DatasetNSCLC_collapsed_to_symbols.NSCLC.cls
#SEN_versus_RES.NSCLC.cls
#SEN_versus_RES_repos
PhenotypeNSCLC.cls#SEN_versus_RES_repos
Upregulated in class0
GeneSetSORAFENIB_KINOME SCAN
Enrichment Score (ES)-0.26226756
Normalized Enrichment Score (NES)-0.8390865
Nominal p-value0.71497583
FDR q-value0.9694289
FWER p-Value1.0
Table: GSEA Results Summary



Fig 1: Enrichment plot: SORAFENIB_KINOME SCAN   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEGENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1DDR1DDR1
Entrez,  Source
discoidin domain receptor family, member 12120.4040.1038No
2FRKFRK
Entrez,  Source
fyn-related kinase2960.3430.1994No
3EPHB6EPHB6
Entrez,  Source
EPH receptor B67010.2150.2326No
4TIE1TIE1
Entrez,  Source
tyrosine kinase with immunoglobulin-like and EGF-like domains 123280.0880.1350No
5MKNK1MKNK1
Entrez,  Source
MAP kinase interacting serine/threonine kinase 129070.0730.1126No
6KDRKDR
Entrez,  Source
kinase insert domain receptor (a type III receptor tyrosine kinase)31460.0680.1146No
7FLT3FLT3
Entrez,  Source
fms-related tyrosine kinase 334030.0630.1137No
8CSF1RCSF1R
Entrez,  Source
colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog34540.0620.1283No
9BRAFBRAF
Entrez,  Source
v-raf murine sarcoma viral oncogene homolog B137720.0560.1209No
10MUSKMUSK
Entrez,  Source
muscle, skeletal, receptor tyrosine kinase41390.0500.1079No
11AURKCAURKC
Entrez,  Source
aurora kinase C44130.0460.1008No
12CDKL2CDKL2
Entrez,  Source
cyclin-dependent kinase-like 2 (CDC2-related kinase)45480.0440.1037No
13FLT1FLT1
Entrez,  Source
fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)48820.0390.0899No
14FLT4FLT4
Entrez,  Source
fms-related tyrosine kinase 448980.0390.1004No
15TNNI3KTNNI3K
Entrez,  Source
TNNI3 interacting kinase52740.0330.0818No
16MAPK11MAPK11
Entrez,  Source
mitogen-activated protein kinase 1153920.0320.0824No
17RETRET
Entrez,  Source
ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease)64710.0160.0053No
18MAPK14MAPK14
Entrez,  Source
mitogen-activated protein kinase 1464920.0160.0085No
19CDK1972630.004-0.0490No
20PDGFRBPDGFRB
Entrez,  Source
platelet-derived growth factor receptor, beta polypeptide7824-0.006-0.0898No
21MKNK2MKNK2
Entrez,  Source
MAP kinase interacting serine/threonine kinase 27841-0.006-0.0891No
22RAF1RAF1
Entrez,  Source
v-raf-1 murine leukemia viral oncogene homolog 18015-0.009-0.0996No
23TAOK2TAOK2
Entrez,  Source
TAO kinase 28059-0.010-0.0999No
24KITKIT
Entrez,  Source
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog8134-0.012-0.1020No
25MAP2K5MAP2K5
Entrez,  Source
mitogen-activated protein kinase kinase 58199-0.013-0.1030No
26CDKL3CDKL3
Entrez,  Source
cyclin-dependent kinase-like 38249-0.014-0.1025No
27NTRK3NTRK3
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 38500-0.019-0.1158No
28AURKBAURKB
Entrez,  Source
aurora kinase B8856-0.027-0.1346No
29HIPK3HIPK3
Entrez,  Source
homeodomain interacting protein kinase 39770-0.050-0.1893No
30DDR2DDR2
Entrez,  Source
discoidin domain receptor family, member 210235-0.064-0.2057No
31NLKNLK
Entrez,  Source
nemo-like kinase10979-0.093-0.2348Yes
32CDK7CDK7
Entrez,  Source
cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase)11160-0.101-0.2185Yes
33STK10STK10
Entrez,  Source
serine/threonine kinase 1011218-0.103-0.1921Yes
34SLKSLK
Entrez,  Source
STE20-like kinase (yeast)11672-0.128-0.1887Yes
35PDGFRAPDGFRA
Entrez,  Source
platelet-derived growth factor receptor, alpha polypeptide12211-0.168-0.1797Yes
36ABL1ABL1
Entrez,  Source
v-abl Abelson murine leukemia viral oncogene homolog 112463-0.197-0.1403Yes
37ZAKZAK
Entrez,  Source
-12544-0.209-0.0842Yes
38MAP3K7MAP3K7
Entrez,  Source
mitogen-activated protein kinase kinase kinase 712613-0.221-0.0238Yes
39CDK8CDK8
Entrez,  Source
cyclin-dependent kinase 812650-0.2260.0405Yes
Table: GSEA details [plain text format]



Fig 2: SORAFENIB_KINOME SCAN   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: SORAFENIB_KINOME SCAN: Random ES distribution   
Gene set null distribution of ES for SORAFENIB_KINOME SCAN