| Dataset | NSCLC_collapsed_to_symbols.NSCLC.cls #SEN_versus_RES.NSCLC.cls #SEN_versus_RES_repos |
| Phenotype | NSCLC.cls#SEN_versus_RES_repos |
| Upregulated in class | 1 |
| GeneSet | CRIZOTINIB_LINCS |
| Enrichment Score (ES) | 0.32271585 |
| Normalized Enrichment Score (NES) | 1.1864914 |
| Nominal p-value | 0.15296052 |
| FDR q-value | 0.62859815 |
| FWER p-Value | 1.0 |

| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | MST1R | MST1R Entrez,  Source | macrophage stimulating 1 receptor (c-met-related tyrosine kinase) | 54 | 0.636 | 0.0449 | Yes |
| 2 | EPHA1 | EPHA1 Entrez,  Source | EPH receptor A1 | 94 | 0.545 | 0.0840 | Yes |
| 3 | RIPK4 | RIPK4 Entrez,  Source | receptor-interacting serine-threonine kinase 4 | 95 | 0.544 | 0.1259 | Yes |
| 4 | DDR1 | DDR1 Entrez,  Source | discoidin domain receptor family, member 1 | 212 | 0.404 | 0.1481 | Yes |
| 5 | FRK | FRK Entrez,  Source | fyn-related kinase | 296 | 0.343 | 0.1682 | Yes |
| 6 | MST4 | 318 | 0.331 | 0.1921 | Yes | ||
| 7 | SYK | SYK Entrez,  Source | spleen tyrosine kinase | 471 | 0.268 | 0.2011 | Yes |
| 8 | MET | MET Entrez,  Source | met proto-oncogene (hepatocyte growth factor receptor) | 499 | 0.259 | 0.2190 | Yes |
| 9 | ROS1 | ROS1 Entrez,  Source | v-ros UR2 sarcoma virus oncogene homolog 1 (avian) | 505 | 0.258 | 0.2385 | Yes |
| 10 | IKBKB | IKBKB Entrez,  Source | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta | 553 | 0.245 | 0.2538 | Yes |
| 11 | MAP3K13 | MAP3K13 Entrez,  Source | mitogen-activated protein kinase kinase kinase 13 | 624 | 0.230 | 0.2661 | Yes |
| 12 | EPHB6 | EPHB6 Entrez,  Source | EPH receptor B6 | 701 | 0.215 | 0.2769 | Yes |
| 13 | EPHA4 | EPHA4 Entrez,  Source | EPH receptor A4 | 798 | 0.197 | 0.2848 | Yes |
| 14 | TAOK3 | TAOK3 Entrez,  Source | TAO kinase 3 | 971 | 0.170 | 0.2847 | Yes |
| 15 | TXK | TXK Entrez,  Source | TXK tyrosine kinase | 1045 | 0.160 | 0.2914 | Yes |
| 16 | DYRK2 | DYRK2 Entrez,  Source | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 | 1230 | 0.142 | 0.2883 | Yes |
| 17 | LCK | LCK Entrez,  Source | lymphocyte-specific protein tyrosine kinase | 1310 | 0.136 | 0.2927 | Yes |
| 18 | TNK1 | TNK1 Entrez,  Source | tyrosine kinase, non-receptor, 1 | 1360 | 0.131 | 0.2991 | Yes |
| 19 | EPHA7 | EPHA7 Entrez,  Source | EPH receptor A7 | 1412 | 0.128 | 0.3050 | Yes |
| 20 | STK3 | STK3 Entrez,  Source | serine/threonine kinase 3 (STE20 homolog, yeast) | 1553 | 0.120 | 0.3035 | Yes |
| 21 | INSR | INSR Entrez,  Source | insulin receptor | 1664 | 0.114 | 0.3039 | Yes |
| 22 | NTRK2 | NTRK2 Entrez,  Source | neurotrophic tyrosine kinase, receptor, type 2 | 1704 | 0.112 | 0.3095 | Yes |
| 23 | TESK1 | TESK1 Entrez,  Source | testis-specific kinase 1 | 1855 | 0.105 | 0.3061 | Yes |
| 24 | RIOK3 | RIOK3 Entrez,  Source | RIO kinase 3 (yeast) | 1942 | 0.101 | 0.3073 | Yes |
| 25 | LYN | LYN Entrez,  Source | v-yes-1 Yamaguchi sarcoma viral related oncogene homolog | 1974 | 0.100 | 0.3126 | Yes |
| 26 | CASK | CASK Entrez,  Source | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | 2007 | 0.099 | 0.3178 | Yes |
| 27 | PTK2B | PTK2B Entrez,  Source | PTK2B protein tyrosine kinase 2 beta | 2042 | 0.098 | 0.3227 | Yes |
| 28 | ULK2 | ULK2 Entrez,  Source | unc-51-like kinase 2 (C. elegans) | 2244 | 0.091 | 0.3143 | No |
| 29 | TIE1 | TIE1 Entrez,  Source | tyrosine kinase with immunoglobulin-like and EGF-like domains 1 | 2328 | 0.088 | 0.3147 | No |
| 30 | JAK3 | JAK3 Entrez,  Source | Janus kinase 3 (a protein tyrosine kinase, leukocyte) | 2444 | 0.084 | 0.3124 | No |
| 31 | MERTK | MERTK Entrez,  Source | c-mer proto-oncogene tyrosine kinase | 2522 | 0.082 | 0.3129 | No |
| 32 | TAOK1 | TAOK1 Entrez,  Source | TAO kinase 1 | 2552 | 0.082 | 0.3170 | No |
| 33 | ADCK4 | ADCK4 Entrez,  Source | aarF domain containing kinase 4 | 2715 | 0.077 | 0.3106 | No |
| 34 | LIMK2 | LIMK2 Entrez,  Source | LIM domain kinase 2 | 2799 | 0.076 | 0.3100 | No |
| 35 | MAP4K1 | MAP4K1 Entrez,  Source | mitogen-activated protein kinase kinase kinase kinase 1 | 2849 | 0.074 | 0.3120 | No |
| 36 | EPHA3 | EPHA3 Entrez,  Source | EPH receptor A3 | 2870 | 0.074 | 0.3161 | No |
| 37 | TNK2 | TNK2 Entrez,  Source | tyrosine kinase, non-receptor, 2 | 3005 | 0.070 | 0.3113 | No |
| 38 | FLT3 | FLT3 Entrez,  Source | fms-related tyrosine kinase 3 | 3403 | 0.063 | 0.2857 | No |
| 39 | BLK | BLK Entrez,  Source | B lymphoid tyrosine kinase | 3419 | 0.062 | 0.2894 | No |
| 40 | CSF1R | CSF1R Entrez,  Source | colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog | 3454 | 0.062 | 0.2915 | No |
| 41 | EPHB4 | EPHB4 Entrez,  Source | EPH receptor B4 | 3879 | 0.054 | 0.2633 | No |
| 42 | PRKD2 | PRKD2 Entrez,  Source | protein kinase D2 | 3900 | 0.054 | 0.2659 | No |
| 43 | EPHB1 | EPHB1 Entrez,  Source | EPH receptor B1 | 4000 | 0.052 | 0.2624 | No |
| 44 | ALK | ALK Entrez,  Source | anaplastic lymphoma kinase (Ki-1) | 4073 | 0.051 | 0.2608 | No |
| 45 | MUSK | MUSK Entrez,  Source | muscle, skeletal, receptor tyrosine kinase | 4139 | 0.050 | 0.2597 | No |
| 46 | FGR | FGR Entrez,  Source | Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog | 4193 | 0.049 | 0.2594 | No |
| 47 | MAP3K1 | MAP3K1 Entrez,  Source | mitogen-activated protein kinase kinase kinase 1 | 4281 | 0.048 | 0.2564 | No |
| 48 | ACVR1B | ACVR1B Entrez,  Source | activin A receptor, type IB | 4328 | 0.047 | 0.2566 | No |
| 49 | AURKC | AURKC Entrez,  Source | aurora kinase C | 4413 | 0.046 | 0.2537 | No |
| 50 | LIMK1 | LIMK1 Entrez,  Source | LIM domain kinase 1 | 4468 | 0.045 | 0.2530 | No |
| 51 | CDKL2 | CDKL2 Entrez,  Source | cyclin-dependent kinase-like 2 (CDC2-related kinase) | 4548 | 0.044 | 0.2504 | No |
| 52 | NEK7 | NEK7 Entrez,  Source | NIMA (never in mitosis gene a)-related kinase 7 | 4877 | 0.039 | 0.2283 | No |
| 53 | EPHA2 | EPHA2 Entrez,  Source | EPH receptor A2 | 4880 | 0.039 | 0.2311 | No |
| 54 | ULK1 | ULK1 Entrez,  Source | unc-51-like kinase 1 (C. elegans) | 5157 | 0.035 | 0.2127 | No |
| 55 | ACVR1 | ACVR1 Entrez,  Source | activin A receptor, type I | 5230 | 0.034 | 0.2098 | No |
| 56 | TNNI3K | TNNI3K Entrez,  Source | TNNI3 interacting kinase | 5274 | 0.033 | 0.2091 | No |
| 57 | INSRR | INSRR Entrez,  Source | insulin receptor-related receptor | 5332 | 0.033 | 0.2073 | No |
| 58 | EPHA5 | EPHA5 Entrez,  Source | EPH receptor A5 | 5475 | 0.031 | 0.1988 | No |
| 59 | SRPK3 | SRPK3 Entrez,  Source | SFRS protein kinase 3 | 5860 | 0.026 | 0.1714 | No |
| 60 | MAP3K3 | MAP3K3 Entrez,  Source | mitogen-activated protein kinase kinase kinase 3 | 5921 | 0.025 | 0.1687 | No |
| 61 | NTRK1 | NTRK1 Entrez,  Source | neurotrophic tyrosine kinase, receptor, type 1 | 6097 | 0.022 | 0.1570 | No |
| 62 | FES | FES Entrez,  Source | feline sarcoma oncogene | 6126 | 0.022 | 0.1565 | No |
| 63 | IRAK1 | IRAK1 Entrez,  Source | interleukin-1 receptor-associated kinase 1 | 6179 | 0.021 | 0.1541 | No |
| 64 | AURKA | AURKA Entrez,  Source | aurora kinase A | 6427 | 0.017 | 0.1365 | No |
| 65 | DCLK2 | 6462 | 0.016 | 0.1352 | No | ||
| 66 | PIP4K2B | 6594 | 0.015 | 0.1263 | No | ||
| 67 | BMPR1B | BMPR1B Entrez,  Source | bone morphogenetic protein receptor, type IB | 6777 | 0.012 | 0.1133 | No |
| 68 | GRK4 | GRK4 Entrez,  Source | G protein-coupled receptor kinase 4 | 6788 | 0.012 | 0.1134 | No |
| 69 | MAP4K2 | MAP4K2 Entrez,  Source | mitogen-activated protein kinase kinase kinase kinase 2 | 6894 | 0.010 | 0.1062 | No |
| 70 | MAPK7 | MAPK7 Entrez,  Source | mitogen-activated protein kinase 7 | 6913 | 0.010 | 0.1055 | No |
| 71 | BMP2K | BMP2K Entrez,  Source | BMP2 inducible kinase | 7029 | 0.008 | 0.0974 | No |
| 72 | TEK | TEK Entrez,  Source | TEK tyrosine kinase, endothelial (venous malformations, multiple cutaneous and mucosal) | 7035 | 0.008 | 0.0976 | No |
| 73 | SIK2 | 7435 | 0.001 | 0.0671 | No | ||
| 74 | MKNK2 | MKNK2 Entrez,  Source | MAP kinase interacting serine/threonine kinase 2 | 7841 | -0.006 | 0.0366 | No |
| 75 | IGF1R | IGF1R Entrez,  Source | insulin-like growth factor 1 receptor | 7959 | -0.008 | 0.0283 | No |
| 76 | TAOK2 | TAOK2 Entrez,  Source | TAO kinase 2 | 8059 | -0.010 | 0.0215 | No |
| 77 | KIT | KIT Entrez,  Source | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog | 8134 | -0.012 | 0.0167 | No |
| 78 | LTK | LTK Entrez,  Source | leukocyte tyrosine kinase | 8158 | -0.012 | 0.0159 | No |
| 79 | DMPK | DMPK Entrez,  Source | dystrophia myotonica-protein kinase | 8344 | -0.016 | 0.0030 | No |
| 80 | PTK2 | PTK2 Entrez,  Source | PTK2 protein tyrosine kinase 2 | 8356 | -0.016 | 0.0034 | No |
| 81 | NTRK3 | NTRK3 Entrez,  Source | neurotrophic tyrosine kinase, receptor, type 3 | 8500 | -0.019 | -0.0061 | No |
| 82 | ROCK1 | ROCK1 Entrez,  Source | Rho-associated, coiled-coil containing protein kinase 1 | 8741 | -0.025 | -0.0225 | No |
| 83 | AURKB | AURKB Entrez,  Source | aurora kinase B | 8856 | -0.027 | -0.0292 | No |
| 84 | CDK11A | 9060 | -0.032 | -0.0422 | No | ||
| 85 | TYK2 | TYK2 Entrez,  Source | tyrosine kinase 2 | 9438 | -0.041 | -0.0680 | No |
| 86 | PAK3 | PAK3 Entrez,  Source | p21 (CDKN1A)-activated kinase 3 | 9490 | -0.042 | -0.0686 | No |
| 87 | NEK9 | NEK9 Entrez,  Source | NIMA (never in mitosis gene a)- related kinase 9 | 9810 | -0.051 | -0.0891 | No |
| 88 | PRKD1 | PRKD1 Entrez,  Source | protein kinase D1 | 9827 | -0.052 | -0.0864 | No |
| 89 | DCLK1 | 9840 | -0.052 | -0.0833 | No | ||
| 90 | DDR2 | DDR2 Entrez,  Source | discoidin domain receptor family, member 2 | 10235 | -0.064 | -0.1086 | No |
| 91 | MARK3 | MARK3 Entrez,  Source | MAP/microtubule affinity-regulating kinase 3 | 10374 | -0.068 | -0.1139 | No |
| 92 | PLK4 | PLK4 Entrez,  Source | polo-like kinase 4 (Drosophila) | 10581 | -0.075 | -0.1238 | No |
| 93 | JAK1 | JAK1 Entrez,  Source | Janus kinase 1 (a protein tyrosine kinase) | 10585 | -0.076 | -0.1182 | No |
| 94 | RPS6KB1 | RPS6KB1 Entrez,  Source | ribosomal protein S6 kinase, 70kDa, polypeptide 1 | 10717 | -0.081 | -0.1220 | No |
| 95 | CAMKK2 | CAMKK2 Entrez,  Source | calcium/calmodulin-dependent protein kinase kinase 2, beta | 10729 | -0.081 | -0.1166 | No |
| 96 | TBK1 | TBK1 Entrez,  Source | TANK-binding kinase 1 | 10732 | -0.082 | -0.1105 | No |
| 97 | SRC | SRC Entrez,  Source | v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | 10776 | -0.083 | -0.1074 | No |
| 98 | PIP5K1A | PIP5K1A Entrez,  Source | phosphatidylinositol-4-phosphate 5-kinase, type I, alpha | 10780 | -0.083 | -0.1012 | No |
| 99 | PRKAA1 | PRKAA1 Entrez,  Source | protein kinase, AMP-activated, alpha 1 catalytic subunit | 10906 | -0.089 | -0.1039 | No |
| 100 | NUAK1 | NUAK1 Entrez,  Source | NUAK family, SNF1-like kinase, 1 | 11032 | -0.095 | -0.1062 | No |
| 101 | ABL2 | ABL2 Entrez,  Source | v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene) | 11090 | -0.098 | -0.1030 | No |
| 102 | CDK7 | CDK7 Entrez,  Source | cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase) | 11160 | -0.101 | -0.1005 | No |
| 103 | STK10 | STK10 Entrez,  Source | serine/threonine kinase 10 | 11218 | -0.103 | -0.0969 | No |
| 104 | RIPK2 | RIPK2 Entrez,  Source | receptor-interacting serine-threonine kinase 2 | 11349 | -0.110 | -0.0984 | No |
| 105 | FER | FER Entrez,  Source | fer (fps/fes related) tyrosine kinase (phosphoprotein NCP94) | 11371 | -0.111 | -0.0915 | No |
| 106 | RIPK1 | RIPK1 Entrez,  Source | receptor (TNFRSF)-interacting serine-threonine kinase 1 | 11427 | -0.113 | -0.0870 | No |
| 107 | STK4 | STK4 Entrez,  Source | serine/threonine kinase 4 | 11518 | -0.118 | -0.0848 | No |
| 108 | JAK2 | JAK2 Entrez,  Source | Janus kinase 2 (a protein tyrosine kinase) | 11530 | -0.119 | -0.0765 | No |
| 109 | TYRO3 | TYRO3 Entrez,  Source | TYRO3 protein tyrosine kinase | 11601 | -0.123 | -0.0723 | No |
| 110 | SLK | SLK Entrez,  Source | STE20-like kinase (yeast) | 11672 | -0.128 | -0.0679 | No |
| 111 | MAP4K5 | MAP4K5 Entrez,  Source | mitogen-activated protein kinase kinase kinase kinase 5 | 11705 | -0.130 | -0.0603 | No |
| 112 | FYN | FYN Entrez,  Source | FYN oncogene related to SRC, FGR, YES | 11767 | -0.133 | -0.0547 | No |
| 113 | ROCK2 | ROCK2 Entrez,  Source | Rho-associated, coiled-coil containing protein kinase 2 | 12033 | -0.152 | -0.0633 | No |
| 114 | MAP3K2 | MAP3K2 Entrez,  Source | mitogen-activated protein kinase kinase kinase 2 | 12210 | -0.168 | -0.0638 | No |
| 115 | MAP3K12 | MAP3K12 Entrez,  Source | mitogen-activated protein kinase kinase kinase 12 | 12384 | -0.186 | -0.0627 | No |
| 116 | MAP4K3 | MAP4K3 Entrez,  Source | mitogen-activated protein kinase kinase kinase kinase 3 | 12403 | -0.189 | -0.0495 | No |
| 117 | TGFBR1 | TGFBR1 Entrez,  Source | transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kDa) | 12447 | -0.195 | -0.0378 | No |
| 118 | IRAK3 | IRAK3 Entrez,  Source | interleukin-1 receptor-associated kinase 3 | 12451 | -0.196 | -0.0229 | No |
| 119 | ABL1 | ABL1 Entrez,  Source | v-abl Abelson murine leukemia viral oncogene homolog 1 | 12463 | -0.197 | -0.0086 | No |
| 120 | MAP3K7 | MAP3K7 Entrez,  Source | mitogen-activated protein kinase kinase kinase 7 | 12613 | -0.221 | -0.0030 | No |
| 121 | AXL | AXL Entrez,  Source | AXL receptor tyrosine kinase | 12789 | -0.257 | 0.0034 | No |
| 122 | PRKD3 | PRKD3 Entrez,  Source | protein kinase D3 | 13008 | -0.345 | 0.0133 | No |

