DatasetNSCLC_collapsed_to_symbols.NSCLC.cls
#SEN_versus_RES.NSCLC.cls
#SEN_versus_RES_repos
PhenotypeNSCLC.cls#SEN_versus_RES_repos
Upregulated in class1
GeneSetAZD-9291_LINCS
Enrichment Score (ES)0.5319162
Normalized Enrichment Score (NES)1.6258174
Nominal p-value0.012544803
FDR q-value0.9952462
FWER p-Value0.817
Table: GSEA Results Summary



Fig 1: Enrichment plot: AZD-9291_LINCS   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEGENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1DAPK1DAPK1
Entrez,  Source
death-associated protein kinase 1880.5570.1070Yes
2ERBB2ERBB2
Entrez,  Source
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)1000.5370.2159Yes
3PTK6PTK6
Entrez,  Source
PTK6 protein tyrosine kinase 61410.4790.3106Yes
4ROS1ROS1
Entrez,  Source
v-ros UR2 sarcoma virus oncogene homolog 1 (avian)5050.2580.3356Yes
5EGFREGFR
Entrez,  Source
epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)6250.2300.3736Yes
6EPHB6EPHB6
Entrez,  Source
EPH receptor B67010.2150.4118Yes
7TXKTXK
Entrez,  Source
TXK tyrosine kinase10450.1600.4183Yes
8TNIKTNIK
Entrez,  Source
TRAF2 and NCK interacting kinase11970.1450.4365Yes
9GAKGAK
Entrez,  Source
cyclin G associated kinase13400.1330.4529Yes
10TNK1TNK1
Entrez,  Source
tyrosine kinase, non-receptor, 113600.1310.4782Yes
11INSRINSR
Entrez,  Source
insulin receptor16640.1140.4785Yes
12PIP4K2C16760.1140.5008Yes
13ERBB4ERBB4
Entrez,  Source
v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)18130.1070.5122Yes
14DAPK2DAPK2
Entrez,  Source
death-associated protein kinase 218380.1050.5319Yes
15AAK1AAK1
Entrez,  Source
AP2 associated kinase 122120.0920.5223No
16JAK3JAK3
Entrez,  Source
Janus kinase 3 (a protein tyrosine kinase, leukocyte)24440.0840.5220No
17MKNK1MKNK1
Entrez,  Source
MAP kinase interacting serine/threonine kinase 129070.0730.5017No
18TNK2TNK2
Entrez,  Source
tyrosine kinase, non-receptor, 230050.0700.5087No
19MINK1MINK1
Entrez,  Source
misshapen-like kinase 1 (zebrafish)30800.0690.5171No
20FLT3FLT3
Entrez,  Source
fms-related tyrosine kinase 334030.0630.5054No
21BLKBLK
Entrez,  Source
B lymphoid tyrosine kinase34190.0620.5170No
22ALKALK
Entrez,  Source
anaplastic lymphoma kinase (Ki-1)40730.0510.4777No
23CAMK2BCAMK2B
Entrez,  Source
calcium/calmodulin-dependent protein kinase (CaM kinase) II beta42130.0490.4771No
24HUNKHUNK
Entrez,  Source
hormonally upregulated Neu-associated kinase46450.0430.4530No
25INSRRINSRR
Entrez,  Source
insulin receptor-related receptor53320.0330.4075No
26TECTEC
Entrez,  Source
tec protein tyrosine kinase53790.0320.4106No
27BTKBTK
Entrez,  Source
Bruton agammaglobulinemia tyrosine kinase56280.0290.3976No
28PDGFRBPDGFRB
Entrez,  Source
platelet-derived growth factor receptor, beta polypeptide7824-0.0060.2318No
29MKNK2MKNK2
Entrez,  Source
MAP kinase interacting serine/threonine kinase 27841-0.0060.2319No
30IGF1RIGF1R
Entrez,  Source
insulin-like growth factor 1 receptor7959-0.0080.2247No
31LTKLTK
Entrez,  Source
leukocyte tyrosine kinase8158-0.0120.2121No
32RPS6KA4RPS6KA4
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 48181-0.0130.2130No
33MAP2K5MAP2K5
Entrez,  Source
mitogen-activated protein kinase kinase 58199-0.0130.2144No
34PTK2PTK2
Entrez,  Source
PTK2 protein tyrosine kinase 28356-0.0160.2059No
35CSNK2A2CSNK2A2
Entrez,  Source
casein kinase 2, alpha prime polypeptide9758-0.0490.1093No
36MAP4K4MAP4K4
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 49922-0.0550.1081No
37HIPK2HIPK2
Entrez,  Source
homeodomain interacting protein kinase 210151-0.0610.1031No
38PLK1PLK1
Entrez,  Source
polo-like kinase 1 (Drosophila)10440-0.0710.0957No
39PLK4PLK4
Entrez,  Source
polo-like kinase 4 (Drosophila)10581-0.0750.1004No
40DAPK3DAPK3
Entrez,  Source
death-associated protein kinase 311066-0.0960.0833No
41MYLKMYLK
Entrez,  Source
myosin, light chain kinase11255-0.1050.0904No
42HIPK1HIPK1
Entrez,  Source
homeodomain interacting protein kinase 111798-0.1350.0768No
43CSNK2A1CSNK2A1
Entrez,  Source
casein kinase 2, alpha 1 polypeptide11861-0.1390.1005No
Table: GSEA details [plain text format]



Fig 2: AZD-9291_LINCS   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: AZD-9291_LINCS: Random ES distribution   
Gene set null distribution of ES for AZD-9291_LINCS