DatasetNSCLC_collapsed_to_symbols.NSCLC.cls
#SEN_versus_RES.NSCLC.cls
#SEN_versus_RES_repos
PhenotypeNSCLC.cls#SEN_versus_RES_repos
Upregulated in class0
GeneSetJAK3 INHIBITOR VI_RBC
Enrichment Score (ES)-0.22496183
Normalized Enrichment Score (NES)-0.7606511
Nominal p-value0.877551
FDR q-value1.0
FWER p-Value1.0
Table: GSEA Results Summary



Fig 1: Enrichment plot: JAK3 INHIBITOR VI_RBC   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEGENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1RPS6KA2RPS6KA2
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 25900.2370.0264No
2DYRK2DYRK2
Entrez,  Source
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 212300.1420.0206No
3STK3STK3
Entrez,  Source
serine/threonine kinase 3 (STE20 homolog, yeast)15530.1200.0321No
4RPS6KA1RPS6KA1
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 116860.1130.0561No
5NTRK2NTRK2
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 217040.1120.0885No
6MARK1MARK1
Entrez,  Source
MAP/microtubule affinity-regulating kinase 121590.0930.0821No
7MAP3K11MAP3K11
Entrez,  Source
mitogen-activated protein kinase kinase kinase 1122950.0890.0986No
8JAK3JAK3
Entrez,  Source
Janus kinase 3 (a protein tyrosine kinase, leukocyte)24440.0840.1128No
9MINK1MINK1
Entrez,  Source
misshapen-like kinase 1 (zebrafish)30800.0690.0853No
10FLT3FLT3
Entrez,  Source
fms-related tyrosine kinase 334030.0630.0796No
11MARK2MARK2
Entrez,  Source
MAP/microtubule affinity-regulating kinase 238340.0550.0634No
12PRKD2PRKD2
Entrez,  Source
protein kinase D239000.0540.0747No
13PRKG2PRKG2
Entrez,  Source
protein kinase, cGMP-dependent, type II40210.0520.0813No
14MUSKMUSK
Entrez,  Source
muscle, skeletal, receptor tyrosine kinase41390.0500.0874No
15RPS6KA6RPS6KA6
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 646850.0420.0586No
16FLT4FLT4
Entrez,  Source
fms-related tyrosine kinase 448980.0390.0542No
17ULK1ULK1
Entrez,  Source
unc-51-like kinase 1 (C. elegans)51570.0350.0451No
18NTRK1NTRK1
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 160970.022-0.0198No
19IRAK1IRAK1
Entrez,  Source
interleukin-1 receptor-associated kinase 161790.021-0.0196No
20PHKG1PHKG1
Entrez,  Source
phosphorylase kinase, gamma 1 (muscle)62450.020-0.0186No
21PKN1PKN1
Entrez,  Source
protein kinase N167830.012-0.0559No
22MAP4K2MAP4K2
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 268940.010-0.0613No
23CLK4CLK4
Entrez,  Source
CDC-like kinase 469350.010-0.0614No
24CLK2CLK2
Entrez,  Source
CDC-like kinase 271810.005-0.0785No
25IKBKEIKBKE
Entrez,  Source
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon72160.004-0.0798No
26GSK3AGSK3A
Entrez,  Source
glycogen synthase kinase 3 alpha73580.002-0.0898No
27CDK5CDK5
Entrez,  Source
cyclin-dependent kinase 574320.001-0.0951No
28MELKMELK
Entrez,  Source
maternal embryonic leucine zipper kinase8047-0.010-0.1389No
29DYRK1BDYRK1B
Entrez,  Source
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B8200-0.013-0.1465No
30MARK4MARK4
Entrez,  Source
MAP/microtubule affinity-regulating kinase 48259-0.014-0.1466No
31CDK18390-0.017-0.1514No
32NTRK3NTRK3
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 38500-0.019-0.1538No
33AURKBAURKB
Entrez,  Source
aurora kinase B8856-0.027-0.1726No
34IRAK4IRAK4
Entrez,  Source
interleukin-1 receptor-associated kinase 48996-0.031-0.1740No
35CDK2CDK2
Entrez,  Source
cyclin-dependent kinase 29409-0.040-0.1932No
36PRKD1PRKD1
Entrez,  Source
protein kinase D19827-0.052-0.2094Yes
37CDK6CDK6
Entrez,  Source
cyclin-dependent kinase 69834-0.052-0.1943Yes
38MAP4K4MAP4K4
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 49922-0.055-0.1844Yes
39STK17ASTK17A
Entrez,  Source
serine/threonine kinase 17a (apoptosis-inducing)10017-0.057-0.1744Yes
40DYRK1ADYRK1A
Entrez,  Source
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A10303-0.066-0.1762Yes
41MARK3MARK3
Entrez,  Source
MAP/microtubule affinity-regulating kinase 310374-0.068-0.1611Yes
42CAMKK2CAMKK2
Entrez,  Source
calcium/calmodulin-dependent protein kinase kinase 2, beta10729-0.081-0.1635Yes
43TBK1TBK1
Entrez,  Source
TANK-binding kinase 110732-0.082-0.1391Yes
44CHEK1CHEK1
Entrez,  Source
CHK1 checkpoint homolog (S. pombe)10792-0.084-0.1183Yes
45CDK4CDK4
Entrez,  Source
cyclin-dependent kinase 410871-0.087-0.0979Yes
46NUAK1NUAK1
Entrez,  Source
NUAK family, SNF1-like kinase, 111032-0.095-0.0815Yes
47STK4STK4
Entrez,  Source
serine/threonine kinase 411518-0.118-0.0830Yes
48MAP4K5MAP4K5
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 511705-0.130-0.0581Yes
49MAP3K7MAP3K7
Entrez,  Source
mitogen-activated protein kinase kinase kinase 712613-0.221-0.0607Yes
50PRKD3PRKD3
Entrez,  Source
protein kinase D313008-0.3450.0132Yes
Table: GSEA details [plain text format]



Fig 2: JAK3 INHIBITOR VI_RBC   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: JAK3 INHIBITOR VI_RBC: Random ES distribution   
Gene set null distribution of ES for JAK3 INHIBITOR VI_RBC