| Dataset | NSCLC_collapsed_to_symbols.NSCLC.cls #SEN_versus_RES.NSCLC.cls #SEN_versus_RES_repos |
| Phenotype | NSCLC.cls#SEN_versus_RES_repos |
| Upregulated in class | 1 |
| GeneSet | AST-487_KINOME SCAN |
| Enrichment Score (ES) | 0.28663054 |
| Normalized Enrichment Score (NES) | 1.0554385 |
| Nominal p-value | 0.3338843 |
| FDR q-value | 0.7747157 |
| FWER p-Value | 1.0 |

| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | MST1R | MST1R Entrez,  Source | macrophage stimulating 1 receptor (c-met-related tyrosine kinase) | 54 | 0.636 | 0.0419 | Yes |
| 2 | RIPK4 | RIPK4 Entrez,  Source | receptor-interacting serine-threonine kinase 4 | 95 | 0.544 | 0.0783 | Yes |
| 3 | MAPK13 | MAPK13 Entrez,  Source | mitogen-activated protein kinase 13 | 110 | 0.525 | 0.1153 | Yes |
| 4 | DDR1 | DDR1 Entrez,  Source | discoidin domain receptor family, member 1 | 212 | 0.404 | 0.1368 | Yes |
| 5 | FRK | FRK Entrez,  Source | fyn-related kinase | 296 | 0.343 | 0.1553 | Yes |
| 6 | SYK | SYK Entrez,  Source | spleen tyrosine kinase | 471 | 0.268 | 0.1614 | Yes |
| 7 | MET | MET Entrez,  Source | met proto-oncogene (hepatocyte growth factor receptor) | 499 | 0.259 | 0.1780 | Yes |
| 8 | IKBKB | IKBKB Entrez,  Source | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta | 553 | 0.245 | 0.1917 | Yes |
| 9 | MAP3K13 | MAP3K13 Entrez,  Source | mitogen-activated protein kinase kinase kinase 13 | 624 | 0.230 | 0.2030 | Yes |
| 10 | EGFR | EGFR Entrez,  Source | epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian) | 625 | 0.230 | 0.2197 | Yes |
| 11 | CDK14 | 659 | 0.222 | 0.2333 | Yes | ||
| 12 | CDK18 | 760 | 0.204 | 0.2404 | Yes | ||
| 13 | EPHA4 | EPHA4 Entrez,  Source | EPH receptor A4 | 798 | 0.197 | 0.2518 | Yes |
| 14 | EPHB2 | EPHB2 Entrez,  Source | EPH receptor B2 | 868 | 0.185 | 0.2600 | Yes |
| 15 | TAOK3 | TAOK3 Entrez,  Source | TAO kinase 3 | 971 | 0.170 | 0.2645 | Yes |
| 16 | MAPK10 | MAPK10 Entrez,  Source | mitogen-activated protein kinase 10 | 1069 | 0.157 | 0.2684 | Yes |
| 17 | TNIK | TNIK Entrez,  Source | TRAF2 and NCK interacting kinase | 1197 | 0.145 | 0.2692 | Yes |
| 18 | DYRK2 | DYRK2 Entrez,  Source | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 | 1230 | 0.142 | 0.2771 | Yes |
| 19 | LCK | LCK Entrez,  Source | lymphocyte-specific protein tyrosine kinase | 1310 | 0.136 | 0.2809 | Yes |
| 20 | TNK1 | TNK1 Entrez,  Source | tyrosine kinase, non-receptor, 1 | 1360 | 0.131 | 0.2866 | Yes |
| 21 | STK3 | STK3 Entrez,  Source | serine/threonine kinase 3 (STE20 homolog, yeast) | 1553 | 0.120 | 0.2806 | No |
| 22 | NTRK2 | NTRK2 Entrez,  Source | neurotrophic tyrosine kinase, receptor, type 2 | 1704 | 0.112 | 0.2772 | No |
| 23 | LYN | LYN Entrez,  Source | v-yes-1 Yamaguchi sarcoma viral related oncogene homolog | 1974 | 0.100 | 0.2638 | No |
| 24 | PTK2B | PTK2B Entrez,  Source | PTK2B protein tyrosine kinase 2 beta | 2042 | 0.098 | 0.2658 | No |
| 25 | ULK2 | ULK2 Entrez,  Source | unc-51-like kinase 2 (C. elegans) | 2244 | 0.091 | 0.2569 | No |
| 26 | TIE1 | TIE1 Entrez,  Source | tyrosine kinase with immunoglobulin-like and EGF-like domains 1 | 2328 | 0.088 | 0.2569 | No |
| 27 | JAK3 | JAK3 Entrez,  Source | Janus kinase 3 (a protein tyrosine kinase, leukocyte) | 2444 | 0.084 | 0.2542 | No |
| 28 | MERTK | MERTK Entrez,  Source | c-mer proto-oncogene tyrosine kinase | 2522 | 0.082 | 0.2543 | No |
| 29 | TAOK1 | TAOK1 Entrez,  Source | TAO kinase 1 | 2552 | 0.082 | 0.2580 | No |
| 30 | RPS6KA5 | RPS6KA5 Entrez,  Source | ribosomal protein S6 kinase, 90kDa, polypeptide 5 | 2610 | 0.080 | 0.2595 | No |
| 31 | MAP4K1 | MAP4K1 Entrez,  Source | mitogen-activated protein kinase kinase kinase kinase 1 | 2849 | 0.074 | 0.2466 | No |
| 32 | EPHA3 | EPHA3 Entrez,  Source | EPH receptor A3 | 2870 | 0.074 | 0.2504 | No |
| 33 | MKNK1 | MKNK1 Entrez,  Source | MAP kinase interacting serine/threonine kinase 1 | 2907 | 0.073 | 0.2529 | No |
| 34 | YES1 | YES1 Entrez,  Source | v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 | 3036 | 0.070 | 0.2481 | No |
| 35 | MINK1 | MINK1 Entrez,  Source | misshapen-like kinase 1 (zebrafish) | 3080 | 0.069 | 0.2499 | No |
| 36 | KDR | KDR Entrez,  Source | kinase insert domain receptor (a type III receptor tyrosine kinase) | 3146 | 0.068 | 0.2498 | No |
| 37 | FLT3 | FLT3 Entrez,  Source | fms-related tyrosine kinase 3 | 3403 | 0.063 | 0.2347 | No |
| 38 | BLK | BLK Entrez,  Source | B lymphoid tyrosine kinase | 3419 | 0.062 | 0.2381 | No |
| 39 | CSF1R | CSF1R Entrez,  Source | colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog | 3454 | 0.062 | 0.2399 | No |
| 40 | MYO3A | MYO3A Entrez,  Source | myosin IIIA | 3735 | 0.057 | 0.2226 | No |
| 41 | BRAF | BRAF Entrez,  Source | v-raf murine sarcoma viral oncogene homolog B1 | 3772 | 0.056 | 0.2239 | No |
| 42 | PRKD2 | PRKD2 Entrez,  Source | protein kinase D2 | 3900 | 0.054 | 0.2181 | No |
| 43 | EPHB1 | EPHB1 Entrez,  Source | EPH receptor B1 | 4000 | 0.052 | 0.2143 | No |
| 44 | MUSK | MUSK Entrez,  Source | muscle, skeletal, receptor tyrosine kinase | 4139 | 0.050 | 0.2074 | No |
| 45 | FGR | FGR Entrez,  Source | Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog | 4193 | 0.049 | 0.2069 | No |
| 46 | CDKL5 | CDKL5 Entrez,  Source | cyclin-dependent kinase-like 5 | 4345 | 0.047 | 0.1987 | No |
| 47 | AURKC | AURKC Entrez,  Source | aurora kinase C | 4413 | 0.046 | 0.1969 | No |
| 48 | LIMK1 | LIMK1 Entrez,  Source | LIM domain kinase 1 | 4468 | 0.045 | 0.1960 | No |
| 49 | CDKL2 | CDKL2 Entrez,  Source | cyclin-dependent kinase-like 2 (CDC2-related kinase) | 4548 | 0.044 | 0.1932 | No |
| 50 | EPHA2 | EPHA2 Entrez,  Source | EPH receptor A2 | 4880 | 0.039 | 0.1707 | No |
| 51 | FLT1 | FLT1 Entrez,  Source | fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor) | 4882 | 0.039 | 0.1734 | No |
| 52 | FLT4 | FLT4 Entrez,  Source | fms-related tyrosine kinase 4 | 4898 | 0.039 | 0.1751 | No |
| 53 | MAK | MAK Entrez,  Source | male germ cell-associated kinase | 5132 | 0.035 | 0.1598 | No |
| 54 | TNNI3K | TNNI3K Entrez,  Source | TNNI3 interacting kinase | 5274 | 0.033 | 0.1514 | No |
| 55 | MAPK11 | MAPK11 Entrez,  Source | mitogen-activated protein kinase 11 | 5392 | 0.032 | 0.1448 | No |
| 56 | EPHA5 | EPHA5 Entrez,  Source | EPH receptor A5 | 5475 | 0.031 | 0.1407 | No |
| 57 | CDK13 | 6062 | 0.023 | 0.0975 | No | ||
| 58 | NTRK1 | NTRK1 Entrez,  Source | neurotrophic tyrosine kinase, receptor, type 1 | 6097 | 0.022 | 0.0965 | No |
| 59 | FES | FES Entrez,  Source | feline sarcoma oncogene | 6126 | 0.022 | 0.0959 | No |
| 60 | IRAK1 | IRAK1 Entrez,  Source | interleukin-1 receptor-associated kinase 1 | 6179 | 0.021 | 0.0934 | No |
| 61 | CSNK1G2 | CSNK1G2 Entrez,  Source | casein kinase 1, gamma 2 | 6328 | 0.018 | 0.0834 | No |
| 62 | RET | RET Entrez,  Source | ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease) | 6471 | 0.016 | 0.0737 | No |
| 63 | MAPK14 | MAPK14 Entrez,  Source | mitogen-activated protein kinase 14 | 6492 | 0.016 | 0.0734 | No |
| 64 | MAPK8 | MAPK8 Entrez,  Source | mitogen-activated protein kinase 8 | 6829 | 0.011 | 0.0484 | No |
| 65 | MAP4K2 | MAP4K2 Entrez,  Source | mitogen-activated protein kinase kinase kinase kinase 2 | 6894 | 0.010 | 0.0442 | No |
| 66 | CLK4 | CLK4 Entrez,  Source | CDC-like kinase 4 | 6935 | 0.010 | 0.0419 | No |
| 67 | TEK | TEK Entrez,  Source | TEK tyrosine kinase, endothelial (venous malformations, multiple cutaneous and mucosal) | 7035 | 0.008 | 0.0349 | No |
| 68 | TGFBR2 | TGFBR2 Entrez,  Source | transforming growth factor, beta receptor II (70/80kDa) | 7103 | 0.007 | 0.0302 | No |
| 69 | ITK | ITK Entrez,  Source | IL2-inducible T-cell kinase | 7220 | 0.004 | 0.0216 | No |
| 70 | CDK19 | 7263 | 0.004 | 0.0187 | No | ||
| 71 | CDK5 | CDK5 Entrez,  Source | cyclin-dependent kinase 5 | 7432 | 0.001 | 0.0059 | No |
| 72 | PDGFRB | PDGFRB Entrez,  Source | platelet-derived growth factor receptor, beta polypeptide | 7824 | -0.006 | -0.0236 | No |
| 73 | MAPK9 | MAPK9 Entrez,  Source | mitogen-activated protein kinase 9 | 7830 | -0.006 | -0.0236 | No |
| 74 | MKNK2 | MKNK2 Entrez,  Source | MAP kinase interacting serine/threonine kinase 2 | 7841 | -0.006 | -0.0239 | No |
| 75 | RAF1 | RAF1 Entrez,  Source | v-raf-1 murine leukemia viral oncogene homolog 1 | 8015 | -0.009 | -0.0365 | No |
| 76 | MELK | MELK Entrez,  Source | maternal embryonic leucine zipper kinase | 8047 | -0.010 | -0.0381 | No |
| 77 | TAOK2 | TAOK2 Entrez,  Source | TAO kinase 2 | 8059 | -0.010 | -0.0383 | No |
| 78 | KIT | KIT Entrez,  Source | v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog | 8134 | -0.012 | -0.0431 | No |
| 79 | LTK | LTK Entrez,  Source | leukocyte tyrosine kinase | 8158 | -0.012 | -0.0440 | No |
| 80 | MAP2K5 | MAP2K5 Entrez,  Source | mitogen-activated protein kinase kinase 5 | 8199 | -0.013 | -0.0461 | No |
| 81 | CDKL3 | CDKL3 Entrez,  Source | cyclin-dependent kinase-like 3 | 8249 | -0.014 | -0.0488 | No |
| 82 | CDK16 | 8353 | -0.016 | -0.0555 | No | ||
| 83 | CDK3 | CDK3 Entrez,  Source | cyclin-dependent kinase 3 | 8440 | -0.018 | -0.0608 | No |
| 84 | NTRK3 | NTRK3 Entrez,  Source | neurotrophic tyrosine kinase, receptor, type 3 | 8500 | -0.019 | -0.0639 | No |
| 85 | CSNK1G1 | CSNK1G1 Entrez,  Source | casein kinase 1, gamma 1 | 8732 | -0.025 | -0.0798 | No |
| 86 | CDKL1 | CDKL1 Entrez,  Source | cyclin-dependent kinase-like 1 (CDC2-related kinase) | 8993 | -0.031 | -0.0975 | No |
| 87 | NEK4 | NEK4 Entrez,  Source | NIMA (never in mitosis gene a)-related kinase 4 | 9362 | -0.039 | -0.1229 | No |
| 88 | CDK2 | CDK2 Entrez,  Source | cyclin-dependent kinase 2 | 9409 | -0.040 | -0.1235 | No |
| 89 | HIPK3 | HIPK3 Entrez,  Source | homeodomain interacting protein kinase 3 | 9770 | -0.050 | -0.1475 | No |
| 90 | MAP2K7 | MAP2K7 Entrez,  Source | mitogen-activated protein kinase kinase 7 | 9831 | -0.052 | -0.1483 | No |
| 91 | MAP4K4 | MAP4K4 Entrez,  Source | mitogen-activated protein kinase kinase kinase kinase 4 | 9922 | -0.055 | -0.1513 | No |
| 92 | TTK | TTK Entrez,  Source | TTK protein kinase | 9930 | -0.055 | -0.1478 | No |
| 93 | HCK | HCK Entrez,  Source | hemopoietic cell kinase | 9981 | -0.056 | -0.1476 | No |
| 94 | LATS1 | LATS1 Entrez,  Source | LATS, large tumor suppressor, homolog 1 (Drosophila) | 10025 | -0.057 | -0.1467 | No |
| 95 | CHEK2 | CHEK2 Entrez,  Source | CHK2 checkpoint homolog (S. pombe) | 10102 | -0.059 | -0.1483 | No |
| 96 | HIPK2 | HIPK2 Entrez,  Source | homeodomain interacting protein kinase 2 | 10151 | -0.061 | -0.1475 | No |
| 97 | DDR2 | DDR2 Entrez,  Source | discoidin domain receptor family, member 2 | 10235 | -0.064 | -0.1493 | No |
| 98 | CIT | CIT Entrez,  Source | citron (rho-interacting, serine/threonine kinase 21) | 10420 | -0.070 | -0.1583 | No |
| 99 | JAK1 | JAK1 Entrez,  Source | Janus kinase 1 (a protein tyrosine kinase) | 10585 | -0.076 | -0.1654 | No |
| 100 | RPS6KB1 | RPS6KB1 Entrez,  Source | ribosomal protein S6 kinase, 70kDa, polypeptide 1 | 10717 | -0.081 | -0.1696 | No |
| 101 | CAMKK2 | CAMKK2 Entrez,  Source | calcium/calmodulin-dependent protein kinase kinase 2, beta | 10729 | -0.081 | -0.1645 | No |
| 102 | SRC | SRC Entrez,  Source | v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | 10776 | -0.083 | -0.1620 | No |
| 103 | CDK4 | CDK4 Entrez,  Source | cyclin-dependent kinase 4 | 10871 | -0.087 | -0.1629 | No |
| 104 | NLK | NLK Entrez,  Source | nemo-like kinase | 10979 | -0.093 | -0.1644 | No |
| 105 | ABL2 | ABL2 Entrez,  Source | v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene) | 11090 | -0.098 | -0.1658 | No |
| 106 | CDK7 | CDK7 Entrez,  Source | cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase) | 11160 | -0.101 | -0.1638 | No |
| 107 | PRKACB | PRKACB Entrez,  Source | protein kinase, cAMP-dependent, catalytic, beta | 11179 | -0.102 | -0.1578 | No |
| 108 | STK10 | STK10 Entrez,  Source | serine/threonine kinase 10 | 11218 | -0.103 | -0.1532 | No |
| 109 | FER | FER Entrez,  Source | fer (fps/fes related) tyrosine kinase (phosphoprotein NCP94) | 11371 | -0.111 | -0.1568 | No |
| 110 | RIPK1 | RIPK1 Entrez,  Source | receptor (TNFRSF)-interacting serine-threonine kinase 1 | 11427 | -0.113 | -0.1528 | No |
| 111 | JAK2 | JAK2 Entrez,  Source | Janus kinase 2 (a protein tyrosine kinase) | 11530 | -0.119 | -0.1520 | No |
| 112 | CDK9 | CDK9 Entrez,  Source | cyclin-dependent kinase 9 (CDC2-related kinase) | 11631 | -0.125 | -0.1506 | No |
| 113 | SLK | SLK Entrez,  Source | STE20-like kinase (yeast) | 11672 | -0.128 | -0.1444 | No |
| 114 | MAP4K5 | MAP4K5 Entrez,  Source | mitogen-activated protein kinase kinase kinase kinase 5 | 11705 | -0.130 | -0.1375 | No |
| 115 | FYN | FYN Entrez,  Source | FYN oncogene related to SRC, FGR, YES | 11767 | -0.133 | -0.1325 | No |
| 116 | HIPK1 | HIPK1 Entrez,  Source | homeodomain interacting protein kinase 1 | 11798 | -0.135 | -0.1250 | No |
| 117 | MAP2K4 | MAP2K4 Entrez,  Source | mitogen-activated protein kinase kinase 4 | 11811 | -0.136 | -0.1160 | No |
| 118 | ROCK2 | ROCK2 Entrez,  Source | Rho-associated, coiled-coil containing protein kinase 2 | 12033 | -0.152 | -0.1220 | No |
| 119 | PDGFRA | PDGFRA Entrez,  Source | platelet-derived growth factor receptor, alpha polypeptide | 12211 | -0.168 | -0.1234 | No |
| 120 | MAP4K3 | MAP4K3 Entrez,  Source | mitogen-activated protein kinase kinase kinase kinase 3 | 12403 | -0.189 | -0.1243 | No |
| 121 | ABL1 | ABL1 Entrez,  Source | v-abl Abelson murine leukemia viral oncogene homolog 1 | 12463 | -0.197 | -0.1145 | No |
| 122 | CSNK1G3 | CSNK1G3 Entrez,  Source | casein kinase 1, gamma 3 | 12464 | -0.197 | -0.1002 | No |
| 123 | RIOK2 | RIOK2 Entrez,  Source | RIO kinase 2 (yeast) | 12467 | -0.198 | -0.0861 | No |
| 124 | ZAK | ZAK Entrez,  Source | - | 12544 | -0.209 | -0.0767 | No |
| 125 | CDK17 | 12578 | -0.213 | -0.0638 | No | ||
| 126 | MAP3K7 | MAP3K7 Entrez,  Source | mitogen-activated protein kinase kinase kinase 7 | 12613 | -0.221 | -0.0504 | No |
| 127 | CDK8 | CDK8 Entrez,  Source | cyclin-dependent kinase 8 | 12650 | -0.226 | -0.0369 | No |
| 128 | AXL | AXL Entrez,  Source | AXL receptor tyrosine kinase | 12789 | -0.257 | -0.0288 | No |
| 129 | CHUK | CHUK Entrez,  Source | conserved helix-loop-helix ubiquitous kinase | 12978 | -0.325 | -0.0197 | No |
| 130 | FGFR1 | FGFR1 Entrez,  Source | fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome) | 13121 | -0.486 | 0.0047 | No |

