DatasetNSCLC_collapsed_to_symbols.NSCLC.cls
#SEN_versus_RES.NSCLC.cls
#SEN_versus_RES_repos
PhenotypeNSCLC.cls#SEN_versus_RES_repos
Upregulated in class1
GeneSetCABOZANTINIB_FDA
Enrichment Score (ES)0.4753255
Normalized Enrichment Score (NES)1.4702251
Nominal p-value0.03125
FDR q-value0.84571344
FWER p-Value0.998
Table: GSEA Results Summary



Fig 1: Enrichment plot: CABOZANTINIB_FDA   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEGENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1MST1RMST1R
Entrez,  Source
macrophage stimulating 1 receptor (c-met-related tyrosine kinase)540.6360.1132Yes
2PTK6PTK6
Entrez,  Source
PTK6 protein tyrosine kinase 61410.4790.1950Yes
3DDR1DDR1
Entrez,  Source
discoidin domain receptor family, member 12120.4040.2641Yes
4FRKFRK
Entrez,  Source
fyn-related kinase2960.3430.3211Yes
5METMET
Entrez,  Source
met proto-oncogene (hepatocyte growth factor receptor)4990.2590.3534Yes
6ROS1ROS1
Entrez,  Source
v-ros UR2 sarcoma virus oncogene homolog 1 (avian)5050.2580.4005Yes
7EPHA4EPHA4
Entrez,  Source
EPH receptor A47980.1970.4147Yes
8EPHB2EPHB2
Entrez,  Source
EPH receptor B28680.1850.4436Yes
9LCKLCK
Entrez,  Source
lymphocyte-specific protein tyrosine kinase13100.1360.4351Yes
10TNK1TNK1
Entrez,  Source
tyrosine kinase, non-receptor, 113600.1310.4556Yes
11EPHA7EPHA7
Entrez,  Source
EPH receptor A714120.1280.4753Yes
12NTRK2NTRK2
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 217040.1120.4738No
13PTK2BPTK2B
Entrez,  Source
PTK2B protein tyrosine kinase 2 beta20420.0980.4662No
14MERTKMERTK
Entrez,  Source
c-mer proto-oncogene tyrosine kinase25220.0820.4449No
15EPHA3EPHA3
Entrez,  Source
EPH receptor A328700.0740.4321No
16YES1YES1
Entrez,  Source
v-yes-1 Yamaguchi sarcoma viral oncogene homolog 130360.0700.4324No
17KDRKDR
Entrez,  Source
kinase insert domain receptor (a type III receptor tyrosine kinase)31460.0680.4366No
18FLT3FLT3
Entrez,  Source
fms-related tyrosine kinase 334030.0630.4286No
19BLKBLK
Entrez,  Source
B lymphoid tyrosine kinase34190.0620.4390No
20EPHB4EPHB4
Entrez,  Source
EPH receptor B438790.0540.4141No
21EPHB1EPHB1
Entrez,  Source
EPH receptor B140000.0520.4146No
22MUSKMUSK
Entrez,  Source
muscle, skeletal, receptor tyrosine kinase41390.0500.4133No
23FGRFGR
Entrez,  Source
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog41930.0490.4184No
24AURKCAURKC
Entrez,  Source
aurora kinase C44130.0460.4102No
25EPHA2EPHA2
Entrez,  Source
EPH receptor A248800.0390.3819No
26FLT1FLT1
Entrez,  Source
fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)48820.0390.3891No
27FLT4FLT4
Entrez,  Source
fms-related tyrosine kinase 448980.0390.3951No
28EPHA5EPHA5
Entrez,  Source
EPH receptor A554750.0310.3570No
29BTKBTK
Entrez,  Source
Bruton agammaglobulinemia tyrosine kinase56280.0290.3507No
30NTRK1NTRK1
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 160970.0220.3192No
31RETRET
Entrez,  Source
ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease)64710.0160.2938No
32TEKTEK
Entrez,  Source
TEK tyrosine kinase, endothelial (venous malformations, multiple cutaneous and mucosal)70350.0080.2524No
33MKNK2MKNK2
Entrez,  Source
MAP kinase interacting serine/threonine kinase 27841-0.0060.1923No
34KITKIT
Entrez,  Source
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog8134-0.0120.1722No
35NTRK3NTRK3
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 38500-0.0190.1480No
36AURKBAURKB
Entrez,  Source
aurora kinase B8856-0.0270.1261No
37HCKHCK
Entrez,  Source
hemopoietic cell kinase9981-0.0560.0509No
38DDR2DDR2
Entrez,  Source
discoidin domain receptor family, member 210235-0.0640.0433No
39SRCSRC
Entrez,  Source
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)10776-0.0830.0176No
40STK10STK10
Entrez,  Source
serine/threonine kinase 1011218-0.1030.0031No
41FERFER
Entrez,  Source
fer (fps/fes related) tyrosine kinase (phosphoprotein NCP94)11371-0.1110.0119No
42TYRO3TYRO3
Entrez,  Source
TYRO3 protein tyrosine kinase11601-0.1230.0172No
43FYNFYN
Entrez,  Source
FYN oncogene related to SRC, FGR, YES11767-0.1330.0292No
44PDGFRAPDGFRA
Entrez,  Source
platelet-derived growth factor receptor, alpha polypeptide12211-0.1680.0265No
45AXLAXL
Entrez,  Source
AXL receptor tyrosine kinase12789-0.2570.0299No
Table: GSEA details [plain text format]



Fig 2: CABOZANTINIB_FDA   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: CABOZANTINIB_FDA: Random ES distribution   
Gene set null distribution of ES for CABOZANTINIB_FDA