DatasetNSCLC_collapsed_to_symbols.NSCLC.cls
#SEN_versus_RES.NSCLC.cls
#SEN_versus_RES_repos
PhenotypeNSCLC.cls#SEN_versus_RES_repos
Upregulated in class0
GeneSetHG-5-113-01_LINCS
Enrichment Score (ES)-0.28979844
Normalized Enrichment Score (NES)-1.120787
Nominal p-value0.21882951
FDR q-value0.9147345
FWER p-Value1.0
Table: GSEA Results Summary



Fig 1: Enrichment plot: HG-5-113-01_LINCS   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEGENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1PRKCDPRKCD
Entrez,  Source
protein kinase C, delta3060.3370.0116No
2SYKSYK
Entrez,  Source
spleen tyrosine kinase4710.2680.0269No
3METMET
Entrez,  Source
met proto-oncogene (hepatocyte growth factor receptor)4990.2590.0517No
4ROS1ROS1
Entrez,  Source
v-ros UR2 sarcoma virus oncogene homolog 1 (avian)5050.2580.0781No
5RPS6KA2RPS6KA2
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 25900.2370.0963No
6TAOK3TAOK3
Entrez,  Source
TAO kinase 39710.1700.0849No
7LCKLCK
Entrez,  Source
lymphocyte-specific protein tyrosine kinase13100.1360.0732No
8GAKGAK
Entrez,  Source
cyclin G associated kinase13400.1330.0848No
9TNK1TNK1
Entrez,  Source
tyrosine kinase, non-receptor, 113600.1310.0970No
10EPHA7EPHA7
Entrez,  Source
EPH receptor A714120.1280.1064No
11STK3STK3
Entrez,  Source
serine/threonine kinase 3 (STE20 homolog, yeast)15530.1200.1081No
12INSRINSR
Entrez,  Source
insulin receptor16640.1140.1116No
13RPS6KA1RPS6KA1
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 116860.1130.1217No
14MAP3K9MAP3K9
Entrez,  Source
mitogen-activated protein kinase kinase kinase 916990.1120.1325No
15NTRK2NTRK2
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 217040.1120.1438No
16RIOK3RIOK3
Entrez,  Source
RIO kinase 3 (yeast)19420.1010.1362No
17PTK2BPTK2B
Entrez,  Source
PTK2B protein tyrosine kinase 2 beta20420.0980.1388No
18AAK1AAK1
Entrez,  Source
AP2 associated kinase 122120.0920.1354No
19ULK2ULK2
Entrez,  Source
unc-51-like kinase 2 (C. elegans)22440.0910.1425No
20MAP3K11MAP3K11
Entrez,  Source
mitogen-activated protein kinase kinase kinase 1122950.0890.1479No
21TIE1TIE1
Entrez,  Source
tyrosine kinase with immunoglobulin-like and EGF-like domains 123280.0880.1546No
22CLK3CLK3
Entrez,  Source
CDC-like kinase 323490.0870.1621No
23JAK3JAK3
Entrez,  Source
Janus kinase 3 (a protein tyrosine kinase, leukocyte)24440.0840.1637No
24MERTKMERTK
Entrez,  Source
c-mer proto-oncogene tyrosine kinase25220.0820.1664No
25TAOK1TAOK1
Entrez,  Source
TAO kinase 125520.0820.1727No
26MAP4K1MAP4K1
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 128490.0740.1577No
27TNK2TNK2
Entrez,  Source
tyrosine kinase, non-receptor, 230050.0700.1532No
28YES1YES1
Entrez,  Source
v-yes-1 Yamaguchi sarcoma viral oncogene homolog 130360.0700.1582No
29FLT3FLT3
Entrez,  Source
fms-related tyrosine kinase 334030.0630.1367No
30BLKBLK
Entrez,  Source
B lymphoid tyrosine kinase34190.0620.1420No
31ALKALK
Entrez,  Source
anaplastic lymphoma kinase (Ki-1)40730.0510.0974No
32MUSKMUSK
Entrez,  Source
muscle, skeletal, receptor tyrosine kinase41390.0500.0976No
33FGRFGR
Entrez,  Source
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog41930.0490.0987No
34AURKCAURKC
Entrez,  Source
aurora kinase C44130.0460.0867No
35BMXBMX
Entrez,  Source
BMX non-receptor tyrosine kinase48260.0400.0593No
36ULK1ULK1
Entrez,  Source
unc-51-like kinase 1 (C. elegans)51570.0350.0377No
37INSRRINSRR
Entrez,  Source
insulin receptor-related receptor53320.0330.0278No
38TECTEC
Entrez,  Source
tec protein tyrosine kinase53790.0320.0277No
39BTKBTK
Entrez,  Source
Bruton agammaglobulinemia tyrosine kinase56280.0290.0117No
40STK16STK16
Entrez,  Source
serine/threonine kinase 1657780.0270.0031No
41SRPK3SRPK3
Entrez,  Source
SFRS protein kinase 358600.026-0.0004No
42MAP3K3MAP3K3
Entrez,  Source
mitogen-activated protein kinase kinase kinase 359210.025-0.0025No
43NTRK1NTRK1
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 160970.022-0.0135No
44FESFES
Entrez,  Source
feline sarcoma oncogene61260.022-0.0135No
45CSNK1G2CSNK1G2
Entrez,  Source
casein kinase 1, gamma 263280.018-0.0269No
46AURKAAURKA
Entrez,  Source
aurora kinase A64270.017-0.0326No
47RETRET
Entrez,  Source
ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease)64710.016-0.0342No
48PIP4K2B65940.015-0.0420No
49PKN1PKN1
Entrez,  Source
protein kinase N167830.012-0.0552No
50MAPK8MAPK8
Entrez,  Source
mitogen-activated protein kinase 868290.011-0.0575No
51MAP4K2MAP4K2
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 268940.010-0.0613No
52CLK4CLK4
Entrez,  Source
CDC-like kinase 469350.010-0.0634No
53BMP2KBMP2K
Entrez,  Source
BMP2 inducible kinase70290.008-0.0697No
54TEKTEK
Entrez,  Source
TEK tyrosine kinase, endothelial (venous malformations, multiple cutaneous and mucosal)70350.008-0.0692No
55CLK2CLK2
Entrez,  Source
CDC-like kinase 271810.005-0.0798No
56ITKITK
Entrez,  Source
IL2-inducible T-cell kinase72200.004-0.0822No
57PRKAA2PRKAA2
Entrez,  Source
protein kinase, AMP-activated, alpha 2 catalytic subunit74180.001-0.0972No
58SIK274350.001-0.0983No
59MAP2K3MAP2K3
Entrez,  Source
mitogen-activated protein kinase kinase 37798-0.005-0.1255No
60PDGFRBPDGFRB
Entrez,  Source
platelet-derived growth factor receptor, beta polypeptide7824-0.006-0.1268No
61MAP2K1MAP2K1
Entrez,  Source
mitogen-activated protein kinase kinase 17939-0.008-0.1346No
62IGF1RIGF1R
Entrez,  Source
insulin-like growth factor 1 receptor7959-0.008-0.1352No
63KITKIT
Entrez,  Source
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog8134-0.012-0.1473No
64LTKLTK
Entrez,  Source
leukocyte tyrosine kinase8158-0.012-0.1478No
65RPS6KA4RPS6KA4
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 48181-0.013-0.1482No
66DYRK1BDYRK1B
Entrez,  Source
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B8200-0.013-0.1482No
67MARK4MARK4
Entrez,  Source
MAP/microtubule affinity-regulating kinase 48259-0.014-0.1511No
68DMPKDMPK
Entrez,  Source
dystrophia myotonica-protein kinase8344-0.016-0.1559No
69PTK2PTK2
Entrez,  Source
PTK2 protein tyrosine kinase 28356-0.016-0.1550No
70NTRK3NTRK3
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 38500-0.019-0.1639No
71PIK3CAPIK3CA
Entrez,  Source
phosphoinositide-3-kinase, catalytic, alpha polypeptide8749-0.025-0.1803No
72AURKBAURKB
Entrez,  Source
aurora kinase B8856-0.027-0.1856No
73TYK2TYK2
Entrez,  Source
tyrosine kinase 29438-0.041-0.2257No
74PAK3PAK3
Entrez,  Source
p21 (CDKN1A)-activated kinase 39490-0.042-0.2253No
75TTKTTK
Entrez,  Source
TTK protein kinase9930-0.055-0.2531No
76HCKHCK
Entrez,  Source
hemopoietic cell kinase9981-0.056-0.2511No
77MARK3MARK3
Entrez,  Source
MAP/microtubule affinity-regulating kinase 310374-0.068-0.2740No
78PLK4PLK4
Entrez,  Source
polo-like kinase 4 (Drosophila)10581-0.075-0.2820Yes
79JAK1JAK1
Entrez,  Source
Janus kinase 1 (a protein tyrosine kinase)10585-0.076-0.2743Yes
80SRCSRC
Entrez,  Source
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)10776-0.083-0.2802Yes
81PIP5K1APIP5K1A
Entrez,  Source
phosphatidylinositol-4-phosphate 5-kinase, type I, alpha10780-0.083-0.2718Yes
82PRKAA1PRKAA1
Entrez,  Source
protein kinase, AMP-activated, alpha 1 catalytic subunit10906-0.089-0.2721Yes
83NUAK1NUAK1
Entrez,  Source
NUAK family, SNF1-like kinase, 111032-0.095-0.2718Yes
84SRPK1SRPK1
Entrez,  Source
SFRS protein kinase 111068-0.096-0.2645Yes
85ABL2ABL2
Entrez,  Source
v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)11090-0.098-0.2559Yes
86CDK7CDK7
Entrez,  Source
cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase)11160-0.101-0.2508Yes
87PRKACBPRKACB
Entrez,  Source
protein kinase, cAMP-dependent, catalytic, beta11179-0.102-0.2415Yes
88STK10STK10
Entrez,  Source
serine/threonine kinase 1011218-0.103-0.2337Yes
89BMPR2BMPR2
Entrez,  Source
bone morphogenetic protein receptor, type II (serine/threonine kinase)11345-0.109-0.2320Yes
90FERFER
Entrez,  Source
fer (fps/fes related) tyrosine kinase (phosphoprotein NCP94)11371-0.111-0.2224Yes
91STK38LSTK38L
Entrez,  Source
serine/threonine kinase 38 like11441-0.114-0.2158Yes
92STK4STK4
Entrez,  Source
serine/threonine kinase 411518-0.118-0.2093Yes
93JAK2JAK2
Entrez,  Source
Janus kinase 2 (a protein tyrosine kinase)11530-0.119-0.1978Yes
94SLKSLK
Entrez,  Source
STE20-like kinase (yeast)11672-0.128-0.1954Yes
95MAP4K5MAP4K5
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 511705-0.130-0.1843Yes
96FYNFYN
Entrez,  Source
FYN oncogene related to SRC, FGR, YES11767-0.133-0.1751Yes
97CSNK2A1CSNK2A1
Entrez,  Source
casein kinase 2, alpha 1 polypeptide11861-0.139-0.1678Yes
98MAP2K2MAP2K2
Entrez,  Source
mitogen-activated protein kinase kinase 211895-0.142-0.1556Yes
99ROCK2ROCK2
Entrez,  Source
Rho-associated, coiled-coil containing protein kinase 212033-0.152-0.1502Yes
100PKN2PKN2
Entrez,  Source
protein kinase N212286-0.175-0.1513Yes
101SIK112319-0.179-0.1352Yes
102MAP3K12MAP3K12
Entrez,  Source
mitogen-activated protein kinase kinase kinase 1212384-0.186-0.1207Yes
103MAP4K3MAP4K3
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 312403-0.189-0.1024Yes
104IRAK3IRAK3
Entrez,  Source
interleukin-1 receptor-associated kinase 312451-0.196-0.0857Yes
105ABL1ABL1
Entrez,  Source
v-abl Abelson murine leukemia viral oncogene homolog 112463-0.197-0.0660Yes
106RIOK2RIOK2
Entrez,  Source
RIO kinase 2 (yeast)12467-0.198-0.0457Yes
107MAP3K7MAP3K7
Entrez,  Source
mitogen-activated protein kinase kinase kinase 712613-0.221-0.0339Yes
108AXLAXL
Entrez,  Source
AXL receptor tyrosine kinase12789-0.257-0.0205Yes
109FGFR1FGFR1
Entrez,  Source
fibroblast growth factor receptor 1 (fms-related tyrosine kinase 2, Pfeiffer syndrome)13121-0.4860.0047Yes
Table: GSEA details [plain text format]



Fig 2: HG-5-113-01_LINCS   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: HG-5-113-01_LINCS: Random ES distribution   
Gene set null distribution of ES for HG-5-113-01_LINCS