DatasetNSCLC_collapsed_to_symbols.NSCLC.cls
#SEN_versus_RES.NSCLC.cls
#SEN_versus_RES_repos
PhenotypeNSCLC.cls#SEN_versus_RES_repos
Upregulated in class0
GeneSetSU-14813_KINOME SCAN
Enrichment Score (ES)-0.20326723
Normalized Enrichment Score (NES)-0.8007042
Nominal p-value0.91292876
FDR q-value0.97768766
FWER p-Value1.0
Table: GSEA Results Summary



Fig 1: Enrichment plot: SU-14813_KINOME SCAN   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEGENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1DAPK1DAPK1
Entrez,  Source
death-associated protein kinase 1880.5570.0420Yes
2FGFR3FGFR3
Entrez,  Source
fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism)1530.4650.0779Yes
3FGFR2FGFR2
Entrez,  Source
ffer syndrome, Jackson-Weiss syndrome)2100.4060.1091Yes
4MST43180.3310.1299Yes
5STK39STK39
Entrez,  Source
serine threonine kinase 39 (STE20/SPS1 homolog, yeast)3840.2990.1511Yes
6RPS6KA2RPS6KA2
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 25900.2370.1562Yes
7MAP3K13MAP3K13
Entrez,  Source
mitogen-activated protein kinase kinase kinase 136240.2300.1738Yes
8TAOK3TAOK3
Entrez,  Source
TAO kinase 39710.1700.1622Yes
9TNIKTNIK
Entrez,  Source
TRAF2 and NCK interacting kinase11970.1450.1577Yes
10GAKGAK
Entrez,  Source
cyclin G associated kinase13400.1330.1585Yes
11CAMK1DCAMK1D
Entrez,  Source
calcium/calmodulin-dependent protein kinase ID13870.1290.1663Yes
12STK3STK3
Entrez,  Source
serine/threonine kinase 3 (STE20 homolog, yeast)15530.1200.1641Yes
13STK17BSTK17B
Entrez,  Source
serine/threonine kinase 17b (apoptosis-inducing)15540.1190.1745Yes
14RPS6KA1RPS6KA1
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 116860.1130.1744Yes
15NTRK2NTRK2
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 217040.1120.1829Yes
16CAMK2ACAMK2A
Entrez,  Source
calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha18010.1070.1849Yes
17DAPK2DAPK2
Entrez,  Source
death-associated protein kinase 218380.1050.1914Yes
18CSNK1DCSNK1D
Entrez,  Source
casein kinase 1, delta18510.1050.1997Yes
19LYNLYN
Entrez,  Source
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog19740.1000.1991Yes
20PTK2BPTK2B
Entrez,  Source
PTK2B protein tyrosine kinase 2 beta20420.0980.2025Yes
21AAK1AAK1
Entrez,  Source
AP2 associated kinase 122120.0920.1976Yes
22ULK2ULK2
Entrez,  Source
unc-51-like kinase 2 (C. elegans)22440.0910.2032Yes
23JAK3JAK3
Entrez,  Source
Janus kinase 3 (a protein tyrosine kinase, leukocyte)24440.0840.1953No
24MERTKMERTK
Entrez,  Source
c-mer proto-oncogene tyrosine kinase25220.0820.1967No
25RPS6KA5RPS6KA5
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 526100.0800.1970No
26MAP4K1MAP4K1
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 128490.0740.1853No
27STK38STK38
Entrez,  Source
serine/threonine kinase 3828780.0730.1896No
28YES1YES1
Entrez,  Source
v-yes-1 Yamaguchi sarcoma viral oncogene homolog 130360.0700.1837No
29MINK1MINK1
Entrez,  Source
misshapen-like kinase 1 (zebrafish)30800.0690.1864No
30KDRKDR
Entrez,  Source
kinase insert domain receptor (a type III receptor tyrosine kinase)31460.0680.1874No
31FLT3FLT3
Entrez,  Source
fms-related tyrosine kinase 334030.0630.1732No
32BLKBLK
Entrez,  Source
B lymphoid tyrosine kinase34190.0620.1775No
33CSF1RCSF1R
Entrez,  Source
colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog34540.0620.1804No
34CSNK1A1CSNK1A1
Entrez,  Source
casein kinase 1, alpha 136980.0580.1668No
35MARK2MARK2
Entrez,  Source
MAP/microtubule affinity-regulating kinase 238340.0550.1613No
36ALKALK
Entrez,  Source
anaplastic lymphoma kinase (Ki-1)40730.0510.1475No
37MUSKMUSK
Entrez,  Source
muscle, skeletal, receptor tyrosine kinase41390.0500.1469No
38FGRFGR
Entrez,  Source
Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog41930.0490.1472No
39AURKCAURKC
Entrez,  Source
aurora kinase C44130.0460.1344No
40CAMK1GCAMK1G
Entrez,  Source
calcium/calmodulin-dependent protein kinase IG45030.0450.1316No
41HUNKHUNK
Entrez,  Source
hormonally upregulated Neu-associated kinase46450.0430.1245No
42PHKG2PHKG2
Entrez,  Source
phosphorylase kinase, gamma 2 (testis)47920.0400.1168No
43FLT1FLT1
Entrez,  Source
fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)48820.0390.1135No
44FLT4FLT4
Entrez,  Source
fms-related tyrosine kinase 448980.0390.1157No
45ULK1ULK1
Entrez,  Source
unc-51-like kinase 1 (C. elegans)51570.0350.0990No
46MAST1MAST1
Entrez,  Source
microtubule associated serine/threonine kinase 154360.0320.0805No
47STK24STK24
Entrez,  Source
serine/threonine kinase 24 (STE20 homolog, yeast)55870.0290.0716No
48STK16STK16
Entrez,  Source
serine/threonine kinase 1657780.0270.0594No
49SRPK3SRPK3
Entrez,  Source
SFRS protein kinase 358600.0260.0555No
50MAP3K3MAP3K3
Entrez,  Source
mitogen-activated protein kinase kinase kinase 359210.0250.0530No
51NTRK1NTRK1
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 160970.0220.0416No
52IRAK1IRAK1
Entrez,  Source
interleukin-1 receptor-associated kinase 161790.0210.0372No
53PHKG1PHKG1
Entrez,  Source
phosphorylase kinase, gamma 1 (muscle)62450.0200.0339No
54CSNK1G2CSNK1G2
Entrez,  Source
casein kinase 1, gamma 263280.0180.0293No
55RETRET
Entrez,  Source
ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease)64710.0160.0198No
56PIP4K2B65940.0150.0118No
57GRK4GRK4
Entrez,  Source
G protein-coupled receptor kinase 467880.012-0.0020No
58CLK4CLK4
Entrez,  Source
CDC-like kinase 469350.010-0.0123No
59BMP2KBMP2K
Entrez,  Source
BMP2 inducible kinase70290.008-0.0187No
60CLK2CLK2
Entrez,  Source
CDC-like kinase 271810.005-0.0298No
61IKBKEIKBKE
Entrez,  Source
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon72160.004-0.0320No
62ITKITK
Entrez,  Source
IL2-inducible T-cell kinase72200.004-0.0319No
63PRKAA2PRKAA2
Entrez,  Source
protein kinase, AMP-activated, alpha 2 catalytic subunit74180.001-0.0469No
64SIK274350.001-0.0480No
65CSNK1ECSNK1E
Entrez,  Source
casein kinase 1, epsilon7742-0.004-0.0711No
66PDGFRBPDGFRB
Entrez,  Source
platelet-derived growth factor receptor, beta polypeptide7824-0.006-0.0767No
67MAP2K1MAP2K1
Entrez,  Source
mitogen-activated protein kinase kinase 17939-0.008-0.0848No
68MELKMELK
Entrez,  Source
maternal embryonic leucine zipper kinase8047-0.010-0.0921No
69KITKIT
Entrez,  Source
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog8134-0.012-0.0977No
70RPS6KA4RPS6KA4
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 48181-0.013-0.1001No
71MAP2K5MAP2K5
Entrez,  Source
mitogen-activated protein kinase kinase 58199-0.013-0.1002No
72CDK168353-0.016-0.1105No
73NTRK3NTRK3
Entrez,  Source
neurotrophic tyrosine kinase, receptor, type 38500-0.019-0.1200No
74STK25STK25
Entrez,  Source
serine/threonine kinase 25 (STE20 homolog, yeast)8561-0.021-0.1228No
75CSNK1G1CSNK1G1
Entrez,  Source
casein kinase 1, gamma 18732-0.025-0.1336No
76AURKBAURKB
Entrez,  Source
aurora kinase B8856-0.027-0.1406No
77IRAK4IRAK4
Entrez,  Source
interleukin-1 receptor-associated kinase 48996-0.031-0.1486No
78STK11STK11
Entrez,  Source
serine/threonine kinase 119183-0.035-0.1598No
79TYK2TYK2
Entrez,  Source
tyrosine kinase 29438-0.041-0.1757No
80PAK3PAK3
Entrez,  Source
p21 (CDKN1A)-activated kinase 39490-0.042-0.1759No
81CSNK2A2CSNK2A2
Entrez,  Source
casein kinase 2, alpha prime polypeptide9758-0.049-0.1920No
82HIPK3HIPK3
Entrez,  Source
homeodomain interacting protein kinase 39770-0.050-0.1885No
83DCLK19840-0.052-0.1892No
84MAP4K4MAP4K4
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 49922-0.055-0.1907No
85TTKTTK
Entrez,  Source
TTK protein kinase9930-0.055-0.1864No
86STK17ASTK17A
Entrez,  Source
serine/threonine kinase 17a (apoptosis-inducing)10017-0.057-0.1880No
87LATS1LATS1
Entrez,  Source
LATS, large tumor suppressor, homolog 1 (Drosophila)10025-0.057-0.1835No
88CHEK2CHEK2
Entrez,  Source
CHK2 checkpoint homolog (S. pombe)10102-0.059-0.1841No
89HIPK2HIPK2
Entrez,  Source
homeodomain interacting protein kinase 210151-0.061-0.1825No
90DYRK1ADYRK1A
Entrez,  Source
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A10303-0.066-0.1883No
91CITCIT
Entrez,  Source
citron (rho-interacting, serine/threonine kinase 21)10420-0.070-0.1910No
92PLK4PLK4
Entrez,  Source
polo-like kinase 4 (Drosophila)10581-0.075-0.1967No
93JAK1JAK1
Entrez,  Source
Janus kinase 1 (a protein tyrosine kinase)10585-0.076-0.1903No
94RPS6KB1RPS6KB1
Entrez,  Source
ribosomal protein S6 kinase, 70kDa, polypeptide 110717-0.081-0.1932No
95TBK1TBK1
Entrez,  Source
TANK-binding kinase 110732-0.082-0.1872No
96PIP5K1APIP5K1A
Entrez,  Source
phosphatidylinositol-4-phosphate 5-kinase, type I, alpha10780-0.083-0.1834No
97PRKAA1PRKAA1
Entrez,  Source
protein kinase, AMP-activated, alpha 1 catalytic subunit10906-0.089-0.1852No
98NUAK1NUAK1
Entrez,  Source
NUAK family, SNF1-like kinase, 111032-0.095-0.1865No
99DAPK3DAPK3
Entrez,  Source
death-associated protein kinase 311066-0.096-0.1806No
100CDK7CDK7
Entrez,  Source
cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase)11160-0.101-0.1789No
101STK10STK10
Entrez,  Source
serine/threonine kinase 1011218-0.103-0.1742No
102MYLKMYLK
Entrez,  Source
myosin, light chain kinase11255-0.105-0.1678No
103BMPR2BMPR2
Entrez,  Source
bone morphogenetic protein receptor, type II (serine/threonine kinase)11345-0.109-0.1650No
104FERFER
Entrez,  Source
fer (fps/fes related) tyrosine kinase (phosphoprotein NCP94)11371-0.111-0.1573No
105SRPK2SRPK2
Entrez,  Source
SFRS protein kinase 211496-0.117-0.1565No
106STK4STK4
Entrez,  Source
serine/threonine kinase 411518-0.118-0.1478No
107TLK2TLK2
Entrez,  Source
tousled-like kinase 211621-0.124-0.1447No
108SLKSLK
Entrez,  Source
STE20-like kinase (yeast)11672-0.128-0.1374No
109MAP4K5MAP4K5
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 511705-0.130-0.1285No
110HIPK1HIPK1
Entrez,  Source
homeodomain interacting protein kinase 111798-0.135-0.1236No
111MAP2K2MAP2K2
Entrez,  Source
mitogen-activated protein kinase kinase 211895-0.142-0.1186No
112ROCK2ROCK2
Entrez,  Source
Rho-associated, coiled-coil containing protein kinase 212033-0.152-0.1158No
113MAP3K2MAP3K2
Entrez,  Source
mitogen-activated protein kinase kinase kinase 212210-0.168-0.1145No
114PDGFRAPDGFRA
Entrez,  Source
platelet-derived growth factor receptor, alpha polypeptide12211-0.168-0.0998No
115MAP3K12MAP3K12
Entrez,  Source
mitogen-activated protein kinase kinase kinase 1212384-0.186-0.0967No
116MAP4K3MAP4K3
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 312403-0.189-0.0815No
117ABL1ABL1
Entrez,  Source
v-abl Abelson murine leukemia viral oncogene homolog 112463-0.197-0.0688No
118CSNK1G3CSNK1G3
Entrez,  Source
casein kinase 1, gamma 312464-0.197-0.0515No
119RIOK2RIOK2
Entrez,  Source
RIO kinase 2 (yeast)12467-0.198-0.0343No
120TLK1TLK1
Entrez,  Source
tousled-like kinase 112558-0.210-0.0228No
121MAP3K7MAP3K7
Entrez,  Source
mitogen-activated protein kinase kinase kinase 712613-0.221-0.0076No
122AXLAXL
Entrez,  Source
AXL receptor tyrosine kinase12789-0.2570.0015No
123CHUKCHUK
Entrez,  Source
conserved helix-loop-helix ubiquitous kinase12978-0.3250.0156No
Table: GSEA details [plain text format]



Fig 2: SU-14813_KINOME SCAN   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: SU-14813_KINOME SCAN: Random ES distribution   
Gene set null distribution of ES for SU-14813_KINOME SCAN