4693106
Nominal p-value0.035523977
FDR q-value0.75809723
FWER p-Value0.998
Table: GSEA Results Summary



Fig 1: Enrichment plot: VANDETANIB_FDA   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEGENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1ERBB3ERBB3
Entrez,  Source
v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)121.0340.1355Yes
2EPHA1EPHA1
Entrez,  Source
EPH receptor A1940.5450.2012Yes
3RIPK4RIPK4
Entrez,  Source
receptor-interacting serine-threonine kinase 4950.5440.2730Yes
4PTK6PTK6
Entrez,  Source
PTK6 protein tyrosine kinase 61410.4790.3327Yes
5DDR1DDR1
Entrez,  Source
discoidin domain receptor family, member 12120.4040.3805Yes
6FRKFRK
Entrez,  Source
fyn-related kinase2960.3430.4195Yes
7EGFREGFR
Entrez,  Source
epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)6250.2300.4248Yes
8EPHB6EPHB6
Entrez,  Source
EPH receptor B67010.2150.4475Yes
9EPHB2EPHB2
Entrez,  Source
EPH receptor B28680.1850.4593Yes
10LCKLCK
Entrez,  Source
lymphocyte-specific protein tyrosine kinase13100.1360.4436No
11GAKGAK
Entrez,  Source
cyclin G associated kinase13400.1330.4590No
12RPS6KA1RPS6KA1
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 116860.1130.4476No
13ERBB4ERBB4
Entrez,  Source
v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)18130.1070.4520No
14LYNLYN
Entrez,  Source
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog19740.1000.4530No
15MKNK1MKNK1
Entrez,  Source
MAP kinase interacting serine/threonine kinase 129070.0730.3916No
16YES1YES1
Entrez,  Source
v-yes-1 Yamaguchi sarcoma viral oncogene homolog 130360.0700.3910No
17KDRKDR
Entrez,  Source
kinase insert domain receptor (a type III receptor tyrosine kinase)31460.0680.3917No
18FLT3FLT3
Entrez,  Source
fms-related tyrosine kinase 334030.0630.3804No
19BLKBLK
Entrez,  Source
B lymphoid tyrosine kinase34190.0620.3875No
20ACVRL1ACVRL1
Entrez,  Source
activin A receptor type II-like 137150.0570.3726No
21EPHB4EPHB4
Entrez,  Source
EPH receptor B438790.0540.3673No
22EPHB1EPHB1
Entrez,  Source
EPH receptor B140000.0520.3651No
23FGRFGR
Entrez,  Source
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog41930.0490.3570No
24RPS6KA6RPS6KA6
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 646850.0420.3251No
25FLT1FLT1
Entrez,  Source
fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)48820.0390.3154No
26ACVR1ACVR1
Entrez,  Source
activin A receptor, type I52300.0340.2934No
27EPHA5EPHA5
Entrez,  Source
EPH receptor A554750.0310.2790No
28RETRET
Entrez,  Source
ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease)64710.0160.2053No
29BMPR1BBMPR1B
Entrez,  Source
bone morphogenetic protein receptor, type IB67770.0120.1837No
30TEKTEK
Entrez,  Source
TEK tyrosine kinase, endothelial (venous malformations, multiple cutaneous and mucosal)70350.0080.1652No
31SIK274350.0010.1349No
32PDGFRBPDGFRB
Entrez,  Source
platelet-derived growth factor receptor, beta polypeptide7824-0.0060.1061No
33KITKIT
Entrez,  Source
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog8134-0.0120.0842No
34LTKLTK
Entrez,  Source
leukocyte tyrosine kinase8158-0.0120.0840No
35MAP2K5MAP2K5
Entrez,  Source
mitogen-activated protein kinase kinase 58199-0.0130.0827No
36IRAK4IRAK4
Entrez,  Source
interleukin-1 receptor-associated kinase 48996-0.0310.0261No
37HCKHCK
Entrez,  Source
hemopoietic cell kinase9981-0.056-0.0414No
38DDR2DDR2
Entrez,  Source
discoidin domain receptor family, member 210235-0.064-0.0523No
39PLK4PLK4
Entrez,  Source
polo-like kinase 4 (Drosophila)10581-0.075-0.0686No
40SRCSRC
Entrez,  Source
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)10776-0.083-0.0724No
41ABL2ABL2
Entrez,  Source
v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)11090-0.098-0.0834No
42STK10STK10
Entrez,  Source
serine/threonine kinase 1011218-0.103-0.0794No
43RIPK2RIPK2
Entrez,  Source
receptor-interacting serine-threonine kinase 211349-0.110-0.0748No
44TYRO3TYRO3
Entrez,  Source
TYRO3 protein tyrosine kinase11601-0.123-0.0777No
45SLKSLK
Entrez,  Source
STE20-like kinase (yeast)11672-0.128-0.0662No
46MAP4K5MAP4K5
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 511705-0.130-0.0515No
47FYNFYN
Entrez,  Source
FYN oncogene related to SRC, FGR, YES11767-0.133-0.0386No
48PDGFRAPDGFRA
Entrez,  Source
platelet-derived growth factor receptor, alpha polypeptide12211-0.168-0.0502No
49ABL1ABL1
Entrez,  Source
v-abl Abelson murine leukemia viral oncogene homolog 112463-0.197-0.0434No
50AXLAXL
Entrez,  Source
AXL receptor tyrosine kinase12789-0.257-0.0342No
51FGFR1FGFR1
Entrez,  Source
fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome)13121-0.4860.0046No
Table: GSEA details [plain text format]



Fig 2: VANDETANIB_FDA   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: VANDETANIB_FDA: Random ES distribution   
Gene set null distribution of ES for VANDETANIB_FDA