DatasetNSCLC_collapsed_to_symbols.NSCLC.cls
#SEN_versus_RES.NSCLC.cls
#SEN_versus_RES_repos
PhenotypeNSCLC.cls#SEN_versus_RES_repos
Upregulated in class1
GeneSetPONATINIB_FDA
Enrichment Score (ES)0.3922117
Normalized Enrichment Score (NES)1.3660117
Nominal p-value0.072026804
FDR q-value0.5974554
FWER p-Value1.0
Table: GSEA Results Summary



Fig 1: Enrichment plot: PONATINIB_FDA   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEGENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1EPHA1EPHA1
Entrez,  Source
EPH receptor A1940.5450.0519Yes
2ERBB2ERBB2
Entrez,  Source
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)1000.5370.1096Yes
3PTK6PTK6
Entrez,  Source
PTK6 protein tyrosine kinase 61410.4790.1584Yes
4FGFR3FGFR3
Entrez,  Source
fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism)1530.4650.2079Yes
5FGFR2FGFR2
Entrez,  Source
ffer syndrome, Jackson-Weiss syndrome)2100.4060.2475Yes
6DDR1DDR1
Entrez,  Source
discoidin domain receptor family, member 12120.4040.2911Yes
7FRKFRK
Entrez,  Source
fyn-related kinase2960.3430.3219Yes
8EGFREGFR
Entrez,  Source
epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)6250.2300.3218Yes
9EPHA4EPHA4
Entrez,  Source
EPH receptor A47980.1970.3300Yes
10EPHB2EPHB2
Entrez,  Source
EPH receptor B28680.1850.3448Yes
11TXKTXK
Entrez,  Source
TXK tyrosine kinase10450.1600.3486Yes
12TNIKTNIK
Entrez,  Source
TRAF2 and NCK interacting kinase11970.1450.3529Yes
13LCKLCK
Entrez,  Source
lymphocyte-specific protein tyrosine kinase13100.1360.3590Yes
14TNK1TNK1
Entrez,  Source
tyrosine kinase, non-receptor, 113600.1310.3695Yes
15EPHA7EPHA7
Entrez,  Source
EPH receptor A714120.1280.3794Yes
16EPHB3EPHB3
Entrez,  Source
EPH receptor B314260.1270.3922Yes
17NTRK2NTRK2
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 217040.1120.3832No
18ERBB4ERBB4
Entrez,  Source
v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)18130.1070.3865No
19LYNLYN
Entrez,  Source
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog19740.1000.3850No
20PTK2BPTK2B
Entrez,  Source
PTK2B protein tyrosine kinase 2 beta20420.0980.3905No
21JAK3JAK3
Entrez,  Source
Janus kinase 3 (a protein tyrosine kinase, leukocyte)24440.0840.3690No
22MERTKMERTK
Entrez,  Source
c-mer proto-oncogene tyrosine kinase25220.0820.3721No
23EPHA3EPHA3
Entrez,  Source
EPH receptor A328700.0740.3535No
24TNK2TNK2
Entrez,  Source
tyrosine kinase, non-receptor, 230050.0700.3509No
25YES1YES1
Entrez,  Source
v-yes-1 Yamaguchi sarcoma viral oncogene homolog 130360.0700.3562No
26CSKCSK
Entrez,  Source
c-src tyrosine kinase30690.0690.3612No
27KDRKDR
Entrez,  Source
kinase insert domain receptor (a type III receptor tyrosine kinase)31460.0680.3628No
28PRKACGPRKACG
Entrez,  Source
protein kinase, cAMP-dependent, catalytic, gamma32240.0660.3640No
29FLT3FLT3
Entrez,  Source
fms-related tyrosine kinase 334030.0630.3572No
30BLKBLK
Entrez,  Source
B lymphoid tyrosine kinase34190.0620.3628No
31CSF1RCSF1R
Entrez,  Source
colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog34540.0620.3669No
32BRAFBRAF
Entrez,  Source
v-raf murine sarcoma viral oncogene homolog B137720.0560.3488No
33EPHB4EPHB4
Entrez,  Source
EPH receptor B438790.0540.3466No
34EPHB1EPHB1
Entrez,  Source
EPH receptor B140000.0520.3431No
35MUSKMUSK
Entrez,  Source
muscle, skeletal, receptor tyrosine kinase41390.0500.3380No
36FGRFGR
Entrez,  Source
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog41930.0490.3393No
37FGFR4FGFR4
Entrez,  Source
fibroblast growth factor receptor 447150.0410.3040No
38BMXBMX
Entrez,  Source
BMX non-receptor tyrosine kinase48260.0400.2999No
39EPHA2EPHA2
Entrez,  Source
EPH receptor A248800.0390.3001No
40FLT1FLT1
Entrez,  Source
fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)48820.0390.3042No
41FLT4FLT4
Entrez,  Source
fms-related tyrosine kinase 448980.0390.3073No
42MAPK11MAPK11
Entrez,  Source
mitogen-activated protein kinase 1153920.0320.2731No
43EPHA5EPHA5
Entrez,  Source
EPH receptor A554750.0310.2702No
44BTKBTK
Entrez,  Source
Bruton agammaglobulinemia tyrosine kinase56280.0290.2617No
45MAP3K3MAP3K3
Entrez,  Source
mitogen-activated protein kinase kinase kinase 359210.0250.2421No
46NTRK1NTRK1
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 160970.0220.2312No
47FESFES
Entrez,  Source
feline sarcoma oncogene61260.0220.2313No
48RETRET
Entrez,  Source
ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease)64710.0160.2069No
49MAPK14MAPK14
Entrez,  Source
mitogen-activated protein kinase 1464920.0160.2071No
50MAP4K2MAP4K2
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 268940.0100.1775No
51TEKTEK
Entrez,  Source
TEK tyrosine kinase, endothelial (venous malformations, multiple cutaneous and mucosal)70350.0080.1677No
52ITKITK
Entrez,  Source
IL2-inducible T-cell kinase72200.0040.1541No
53PRKAA2PRKAA2
Entrez,  Source
protein kinase, AMP-activated, alpha 2 catalytic subunit74180.0010.1392No
54MAP2K3MAP2K3
Entrez,  Source
mitogen-activated protein kinase kinase 37798-0.0050.1109No
55PDGFRBPDGFRB
Entrez,  Source
platelet-derived growth factor receptor, beta polypeptide7824-0.0060.1096No
56MKNK2MKNK2
Entrez,  Source
MAP kinase interacting serine/threonine kinase 27841-0.0060.1091No
57RAF1RAF1
Entrez,  Source
v-raf-1 murine leukemia viral oncogene homolog 18015-0.0090.0968No
58MELKMELK
Entrez,  Source
maternal embryonic leucine zipper kinase8047-0.0100.0955No
59PRKACAPRKACA
Entrez,  Source
protein kinase, cAMP-dependent, catalytic, alpha8112-0.0110.0919No
60KITKIT
Entrez,  Source
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog8134-0.0120.0915No
61LTKLTK
Entrez,  Source
leukocyte tyrosine kinase8158-0.0120.0911No
62NTRK3NTRK3
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 38500-0.0190.0672No
63AURKBAURKB
Entrez,  Source
aurora kinase B8856-0.0270.0430No
64NEK4NEK4
Entrez,  Source
NIMA (never in mitosis gene a)-related kinase 49362-0.0390.0087No
65TYK2TYK2
Entrez,  Source
tyrosine kinase 29438-0.0410.0074No
66MAP4K4MAP4K4
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 49922-0.055-0.0235No
67HCKHCK
Entrez,  Source
hemopoietic cell kinase9981-0.056-0.0219No
68CHEK2CHEK2
Entrez,  Source
CHK2 checkpoint homolog (S. pombe)10102-0.059-0.0246No
69DDR2DDR2
Entrez,  Source
discoidin domain receptor family, member 210235-0.064-0.0278No
70JAK1JAK1
Entrez,  Source
Janus kinase 1 (a protein tyrosine kinase)10585-0.076-0.0463No
71RPS6KB1RPS6KB1
Entrez,  Source
ribosomal protein S6 kinase, 70kDa, polypeptide 110717-0.081-0.0475No
72SRCSRC
Entrez,  Source
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)10776-0.083-0.0430No
73ABL2ABL2
Entrez,  Source
v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)11090-0.098-0.0563No
74STK10STK10
Entrez,  Source
serine/threonine kinase 1011218-0.103-0.0548No
75FERFER
Entrez,  Source
fer (fps/fes related) tyrosine kinase (phosphoprotein NCP94)11371-0.111-0.0545No
76JAK2JAK2
Entrez,  Source
Janus kinase 2 (a protein tyrosine kinase)11530-0.119-0.0537No
77SLKSLK
Entrez,  Source
STE20-like kinase (yeast)11672-0.128-0.0506No
78FYNFYN
Entrez,  Source
FYN oncogene related to SRC, FGR, YES11767-0.133-0.0434No
79MAP2K6MAP2K6
Entrez,  Source
mitogen-activated protein kinase kinase 611934-0.144-0.0404No
80PDGFRAPDGFRA
Entrez,  Source
platelet-derived growth factor receptor, alpha polypeptide12211-0.168-0.0433No
81SIK112319-0.179-0.0321No
82ABL1ABL1
Entrez,  Source
v-abl Abelson murine leukemia viral oncogene homolog 112463-0.197-0.0217No
83MAP3K7MAP3K7
Entrez,  Source
mitogen-activated protein kinase kinase kinase 712613-0.221-0.0092No
84FGFR1FGFR1
Entrez,  Source
fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome)13121-0.4860.0047No
Table: GSEA details [plain text format]



Fig 2: PONATINIB_FDA   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: PONATINIB_FDA: Random ES distribution   
Gene set null distribution of ES for PONATINIB_FDA