DatasetNSCLC_collapsed_to_symbols.NSCLC.cls
#SEN_versus_RES.NSCLC.cls
#SEN_versus_RES_repos
PhenotypeNSCLC.cls#SEN_versus_RES_repos
Upregulated in class1
GeneSetSTAUROSPORINE_KINOME SCAN
Enrichment Score (ES)0.30334294
Normalized Enrichment Score (NES)1.2196718
Nominal p-value0.07320644
FDR q-value0.6416866
FWER p-Value1.0
Table: GSEA Results Summary



Fig 1: Enrichment plot: STAUROSPORINE_KINOME SCAN   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEGENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1MST1RMST1R
Entrez,  Source
macrophage stimulating 1 receptor (c-met-related tyrosine kinase)540.6360.0185Yes
2DAPK1DAPK1
Entrez,  Source
death-associated protein kinase 1880.5570.0358Yes
3EPHA1EPHA1
Entrez,  Source
EPH receptor A1940.5450.0548Yes
4RIPK4RIPK4
Entrez,  Source
receptor-interacting serine-threonine kinase 4950.5440.0742Yes
5ERBB2ERBB2
Entrez,  Source
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)1000.5370.0931Yes
6MAPK13MAPK13
Entrez,  Source
mitogen-activated protein kinase 131100.5250.1111Yes
7FGFR3FGFR3
Entrez,  Source
fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism)1530.4650.1244Yes
8PAK6PAK6
Entrez,  Source
p21(CDKN1A)-activated kinase 61580.4590.1405Yes
9FGFR2FGFR2
Entrez,  Source
ffer syndrome, Jackson-Weiss syndrome)2100.4060.1510Yes
10DDR1DDR1
Entrez,  Source
discoidin domain receptor family, member 12120.4040.1653Yes
11FRKFRK
Entrez,  Source
fyn-related kinase2960.3430.1711Yes
12PRKCDPRKCD
Entrez,  Source
protein kinase C, delta3060.3370.1824Yes
13MST43180.3310.1933Yes
14PRKCHPRKCH
Entrez,  Source
protein kinase C, eta3560.3090.2015Yes
15STK39STK39
Entrez,  Source
serine threonine kinase 39 (STE20/SPS1 homolog, yeast)3840.2990.2100Yes
16SYKSYK
Entrez,  Source
spleen tyrosine kinase4710.2680.2129Yes
17METMET
Entrez,  Source
met proto-oncogene (hepatocyte growth factor receptor)4990.2590.2201Yes
18ROS1ROS1
Entrez,  Source
v-ros UR2 sarcoma virus oncogene homolog 1 (avian)5050.2580.2289Yes
19IKBKBIKBKB
Entrez,  Source
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta5530.2450.2340Yes
20RPS6KA2RPS6KA2
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 25900.2370.2396Yes
21MAP3K13MAP3K13
Entrez,  Source
mitogen-activated protein kinase kinase kinase 136240.2300.2452Yes
22EGFREGFR
Entrez,  Source
epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)6250.2300.2535Yes
23CDK146590.2220.2588Yes
24PAK1PAK1
Entrez,  Source
p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast)6740.2190.2655Yes
25EPHB6EPHB6
Entrez,  Source
EPH receptor B67010.2150.2712Yes
26CDK187600.2040.2739Yes
27EPHA4EPHA4
Entrez,  Source
EPH receptor A47980.1970.2781Yes
28MAP3K6MAP3K6
Entrez,  Source
mitogen-activated protein kinase kinase kinase 68990.1800.2768Yes
29TAOK3TAOK3
Entrez,  Source
TAO kinase 39710.1700.2773Yes
30TXKTXK
Entrez,  Source
TXK tyrosine kinase10450.1600.2774Yes
31MAPK10MAPK10
Entrez,  Source
mitogen-activated protein kinase 1010690.1570.2812Yes
32TNIKTNIK
Entrez,  Source
TRAF2 and NCK interacting kinase11970.1450.2765Yes
33DYRK2DYRK2
Entrez,  Source
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 212300.1420.2791Yes
34LCKLCK
Entrez,  Source
lymphocyte-specific protein tyrosine kinase13100.1360.2778Yes
35GAKGAK
Entrez,  Source
cyclin G associated kinase13400.1330.2803Yes
36TNK1TNK1
Entrez,  Source
tyrosine kinase, non-receptor, 113600.1310.2835Yes
37CAMK1DCAMK1D
Entrez,  Source
calcium/calmodulin-dependent protein kinase ID13870.1290.2861Yes
38EPHA7EPHA7
Entrez,  Source
EPH receptor A714120.1280.2888Yes
39PIK3C2GPIK3C2G
Entrez,  Source
phosphoinositide-3-kinase, class 2, gamma polypeptide14980.1230.2866Yes
40STK3STK3
Entrez,  Source
serine/threonine kinase 3 (STE20 homolog, yeast)15530.1200.2867Yes
41STK17BSTK17B
Entrez,  Source
serine/threonine kinase 17b (apoptosis-inducing)15540.1190.2910Yes
42INSRINSR
Entrez,  Source
insulin receptor16640.1140.2866Yes
43RPS6KA1RPS6KA1
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 116860.1130.2890Yes
44MAP3K9MAP3K9
Entrez,  Source
mitogen-activated protein kinase kinase kinase 916990.1120.2921Yes
45NTRK2NTRK2
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 217040.1120.2958Yes
46CAMK2ACAMK2A
Entrez,  Source
calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha18010.1070.2921Yes
47CAMK2GCAMK2G
Entrez,  Source
calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma18110.1070.2952Yes
48ERBB4ERBB4
Entrez,  Source
v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)18130.1070.2990Yes
49DAPK2DAPK2
Entrez,  Source
death-associated protein kinase 218380.1050.3009Yes
50TESK1TESK1
Entrez,  Source
testis-specific kinase 118550.1050.3033Yes
51RIOK3RIOK3
Entrez,  Source
RIO kinase 3 (yeast)19420.1010.3003No
52LYNLYN
Entrez,  Source
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog19740.1000.3014No
53CASKCASK
Entrez,  Source
calcium/calmodulin-dependent serine protein kinase (MAGUK family)20070.0990.3025No
54PTK2BPTK2B
Entrez,  Source
PTK2B protein tyrosine kinase 2 beta20420.0980.3033No
55MAP3K5MAP3K5
Entrez,  Source
mitogen-activated protein kinase kinase kinase 521470.0940.2986No
56MARK1MARK1
Entrez,  Source
MAP/microtubule affinity-regulating kinase 121590.0930.3011No
57AAK1AAK1
Entrez,  Source
AP2 associated kinase 122120.0920.3003No
58ULK2ULK2
Entrez,  Source
unc-51-like kinase 2 (C. elegans)22440.0910.3012No
59MAP3K11MAP3K11
Entrez,  Source
mitogen-activated protein kinase kinase kinase 1122950.0890.3005No
60TIE1TIE1
Entrez,  Source
tyrosine kinase with immunoglobulin-like and EGF-like domains 123280.0880.3011No
61CLK3CLK3
Entrez,  Source
CDC-like kinase 323490.0870.3027No
62JAK3JAK3
Entrez,  Source
Janus kinase 3 (a protein tyrosine kinase, leukocyte)24440.0840.2984No
63MERTKMERTK
Entrez,  Source
c-mer proto-oncogene tyrosine kinase25220.0820.2954No
64TAOK1TAOK1
Entrez,  Source
TAO kinase 125520.0820.2960No
65RPS6KA5RPS6KA5
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 526100.0800.2945No
66MAP4K1MAP4K1
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 128490.0740.2787No
67EPHA3EPHA3
Entrez,  Source
EPH receptor A328700.0740.2798No
68STK38STK38
Entrez,  Source
serine/threonine kinase 3828780.0730.2818No
69MKNK1MKNK1
Entrez,  Source
MAP kinase interacting serine/threonine kinase 129070.0730.2823No
70PIM2PIM2
Entrez,  Source
pim-2 oncogene29560.0710.2811No
71TNK2TNK2
Entrez,  Source
tyrosine kinase, non-receptor, 230050.0700.2799No
72YES1YES1
Entrez,  Source
v-yes-1 Yamaguchi sarcoma viral oncogene homolog 130360.0700.2800No
73CSKCSK
Entrez,  Source
c-src tyrosine kinase30690.0690.2800No
74MINK1MINK1
Entrez,  Source
misshapen-like kinase 1 (zebrafish)30800.0690.2817No
75KDRKDR
Entrez,  Source
kinase insert domain receptor (a type III receptor tyrosine kinase)31460.0680.2791No
76FLT3FLT3
Entrez,  Source
fms-related tyrosine kinase 334030.0630.2615No
77BLKBLK
Entrez,  Source
B lymphoid tyrosine kinase34190.0620.2625No
78TSSK1B34450.0620.2628No
79CSF1RCSF1R
Entrez,  Source
colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog34540.0620.2644No
80CSNK1A1CSNK1A1
Entrez,  Source
casein kinase 1, alpha 136980.0580.2476No
81MYO3AMYO3A
Entrez,  Source
myosin IIIA37350.0570.2468No
82MARK2MARK2
Entrez,  Source
MAP/microtubule affinity-regulating kinase 238340.0550.2412No
83PRKD2PRKD2
Entrez,  Source
protein kinase D239000.0540.2381No
84EPHB1EPHB1
Entrez,  Source
EPH receptor B140000.0520.2323No
85PRKG2PRKG2
Entrez,  Source
protein kinase, cGMP-dependent, type II40210.0520.2326No
86ALKALK
Entrez,  Source
anaplastic lymphoma kinase (Ki-1)40730.0510.2305No
87PIM1PIM1
Entrez,  Source
pim-1 oncogene41360.0500.2275No
88MUSKMUSK
Entrez,  Source
muscle, skeletal, receptor tyrosine kinase41390.0500.2291No
89FGRFGR
Entrez,  Source
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog41930.0490.2267No
90CAMK2BCAMK2B
Entrez,  Source
calcium/calmodulin-dependent protein kinase (CaM kinase) II beta42130.0490.2270No
91MAP3K1MAP3K1
Entrez,  Source
mitogen-activated protein kinase kinase kinase 142810.0480.2235No
92ACVR1BACVR1B
Entrez,  Source
activin A receptor, type IB43280.0470.2216No
93CDKL5CDKL5
Entrez,  Source
cyclin-dependent kinase-like 543450.0470.2221No
94AURKCAURKC
Entrez,  Source
aurora kinase C44130.0460.2185No
95LIMK1LIMK1
Entrez,  Source
LIM domain kinase 144680.0450.2160No
96NEK2NEK2
Entrez,  Source
NIMA (never in mitosis gene a)-related kinase 244830.0450.2165No
97CAMK1GCAMK1G
Entrez,  Source
calcium/calmodulin-dependent protein kinase IG45030.0450.2166No
98CDKL2CDKL2
Entrez,  Source
cyclin-dependent kinase-like 2 (CDC2-related kinase)45480.0440.2148No
99HUNKHUNK
Entrez,  Source
hormonally upregulated Neu-associated kinase46450.0430.2088No
100RPS6KA6RPS6KA6
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 646850.0420.2073No
101FGFR4FGFR4
Entrez,  Source
fibroblast growth factor receptor 447150.0410.2065No
102PHKG2PHKG2
Entrez,  Source
phosphorylase kinase, gamma 2 (testis)47920.0400.2021No
103BMXBMX
Entrez,  Source
BMX non-receptor tyrosine kinase48260.0400.2010No
104FLT1FLT1
Entrez,  Source
fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)48820.0390.1981No
105FLT4FLT4
Entrez,  Source
fms-related tyrosine kinase 448980.0390.1983No
106GRK1GRK1
Entrez,  Source
G protein-coupled receptor kinase 149070.0390.1991No
107PRKG1PRKG1
Entrez,  Source
protein kinase, cGMP-dependent, type I49360.0380.1983No
108PAK4PAK4
Entrez,  Source
p21(CDKN1A)-activated kinase 450140.0370.1936No
109ULK1ULK1
Entrez,  Source
unc-51-like kinase 1 (C. elegans)51570.0350.1839No
110ACVR1ACVR1
Entrez,  Source
activin A receptor, type I52300.0340.1795No
111TNNI3KTNNI3K
Entrez,  Source
TNNI3 interacting kinase52740.0330.1774No
112INSRRINSRR
Entrez,  Source
insulin receptor-related receptor53320.0330.1741No
113MAST1MAST1
Entrez,  Source
microtubule associated serine/threonine kinase 154360.0320.1673No
114EPHA5EPHA5
Entrez,  Source
EPH receptor A554750.0310.1654No
115PDPK1PDPK1
Entrez,  Source
3-phosphoinositide dependent protein kinase-155490.0300.1609No
116STK24STK24
Entrez,  Source
serine/threonine kinase 24 (STE20 homolog, yeast)55870.0290.1590No
117BTKBTK
Entrez,  Source
Bruton agammaglobulinemia tyrosine kinase56280.0290.1570No
118STK16STK16
Entrez,  Source
serine/threonine kinase 1657780.0270.1464No
119SRPK3SRPK3
Entrez,  Source
SFRS protein kinase 358600.0260.1410No
120PAK7PAK7
Entrez,  Source
p21(CDKN1A)-activated kinase 758810.0250.1404No
121PRKXPRKX
Entrez,  Source
protein kinase, X-linked59930.0240.1326No
122CDK1360620.0230.1282No
123NTRK1NTRK1
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 160970.0220.1263No
124FESFES
Entrez,  Source
feline sarcoma oncogene61260.0220.1249No
125IRAK1IRAK1
Entrez,  Source
interleukin-1 receptor-associated kinase 161790.0210.1216No
126PHKG1PHKG1
Entrez,  Source
phosphorylase kinase, gamma 1 (muscle)62450.0200.1173No
127CSNK1G2CSNK1G2
Entrez,  Source
casein kinase 1, gamma 263280.0180.1116No
128CAMK4CAMK4
Entrez,  Source
calcium/calmodulin-dependent protein kinase IV63930.0170.1073No
129AURKAAURKA
Entrez,  Source
aurora kinase A64270.0170.1053No
130DCLK264620.0160.1032No
131RETRET
Entrez,  Source
ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease)64710.0160.1032No
132EIF2AK2EIF2AK2
Entrez,  Source
eukaryotic translation initiation factor 2-alpha kinase 264890.0160.1025No
133MAP3K10MAP3K10
Entrez,  Source
mitogen-activated protein kinase kinase kinase 1065490.0150.0984No
134PIP4K2B65940.0150.0956No
135PLK3PLK3
Entrez,  Source
polo-like kinase 3 (Drosophila)67550.0120.0836No
136BMPR1BBMPR1B
Entrez,  Source
bone morphogenetic protein receptor, type IB67770.0120.0824No
137PKN1PKN1
Entrez,  Source
protein kinase N167830.0120.0824No
138GRK4GRK4
Entrez,  Source
G protein-coupled receptor kinase 467880.0120.0826No
139MAPK8MAPK8
Entrez,  Source
mitogen-activated protein kinase 868290.0110.0798No
140MAP4K2MAP4K2
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 268940.0100.0752No
141STK32BSTK32B
Entrez,  Source
serine/threonine kinase 32B69190.0100.0737No
142CLK4CLK4
Entrez,  Source
CDC-like kinase 469350.0100.0729No
143BMP2KBMP2K
Entrez,  Source
BMP2 inducible kinase70290.0080.0660No
144TEKTEK
Entrez,  Source
TEK tyrosine kinase, endothelial (venous malformations, multiple cutaneous and mucosal)70350.0080.0659No
145CLK2CLK2
Entrez,  Source
CDC-like kinase 271810.0050.0548No
146IKBKEIKBKE
Entrez,  Source
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon72160.0040.0524No
147ITKITK
Entrez,  Source
IL2-inducible T-cell kinase72200.0040.0523No
148CDK1972630.0040.0492No
149GSK3AGSK3A
Entrez,  Source
glycogen synthase kinase 3 alpha73580.0020.0420No
150AKT1AKT1
Entrez,  Source
v-akt murine thymoma viral oncogene homolog 173870.0020.0399No
151PRKAA2PRKAA2
Entrez,  Source
protein kinase, AMP-activated, alpha 2 catalytic subunit74180.0010.0376No
152CDK5CDK5
Entrez,  Source
cyclin-dependent kinase 574320.0010.0366No
153SIK274350.0010.0365No
154SNRKSNRK
Entrez,  Source
SNF related kinase7658-0.0030.0194No
155PI4KB7697-0.0030.0165No
156SIK37726-0.0040.0145No
157CSNK1ECSNK1E
Entrez,  Source
casein kinase 1, epsilon7742-0.0040.0135No
158MAP2K3MAP2K3
Entrez,  Source
mitogen-activated protein kinase kinase 37798-0.0050.0094No
159PDGFRBPDGFRB
Entrez,  Source
platelet-derived growth factor receptor, beta polypeptide7824-0.0060.0077No
160MAPK9MAPK9
Entrez,  Source
mitogen-activated protein kinase 97830-0.0060.0075No
161MKNK2MKNK2
Entrez,  Source
MAP kinase interacting serine/threonine kinase 27841-0.0060.0070No
162MAP2K1MAP2K1
Entrez,  Source
mitogen-activated protein kinase kinase 17939-0.008-0.0003No
163IGF1RIGF1R
Entrez,  Source
insulin-like growth factor 1 receptor7959-0.008-0.0014No
164MATKMATK
Entrez,  Source
megakaryocyte-associated tyrosine kinase7989-0.009-0.0034No
165MELKMELK
Entrez,  Source
maternal embryonic leucine zipper kinase8047-0.010-0.0074No
166TAOK2TAOK2
Entrez,  Source
TAO kinase 28059-0.010-0.0079No
167PRKACAPRKACA
Entrez,  Source
protein kinase, cAMP-dependent, catalytic, alpha8112-0.011-0.0116No
168KITKIT
Entrez,  Source
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog8134-0.012-0.0128No
169LTKLTK
Entrez,  Source
leukocyte tyrosine kinase8158-0.012-0.0141No
170RPS6KA4RPS6KA4
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 48181-0.013-0.0154No
171MAP2K5MAP2K5
Entrez,  Source
mitogen-activated protein kinase kinase 58199-0.013-0.0162No
172DYRK1BDYRK1B
Entrez,  Source
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B8200-0.013-0.0157No
173PRKCIPRKCI
Entrez,  Source
protein kinase C, iota8226-0.014-0.0172No
174MARK4MARK4
Entrez,  Source
MAP/microtubule affinity-regulating kinase 48259-0.014-0.0192No
175DMPKDMPK
Entrez,  Source
dystrophia myotonica-protein kinase8344-0.016-0.0251No
176CDK168353-0.016-0.0251No
177PTK2PTK2
Entrez,  Source
PTK2 protein tyrosine kinase 28356-0.016-0.0247No
178CDK3CDK3
Entrez,  Source
cyclin-dependent kinase 38440-0.018-0.0305No
179NTRK3NTRK3
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 38500-0.019-0.0344No
180STK25STK25
Entrez,  Source
serine/threonine kinase 25 (STE20 homolog, yeast)8561-0.021-0.0383No
181ROCK1ROCK1
Entrez,  Source
Rho-associated, coiled-coil containing protein kinase 18741-0.025-0.0513No
182PIK3CAPIK3CA
Entrez,  Source
phosphoinositide-3-kinase, catalytic, alpha polypeptide8749-0.025-0.0509No
183AURKBAURKB
Entrez,  Source
aurora kinase B8856-0.027-0.0582No
184ZAP70ZAP70
Entrez,  Source
zeta-chain (TCR) associated protein kinase 70kDa8954-0.030-0.0646No
185CDKL1CDKL1
Entrez,  Source
cyclin-dependent kinase-like 1 (CDC2-related kinase)8993-0.031-0.0665No
186IRAK4IRAK4
Entrez,  Source
interleukin-1 receptor-associated kinase 48996-0.031-0.0655No
187STK11STK11
Entrez,  Source
serine/threonine kinase 119183-0.035-0.0787No
188MAPKAPK2MAPKAPK2
Entrez,  Source
mitogen-activated protein kinase-activated protein kinase 29187-0.035-0.0777No
189ERN1ERN1
Entrez,  Source
endoplasmic reticulum to nucleus signalling 19341-0.039-0.0882No
190CDK2CDK2
Entrez,  Source
cyclin-dependent kinase 29409-0.040-0.0919No
191TYK2TYK2
Entrez,  Source
tyrosine kinase 29438-0.041-0.0926No
192PAK3PAK3
Entrez,  Source
p21 (CDKN1A)-activated kinase 39490-0.042-0.0951No
193CSNK2A2CSNK2A2
Entrez,  Source
casein kinase 2, alpha prime polypeptide9758-0.049-0.1140No
194HIPK3HIPK3
Entrez,  Source
homeodomain interacting protein kinase 39770-0.050-0.1131No
195PRKD1PRKD1
Entrez,  Source
protein kinase D19827-0.052-0.1156No
196MAP2K7MAP2K7
Entrez,  Source
mitogen-activated protein kinase kinase 79831-0.052-0.1140No
197DCLK19840-0.052-0.1128No
198MAP4K4MAP4K4
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 49922-0.055-0.1171No
199TTKTTK
Entrez,  Source
TTK protein kinase9930-0.055-0.1157No
200HCKHCK
Entrez,  Source
hemopoietic cell kinase9981-0.056-0.1176No
201PLK2PLK2
Entrez,  Source
polo-like kinase 2 (Drosophila)9994-0.057-0.1165No
202STK17ASTK17A
Entrez,  Source
serine/threonine kinase 17a (apoptosis-inducing)10017-0.057-0.1161No
203LATS1LATS1
Entrez,  Source
LATS, large tumor suppressor, homolog 1 (Drosophila)10025-0.057-0.1146No
204CHEK2CHEK2
Entrez,  Source
CHK2 checkpoint homolog (S. pombe)10102-0.059-0.1184No
205HIPK2HIPK2
Entrez,  Source
homeodomain interacting protein kinase 210151-0.061-0.1200No
206DDR2DDR2
Entrez,  Source
discoidin domain receptor family, member 210235-0.064-0.1241No
207DYRK1ADYRK1A
Entrez,  Source
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A10303-0.066-0.1270No
208MARK3MARK3
Entrez,  Source
MAP/microtubule affinity-regulating kinase 310374-0.068-0.1300No
209CITCIT
Entrez,  Source
citron (rho-interacting, serine/threonine kinase 21)10420-0.070-0.1310No
210RPS6KA3RPS6KA3
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 310427-0.070-0.1289No
211PLK1PLK1
Entrez,  Source
polo-like kinase 1 (Drosophila)10440-0.071-0.1273No
212ICKICK
Entrez,  Source
intestinal cell (MAK-like) kinase10499-0.073-0.1292No
213OXSR1OXSR1
Entrez,  Source
oxidative-stress responsive 110514-0.073-0.1277No
214PLK4PLK4
Entrez,  Source
polo-like kinase 4 (Drosophila)10581-0.075-0.1301No
215JAK1JAK1
Entrez,  Source
Janus kinase 1 (a protein tyrosine kinase)10585-0.076-0.1277No
216RPS6KB1RPS6KB1
Entrez,  Source
ribosomal protein S6 kinase, 70kDa, polypeptide 110717-0.081-0.1349No
217CAMKK2CAMKK2
Entrez,  Source
calcium/calmodulin-dependent protein kinase kinase 2, beta10729-0.081-0.1329No
218TBK1TBK1
Entrez,  Source
TANK-binding kinase 110732-0.082-0.1301No
219BRSK2BRSK2
Entrez,  Source
BR serine/threonine kinase 210749-0.082-0.1285No
220SRCSRC
Entrez,  Source
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)10776-0.083-0.1275No
221PIP5K1APIP5K1A
Entrez,  Source
phosphatidylinositol-4-phosphate 5-kinase, type I, alpha10780-0.083-0.1248No
222CHEK1CHEK1
Entrez,  Source
CHK1 checkpoint homolog (S. pombe)10792-0.084-0.1226No
223PRKCEPRKCE
Entrez,  Source
protein kinase C, epsilon10801-0.084-0.1202No
224PAK2PAK2
Entrez,  Source
p21 (CDKN1A)-activated kinase 210809-0.085-0.1178No
225CDK4CDK4
Entrez,  Source
cyclin-dependent kinase 410871-0.087-0.1194No
226PRKAA1PRKAA1
Entrez,  Source
protein kinase, AMP-activated, alpha 1 catalytic subunit10906-0.089-0.1189No
227PRKCQPRKCQ
Entrez,  Source
protein kinase C, theta10961-0.092-0.1198No
228MAPKAPK5MAPKAPK5
Entrez,  Source
mitogen-activated protein kinase-activated protein kinase 510962-0.092-0.1165No
229NLKNLK
Entrez,  Source
nemo-like kinase10979-0.093-0.1144No
230NUAK1NUAK1
Entrez,  Source
NUAK family, SNF1-like kinase, 111032-0.095-0.1151No
231DAPK3DAPK3
Entrez,  Source
death-associated protein kinase 311066-0.096-0.1142No
232SRPK1SRPK1
Entrez,  Source
SFRS protein kinase 111068-0.096-0.1109No
233ABL2ABL2
Entrez,  Source
v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)11090-0.098-0.1090No
234GSK3BGSK3B
Entrez,  Source
glycogen synthase kinase 3 beta11131-0.100-0.1086No
235CDK7CDK7
Entrez,  Source
cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase)11160-0.101-0.1071No
236PRKACBPRKACB
Entrez,  Source
protein kinase, cAMP-dependent, catalytic, beta11179-0.102-0.1049No
237STK10STK10
Entrez,  Source
serine/threonine kinase 1011218-0.103-0.1042No
238MYLKMYLK
Entrez,  Source
myosin, light chain kinase11255-0.105-0.1032No
239FERFER
Entrez,  Source
fer (fps/fes related) tyrosine kinase (phosphoprotein NCP94)11371-0.111-0.1082No
240NEK1NEK1
Entrez,  Source
NIMA (never in mitosis gene a)-related kinase 111428-0.113-0.1085No
241STK38LSTK38L
Entrez,  Source
serine/threonine kinase 38 like11441-0.114-0.1053No
242SRPK2SRPK2
Entrez,  Source
SFRS protein kinase 211496-0.117-0.1053No
243STK4STK4
Entrez,  Source
serine/threonine kinase 411518-0.118-0.1028No
244JAK2JAK2
Entrez,  Source
Janus kinase 2 (a protein tyrosine kinase)11530-0.119-0.0994No
245TYRO3TYRO3
Entrez,  Source
TYRO3 protein tyrosine kinase11601-0.123-0.1004No
246TLK2TLK2
Entrez,  Source
tousled-like kinase 211621-0.124-0.0975No
247CDK9CDK9
Entrez,  Source
cyclin-dependent kinase 9 (CDC2-related kinase)11631-0.125-0.0937No
248SLKSLK
Entrez,  Source
STE20-like kinase (yeast)11672-0.128-0.0922No
249MAP4K5MAP4K5
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 511705-0.130-0.0901No
250FYNFYN
Entrez,  Source
FYN oncogene related to SRC, FGR, YES11767-0.133-0.0901No
251MAP2K4MAP2K4
Entrez,  Source
mitogen-activated protein kinase kinase 411811-0.136-0.0886No
252PRPF4BPRPF4B
Entrez,  Source
PRP4 pre-mRNA processing factor 4 homolog B (yeast)11856-0.139-0.0870No
253CSNK2A1CSNK2A1
Entrez,  Source
casein kinase 2, alpha 1 polypeptide11861-0.139-0.0823No
254MAP2K2MAP2K2
Entrez,  Source
mitogen-activated protein kinase kinase 211895-0.142-0.0799No
255MAP2K6MAP2K6
Entrez,  Source
mitogen-activated protein kinase kinase 611934-0.144-0.0777No
256CDC42BPACDC42BPA
Entrez,  Source
CDC42 binding protein kinase alpha (DMPK-like)11941-0.145-0.0730No
257ROCK2ROCK2
Entrez,  Source
Rho-associated, coiled-coil containing protein kinase 212033-0.152-0.0746No
258CDC42BPBCDC42BPB
Entrez,  Source
CDC42 binding protein kinase beta (DMPK-like)12053-0.154-0.0706No
259CAMK1CAMK1
Entrez,  Source
calcium/calmodulin-dependent protein kinase I12150-0.162-0.0722No
260MAP3K2MAP3K2
Entrez,  Source
mitogen-activated protein kinase kinase kinase 212210-0.168-0.0708No
261PDGFRAPDGFRA
Entrez,  Source
platelet-derived growth factor receptor, alpha polypeptide12211-0.168-0.0648No
262PKN2PKN2
Entrez,  Source
protein kinase N212286-0.175-0.0643No
263SIK112319-0.179-0.0604No
264MAP4K3MAP4K3
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 312403-0.189-0.0601No
265IRAK3IRAK3
Entrez,  Source
interleukin-1 receptor-associated kinase 312451-0.196-0.0568No
266ABL1ABL1
Entrez,  Source
v-abl Abelson murine leukemia viral oncogene homolog 112463-0.197-0.0506No
267RIOK2RIOK2
Entrez,  Source
RIO kinase 2 (yeast)12467-0.198-0.0438No
268AKT3AKT3
Entrez,  Source
v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)12533-0.207-0.0415No
269TLK1TLK1
Entrez,  Source
tousled-like kinase 112558-0.210-0.0358No
270CDK1712578-0.213-0.0297No
271MAP3K7MAP3K7
Entrez,  Source
mitogen-activated protein kinase kinase kinase 712613-0.221-0.0245No
272CDK8CDK8
Entrez,  Source
cyclin-dependent kinase 812650-0.226-0.0192No
273AXLAXL
Entrez,  Source
AXL receptor tyrosine kinase12789-0.257-0.0207No
274AKT2AKT2
Entrez,  Source
v-akt murine thymoma viral oncogene homolog 212829-0.271-0.0141No
275CHUKCHUK
Entrez,  Source
conserved helix-loop-helix ubiquitous kinase12978-0.325-0.0140No
276PRKD3PRKD3
Entrez,  Source
protein kinase D313008-0.345-0.0039No
277FGFR1FGFR1
Entrez,  Source
fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome)13121-0.4860.0047No
Table: GSEA details [plain text format]



Fig 2: STAUROSPORINE_KINOME SCAN   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: STAUROSPORINE_KINOME SCAN: Random ES distribution   
Gene set null distribution of ES for STAUROSPORINE_KINOME SCAN