DatasetNSCLC_collapsed_to_symbols.NSCLC.cls
#SEN_versus_RES.NSCLC.cls
#SEN_versus_RES_repos
PhenotypeNSCLC.cls#SEN_versus_RES_repos
Upregulated in class1
GeneSetAZD7762_LINCS
Enrichment Score (ES)0.31841034
Normalized Enrichment Score (NES)1.2647921
Nominal p-value0.055469953
FDR q-value0.6377778
FWER p-Value1.0
Table: GSEA Results Summary



Fig 1: Enrichment plot: AZD7762_LINCS   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEGENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1MST1RMST1R
Entrez,  Source
macrophage stimulating 1 receptor (c-met-related tyrosine kinase)540.6360.0227Yes
2DAPK1DAPK1
Entrez,  Source
death-associated protein kinase 1880.5570.0436Yes
3EPHA1EPHA1
Entrez,  Source
EPH receptor A1940.5450.0662Yes
4RIPK4RIPK4
Entrez,  Source
receptor-interacting serine-threonine kinase 4950.5440.0891Yes
5ERBB2ERBB2
Entrez,  Source
v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)1000.5370.1115Yes
6PTK6PTK6
Entrez,  Source
PTK6 protein tyrosine kinase 61410.4790.1286Yes
7PAK6PAK6
Entrez,  Source
p21(CDKN1A)-activated kinase 61580.4590.1467Yes
8FGFR2FGFR2
Entrez,  Source
ffer syndrome, Jackson-Weiss syndrome)2100.4060.1599Yes
9DDR1DDR1
Entrez,  Source
discoidin domain receptor family, member 12120.4040.1768Yes
10FRKFRK
Entrez,  Source
fyn-related kinase2960.3430.1849Yes
11PRKCDPRKCD
Entrez,  Source
protein kinase C, delta3060.3370.1984Yes
12MST43180.3310.2115Yes
13PRKCHPRKCH
Entrez,  Source
protein kinase C, eta3560.3090.2216Yes
14STK39STK39
Entrez,  Source
serine threonine kinase 39 (STE20/SPS1 homolog, yeast)3840.2990.2322Yes
15SYKSYK
Entrez,  Source
spleen tyrosine kinase4710.2680.2368Yes
16METMET
Entrez,  Source
met proto-oncogene (hepatocyte growth factor receptor)4990.2590.2457Yes
17ROS1ROS1
Entrez,  Source
v-ros UR2 sarcoma virus oncogene homolog 1 (avian)5050.2580.2561Yes
18IKBKBIKBKB
Entrez,  Source
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta5530.2450.2628Yes
19RPS6KA2RPS6KA2
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 25900.2370.2700Yes
20MAP3K13MAP3K13
Entrez,  Source
mitogen-activated protein kinase kinase kinase 136240.2300.2772Yes
21EGFREGFR
Entrez,  Source
epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)6250.2300.2869Yes
22PAK1PAK1
Entrez,  Source
p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast)6740.2190.2924Yes
23EPHA4EPHA4
Entrez,  Source
EPH receptor A47980.1970.2912Yes
24EPHB2EPHB2
Entrez,  Source
EPH receptor B28680.1850.2937Yes
25TAOK3TAOK3
Entrez,  Source
TAO kinase 39710.1700.2930Yes
26TXKTXK
Entrez,  Source
TXK tyrosine kinase10450.1600.2941Yes
27TNIKTNIK
Entrez,  Source
TRAF2 and NCK interacting kinase11970.1450.2886Yes
28LCKLCK
Entrez,  Source
lymphocyte-specific protein tyrosine kinase13100.1360.2857Yes
29GAKGAK
Entrez,  Source
cyclin G associated kinase13400.1330.2891Yes
30TNK1TNK1
Entrez,  Source
tyrosine kinase, non-receptor, 113600.1310.2931Yes
31CAMK1DCAMK1D
Entrez,  Source
calcium/calmodulin-dependent protein kinase ID13870.1290.2966Yes
32EPHA7EPHA7
Entrez,  Source
EPH receptor A714120.1280.3001Yes
33SLC12A7SLC12A7
Entrez,  Source
solute carrier family 12 (potassium/chloride transporters), member 715430.1200.2952Yes
34STK3STK3
Entrez,  Source
serine/threonine kinase 3 (STE20 homolog, yeast)15530.1200.2995Yes
35STK17BSTK17B
Entrez,  Source
serine/threonine kinase 17b (apoptosis-inducing)15540.1190.3045Yes
36RPS6KA1RPS6KA1
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 116860.1130.2992Yes
37MAP3K9MAP3K9
Entrez,  Source
mitogen-activated protein kinase kinase kinase 916990.1120.3030Yes
38NTRK2NTRK2
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 217040.1120.3074Yes
39CAMK2ACAMK2A
Entrez,  Source
calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha18010.1070.3045Yes
40ERBB4ERBB4
Entrez,  Source
v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)18130.1070.3082Yes
41DAPK2DAPK2
Entrez,  Source
death-associated protein kinase 218380.1050.3107Yes
42CSNK1DCSNK1D
Entrez,  Source
casein kinase 1, delta18510.1050.3142Yes
43TESK1TESK1
Entrez,  Source
testis-specific kinase 118550.1050.3184Yes
44RIOK3RIOK3
Entrez,  Source
RIO kinase 3 (yeast)19420.1010.3160No
45LYNLYN
Entrez,  Source
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog19740.1000.3178No
46PTK2BPTK2B
Entrez,  Source
PTK2B protein tyrosine kinase 2 beta20420.0980.3168No
47MARK1MARK1
Entrez,  Source
MAP/microtubule affinity-regulating kinase 121590.0930.3118No
48AAK1AAK1
Entrez,  Source
AP2 associated kinase 122120.0920.3116No
49ULK2ULK2
Entrez,  Source
unc-51-like kinase 2 (C. elegans)22440.0910.3131No
50MAP3K11MAP3K11
Entrez,  Source
mitogen-activated protein kinase kinase kinase 1122950.0890.3130No
51TIE1TIE1
Entrez,  Source
tyrosine kinase with immunoglobulin-like and EGF-like domains 123280.0880.3142No
52JAK3JAK3
Entrez,  Source
Janus kinase 3 (a protein tyrosine kinase, leukocyte)24440.0840.3089No
53MERTKMERTK
Entrez,  Source
c-mer proto-oncogene tyrosine kinase25220.0820.3064No
54TAOK1TAOK1
Entrez,  Source
TAO kinase 125520.0820.3076No
55RPS6KA5RPS6KA5
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 526100.0800.3066No
56MAP4K1MAP4K1
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 128490.0740.2914No
57EPHA3EPHA3
Entrez,  Source
EPH receptor A328700.0740.2929No
58STK38STK38
Entrez,  Source
serine/threonine kinase 3828780.0730.2955No
59MKNK1MKNK1
Entrez,  Source
MAP kinase interacting serine/threonine kinase 129070.0730.2964No
60TNK2TNK2
Entrez,  Source
tyrosine kinase, non-receptor, 230050.0700.2919No
61YES1YES1
Entrez,  Source
v-yes-1 Yamaguchi sarcoma viral oncogene homolog 130360.0700.2925No
62CSKCSK
Entrez,  Source
c-src tyrosine kinase30690.0690.2929No
63MINK1MINK1
Entrez,  Source
misshapen-like kinase 1 (zebrafish)30800.0690.2951No
64KDRKDR
Entrez,  Source
kinase insert domain receptor (a type III receptor tyrosine kinase)31460.0680.2929No
65FLT3FLT3
Entrez,  Source
fms-related tyrosine kinase 334030.0630.2758No
66BLKBLK
Entrez,  Source
B lymphoid tyrosine kinase34190.0620.2773No
67TSSK1B34450.0620.2779No
68CSF1RCSF1R
Entrez,  Source
colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog34540.0620.2799No
69CSNK1A1CSNK1A1
Entrez,  Source
casein kinase 1, alpha 136980.0580.2636No
70MYO3AMYO3A
Entrez,  Source
myosin IIIA37350.0570.2632No
71MARK2MARK2
Entrez,  Source
MAP/microtubule affinity-regulating kinase 238340.0550.2580No
72EPHB4EPHB4
Entrez,  Source
EPH receptor B438790.0540.2569No
73PRKD2PRKD2
Entrez,  Source
protein kinase D239000.0540.2576No
74EPHB1EPHB1
Entrez,  Source
EPH receptor B140000.0520.2522No
75PRKG2PRKG2
Entrez,  Source
protein kinase, cGMP-dependent, type II40210.0520.2528No
76ALKALK
Entrez,  Source
anaplastic lymphoma kinase (Ki-1)40730.0510.2510No
77FGRFGR
Entrez,  Source
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog41930.0490.2439No
78AURKCAURKC
Entrez,  Source
aurora kinase C44130.0460.2290No
79CAMK1GCAMK1G
Entrez,  Source
calcium/calmodulin-dependent protein kinase IG45030.0450.2240No
80RPS6KA6RPS6KA6
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 646850.0420.2118No
81FGFR4FGFR4
Entrez,  Source
fibroblast growth factor receptor 447150.0410.2113No
82PHKG2PHKG2
Entrez,  Source
phosphorylase kinase, gamma 2 (testis)47920.0400.2071No
83BMXBMX
Entrez,  Source
BMX non-receptor tyrosine kinase48260.0400.2062No
84EPHA2EPHA2
Entrez,  Source
EPH receptor A248800.0390.2038No
85FLT1FLT1
Entrez,  Source
fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)48820.0390.2054No
86FLT4FLT4
Entrez,  Source
fms-related tyrosine kinase 448980.0390.2059No
87GRK1GRK1
Entrez,  Source
G protein-coupled receptor kinase 149070.0390.2069No
88PRKG1PRKG1
Entrez,  Source
protein kinase, cGMP-dependent, type I49360.0380.2063No
89PAK4PAK4
Entrez,  Source
p21(CDKN1A)-activated kinase 450140.0370.2020No
90ULK1ULK1
Entrez,  Source
unc-51-like kinase 1 (C. elegans)51570.0350.1925No
91ACVR1ACVR1
Entrez,  Source
activin A receptor, type I52300.0340.1884No
92TNNI3KTNNI3K
Entrez,  Source
TNNI3 interacting kinase52740.0330.1864No
93TECTEC
Entrez,  Source
tec protein tyrosine kinase53790.0320.1798No
94MAST1MAST1
Entrez,  Source
microtubule associated serine/threonine kinase 154360.0320.1768No
95EPHA5EPHA5
Entrez,  Source
EPH receptor A554750.0310.1752No
96PDPK1PDPK1
Entrez,  Source
3-phosphoinositide dependent protein kinase-155490.0300.1708No
97STK24STK24
Entrez,  Source
serine/threonine kinase 24 (STE20 homolog, yeast)55870.0290.1692No
98BTKBTK
Entrez,  Source
Bruton agammaglobulinemia tyrosine kinase56280.0290.1673No
99SRPK3SRPK3
Entrez,  Source
SFRS protein kinase 358600.0260.1506No
100PAK7PAK7
Entrez,  Source
p21(CDKN1A)-activated kinase 758810.0250.1501No
101MAP3K3MAP3K3
Entrez,  Source
mitogen-activated protein kinase kinase kinase 359210.0250.1481No
102PRKXPRKX
Entrez,  Source
protein kinase, X-linked59930.0240.1436No
103NTRK1NTRK1
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 160970.0220.1366No
104FESFES
Entrez,  Source
feline sarcoma oncogene61260.0220.1354No
105IRAK1IRAK1
Entrez,  Source
interleukin-1 receptor-associated kinase 161790.0210.1322No
106PHKG1PHKG1
Entrez,  Source
phosphorylase kinase, gamma 1 (muscle)62450.0200.1281No
107CSNK1G2CSNK1G2
Entrez,  Source
casein kinase 1, gamma 263280.0180.1225No
108DCLK264620.0160.1129No
109RETRET
Entrez,  Source
ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease)64710.0160.1130No
110EIF2AK2EIF2AK2
Entrez,  Source
eukaryotic translation initiation factor 2-alpha kinase 264890.0160.1124No
111MAP3K10MAP3K10
Entrez,  Source
mitogen-activated protein kinase kinase kinase 1065490.0150.1085No
112PIP4K2B65940.0150.1057No
113BMPR1BBMPR1B
Entrez,  Source
bone morphogenetic protein receptor, type IB67770.0120.0921No
114PKN1PKN1
Entrez,  Source
protein kinase N167830.0120.0923No
115GRK4GRK4
Entrez,  Source
G protein-coupled receptor kinase 467880.0120.0924No
116MAP4K2MAP4K2
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 268940.0100.0848No
117STK32BSTK32B
Entrez,  Source
serine/threonine kinase 32B69190.0100.0833No
118CLK4CLK4
Entrez,  Source
CDC-like kinase 469350.0100.0826No
119BMP2KBMP2K
Entrez,  Source
BMP2 inducible kinase70290.0080.0757No
120TGFBR2TGFBR2
Entrez,  Source
transforming growth factor, beta receptor II (70/80kDa)71030.0070.0704No
121CLK2CLK2
Entrez,  Source
CDC-like kinase 271810.0050.0646No
122IKBKEIKBKE
Entrez,  Source
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon72160.0040.0622No
123ITKITK
Entrez,  Source
IL2-inducible T-cell kinase72200.0040.0622No
124ACVR2BACVR2B
Entrez,  Source
activin A receptor, type IIB73820.0020.0498No
125AKT1AKT1
Entrez,  Source
v-akt murine thymoma viral oncogene homolog 173870.0020.0496No
126PRKAA2PRKAA2
Entrez,  Source
protein kinase, AMP-activated, alpha 2 catalytic subunit74180.0010.0473No
127SIK274350.0010.0461No
128SNRKSNRK
Entrez,  Source
SNF related kinase7658-0.0030.0291No
129SIK37726-0.0040.0241No
130CSNK1ECSNK1E
Entrez,  Source
casein kinase 1, epsilon7742-0.0040.0231No
131MAP2K3MAP2K3
Entrez,  Source
mitogen-activated protein kinase kinase 37798-0.0050.0191No
132PDGFRBPDGFRB
Entrez,  Source
platelet-derived growth factor receptor, beta polypeptide7824-0.0060.0174No
133MKNK2MKNK2
Entrez,  Source
MAP kinase interacting serine/threonine kinase 27841-0.0060.0164No
134MAP2K1MAP2K1
Entrez,  Source
mitogen-activated protein kinase kinase 17939-0.0080.0093No
135MELKMELK
Entrez,  Source
maternal embryonic leucine zipper kinase8047-0.0100.0014No
136PRKACAPRKACA
Entrez,  Source
protein kinase, cAMP-dependent, catalytic, alpha8112-0.011-0.0030No
137KITKIT
Entrez,  Source
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog8134-0.012-0.0042No
138LTKLTK
Entrez,  Source
leukocyte tyrosine kinase8158-0.012-0.0054No
139RPS6KA4RPS6KA4
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 48181-0.013-0.0066No
140MAP2K5MAP2K5
Entrez,  Source
mitogen-activated protein kinase kinase 58199-0.013-0.0073No
141DYRK1BDYRK1B
Entrez,  Source
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B8200-0.013-0.0068No
142PRKCIPRKCI
Entrez,  Source
protein kinase C, iota8226-0.014-0.0081No
143MARK4MARK4
Entrez,  Source
MAP/microtubule affinity-regulating kinase 48259-0.014-0.0100No
144DMPKDMPK
Entrez,  Source
dystrophia myotonica-protein kinase8344-0.016-0.0158No
145PTK2PTK2
Entrez,  Source
PTK2 protein tyrosine kinase 28356-0.016-0.0160No
146NTRK3NTRK3
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 38500-0.019-0.0262No
147STK25STK25
Entrez,  Source
serine/threonine kinase 25 (STE20 homolog, yeast)8561-0.021-0.0299No
148CSNK1G1CSNK1G1
Entrez,  Source
casein kinase 1, gamma 18732-0.025-0.0420No
149ROCK1ROCK1
Entrez,  Source
Rho-associated, coiled-coil containing protein kinase 18741-0.025-0.0416No
150AURKBAURKB
Entrez,  Source
aurora kinase B8856-0.027-0.0492No
151ZAP70ZAP70
Entrez,  Source
zeta-chain (TCR) associated protein kinase 70kDa8954-0.030-0.0555No
152IRAK4IRAK4
Entrez,  Source
interleukin-1 receptor-associated kinase 48996-0.031-0.0574No
153STK11STK11
Entrez,  Source
serine/threonine kinase 119183-0.035-0.0702No
154MAPKAPK2MAPKAPK2
Entrez,  Source
mitogen-activated protein kinase-activated protein kinase 29187-0.035-0.0690No
155ACVR2AACVR2A
Entrez,  Source
activin A receptor, type IIA9293-0.038-0.0755No
156TYK2TYK2
Entrez,  Source
tyrosine kinase 29438-0.041-0.0849No
157PAK3PAK3
Entrez,  Source
p21 (CDKN1A)-activated kinase 39490-0.042-0.0871No
158CSNK2A2CSNK2A2
Entrez,  Source
casein kinase 2, alpha prime polypeptide9758-0.049-0.1056No
159HIPK3HIPK3
Entrez,  Source
homeodomain interacting protein kinase 39770-0.050-0.1043No
160PRKD1PRKD1
Entrez,  Source
protein kinase D19827-0.052-0.1065No
161DCLK19840-0.052-0.1052No
162MAP4K4MAP4K4
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 49922-0.055-0.1092No
163TTKTTK
Entrez,  Source
TTK protein kinase9930-0.055-0.1074No
164HCKHCK
Entrez,  Source
hemopoietic cell kinase9981-0.056-0.1089No
165STK17ASTK17A
Entrez,  Source
serine/threonine kinase 17a (apoptosis-inducing)10017-0.057-0.1092No
166LATS1LATS1
Entrez,  Source
LATS, large tumor suppressor, homolog 1 (Drosophila)10025-0.057-0.1073No
167CHEK2CHEK2
Entrez,  Source
CHK2 checkpoint homolog (S. pombe)10102-0.059-0.1107No
168HIPK2HIPK2
Entrez,  Source
homeodomain interacting protein kinase 210151-0.061-0.1118No
169DDR2DDR2
Entrez,  Source
discoidin domain receptor family, member 210235-0.064-0.1156No
170DYRK1ADYRK1A
Entrez,  Source
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A10303-0.066-0.1179No
171MARK3MARK3
Entrez,  Source
MAP/microtubule affinity-regulating kinase 310374-0.068-0.1205No
172CITCIT
Entrez,  Source
citron (rho-interacting, serine/threonine kinase 21)10420-0.070-0.1210No
173RPS6KA3RPS6KA3
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 310427-0.070-0.1185No
174OXSR1OXSR1
Entrez,  Source
oxidative-stress responsive 110514-0.073-0.1221No
175PLK4PLK4
Entrez,  Source
polo-like kinase 4 (Drosophila)10581-0.075-0.1240No
176JAK1JAK1
Entrez,  Source
Janus kinase 1 (a protein tyrosine kinase)10585-0.076-0.1210No
177RPS6KB1RPS6KB1
Entrez,  Source
ribosomal protein S6 kinase, 70kDa, polypeptide 110717-0.081-0.1277No
178CAMKK2CAMKK2
Entrez,  Source
calcium/calmodulin-dependent protein kinase kinase 2, beta10729-0.081-0.1251No
179TBK1TBK1
Entrez,  Source
TANK-binding kinase 110732-0.082-0.1219No
180BRSK2BRSK2
Entrez,  Source
BR serine/threonine kinase 210749-0.082-0.1196No
181SRCSRC
Entrez,  Source
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)10776-0.083-0.1181No
182PIP5K1APIP5K1A
Entrez,  Source
phosphatidylinositol-4-phosphate 5-kinase, type I, alpha10780-0.083-0.1149No
183CHEK1CHEK1
Entrez,  Source
CHK1 checkpoint homolog (S. pombe)10792-0.084-0.1122No
184PRKCEPRKCE
Entrez,  Source
protein kinase C, epsilon10801-0.084-0.1092No
185PRKAA1PRKAA1
Entrez,  Source
protein kinase, AMP-activated, alpha 1 catalytic subunit10906-0.089-0.1135No
186PRKCQPRKCQ
Entrez,  Source
protein kinase C, theta10961-0.092-0.1138No
187MAPKAPK5MAPKAPK5
Entrez,  Source
mitogen-activated protein kinase-activated protein kinase 510962-0.092-0.1099No
188NUAK1NUAK1
Entrez,  Source
NUAK family, SNF1-like kinase, 111032-0.095-0.1113No
189DAPK3DAPK3
Entrez,  Source
death-associated protein kinase 311066-0.096-0.1097No
190SRPK1SRPK1
Entrez,  Source
SFRS protein kinase 111068-0.096-0.1058No
191ABL2ABL2
Entrez,  Source
v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)11090-0.098-0.1033No
192CDK7CDK7
Entrez,  Source
cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase)11160-0.101-0.1044No
193PRKACBPRKACB
Entrez,  Source
protein kinase, cAMP-dependent, catalytic, beta11179-0.102-0.1014No
194STK10STK10
Entrez,  Source
serine/threonine kinase 1011218-0.103-0.1000No
195MYLKMYLK
Entrez,  Source
myosin, light chain kinase11255-0.105-0.0984No
196BMPR2BMPR2
Entrez,  Source
bone morphogenetic protein receptor, type II (serine/threonine kinase)11345-0.109-0.1006No
197FERFER
Entrez,  Source
fer (fps/fes related) tyrosine kinase (phosphoprotein NCP94)11371-0.111-0.0979No
198STK38LSTK38L
Entrez,  Source
serine/threonine kinase 38 like11441-0.114-0.0984No
199SRPK2SRPK2
Entrez,  Source
SFRS protein kinase 211496-0.117-0.0976No
200STK4STK4
Entrez,  Source
serine/threonine kinase 411518-0.118-0.0943No
201JAK2JAK2
Entrez,  Source
Janus kinase 2 (a protein tyrosine kinase)11530-0.119-0.0901No
202TYRO3TYRO3
Entrez,  Source
TYRO3 protein tyrosine kinase11601-0.123-0.0903No
203TLK2TLK2
Entrez,  Source
tousled-like kinase 211621-0.124-0.0866No
204SLKSLK
Entrez,  Source
STE20-like kinase (yeast)11672-0.128-0.0850No
205MAP4K5MAP4K5
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 511705-0.130-0.0821No
206FYNFYN
Entrez,  Source
FYN oncogene related to SRC, FGR, YES11767-0.133-0.0811No
207HIPK1HIPK1
Entrez,  Source
homeodomain interacting protein kinase 111798-0.135-0.0777No
208MAP2K4MAP2K4
Entrez,  Source
mitogen-activated protein kinase kinase 411811-0.136-0.0729No
209PRPF4BPRPF4B
Entrez,  Source
PRP4 pre-mRNA processing factor 4 homolog B (yeast)11856-0.139-0.0705No
210CSNK2A1CSNK2A1
Entrez,  Source
casein kinase 2, alpha 1 polypeptide11861-0.139-0.0649No
211MAP2K2MAP2K2
Entrez,  Source
mitogen-activated protein kinase kinase 211895-0.142-0.0615No
212MAP2K6MAP2K6
Entrez,  Source
mitogen-activated protein kinase kinase 611934-0.144-0.0583No
213ROCK2ROCK2
Entrez,  Source
Rho-associated, coiled-coil containing protein kinase 212033-0.152-0.0595No
214CAMK1CAMK1
Entrez,  Source
calcium/calmodulin-dependent protein kinase I12150-0.162-0.0616No
215MAP3K2MAP3K2
Entrez,  Source
mitogen-activated protein kinase kinase kinase 212210-0.168-0.0591No
216PDGFRAPDGFRA
Entrez,  Source
platelet-derived growth factor receptor, alpha polypeptide12211-0.168-0.0520No
217SIK112319-0.179-0.0527No
218MAP3K12MAP3K12
Entrez,  Source
mitogen-activated protein kinase kinase kinase 1212384-0.186-0.0498No
219MAP4K3MAP4K3
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 312403-0.189-0.0432No
220IRAK3IRAK3
Entrez,  Source
interleukin-1 receptor-associated kinase 312451-0.196-0.0386No
221ABL1ABL1
Entrez,  Source
v-abl Abelson murine leukemia viral oncogene homolog 112463-0.197-0.0311No
222CSNK1G3CSNK1G3
Entrez,  Source
casein kinase 1, gamma 312464-0.197-0.0228No
223TLK1TLK1
Entrez,  Source
tousled-like kinase 112558-0.210-0.0211No
224MAP3K7MAP3K7
Entrez,  Source
mitogen-activated protein kinase kinase kinase 712613-0.221-0.0160No
225AXLAXL
Entrez,  Source
AXL receptor tyrosine kinase12789-0.257-0.0186No
226CHUKCHUK
Entrez,  Source
conserved helix-loop-helix ubiquitous kinase12978-0.325-0.0194No
227PRKD3PRKD3
Entrez,  Source
protein kinase D313008-0.345-0.0071No
228FGFR1FGFR1
Entrez,  Source
fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome)13121-0.4860.0047No
Table: GSEA details [plain text format]



Fig 2: AZD7762_LINCS   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: AZD7762_LINCS: Random ES distribution   
Gene set null distribution of ES for AZD7762_LINCS