DatasetNSCLC_collapsed_to_symbols.NSCLC.cls
#SEN_versus_RES.NSCLC.cls
#SEN_versus_RES_repos
PhenotypeNSCLC.cls#SEN_versus_RES_repos
Upregulated in class1
GeneSetDABRAFENIB_LINCS
Enrichment Score (ES)0.34392664
Normalized Enrichment Score (NES)1.262686
Nominal p-value0.090756305
FDR q-value0.6273419
FWER p-Value1.0
Table: GSEA Results Summary



Fig 1: Enrichment plot: DABRAFENIB_LINCS   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEGENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1ERBB3ERBB3
Entrez,  Source
v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)121.0340.0822Yes
2EPHA1EPHA1
Entrez,  Source
EPH receptor A1940.5450.1198Yes
3ERBB2ERBB2
Entrez,  Source
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)1000.5370.1626Yes
4PTK6PTK6
Entrez,  Source
PTK6 protein tyrosine kinase 61410.4790.1980Yes
5DDR1DDR1
Entrez,  Source
discoidin domain receptor family, member 12120.4040.2251Yes
6FRKFRK
Entrez,  Source
fyn-related kinase2960.3430.2463Yes
7METMET
Entrez,  Source
met proto-oncogene (hepatocyte growth factor receptor)4990.2590.2516Yes
8EGFREGFR
Entrez,  Source
epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)6250.2300.2605Yes
9CDK146590.2220.2758Yes
10EPHB6EPHB6
Entrez,  Source
EPH receptor B67010.2150.2900Yes
11CDK187600.2040.3019Yes
12MAPK10MAPK10
Entrez,  Source
mitogen-activated protein kinase 1010690.1570.2910Yes
13TNIKTNIK
Entrez,  Source
TRAF2 and NCK interacting kinase11970.1450.2930Yes
14LCKLCK
Entrez,  Source
lymphocyte-specific protein tyrosine kinase13100.1360.2953Yes
15GAKGAK
Entrez,  Source
cyclin G associated kinase13400.1330.3038Yes
16TNK1TNK1
Entrez,  Source
tyrosine kinase, non-receptor, 113600.1310.3129Yes
17CAMK1DCAMK1D
Entrez,  Source
calcium/calmodulin-dependent protein kinase ID13870.1290.3213Yes
18NEK11NEK11
Entrez,  Source
NIMA (never in mitosis gene a)- related kinase 1115220.1220.3208Yes
19SLC12A7SLC12A7
Entrez,  Source
solute carrier family 12 (potassium/chloride transporters), member 715430.1200.3289Yes
20RPS6KA1RPS6KA1
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 116860.1130.3271Yes
21MAP3K9MAP3K9
Entrez,  Source
mitogen-activated protein kinase kinase kinase 916990.1120.3352Yes
22NTRK2NTRK2
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 217040.1120.3439Yes
23TESK1TESK1
Entrez,  Source
testis-specific kinase 118550.1050.3409No
24LYNLYN
Entrez,  Source
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog19740.1000.3398No
25ULK2ULK2
Entrez,  Source
unc-51-like kinase 2 (C. elegans)22440.0910.3265No
26MAP3K11MAP3K11
Entrez,  Source
mitogen-activated protein kinase kinase kinase 1122950.0890.3299No
27TIE1TIE1
Entrez,  Source
tyrosine kinase with immunoglobulin-like and EGF-like domains 123280.0880.3345No
28CLK3CLK3
Entrez,  Source
CDC-like kinase 323490.0870.3400No
29JAK3JAK3
Entrez,  Source
Janus kinase 3 (a protein tyrosine kinase, leukocyte)24440.0840.3395No
30ADCK4ADCK4
Entrez,  Source
aarF domain containing kinase 427150.0770.3251No
31LIMK2LIMK2
Entrez,  Source
LIM domain kinase 227990.0760.3248No
32EPHA3EPHA3
Entrez,  Source
EPH receptor A328700.0740.3254No
33EIF2AK1EIF2AK1
Entrez,  Source
eukaryotic translation initiation factor 2-alpha kinase 130080.0700.3206No
34YES1YES1
Entrez,  Source
v-yes-1 Yamaguchi sarcoma viral oncogene homolog 130360.0700.3241No
35CSKCSK
Entrez,  Source
c-src tyrosine kinase30690.0690.3272No
36BLKBLK
Entrez,  Source
B lymphoid tyrosine kinase34190.0620.3055No
37CSF1RCSF1R
Entrez,  Source
colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog34540.0620.3079No
38BRAFBRAF
Entrez,  Source
v-raf murine sarcoma viral oncogene homolog B137720.0560.2881No
39PRKD2PRKD2
Entrez,  Source
protein kinase D239000.0540.2827No
40FGRFGR
Entrez,  Source
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog41930.0490.2643No
41ACVR1BACVR1B
Entrez,  Source
activin A receptor, type IB43280.0470.2579No
42CDKL5CDKL5
Entrez,  Source
cyclin-dependent kinase-like 543450.0470.2604No
43LIMK1LIMK1
Entrez,  Source
LIM domain kinase 144680.0450.2547No
44NEK2NEK2
Entrez,  Source
NIMA (never in mitosis gene a)-related kinase 244830.0450.2573No
45CDKL2CDKL2
Entrez,  Source
cyclin-dependent kinase-like 2 (CDC2-related kinase)45480.0440.2559No
46NEK7NEK7
Entrez,  Source
NIMA (never in mitosis gene a)-related kinase 748770.0390.2340No
47PAK4PAK4
Entrez,  Source
p21(CDKN1A)-activated kinase 450140.0370.2265No
48ULK1ULK1
Entrez,  Source
unc-51-like kinase 1 (C. elegans)51570.0350.2185No
49ACVR1ACVR1
Entrez,  Source
activin A receptor, type I52300.0340.2157No
50PIK3C2BPIK3C2B
Entrez,  Source
phosphoinositide-3-kinase, class 2, beta polypeptide54150.0320.2042No
51BTKBTK
Entrez,  Source
Bruton agammaglobulinemia tyrosine kinase56280.0290.1903No
52STK16STK16
Entrez,  Source
serine/threonine kinase 1657780.0270.1810No
53PAK7PAK7
Entrez,  Source
p21(CDKN1A)-activated kinase 758810.0250.1753No
54CDK1360620.0230.1633No
55DCLK264620.0160.1341No
56MAP3K10MAP3K10
Entrez,  Source
mitogen-activated protein kinase kinase kinase 1065490.0150.1287No
57BMPR1BBMPR1B
Entrez,  Source
bone morphogenetic protein receptor, type IB67770.0120.1123No
58MAPK8MAPK8
Entrez,  Source
mitogen-activated protein kinase 868290.0110.1093No
59TEKTEK
Entrez,  Source
TEK tyrosine kinase, endothelial (venous malformations, multiple cutaneous and mucosal)70350.0080.0943No
60TGFBR2TGFBR2
Entrez,  Source
transforming growth factor, beta receptor II (70/80kDa)71030.0070.0897No
61ITKITK
Entrez,  Source
IL2-inducible T-cell kinase72200.0040.0812No
62CDK1972630.0040.0782No
63PRKAA2PRKAA2
Entrez,  Source
protein kinase, AMP-activated, alpha 2 catalytic subunit74180.0010.0666No
64CDK5CDK5
Entrez,  Source
cyclin-dependent kinase 574320.0010.0656No
65PI4KB7697-0.0030.0457No
66PDGFRBPDGFRB
Entrez,  Source
platelet-derived growth factor receptor, beta polypeptide7824-0.0060.0365No
67MKNK2MKNK2
Entrez,  Source
MAP kinase interacting serine/threonine kinase 27841-0.0060.0358No
68RAF1RAF1
Entrez,  Source
v-raf-1 murine leukemia viral oncogene homolog 18015-0.0090.0233No
69MELKMELK
Entrez,  Source
maternal embryonic leucine zipper kinase8047-0.0100.0217No
70TAOK2TAOK2
Entrez,  Source
TAO kinase 28059-0.0100.0217No
71KITKIT
Entrez,  Source
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog8134-0.0120.0170No
72MAP2K5MAP2K5
Entrez,  Source
mitogen-activated protein kinase kinase 58199-0.0130.0131No
73DYRK1BDYRK1B
Entrez,  Source
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B8200-0.0130.0142No
74CDK168353-0.0160.0038No
75CDK3CDK3
Entrez,  Source
cyclin-dependent kinase 38440-0.018-0.0013No
76STK25STK25
Entrez,  Source
serine/threonine kinase 25 (STE20 homolog, yeast)8561-0.021-0.0088No
77AURKBAURKB
Entrez,  Source
aurora kinase B8856-0.027-0.0291No
78CDK2CDK2
Entrez,  Source
cyclin-dependent kinase 29409-0.040-0.0681No
79TYK2TYK2
Entrez,  Source
tyrosine kinase 29438-0.041-0.0670No
80PAK3PAK3
Entrez,  Source
p21 (CDKN1A)-activated kinase 39490-0.042-0.0675No
81HIPK3HIPK3
Entrez,  Source
homeodomain interacting protein kinase 39770-0.050-0.0848No
82NEK9NEK9
Entrez,  Source
NIMA (never in mitosis gene a)- related kinase 99810-0.051-0.0838No
83PRKD1PRKD1
Entrez,  Source
protein kinase D19827-0.052-0.0808No
84DCLK19840-0.052-0.0776No
85HCKHCK
Entrez,  Source
hemopoietic cell kinase9981-0.056-0.0838No
86HIPK2HIPK2
Entrez,  Source
homeodomain interacting protein kinase 210151-0.061-0.0918No
87BUB1BUB1
Entrez,  Source
BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast)10160-0.061-0.0875No
88ADCK310237-0.064-0.0882No
89CITCIT
Entrez,  Source
citron (rho-interacting, serine/threonine kinase 21)10420-0.070-0.0965No
90PLK4PLK4
Entrez,  Source
polo-like kinase 4 (Drosophila)10581-0.075-0.1027No
91JAK1JAK1
Entrez,  Source
Janus kinase 1 (a protein tyrosine kinase)10585-0.076-0.0969No
92RPS6KB1RPS6KB1
Entrez,  Source
ribosomal protein S6 kinase, 70kDa, polypeptide 110717-0.081-0.1004No
93BRSK2BRSK2
Entrez,  Source
BR serine/threonine kinase 210749-0.082-0.0962No
94SRCSRC
Entrez,  Source
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)10776-0.083-0.0915No
95CDK4CDK4
Entrez,  Source
cyclin-dependent kinase 410871-0.087-0.0917No
96PRKAA1PRKAA1
Entrez,  Source
protein kinase, AMP-activated, alpha 1 catalytic subunit10906-0.089-0.0872No
97NLKNLK
Entrez,  Source
nemo-like kinase10979-0.093-0.0852No
98ABL2ABL2
Entrez,  Source
v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)11090-0.098-0.0858No
99CDK7CDK7
Entrez,  Source
cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase)11160-0.101-0.0830No
100STK10STK10
Entrez,  Source
serine/threonine kinase 1011218-0.103-0.0791No
101BMPR2BMPR2
Entrez,  Source
bone morphogenetic protein receptor, type II (serine/threonine kinase)11345-0.109-0.0799No
102RIPK2RIPK2
Entrez,  Source
receptor-interacting serine-threonine kinase 211349-0.110-0.0713No
103NEK1NEK1
Entrez,  Source
NIMA (never in mitosis gene a)-related kinase 111428-0.113-0.0682No
104JAK2JAK2
Entrez,  Source
Janus kinase 2 (a protein tyrosine kinase)11530-0.119-0.0664No
105FYNFYN
Entrez,  Source
FYN oncogene related to SRC, FGR, YES11767-0.133-0.0737No
106HIPK1HIPK1
Entrez,  Source
homeodomain interacting protein kinase 111798-0.135-0.0651No
107MAP2K4MAP2K4
Entrez,  Source
mitogen-activated protein kinase kinase 411811-0.136-0.0551No
108CAMK1CAMK1
Entrez,  Source
calcium/calmodulin-dependent protein kinase I12150-0.162-0.0680No
109SIK112319-0.179-0.0664No
110TGFBR1TGFBR1
Entrez,  Source
transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kDa)12447-0.195-0.0605No
111ABL1ABL1
Entrez,  Source
v-abl Abelson murine leukemia viral oncogene homolog 112463-0.197-0.0458No
112ZAKZAK
Entrez,  Source
-12544-0.209-0.0351No
113CDK1712578-0.213-0.0205No
114CDK8CDK8
Entrez,  Source
cyclin-dependent kinase 812650-0.226-0.0078No
115AXLAXL
Entrez,  Source
AXL receptor tyrosine kinase12789-0.2570.0023No
116PRKD3PRKD3
Entrez,  Source
protein kinase D313008-0.3450.0133No
Table: GSEA details [plain text format]



Fig 2: DABRAFENIB_LINCS   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: DABRAFENIB_LINCS: Random ES distribution   
Gene set null distribution of ES for DABRAFENIB_LINCS