DatasetNSCLC_collapsed_to_symbols.NSCLC.cls
#SEN_versus_RES.NSCLC.cls
#SEN_versus_RES_repos
PhenotypeNSCLC.cls#SEN_versus_RES_repos
Upregulated in class0
GeneSetSUNITINIB_FDA
Enrichment Score (ES)-0.23445709
Normalized Enrichment Score (NES)-0.9570958
Nominal p-value0.56582636
FDR q-value0.8991053
FWER p-Value1.0
Table: GSEA Results Summary



Fig 1: Enrichment plot: SUNITINIB_FDA   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEGENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1DAPK1DAPK1
Entrez,  Source
death-associated protein kinase 1880.5570.0279No
2FGFR3FGFR3
Entrez,  Source
fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism)1530.4650.0520No
3FGFR2FGFR2
Entrez,  Source
ffer syndrome, Jackson-Weiss syndrome)2100.4060.0729No
4FRKFRK
Entrez,  Source
fyn-related kinase2960.3430.0877No
5MST43180.3310.1067No
6STK39STK39
Entrez,  Source
serine threonine kinase 39 (STE20/SPS1 homolog, yeast)3840.2990.1204No
7RPS6KA2RPS6KA2
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 25900.2370.1193No
8MAP3K13MAP3K13
Entrez,  Source
mitogen-activated protein kinase kinase kinase 136240.2300.1311No
9EGFREGFR
Entrez,  Source
epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)6250.2300.1455No
10CDK146590.2220.1567No
11EPHB6EPHB6
Entrez,  Source
EPH receptor B67010.2150.1670No
12TAOK3TAOK3
Entrez,  Source
TAO kinase 39710.1700.1569No
13TNIKTNIK
Entrez,  Source
TRAF2 and NCK interacting kinase11970.1450.1487No
14DYRK2DYRK2
Entrez,  Source
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 212300.1420.1551No
15LCKLCK
Entrez,  Source
lymphocyte-specific protein tyrosine kinase13100.1360.1575No
16GAKGAK
Entrez,  Source
cyclin G associated kinase13400.1330.1635No
17TNK1TNK1
Entrez,  Source
tyrosine kinase, non-receptor, 113600.1310.1702No
18CAMK1DCAMK1D
Entrez,  Source
calcium/calmodulin-dependent protein kinase ID13870.1290.1763No
19STK3STK3
Entrez,  Source
serine/threonine kinase 3 (STE20 homolog, yeast)15530.1200.1710No
20STK17BSTK17B
Entrez,  Source
serine/threonine kinase 17b (apoptosis-inducing)15540.1190.1785No
21INSRINSR
Entrez,  Source
insulin receptor16640.1140.1772No
22RPS6KA1RPS6KA1
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 116860.1130.1826No
23NTRK2NTRK2
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 217040.1120.1883No
24CAMK2ACAMK2A
Entrez,  Source
calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha18010.1070.1876No
25CAMK2GCAMK2G
Entrez,  Source
calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma18110.1070.1935No
26DAPK2DAPK2
Entrez,  Source
death-associated protein kinase 218380.1050.1981No
27CSNK1DCSNK1D
Entrez,  Source
casein kinase 1, delta18510.1050.2037No
28LYNLYN
Entrez,  Source
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog19740.1000.2005No
29PTK2BPTK2B
Entrez,  Source
PTK2B protein tyrosine kinase 2 beta20420.0980.2015No
30AAK1AAK1
Entrez,  Source
AP2 associated kinase 122120.0920.1942No
31ULK2ULK2
Entrez,  Source
unc-51-like kinase 2 (C. elegans)22440.0910.1975No
32MERTKMERTK
Entrez,  Source
c-mer proto-oncogene tyrosine kinase25220.0820.1813No
33TAOK1TAOK1
Entrez,  Source
TAO kinase 125520.0820.1842No
34RPS6KA5RPS6KA5
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 526100.0800.1848No
35MAP4K1MAP4K1
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 128490.0740.1711No
36STK38STK38
Entrez,  Source
serine/threonine kinase 3828780.0730.1736No
37YES1YES1
Entrez,  Source
v-yes-1 Yamaguchi sarcoma viral oncogene homolog 130360.0700.1658No
38MINK1MINK1
Entrez,  Source
misshapen-like kinase 1 (zebrafish)30800.0690.1668No
39KDRKDR
Entrez,  Source
kinase insert domain receptor (a type III receptor tyrosine kinase)31460.0680.1661No
40FLT3FLT3
Entrez,  Source
fms-related tyrosine kinase 334030.0630.1503No
41BLKBLK
Entrez,  Source
B lymphoid tyrosine kinase34190.0620.1530No
42CSF1RCSF1R
Entrez,  Source
colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog34540.0620.1542No
43CSNK1A1CSNK1A1
Entrez,  Source
casein kinase 1, alpha 136980.0580.1392No
44MARK2MARK2
Entrez,  Source
MAP/microtubule affinity-regulating kinase 238340.0550.1322No
45PRKD2PRKD2
Entrez,  Source
protein kinase D239000.0540.1306No
46EPHB1EPHB1
Entrez,  Source
EPH receptor B140000.0520.1262No
47ALKALK
Entrez,  Source
anaplastic lymphoma kinase (Ki-1)40730.0510.1239No
48MUSKMUSK
Entrez,  Source
muscle, skeletal, receptor tyrosine kinase41390.0500.1220No
49FGRFGR
Entrez,  Source
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog41930.0490.1210No
50AURKCAURKC
Entrez,  Source
aurora kinase C44130.0460.1071No
51CAMK1GCAMK1G
Entrez,  Source
calcium/calmodulin-dependent protein kinase IG45030.0450.1030No
52HUNKHUNK
Entrez,  Source
hormonally upregulated Neu-associated kinase46450.0430.0948No
53PHKG2PHKG2
Entrez,  Source
phosphorylase kinase, gamma 2 (testis)47920.0400.0861No
54FLT1FLT1
Entrez,  Source
fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)48820.0390.0817No
55FLT4FLT4
Entrez,  Source
fms-related tyrosine kinase 448980.0390.0830No
56GRK1GRK1
Entrez,  Source
G protein-coupled receptor kinase 149070.0390.0848No
57ULK1ULK1
Entrez,  Source
unc-51-like kinase 1 (C. elegans)51570.0350.0678No
58INSRRINSRR
Entrez,  Source
insulin receptor-related receptor53320.0330.0565No
59MAST1MAST1
Entrez,  Source
microtubule associated serine/threonine kinase 154360.0320.0506No
60STK24STK24
Entrez,  Source
serine/threonine kinase 24 (STE20 homolog, yeast)55870.0290.0409No
61STK16STK16
Entrez,  Source
serine/threonine kinase 1657780.0270.0280No
62SRPK3SRPK3
Entrez,  Source
SFRS protein kinase 358600.0260.0233No
63PAK7PAK7
Entrez,  Source
p21(CDKN1A)-activated kinase 758810.0250.0234No
64MAP3K3MAP3K3
Entrez,  Source
mitogen-activated protein kinase kinase kinase 359210.0250.0219No
65NTRK1NTRK1
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 160970.0220.0099No
66FESFES
Entrez,  Source
feline sarcoma oncogene61260.0220.0091No
67IRAK1IRAK1
Entrez,  Source
interleukin-1 receptor-associated kinase 161790.0210.0064No
68PHKG1PHKG1
Entrez,  Source
phosphorylase kinase, gamma 1 (muscle)62450.0200.0026No
69CSNK1G2CSNK1G2
Entrez,  Source
casein kinase 1, gamma 263280.018-0.0025No
70CAMK4CAMK4
Entrez,  Source
calcium/calmodulin-dependent protein kinase IV63930.017-0.0064No
71RETRET
Entrez,  Source
ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease)64710.016-0.0113No
72EIF2AK2EIF2AK2
Entrez,  Source
eukaryotic translation initiation factor 2-alpha kinase 264890.016-0.0116No
73PIP4K2B65940.015-0.0186No
74PKN1PKN1
Entrez,  Source
protein kinase N167830.012-0.0324No
75GRK4GRK4
Entrez,  Source
G protein-coupled receptor kinase 467880.012-0.0319No
76MAP4K2MAP4K2
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 268940.010-0.0394No
77CLK4CLK4
Entrez,  Source
CDC-like kinase 469350.010-0.0418No
78BMP2KBMP2K
Entrez,  Source
BMP2 inducible kinase70290.008-0.0485No
79CLK2CLK2
Entrez,  Source
CDC-like kinase 271810.005-0.0598No
80IKBKEIKBKE
Entrez,  Source
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon72160.004-0.0621No
81ITKITK
Entrez,  Source
IL2-inducible T-cell kinase72200.004-0.0621No
82PRKAA2PRKAA2
Entrez,  Source
protein kinase, AMP-activated, alpha 2 catalytic subunit74180.001-0.0771No
83SIK274350.001-0.0783No
84SNRKSNRK
Entrez,  Source
SNF related kinase7658-0.003-0.0952No
85CSNK1ECSNK1E
Entrez,  Source
casein kinase 1, epsilon7742-0.004-0.1013No
86PDGFRBPDGFRB
Entrez,  Source
platelet-derived growth factor receptor, beta polypeptide7824-0.006-0.1071No
87MAP2K1MAP2K1
Entrez,  Source
mitogen-activated protein kinase kinase 17939-0.008-0.1154No
88MELKMELK
Entrez,  Source
maternal embryonic leucine zipper kinase8047-0.010-0.1230No
89KITKIT
Entrez,  Source
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog8134-0.012-0.1289No
90RPS6KA4RPS6KA4
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 48181-0.013-0.1316No
91MAP2K5MAP2K5
Entrez,  Source
mitogen-activated protein kinase kinase 58199-0.013-0.1321No
92CDK168353-0.016-0.1429No
93PTK2PTK2
Entrez,  Source
PTK2 protein tyrosine kinase 28356-0.016-0.1420No
94NTRK3NTRK3
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 38500-0.019-0.1518No
95STK25STK25
Entrez,  Source
serine/threonine kinase 25 (STE20 homolog, yeast)8561-0.021-0.1551No
96CSNK1G1CSNK1G1
Entrez,  Source
casein kinase 1, gamma 18732-0.025-0.1666No
97ROCK1ROCK1
Entrez,  Source
Rho-associated, coiled-coil containing protein kinase 18741-0.025-0.1657No
98AURKBAURKB
Entrez,  Source
aurora kinase B8856-0.027-0.1727No
99IRAK4IRAK4
Entrez,  Source
interleukin-1 receptor-associated kinase 48996-0.031-0.1815No
100PHKA2PHKA2
Entrez,  Source
phosphorylase kinase, alpha 2 (liver)9057-0.032-0.1841No
101STK11STK11
Entrez,  Source
serine/threonine kinase 119183-0.035-0.1916No
102ERN1ERN1
Entrez,  Source
endoplasmic reticulum to nucleus signalling 19341-0.039-0.2012No
103TYK2TYK2
Entrez,  Source
tyrosine kinase 29438-0.041-0.2061No
104PAK3PAK3
Entrez,  Source
p21 (CDKN1A)-activated kinase 39490-0.042-0.2073No
105CSNK2A2CSNK2A2
Entrez,  Source
casein kinase 2, alpha prime polypeptide9758-0.049-0.2248No
106HIPK3HIPK3
Entrez,  Source
homeodomain interacting protein kinase 39770-0.050-0.2225No
107PRKD1PRKD1
Entrez,  Source
protein kinase D19827-0.052-0.2236No
108DCLK19840-0.052-0.2213No
109MAP4K4MAP4K4
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 49922-0.055-0.2241No
110TTKTTK
Entrez,  Source
TTK protein kinase9930-0.055-0.2213No
111HCKHCK
Entrez,  Source
hemopoietic cell kinase9981-0.056-0.2216No
112STK17ASTK17A
Entrez,  Source
serine/threonine kinase 17a (apoptosis-inducing)10017-0.057-0.2208No
113LATS1LATS1
Entrez,  Source
LATS, large tumor suppressor, homolog 1 (Drosophila)10025-0.057-0.2177No
114CHEK2CHEK2
Entrez,  Source
CHK2 checkpoint homolog (S. pombe)10102-0.059-0.2199No
115HIPK2HIPK2
Entrez,  Source
homeodomain interacting protein kinase 210151-0.061-0.2198No
116DYRK1ADYRK1A
Entrez,  Source
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A10303-0.066-0.2273No
117MARK3MARK3
Entrez,  Source
MAP/microtubule affinity-regulating kinase 310374-0.068-0.2284No
118RPS6KA3RPS6KA3
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 310427-0.070-0.2280No
119ICKICK
Entrez,  Source
intestinal cell (MAK-like) kinase10499-0.073-0.2289Yes
120OXSR1OXSR1
Entrez,  Source
oxidative-stress responsive 110514-0.073-0.2255Yes
121PLK4PLK4
Entrez,  Source
polo-like kinase 4 (Drosophila)10581-0.075-0.2258Yes
122JAK1JAK1
Entrez,  Source
Janus kinase 1 (a protein tyrosine kinase)10585-0.076-0.2214Yes
123RPS6KB1RPS6KB1
Entrez,  Source
ribosomal protein S6 kinase, 70kDa, polypeptide 110717-0.081-0.2264Yes
124TBK1TBK1
Entrez,  Source
TANK-binding kinase 110732-0.082-0.2224Yes
125CHEK1CHEK1
Entrez,  Source
CHK1 checkpoint homolog (S. pombe)10792-0.084-0.2217Yes
126PRKAA1PRKAA1
Entrez,  Source
protein kinase, AMP-activated, alpha 1 catalytic subunit10906-0.089-0.2249Yes
127NUAK1NUAK1
Entrez,  Source
NUAK family, SNF1-like kinase, 111032-0.095-0.2286Yes
128DAPK3DAPK3
Entrez,  Source
death-associated protein kinase 311066-0.096-0.2251Yes
129SRPK1SRPK1
Entrez,  Source
SFRS protein kinase 111068-0.096-0.2192Yes
130ABL2ABL2
Entrez,  Source
v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)11090-0.098-0.2147Yes
131CDK7CDK7
Entrez,  Source
cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase)11160-0.101-0.2138Yes
132STK10STK10
Entrez,  Source
serine/threonine kinase 1011218-0.103-0.2117Yes
133MYLKMYLK
Entrez,  Source
myosin, light chain kinase11255-0.105-0.2079Yes
134BMPR2BMPR2
Entrez,  Source
bone morphogenetic protein receptor, type II (serine/threonine kinase)11345-0.109-0.2080Yes
135RIPK1RIPK1
Entrez,  Source
receptor (TNFRSF)-interacting serine-threonine kinase 111427-0.113-0.2071Yes
136STK38LSTK38L
Entrez,  Source
serine/threonine kinase 38 like11441-0.114-0.2010Yes
137SRPK2SRPK2
Entrez,  Source
SFRS protein kinase 211496-0.117-0.1979Yes
138STK4STK4
Entrez,  Source
serine/threonine kinase 411518-0.118-0.1921Yes
139JAK2JAK2
Entrez,  Source
Janus kinase 2 (a protein tyrosine kinase)11530-0.119-0.1856Yes
140TYRO3TYRO3
Entrez,  Source
TYRO3 protein tyrosine kinase11601-0.123-0.1833Yes
141TLK2TLK2
Entrez,  Source
tousled-like kinase 211621-0.124-0.1770Yes
142SLKSLK
Entrez,  Source
STE20-like kinase (yeast)11672-0.128-0.1729Yes
143MAP4K5MAP4K5
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 511705-0.130-0.1673Yes
144FYNFYN
Entrez,  Source
FYN oncogene related to SRC, FGR, YES11767-0.133-0.1637Yes
145HIPK1HIPK1
Entrez,  Source
homeodomain interacting protein kinase 111798-0.135-0.1576Yes
146MAP2K4MAP2K4
Entrez,  Source
mitogen-activated protein kinase kinase 411811-0.136-0.1500Yes
147PRPF4BPRPF4B
Entrez,  Source
PRP4 pre-mRNA processing factor 4 homolog B (yeast)11856-0.139-0.1447Yes
148CSNK2A1CSNK2A1
Entrez,  Source
casein kinase 2, alpha 1 polypeptide11861-0.139-0.1363Yes
149MAP2K2MAP2K2
Entrez,  Source
mitogen-activated protein kinase kinase 211895-0.142-0.1301Yes
150ROCK2ROCK2
Entrez,  Source
Rho-associated, coiled-coil containing protein kinase 212033-0.152-0.1311Yes
151CAMK1CAMK1
Entrez,  Source
calcium/calmodulin-dependent protein kinase I12150-0.162-0.1299Yes
152MAP3K2MAP3K2
Entrez,  Source
mitogen-activated protein kinase kinase kinase 212210-0.168-0.1240Yes
153PDGFRAPDGFRA
Entrez,  Source
platelet-derived growth factor receptor, alpha polypeptide12211-0.168-0.1136Yes
154MAP3K12MAP3K12
Entrez,  Source
mitogen-activated protein kinase kinase kinase 1212384-0.186-0.1152Yes
155MAP4K3MAP4K3
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 312403-0.189-0.1048Yes
156IRAK3IRAK3
Entrez,  Source
interleukin-1 receptor-associated kinase 312451-0.196-0.0962Yes
157ABL1ABL1
Entrez,  Source
v-abl Abelson murine leukemia viral oncogene homolog 112463-0.197-0.0848Yes
158CSNK1G3CSNK1G3
Entrez,  Source
casein kinase 1, gamma 312464-0.197-0.0725Yes
159RIOK2RIOK2
Entrez,  Source
RIO kinase 2 (yeast)12467-0.198-0.0603Yes
160TLK1TLK1
Entrez,  Source
tousled-like kinase 112558-0.210-0.0542Yes
161MAP3K7MAP3K7
Entrez,  Source
mitogen-activated protein kinase kinase kinase 712613-0.221-0.0446Yes
162AXLAXL
Entrez,  Source
AXL receptor tyrosine kinase12789-0.257-0.0420Yes
163CHUKCHUK
Entrez,  Source
conserved helix-loop-helix ubiquitous kinase12978-0.325-0.0362Yes
164PRKD3PRKD3
Entrez,  Source
protein kinase D313008-0.345-0.0170Yes
165FGFR1FGFR1
Entrez,  Source
fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome)13121-0.4860.0047Yes
Table: GSEA details [plain text format]



Fig 2: SUNITINIB_FDA   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: SUNITINIB_FDA: Random ES distribution   
Gene set null distribution of ES for SUNITINIB_FDA