DatasetNSCLC_collapsed_to_symbols.NSCLC.cls
#SEN_versus_RES.NSCLC.cls
#SEN_versus_RES_repos
PhenotypeNSCLC.cls#SEN_versus_RES_repos
Upregulated in class1
GeneSetR406_LINCS
Enrichment Score (ES)0.32190877
Normalized Enrichment Score (NES)1.2479438
Nominal p-value0.083728276
FDR q-value0.6419622
FWER p-Value1.0
Table: GSEA Results Summary



Fig 1: Enrichment plot: R406_LINCS   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEGENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1MST1RMST1R
Entrez,  Source
macrophage stimulating 1 receptor (c-met-related tyrosine kinase)540.6360.0306Yes
2DAPK1DAPK1
Entrez,  Source
death-associated protein kinase 1880.5570.0585Yes
3EPHA1EPHA1
Entrez,  Source
EPH receptor A1940.5450.0879Yes
4MAPK13MAPK13
Entrez,  Source
mitogen-activated protein kinase 131100.5250.1154Yes
5PTK6PTK6
Entrez,  Source
PTK6 protein tyrosine kinase 61410.4790.1392Yes
6FGFR3FGFR3
Entrez,  Source
fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism)1530.4650.1638Yes
7PAK6PAK6
Entrez,  Source
p21(CDKN1A)-activated kinase 61580.4590.1886Yes
8FGFR2FGFR2
Entrez,  Source
ffer syndrome, Jackson-Weiss syndrome)2100.4060.2068Yes
9DDR1DDR1
Entrez,  Source
discoidin domain receptor family, member 12120.4040.2287Yes
10FRKFRK
Entrez,  Source
fyn-related kinase2960.3430.2411Yes
11SYKSYK
Entrez,  Source
spleen tyrosine kinase4710.2680.2424Yes
12METMET
Entrez,  Source
met proto-oncogene (hepatocyte growth factor receptor)4990.2590.2544Yes
13ROS1ROS1
Entrez,  Source
v-ros UR2 sarcoma virus oncogene homolog 1 (avian)5050.2580.2681Yes
14IKBKBIKBKB
Entrez,  Source
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta5530.2450.2779Yes
15EGFREGFR
Entrez,  Source
epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)6250.2300.2850Yes
16PAK1PAK1
Entrez,  Source
p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast)6740.2190.2933Yes
17EPHA4EPHA4
Entrez,  Source
EPH receptor A47980.1970.2946Yes
18TXKTXK
Entrez,  Source
TXK tyrosine kinase10450.1600.2844Yes
19MAPK10MAPK10
Entrez,  Source
mitogen-activated protein kinase 1010690.1570.2912Yes
20LCKLCK
Entrez,  Source
lymphocyte-specific protein tyrosine kinase13100.1360.2802Yes
21GAKGAK
Entrez,  Source
cyclin G associated kinase13400.1330.2852Yes
22TNK1TNK1
Entrez,  Source
tyrosine kinase, non-receptor, 113600.1310.2909Yes
23CAMK1DCAMK1D
Entrez,  Source
calcium/calmodulin-dependent protein kinase ID13870.1290.2960Yes
24EPHA7EPHA7
Entrez,  Source
EPH receptor A714120.1280.3011Yes
25STK17BSTK17B
Entrez,  Source
serine/threonine kinase 17b (apoptosis-inducing)15540.1190.2968Yes
26WEE1WEE1
Entrez,  Source
WEE1 homolog (S. pombe)16390.1150.2967Yes
27RPS6KA1RPS6KA1
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 116860.1130.2993Yes
28MAP3K9MAP3K9
Entrez,  Source
mitogen-activated protein kinase kinase kinase 916990.1120.3045Yes
29NTRK2NTRK2
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 217040.1120.3103Yes
30ERBB4ERBB4
Entrez,  Source
v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)18130.1070.3078Yes
31DAPK2DAPK2
Entrez,  Source
death-associated protein kinase 218380.1050.3117Yes
32RIOK3RIOK3
Entrez,  Source
RIO kinase 3 (yeast)19420.1010.3093Yes
33LYNLYN
Entrez,  Source
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog19740.1000.3124Yes
34PTK2BPTK2B
Entrez,  Source
PTK2B protein tyrosine kinase 2 beta20420.0980.3126Yes
35MARK1MARK1
Entrez,  Source
MAP/microtubule affinity-regulating kinase 121590.0930.3087Yes
36AAK1AAK1
Entrez,  Source
AP2 associated kinase 122120.0920.3098Yes
37ULK2ULK2
Entrez,  Source
unc-51-like kinase 2 (C. elegans)22440.0910.3123Yes
38MAP3K11MAP3K11
Entrez,  Source
mitogen-activated protein kinase kinase kinase 1122950.0890.3134Yes
39TIE1TIE1
Entrez,  Source
tyrosine kinase with immunoglobulin-like and EGF-like domains 123280.0880.3157Yes
40CLK3CLK3
Entrez,  Source
CDC-like kinase 323490.0870.3189Yes
41JAK3JAK3
Entrez,  Source
Janus kinase 3 (a protein tyrosine kinase, leukocyte)24440.0840.3163Yes
42MAP3K4MAP3K4
Entrez,  Source
mitogen-activated protein kinase kinase kinase 424890.0830.3175Yes
43MERTKMERTK
Entrez,  Source
c-mer proto-oncogene tyrosine kinase25220.0820.3195Yes
44TAOK1TAOK1
Entrez,  Source
TAO kinase 125520.0820.3218Yes
45RPS6KA5RPS6KA5
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 526100.0800.3217Yes
46ADCK4ADCK4
Entrez,  Source
aarF domain containing kinase 427150.0770.3180Yes
47LIMK2LIMK2
Entrez,  Source
LIM domain kinase 227990.0760.3157Yes
48MAP4K1MAP4K1
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 128490.0740.3160Yes
49EPHA3EPHA3
Entrez,  Source
EPH receptor A328700.0740.3185Yes
50MKNK1MKNK1
Entrez,  Source
MAP kinase interacting serine/threonine kinase 129070.0730.3197Yes
51TNK2TNK2
Entrez,  Source
tyrosine kinase, non-receptor, 230050.0700.3161Yes
52YES1YES1
Entrez,  Source
v-yes-1 Yamaguchi sarcoma viral oncogene homolog 130360.0700.3176Yes
53CSKCSK
Entrez,  Source
c-src tyrosine kinase30690.0690.3189Yes
54MINK1MINK1
Entrez,  Source
misshapen-like kinase 1 (zebrafish)30800.0690.3219Yes
55KDRKDR
Entrez,  Source
kinase insert domain receptor (a type III receptor tyrosine kinase)31460.0680.3206No
56FLT3FLT3
Entrez,  Source
fms-related tyrosine kinase 334030.0630.3043No
57BLKBLK
Entrez,  Source
B lymphoid tyrosine kinase34190.0620.3066No
58TSSK1B34450.0620.3081No
59CSF1RCSF1R
Entrez,  Source
colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog34540.0620.3108No
60MARK2MARK2
Entrez,  Source
MAP/microtubule affinity-regulating kinase 238340.0550.2847No
61EPHB1EPHB1
Entrez,  Source
EPH receptor B140000.0520.2749No
62PRKG2PRKG2
Entrez,  Source
protein kinase, cGMP-dependent, type II40210.0520.2762No
63ALKALK
Entrez,  Source
anaplastic lymphoma kinase (Ki-1)40730.0510.2750No
64MUSKMUSK
Entrez,  Source
muscle, skeletal, receptor tyrosine kinase41390.0500.2728No
65FGRFGR
Entrez,  Source
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog41930.0490.2714No
66AURKCAURKC
Entrez,  Source
aurora kinase C44130.0460.2571No
67LIMK1LIMK1
Entrez,  Source
LIM domain kinase 144680.0450.2554No
68NEK2NEK2
Entrez,  Source
NIMA (never in mitosis gene a)-related kinase 244830.0450.2568No
69FGFR4FGFR4
Entrez,  Source
fibroblast growth factor receptor 447150.0410.2413No
70PHKG2PHKG2
Entrez,  Source
phosphorylase kinase, gamma 2 (testis)47920.0400.2376No
71BMXBMX
Entrez,  Source
BMX non-receptor tyrosine kinase48260.0400.2373No
72NEK7NEK7
Entrez,  Source
NIMA (never in mitosis gene a)-related kinase 748770.0390.2356No
73EPHA2EPHA2
Entrez,  Source
EPH receptor A248800.0390.2375No
74FLT1FLT1
Entrez,  Source
fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)48820.0390.2396No
75FLT4FLT4
Entrez,  Source
fms-related tyrosine kinase 448980.0390.2406No
76PAK4PAK4
Entrez,  Source
p21(CDKN1A)-activated kinase 450140.0370.2338No
77ULK1ULK1
Entrez,  Source
unc-51-like kinase 1 (C. elegans)51570.0350.2248No
78TNNI3KTNNI3K
Entrez,  Source
TNNI3 interacting kinase52740.0330.2177No
79INSRRINSRR
Entrez,  Source
insulin receptor-related receptor53320.0330.2151No
80TECTEC
Entrez,  Source
tec protein tyrosine kinase53790.0320.2133No
81EPHA5EPHA5
Entrez,  Source
EPH receptor A554750.0310.2077No
82PDPK1PDPK1
Entrez,  Source
3-phosphoinositide dependent protein kinase-155490.0300.2037No
83BTKBTK
Entrez,  Source
Bruton agammaglobulinemia tyrosine kinase56280.0290.1993No
84STK16STK16
Entrez,  Source
serine/threonine kinase 1657780.0270.1893No
85SRPK3SRPK3
Entrez,  Source
SFRS protein kinase 358600.0260.1845No
86PAK7PAK7
Entrez,  Source
p21(CDKN1A)-activated kinase 758810.0250.1844No
87MAP3K3MAP3K3
Entrez,  Source
mitogen-activated protein kinase kinase kinase 359210.0250.1827No
88NTRK1NTRK1
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 160970.0220.1705No
89FESFES
Entrez,  Source
feline sarcoma oncogene61260.0220.1695No
90AURKAAURKA
Entrez,  Source
aurora kinase A64270.0170.1473No
91RETRET
Entrez,  Source
ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease)64710.0160.1449No
92EIF2AK2EIF2AK2
Entrez,  Source
eukaryotic translation initiation factor 2-alpha kinase 264890.0160.1445No
93MAP3K10MAP3K10
Entrez,  Source
mitogen-activated protein kinase kinase kinase 1065490.0150.1408No
94PIP4K2B65940.0150.1382No
95PLK3PLK3
Entrez,  Source
polo-like kinase 3 (Drosophila)67550.0120.1266No
96PKN1PKN1
Entrez,  Source
protein kinase N167830.0120.1252No
97MAPK8MAPK8
Entrez,  Source
mitogen-activated protein kinase 868290.0110.1223No
98CLK4CLK4
Entrez,  Source
CDC-like kinase 469350.0100.1148No
99BMP2KBMP2K
Entrez,  Source
BMP2 inducible kinase70290.0080.1081No
100TEKTEK
Entrez,  Source
TEK tyrosine kinase, endothelial (venous malformations, multiple cutaneous and mucosal)70350.0080.1081No
101TGFBR2TGFBR2
Entrez,  Source
transforming growth factor, beta receptor II (70/80kDa)71030.0070.1033No
102CLK2CLK2
Entrez,  Source
CDC-like kinase 271810.0050.0977No
103IKBKEIKBKE
Entrez,  Source
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon72160.0040.0953No
104ITKITK
Entrez,  Source
IL2-inducible T-cell kinase72200.0040.0953No
105GSK3AGSK3A
Entrez,  Source
glycogen synthase kinase 3 alpha73580.0020.0849No
106PRKAA2PRKAA2
Entrez,  Source
protein kinase, AMP-activated, alpha 2 catalytic subunit74180.0010.0804No
107SIK274350.0010.0793No
108MAP2K3MAP2K3
Entrez,  Source
mitogen-activated protein kinase kinase 37798-0.0050.0517No
109PDGFRBPDGFRB
Entrez,  Source
platelet-derived growth factor receptor, beta polypeptide7824-0.0060.0501No
110MAPK9MAPK9
Entrez,  Source
mitogen-activated protein kinase 97830-0.0060.0501No
111MKNK2MKNK2
Entrez,  Source
MAP kinase interacting serine/threonine kinase 27841-0.0060.0496No
112MAP2K1MAP2K1
Entrez,  Source
mitogen-activated protein kinase kinase 17939-0.0080.0426No
113IGF1RIGF1R
Entrez,  Source
insulin-like growth factor 1 receptor7959-0.0080.0416No
114MELKMELK
Entrez,  Source
maternal embryonic leucine zipper kinase8047-0.0100.0355No
115PRKACAPRKACA
Entrez,  Source
protein kinase, cAMP-dependent, catalytic, alpha8112-0.0110.0312No
116KITKIT
Entrez,  Source
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog8134-0.0120.0302No
117LTKLTK
Entrez,  Source
leukocyte tyrosine kinase8158-0.0120.0291No
118RPS6KA4RPS6KA4
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 48181-0.0130.0281No
119DYRK1BDYRK1B
Entrez,  Source
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B8200-0.0130.0274No
120MARK4MARK4
Entrez,  Source
MAP/microtubule affinity-regulating kinase 48259-0.0140.0237No
121DMPKDMPK
Entrez,  Source
dystrophia myotonica-protein kinase8344-0.0160.0182No
122PTK2PTK2
Entrez,  Source
PTK2 protein tyrosine kinase 28356-0.0160.0182No
123NTRK3NTRK3
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 38500-0.0190.0083No
124STK25STK25
Entrez,  Source
serine/threonine kinase 25 (STE20 homolog, yeast)8561-0.0210.0048No
125AURKBAURKB
Entrez,  Source
aurora kinase B8856-0.027-0.0163No
126ZAP70ZAP70
Entrez,  Source
zeta-chain (TCR) associated protein kinase 70kDa8954-0.030-0.0221No
127TYK2TYK2
Entrez,  Source
tyrosine kinase 29438-0.041-0.0570No
128PAK3PAK3
Entrez,  Source
p21 (CDKN1A)-activated kinase 39490-0.042-0.0587No
129CSNK2A2CSNK2A2
Entrez,  Source
casein kinase 2, alpha prime polypeptide9758-0.049-0.0765No
130NEK9NEK9
Entrez,  Source
NIMA (never in mitosis gene a)- related kinase 99810-0.051-0.0776No
131DCLK19840-0.052-0.0770No
132HCKHCK
Entrez,  Source
hemopoietic cell kinase9981-0.056-0.0847No
133STK17ASTK17A
Entrez,  Source
serine/threonine kinase 17a (apoptosis-inducing)10017-0.057-0.0843No
134DDR2DDR2
Entrez,  Source
discoidin domain receptor family, member 210235-0.064-0.0975No
135ADCK310237-0.064-0.0941No
136MARK3MARK3
Entrez,  Source
MAP/microtubule affinity-regulating kinase 310374-0.068-0.1008No
137CITCIT
Entrez,  Source
citron (rho-interacting, serine/threonine kinase 21)10420-0.070-0.1005No
138PLK1PLK1
Entrez,  Source
polo-like kinase 1 (Drosophila)10440-0.071-0.0981No
139PLK4PLK4
Entrez,  Source
polo-like kinase 4 (Drosophila)10581-0.075-0.1047No
140JAK1JAK1
Entrez,  Source
Janus kinase 1 (a protein tyrosine kinase)10585-0.076-0.1008No
141SRCSRC
Entrez,  Source
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)10776-0.083-0.1109No
142PIP5K1APIP5K1A
Entrez,  Source
phosphatidylinositol-4-phosphate 5-kinase, type I, alpha10780-0.083-0.1066No
143CHEK1CHEK1
Entrez,  Source
CHK1 checkpoint homolog (S. pombe)10792-0.084-0.1028No
144PRKAA1PRKAA1
Entrez,  Source
protein kinase, AMP-activated, alpha 1 catalytic subunit10906-0.089-0.1066No
145NUAK1NUAK1
Entrez,  Source
NUAK family, SNF1-like kinase, 111032-0.095-0.1111No
146DAPK3DAPK3
Entrez,  Source
death-associated protein kinase 311066-0.096-0.1084No
147SRPK1SRPK1
Entrez,  Source
SFRS protein kinase 111068-0.096-0.1032No
148ABL2ABL2
Entrez,  Source
v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)11090-0.098-0.0995No
149PRKACBPRKACB
Entrez,  Source
protein kinase, cAMP-dependent, catalytic, beta11179-0.102-0.1007No
150STK10STK10
Entrez,  Source
serine/threonine kinase 1011218-0.103-0.0979No
151RIPK2RIPK2
Entrez,  Source
receptor-interacting serine-threonine kinase 211349-0.110-0.1020No
152FERFER
Entrez,  Source
fer (fps/fes related) tyrosine kinase (phosphoprotein NCP94)11371-0.111-0.0975No
153NEK1NEK1
Entrez,  Source
NIMA (never in mitosis gene a)-related kinase 111428-0.113-0.0956No
154JAK2JAK2
Entrez,  Source
Janus kinase 2 (a protein tyrosine kinase)11530-0.119-0.0969No
155TLK2TLK2
Entrez,  Source
tousled-like kinase 211621-0.124-0.0970No
156SLKSLK
Entrez,  Source
STE20-like kinase (yeast)11672-0.128-0.0939No
157FYNFYN
Entrez,  Source
FYN oncogene related to SRC, FGR, YES11767-0.133-0.0939No
158HIPK1HIPK1
Entrez,  Source
homeodomain interacting protein kinase 111798-0.135-0.0888No
159MAP2K4MAP2K4
Entrez,  Source
mitogen-activated protein kinase kinase 411811-0.136-0.0823No
160CSNK2A1CSNK2A1
Entrez,  Source
casein kinase 2, alpha 1 polypeptide11861-0.139-0.0784No
161MAP2K6MAP2K6
Entrez,  Source
mitogen-activated protein kinase kinase 611934-0.144-0.0761No
162ROCK2ROCK2
Entrez,  Source
Rho-associated, coiled-coil containing protein kinase 212033-0.152-0.0753No
163CAMK1CAMK1
Entrez,  Source
calcium/calmodulin-dependent protein kinase I12150-0.162-0.0754No
164PDGFRAPDGFRA
Entrez,  Source
platelet-derived growth factor receptor, alpha polypeptide12211-0.168-0.0708No
165PKN2PKN2
Entrez,  Source
protein kinase N212286-0.175-0.0669No
166SIK112319-0.179-0.0596No
167MAP4K3MAP4K3
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 312403-0.189-0.0557No
168IRAK3IRAK3
Entrez,  Source
interleukin-1 receptor-associated kinase 312451-0.196-0.0486No
169ABL1ABL1
Entrez,  Source
v-abl Abelson murine leukemia viral oncogene homolog 112463-0.197-0.0387No
170TLK1TLK1
Entrez,  Source
tousled-like kinase 112558-0.210-0.0344No
171CDK1712578-0.213-0.0243No
172MAP3K7MAP3K7
Entrez,  Source
mitogen-activated protein kinase kinase kinase 712613-0.221-0.0148No
173AXLAXL
Entrez,  Source
AXL receptor tyrosine kinase12789-0.257-0.0142No
174CHUKCHUK
Entrez,  Source
conserved helix-loop-helix ubiquitous kinase12978-0.325-0.0109No
175FGFR1FGFR1
Entrez,  Source
fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome)13121-0.4860.0047No
Table: GSEA details [plain text format]



Fig 2: R406_LINCS   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: R406_LINCS: Random ES distribution   
Gene set null distribution of ES for R406_LINCS