DatasetNSCLC_collapsed_to_symbols.NSCLC.cls
#SEN_versus_RES.NSCLC.cls
#SEN_versus_RES_repos
PhenotypeNSCLC.cls#SEN_versus_RES_repos
Upregulated in class1
GeneSetHG-14-10-04_LINCS
Enrichment Score (ES)0.31270874
Normalized Enrichment Score (NES)1.2108393
Nominal p-value0.11179173
FDR q-value0.64331067
FWER p-Value1.0
Table: GSEA Results Summary



Fig 1: Enrichment plot: HG-14-10-04_LINCS   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEGENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1DAPK1DAPK1
Entrez,  Source
death-associated protein kinase 1880.5570.0243Yes
2EPHA1EPHA1
Entrez,  Source
EPH receptor A1940.5450.0543Yes
3ERBB2ERBB2
Entrez,  Source
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)1000.5370.0839Yes
4PTK6PTK6
Entrez,  Source
PTK6 protein tyrosine kinase 61410.4790.1075Yes
5FGFR3FGFR3
Entrez,  Source
fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism)1530.4650.1326Yes
6FGFR2FGFR2
Entrez,  Source
ffer syndrome, Jackson-Weiss syndrome)2100.4060.1509Yes
7DDR1DDR1
Entrez,  Source
discoidin domain receptor family, member 12120.4040.1733Yes
8FRKFRK
Entrez,  Source
fyn-related kinase2960.3430.1861Yes
9STK39STK39
Entrez,  Source
serine threonine kinase 39 (STE20/SPS1 homolog, yeast)3840.2990.1961Yes
10SYKSYK
Entrez,  Source
spleen tyrosine kinase4710.2680.2044Yes
11METMET
Entrez,  Source
met proto-oncogene (hepatocyte growth factor receptor)4990.2590.2168Yes
12ROS1ROS1
Entrez,  Source
v-ros UR2 sarcoma virus oncogene homolog 1 (avian)5050.2580.2308Yes
13RPS6KA2RPS6KA2
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 25900.2370.2375Yes
14MAP3K13MAP3K13
Entrez,  Source
mitogen-activated protein kinase kinase kinase 136240.2300.2478Yes
15EGFREGFR
Entrez,  Source
epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)6250.2300.2606Yes
16EPHB6EPHB6
Entrez,  Source
EPH receptor B67010.2150.2668Yes
17MAPK10MAPK10
Entrez,  Source
mitogen-activated protein kinase 1010690.1570.2474Yes
18TNIKTNIK
Entrez,  Source
TRAF2 and NCK interacting kinase11970.1450.2457Yes
19DYRK2DYRK2
Entrez,  Source
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 212300.1420.2512Yes
20LCKLCK
Entrez,  Source
lymphocyte-specific protein tyrosine kinase13100.1360.2527Yes
21GAKGAK
Entrez,  Source
cyclin G associated kinase13400.1330.2579Yes
22TNK1TNK1
Entrez,  Source
tyrosine kinase, non-receptor, 113600.1310.2638Yes
23CAMK1DCAMK1D
Entrez,  Source
calcium/calmodulin-dependent protein kinase ID13870.1290.2690Yes
24EPHA7EPHA7
Entrez,  Source
EPH receptor A714120.1280.2743Yes
25SLC12A7SLC12A7
Entrez,  Source
solute carrier family 12 (potassium/chloride transporters), member 715430.1200.2710Yes
26STK17BSTK17B
Entrez,  Source
serine/threonine kinase 17b (apoptosis-inducing)15540.1190.2769Yes
27INSRINSR
Entrez,  Source
insulin receptor16640.1140.2749Yes
28RPS6KA1RPS6KA1
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 116860.1130.2795Yes
29MAP3K9MAP3K9
Entrez,  Source
mitogen-activated protein kinase kinase kinase 916990.1120.2849Yes
30NTRK2NTRK2
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 217040.1120.2908Yes
31CAMK2ACAMK2A
Entrez,  Source
calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha18010.1070.2894Yes
32CAMK2GCAMK2G
Entrez,  Source
calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma18110.1070.2947Yes
33ERBB4ERBB4
Entrez,  Source
v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)18130.1070.3005Yes
34DAPK2DAPK2
Entrez,  Source
death-associated protein kinase 218380.1050.3045Yes
35RIOK3RIOK3
Entrez,  Source
RIO kinase 3 (yeast)19420.1010.3023Yes
36LYNLYN
Entrez,  Source
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog19740.1000.3054Yes
37PTK2BPTK2B
Entrez,  Source
PTK2B protein tyrosine kinase 2 beta20420.0980.3057Yes
38MARK1MARK1
Entrez,  Source
MAP/microtubule affinity-regulating kinase 121590.0930.3020Yes
39AAK1AAK1
Entrez,  Source
AP2 associated kinase 122120.0920.3031Yes
40ULK2ULK2
Entrez,  Source
unc-51-like kinase 2 (C. elegans)22440.0910.3058Yes
41MAP3K11MAP3K11
Entrez,  Source
mitogen-activated protein kinase kinase kinase 1122950.0890.3069Yes
42TIE1TIE1
Entrez,  Source
tyrosine kinase with immunoglobulin-like and EGF-like domains 123280.0880.3094Yes
43CLK3CLK3
Entrez,  Source
CDC-like kinase 323490.0870.3127Yes
44JAK3JAK3
Entrez,  Source
Janus kinase 3 (a protein tyrosine kinase, leukocyte)24440.0840.3102No
45MERTKMERTK
Entrez,  Source
c-mer proto-oncogene tyrosine kinase25220.0820.3089No
46ADCK4ADCK4
Entrez,  Source
aarF domain containing kinase 427150.0770.2984No
47MKNK1MKNK1
Entrez,  Source
MAP kinase interacting serine/threonine kinase 129070.0730.2878No
48TNK2TNK2
Entrez,  Source
tyrosine kinase, non-receptor, 230050.0700.2843No
49YES1YES1
Entrez,  Source
v-yes-1 Yamaguchi sarcoma viral oncogene homolog 130360.0700.2858No
50MINK1MINK1
Entrez,  Source
misshapen-like kinase 1 (zebrafish)30800.0690.2864No
51KDRKDR
Entrez,  Source
kinase insert domain receptor (a type III receptor tyrosine kinase)31460.0680.2852No
52FLT3FLT3
Entrez,  Source
fms-related tyrosine kinase 334030.0630.2690No
53BLKBLK
Entrez,  Source
B lymphoid tyrosine kinase34190.0620.2713No
54TSSK1B34450.0620.2728No
55CSF1RCSF1R
Entrez,  Source
colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog34540.0620.2756No
56MYO3AMYO3A
Entrez,  Source
myosin IIIA37350.0570.2573No
57MARK2MARK2
Entrez,  Source
MAP/microtubule affinity-regulating kinase 238340.0550.2528No
58PRKD2PRKD2
Entrez,  Source
protein kinase D239000.0540.2508No
59ALKALK
Entrez,  Source
anaplastic lymphoma kinase (Ki-1)40730.0510.2404No
60PIM1PIM1
Entrez,  Source
pim-1 oncogene41360.0500.2385No
61MUSKMUSK
Entrez,  Source
muscle, skeletal, receptor tyrosine kinase41390.0500.2411No
62CAMK2BCAMK2B
Entrez,  Source
calcium/calmodulin-dependent protein kinase (CaM kinase) II beta42130.0490.2382No
63AURKCAURKC
Entrez,  Source
aurora kinase C44130.0460.2255No
64CAMK1GCAMK1G
Entrez,  Source
calcium/calmodulin-dependent protein kinase IG45030.0450.2211No
65HUNKHUNK
Entrez,  Source
hormonally upregulated Neu-associated kinase46450.0430.2127No
66RPS6KA6RPS6KA6
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 646850.0420.2120No
67FGFR4FGFR4
Entrez,  Source
fibroblast growth factor receptor 447150.0410.2121No
68PHKG2PHKG2
Entrez,  Source
phosphorylase kinase, gamma 2 (testis)47920.0400.2085No
69NEK7NEK7
Entrez,  Source
NIMA (never in mitosis gene a)-related kinase 748770.0390.2042No
70FLT1FLT1
Entrez,  Source
fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)48820.0390.2061No
71FLT4FLT4
Entrez,  Source
fms-related tyrosine kinase 448980.0390.2071No
72PAK4PAK4
Entrez,  Source
p21(CDKN1A)-activated kinase 450140.0370.2003No
73ULK1ULK1
Entrez,  Source
unc-51-like kinase 1 (C. elegans)51570.0350.1914No
74INSRRINSRR
Entrez,  Source
insulin receptor-related receptor53320.0330.1798No
75MAST1MAST1
Entrez,  Source
microtubule associated serine/threonine kinase 154360.0320.1737No
76STK16STK16
Entrez,  Source
serine/threonine kinase 1657780.0270.1490No
77PAK7PAK7
Entrez,  Source
p21(CDKN1A)-activated kinase 758810.0250.1425No
78MAP3K3MAP3K3
Entrez,  Source
mitogen-activated protein kinase kinase kinase 359210.0250.1409No
79NTRK1NTRK1
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 160970.0220.1287No
80FESFES
Entrez,  Source
feline sarcoma oncogene61260.0220.1277No
81IRAK1IRAK1
Entrez,  Source
interleukin-1 receptor-associated kinase 161790.0210.1249No
82PHKG1PHKG1
Entrez,  Source
phosphorylase kinase, gamma 1 (muscle)62450.0200.1210No
83AURKAAURKA
Entrez,  Source
aurora kinase A64270.0170.1080No
84DCLK264620.0160.1063No
85RETRET
Entrez,  Source
ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease)64710.0160.1066No
86MAP3K10MAP3K10
Entrez,  Source
mitogen-activated protein kinase kinase kinase 1065490.0150.1016No
87PIP4K2B65940.0150.0990No
88PLK3PLK3
Entrez,  Source
polo-like kinase 3 (Drosophila)67550.0120.0874No
89MAPK8MAPK8
Entrez,  Source
mitogen-activated protein kinase 868290.0110.0824No
90MAPK7MAPK7
Entrez,  Source
mitogen-activated protein kinase 769130.0100.0766No
91STK32BSTK32B
Entrez,  Source
serine/threonine kinase 32B69190.0100.0767No
92CLK4CLK4
Entrez,  Source
CDC-like kinase 469350.0100.0761No
93BMP2KBMP2K
Entrez,  Source
BMP2 inducible kinase70290.0080.0694No
94TEKTEK
Entrez,  Source
TEK tyrosine kinase, endothelial (venous malformations, multiple cutaneous and mucosal)70350.0080.0694No
95TGFBR2TGFBR2
Entrez,  Source
transforming growth factor, beta receptor II (70/80kDa)71030.0070.0647No
96CLK2CLK2
Entrez,  Source
CDC-like kinase 271810.0050.0590No
97IKBKEIKBKE
Entrez,  Source
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon72160.0040.0567No
98ITKITK
Entrez,  Source
IL2-inducible T-cell kinase72200.0040.0567No
99PRKAA2PRKAA2
Entrez,  Source
protein kinase, AMP-activated, alpha 2 catalytic subunit74180.0010.0416No
100SIK274350.0010.0404No
101MAP2K3MAP2K3
Entrez,  Source
mitogen-activated protein kinase kinase 37798-0.0050.0129No
102PDGFRBPDGFRB
Entrez,  Source
platelet-derived growth factor receptor, beta polypeptide7824-0.0060.0113No
103MAPK9MAPK9
Entrez,  Source
mitogen-activated protein kinase 97830-0.0060.0112No
104MKNK2MKNK2
Entrez,  Source
MAP kinase interacting serine/threonine kinase 27841-0.0060.0108No
105MAP2K1MAP2K1
Entrez,  Source
mitogen-activated protein kinase kinase 17939-0.0080.0038No
106IGF1RIGF1R
Entrez,  Source
insulin-like growth factor 1 receptor7959-0.0080.0028No
107MELKMELK
Entrez,  Source
maternal embryonic leucine zipper kinase8047-0.010-0.0033No
108PRKACAPRKACA
Entrez,  Source
protein kinase, cAMP-dependent, catalytic, alpha8112-0.011-0.0076No
109KITKIT
Entrez,  Source
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog8134-0.012-0.0086No
110LTKLTK
Entrez,  Source
leukocyte tyrosine kinase8158-0.012-0.0097No
111RPS6KA4RPS6KA4
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 48181-0.013-0.0107No
112MAP2K5MAP2K5
Entrez,  Source
mitogen-activated protein kinase kinase 58199-0.013-0.0112No
113DYRK1BDYRK1B
Entrez,  Source
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B8200-0.013-0.0105No
114MARK4MARK4
Entrez,  Source
MAP/microtubule affinity-regulating kinase 48259-0.014-0.0142No
115DMPKDMPK
Entrez,  Source
dystrophia myotonica-protein kinase8344-0.016-0.0197No
116PTK2PTK2
Entrez,  Source
PTK2 protein tyrosine kinase 28356-0.016-0.0197No
117ROCK1ROCK1
Entrez,  Source
Rho-associated, coiled-coil containing protein kinase 18741-0.025-0.0478No
118ZAP70ZAP70
Entrez,  Source
zeta-chain (TCR) associated protein kinase 70kDa8954-0.030-0.0625No
119IRAK4IRAK4
Entrez,  Source
interleukin-1 receptor-associated kinase 48996-0.031-0.0639No
120TYK2TYK2
Entrez,  Source
tyrosine kinase 29438-0.041-0.0955No
121PAK3PAK3
Entrez,  Source
p21 (CDKN1A)-activated kinase 39490-0.042-0.0971No
122CSNK2A2CSNK2A2
Entrez,  Source
casein kinase 2, alpha prime polypeptide9758-0.049-0.1149No
123HIPK3HIPK3
Entrez,  Source
homeodomain interacting protein kinase 39770-0.050-0.1130No
124NEK9NEK9
Entrez,  Source
NIMA (never in mitosis gene a)- related kinase 99810-0.051-0.1131No
125PRKD1PRKD1
Entrez,  Source
protein kinase D19827-0.052-0.1115No
126DCLK19840-0.052-0.1095No
127MAP4K4MAP4K4
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 49922-0.055-0.1127No
128TTKTTK
Entrez,  Source
TTK protein kinase9930-0.055-0.1102No
129HCKHCK
Entrez,  Source
hemopoietic cell kinase9981-0.056-0.1109No
130STK17ASTK17A
Entrez,  Source
serine/threonine kinase 17a (apoptosis-inducing)10017-0.057-0.1104No
131LATS1LATS1
Entrez,  Source
LATS, large tumor suppressor, homolog 1 (Drosophila)10025-0.057-0.1077No
132CHEK2CHEK2
Entrez,  Source
CHK2 checkpoint homolog (S. pombe)10102-0.059-0.1103No
133HIPK2HIPK2
Entrez,  Source
homeodomain interacting protein kinase 210151-0.061-0.1106No
134BUB1BUB1
Entrez,  Source
BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast)10160-0.061-0.1078No
135DYRK1ADYRK1A
Entrez,  Source
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A10303-0.066-0.1150No
136MARK3MARK3
Entrez,  Source
MAP/microtubule affinity-regulating kinase 310374-0.068-0.1166No
137CITCIT
Entrez,  Source
citron (rho-interacting, serine/threonine kinase 21)10420-0.070-0.1162No
138RPS6KA3RPS6KA3
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 310427-0.070-0.1127No
139PLK1PLK1
Entrez,  Source
polo-like kinase 1 (Drosophila)10440-0.071-0.1097No
140OXSR1OXSR1
Entrez,  Source
oxidative-stress responsive 110514-0.073-0.1112No
141PLK4PLK4
Entrez,  Source
polo-like kinase 4 (Drosophila)10581-0.075-0.1121No
142JAK1JAK1
Entrez,  Source
Janus kinase 1 (a protein tyrosine kinase)10585-0.076-0.1081No
143CAMKK2CAMKK2
Entrez,  Source
calcium/calmodulin-dependent protein kinase kinase 2, beta10729-0.081-0.1146No
144TBK1TBK1
Entrez,  Source
TANK-binding kinase 110732-0.082-0.1102No
145SRCSRC
Entrez,  Source
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)10776-0.083-0.1088No
146PIP5K1APIP5K1A
Entrez,  Source
phosphatidylinositol-4-phosphate 5-kinase, type I, alpha10780-0.083-0.1044No
147CHEK1CHEK1
Entrez,  Source
CHK1 checkpoint homolog (S. pombe)10792-0.084-0.1006No
148PAK2PAK2
Entrez,  Source
p21 (CDKN1A)-activated kinase 210809-0.085-0.0971No
149PRKAA1PRKAA1
Entrez,  Source
protein kinase, AMP-activated, alpha 1 catalytic subunit10906-0.089-0.0995No
150NUAK1NUAK1
Entrez,  Source
NUAK family, SNF1-like kinase, 111032-0.095-0.1039No
151DAPK3DAPK3
Entrez,  Source
death-associated protein kinase 311066-0.096-0.1010No
152SRPK1SRPK1
Entrez,  Source
SFRS protein kinase 111068-0.096-0.0957No
153ABL2ABL2
Entrez,  Source
v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)11090-0.098-0.0919No
154STK10STK10
Entrez,  Source
serine/threonine kinase 1011218-0.103-0.0959No
155MYLKMYLK
Entrez,  Source
myosin, light chain kinase11255-0.105-0.0928No
156FERFER
Entrez,  Source
fer (fps/fes related) tyrosine kinase (phosphoprotein NCP94)11371-0.111-0.0955No
157SRPK2SRPK2
Entrez,  Source
SFRS protein kinase 211496-0.117-0.0985No
158JAK2JAK2
Entrez,  Source
Janus kinase 2 (a protein tyrosine kinase)11530-0.119-0.0944No
159SLKSLK
Entrez,  Source
STE20-like kinase (yeast)11672-0.128-0.0982No
160HIPK1HIPK1
Entrez,  Source
homeodomain interacting protein kinase 111798-0.135-0.1002No
161MAP2K4MAP2K4
Entrez,  Source
mitogen-activated protein kinase kinase 411811-0.136-0.0935No
162CSNK2A1CSNK2A1
Entrez,  Source
casein kinase 2, alpha 1 polypeptide11861-0.139-0.0895No
163MAP2K2MAP2K2
Entrez,  Source
mitogen-activated protein kinase kinase 211895-0.142-0.0842No
164MAP2K6MAP2K6
Entrez,  Source
mitogen-activated protein kinase kinase 611934-0.144-0.0790No
165ROCK2ROCK2
Entrez,  Source
Rho-associated, coiled-coil containing protein kinase 212033-0.152-0.0781No
166CAMK1CAMK1
Entrez,  Source
calcium/calmodulin-dependent protein kinase I12150-0.162-0.0780No
167PDGFRAPDGFRA
Entrez,  Source
platelet-derived growth factor receptor, alpha polypeptide12211-0.168-0.0732No
168SIK112319-0.179-0.0715No
169MAP3K14MAP3K14
Entrez,  Source
mitogen-activated protein kinase kinase kinase 1412365-0.184-0.0647No
170MAP3K12MAP3K12
Entrez,  Source
mitogen-activated protein kinase kinase kinase 1212384-0.186-0.0557No
171MAP4K3MAP4K3
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 312403-0.189-0.0465No
172IRAK3IRAK3
Entrez,  Source
interleukin-1 receptor-associated kinase 312451-0.196-0.0392No
173ABL1ABL1
Entrez,  Source
v-abl Abelson murine leukemia viral oncogene homolog 112463-0.197-0.0291No
174RIOK2RIOK2
Entrez,  Source
RIO kinase 2 (yeast)12467-0.198-0.0183No
175MAP3K7MAP3K7
Entrez,  Source
mitogen-activated protein kinase kinase kinase 712613-0.221-0.0171No
176AXLAXL
Entrez,  Source
AXL receptor tyrosine kinase12789-0.257-0.0163No
177PRKD3PRKD3
Entrez,  Source
protein kinase D313008-0.345-0.0138No
178FGFR1FGFR1
Entrez,  Source
fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome)13121-0.4860.0047No
Table: GSEA details [plain text format]



Fig 2: HG-14-10-04_LINCS   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HG-14-10-04_LINCS: Random ES distribution   
Gene set null distribution of ES for HG-14-10-04_LINCS